CA2607331A1 - Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative - Google Patents
Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative Download PDFInfo
- Publication number
- CA2607331A1 CA2607331A1 CA002607331A CA2607331A CA2607331A1 CA 2607331 A1 CA2607331 A1 CA 2607331A1 CA 002607331 A CA002607331 A CA 002607331A CA 2607331 A CA2607331 A CA 2607331A CA 2607331 A1 CA2607331 A1 CA 2607331A1
- Authority
- CA
- Canada
- Prior art keywords
- roflumilast
- acceptable salt
- combination product
- amount
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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- Veterinary Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103938.6 | 2005-05-11 | ||
| EP05103938 | 2005-05-11 | ||
| PCT/EP2006/062117 WO2006120176A2 (en) | 2005-05-11 | 2006-05-08 | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
Publications (1)
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| CA2607331A1 true CA2607331A1 (en) | 2006-11-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA002607331A Abandoned CA2607331A1 (en) | 2005-05-11 | 2006-05-08 | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
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| EP (1) | EP1940392A2 (enExample) |
| JP (1) | JP2008540486A (enExample) |
| KR (1) | KR20080005601A (enExample) |
| CN (1) | CN101171005A (enExample) |
| AU (1) | AU2006245770A1 (enExample) |
| BR (1) | BRPI0612796A2 (enExample) |
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| EA (1) | EA200702358A1 (enExample) |
| IL (1) | IL186804A0 (enExample) |
| MX (1) | MX2007013766A (enExample) |
| NO (1) | NO20076206L (enExample) |
| WO (1) | WO2006120176A2 (enExample) |
| ZA (1) | ZA200708776B (enExample) |
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| CA2631740A1 (en) * | 2005-12-05 | 2007-06-14 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
| US20100009997A1 (en) * | 2007-01-12 | 2010-01-14 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug |
| PT2215092E (pt) | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| US20110144117A1 (en) * | 2008-08-12 | 2011-06-16 | Orpha Swiss Gmbh | Pharmaceutical Dosage Form Containing Tetrahydrobiopterin |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| EP2401256B1 (de) | 2009-02-26 | 2013-04-17 | Boehringer Ingelheim International GmbH | Verbindungen als Bradykinin-B1-Antagonisten |
| WO2010097373A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
| WO2010097374A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
| MX2012009224A (es) | 2010-02-23 | 2012-08-23 | Boehringer Ingelheim Int | Compuestos en calidad de antagonistas de bradiquinina-b1. |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| CN102274222B (zh) * | 2011-08-18 | 2013-04-10 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特药物组合物及其制备方法 |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
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| WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
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| US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
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| US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
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| US9573927B2 (en) | 2012-05-10 | 2017-02-21 | Cellix Bio Private Limited | Compositions and methods for the treatment of severe pain |
| WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
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| US9499526B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
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|---|---|---|---|---|
| US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| US5830461A (en) * | 1992-11-25 | 1998-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for promoting wound healing and treating transplant-associated vasculopathy |
| HU220041B (hu) * | 1993-07-02 | 2001-10-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Fluor-alkoxi-helyettesített benzamidszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyászati készítmények |
| DE4418097A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
| DE69725721T3 (de) * | 1996-08-30 | 2007-10-31 | Daiichi Asubio Pharma Co., Ltd. | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind |
| SE0000307D0 (sv) * | 2000-01-31 | 2000-01-31 | Univ Zuerich | Method and formulation för treatment of vasoconstriction |
| US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
| BRPI0416105A (pt) * | 2003-10-31 | 2007-01-02 | Altana Pharma Ag | uso da bh4 para o tratamento de doença respiratórias |
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- 2006-05-08 EP EP06755065A patent/EP1940392A2/en not_active Withdrawn
- 2006-05-08 EA EA200702358A patent/EA200702358A1/ru unknown
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- 2006-05-08 WO PCT/EP2006/062117 patent/WO2006120176A2/en not_active Ceased
- