JP2009518415A5 - - Google Patents
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- Publication number
- JP2009518415A5 JP2009518415A5 JP2008544453A JP2008544453A JP2009518415A5 JP 2009518415 A5 JP2009518415 A5 JP 2009518415A5 JP 2008544453 A JP2008544453 A JP 2008544453A JP 2008544453 A JP2008544453 A JP 2008544453A JP 2009518415 A5 JP2009518415 A5 JP 2009518415A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- solvate
- composition according
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74257805P | 2005-12-05 | 2005-12-05 | |
| US76497906P | 2006-02-03 | 2006-02-03 | |
| US81784706P | 2006-06-30 | 2006-06-30 | |
| PCT/US2006/046449 WO2007067570A1 (en) | 2005-12-05 | 2006-12-05 | Methods and compositions for the treatment of disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518415A JP2009518415A (ja) | 2009-05-07 |
| JP2009518415A5 true JP2009518415A5 (enExample) | 2011-01-27 |
Family
ID=37877059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544453A Withdrawn JP2009518415A (ja) | 2005-12-05 | 2006-12-05 | 疾患の処置のための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090018136A1 (enExample) |
| EP (1) | EP1965803A1 (enExample) |
| JP (1) | JP2009518415A (enExample) |
| AU (1) | AU2006321942A1 (enExample) |
| CA (1) | CA2631740A1 (enExample) |
| WO (1) | WO2007067570A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006055511A2 (en) | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
| KR101002490B1 (ko) * | 2007-06-09 | 2010-12-17 | 동아제약주식회사 | 유데나필을 유효성분으로 함유하는 만성 심부전증 치료용약학적 조성물 |
| ES2524026T3 (es) | 2008-01-03 | 2014-12-03 | Biomarin Pharmaceutical Inc. | Análogo de pterina para tratar una afección que responde a BH4 |
| WO2009138437A1 (en) * | 2008-05-13 | 2009-11-19 | Genmedica Therapeutics Sl | Salicylate conjugates useful for treating metabolic disorders |
| US20100239552A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Combination Therapies for Treating Metabolic Disorders |
| US8575217B2 (en) * | 2009-03-16 | 2013-11-05 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| CA3130908A1 (en) | 2009-06-30 | 2010-12-30 | Mallinckrodt Hospital Products IP Limited | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| WO2011019399A1 (en) * | 2009-08-13 | 2011-02-17 | Medstar Health Research Institute, Inc. | Preservation of blood vessels using phosphodiesterase inhibitors |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| MX2015000810A (es) * | 2012-07-19 | 2015-06-05 | Relypsa Inc | Composiciones que comprenden polímeros reticulados con enlace a cationes. |
| US20150013695A1 (en) * | 2013-07-10 | 2015-01-15 | Ahkeo Ventures LLC | Inhalable compositions comprising caffeine, methods of use and an apparatus for using the same |
| CN104530054B (zh) * | 2014-12-19 | 2018-01-19 | 扬子江药业集团有限公司 | 盐酸优克那非的多晶型物及其制备方法 |
| JP7553906B2 (ja) * | 2018-11-01 | 2024-09-19 | 宏 一瀬 | Sprをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物 |
| WO2021009091A1 (en) * | 2019-07-15 | 2021-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and treating cardiac dysfunction |
| WO2022173818A1 (en) * | 2021-02-09 | 2022-08-18 | University Of Virginia Patent Foundation | Use of biliverdin reductase b inhibitors to allow malaria eradication in patients with g6pd deficiency |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2601215A (en) * | 1948-03-17 | 1952-06-17 | American Cyanamid Co | Process of preparing dihydropterins |
| US3505329A (en) * | 1968-02-06 | 1970-04-07 | Smithkline Corp | Process for the synthesis of biopterin |
| JPS5883691A (ja) * | 1981-11-13 | 1983-05-19 | Kanegafuchi Chem Ind Co Ltd | 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法 |
| JPS5925323A (ja) * | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| ZA836957B (en) * | 1982-09-20 | 1985-04-24 | Wellcome Found | Neurologically active chemical compounds |
| GB8318833D0 (en) * | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
| US5196533A (en) * | 1983-04-11 | 1993-03-23 | South Alabama Medical Science Foundation, Usa | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines |
| US4587340A (en) * | 1983-09-19 | 1986-05-06 | Burroughs Wellcome Co. | Biopterin analogs |
| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
| JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法 |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| DE3437944A1 (de) * | 1984-10-17 | 1986-07-31 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verwendung von pterinen zur steigerung der aktivitaet von lymphokinen und anderen blutfaktoren, sowie ein diagnostisches oder therapeutisches praeparat, das pterine in kombination mit lymphokinen enthaelt |
| CA1262347A (en) * | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
| JPS61277618A (ja) * | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
| EP0318926B1 (en) * | 1987-11-30 | 1995-05-03 | Kabushiki Kaisha Vitamin Kenkyusyo | Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives |
| JP2534423B2 (ja) * | 1991-12-26 | 1996-09-18 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤 |
| US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
| DE4308739C1 (de) * | 1993-03-19 | 1994-06-23 | Henning Berlin Gmbh | Pterinderivate, ihre Herstellung und ihre Verwendung |
| US5945452A (en) * | 1993-06-11 | 1999-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity |
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| US5753656A (en) * | 1994-08-05 | 1998-05-19 | Suntory Limited | Method for treating spinocerebellar degeneration |
| US20020076782A1 (en) * | 1996-07-05 | 2002-06-20 | John P.N. Rosazza | Purified nitric oxide synthase |
| GB9617990D0 (en) * | 1996-08-29 | 1996-10-09 | Scotia Holdings Plc | Treatment of pain |
| US5922713A (en) * | 1997-06-26 | 1999-07-13 | Werner; Ernst | Inhibition of nitric oxide synthase |
| JP4306825B2 (ja) * | 1998-02-27 | 2009-08-05 | アスビオファーマ株式会社 | インスリン抵抗性が関与する血管機能異常を伴う疾患の予防または治療剤 |
| US6200758B1 (en) * | 1999-02-19 | 2001-03-13 | New York State Office Of Mental Health | Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders |
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| WO2000056328A1 (en) * | 1999-03-19 | 2000-09-28 | Enos Pharmaceuticals, Inc. | Increasing cerebral bioavailability of drugs |
| GB2355191A (en) * | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
| SE0000307D0 (sv) * | 2000-01-31 | 2000-01-31 | Univ Zuerich | Method and formulation för treatment of vasoconstriction |
| US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
| US20050119270A1 (en) * | 2000-08-04 | 2005-06-02 | Mason R. P. | Synergistic effect of amlodipine and atorvastatin on aortic endothelial cell nitric oxide release |
| US20030007961A1 (en) * | 2001-06-22 | 2003-01-09 | Wilburn Michael D. | Orthomolecular vitamin E derivatives |
| US20030078231A1 (en) * | 2001-06-22 | 2003-04-24 | Wilburn Michael D. | Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties |
| US6685458B2 (en) * | 2001-10-11 | 2004-02-03 | Acushnet Company | Split metal die assembly with injection cycle monitor |
| WO2005018620A2 (en) * | 2003-08-26 | 2005-03-03 | Cell Center Cologne Gmbh | Use of nitric oxide synthase (nos) cofactor for the treatment of sexual dysfunction |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| JP2008523090A (ja) * | 2004-12-08 | 2008-07-03 | バイオマリン ファーマシューティカル インコーポレイテッド | 新生児肺高血圧症の治療のための方法および組成物 |
| TW200719896A (en) * | 2005-04-18 | 2007-06-01 | Astrazeneca Ab | Combination product |
| WO2006120176A2 (en) * | 2005-05-11 | 2006-11-16 | Nycomed Gmbh | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
-
2006
- 2006-12-05 AU AU2006321942A patent/AU2006321942A1/en not_active Abandoned
- 2006-12-05 EP EP06839043A patent/EP1965803A1/en not_active Ceased
- 2006-12-05 CA CA002631740A patent/CA2631740A1/en not_active Abandoned
- 2006-12-05 JP JP2008544453A patent/JP2009518415A/ja not_active Withdrawn
- 2006-12-05 WO PCT/US2006/046449 patent/WO2007067570A1/en not_active Ceased
-
2008
- 2008-06-05 US US12/134,023 patent/US20090018136A1/en not_active Abandoned
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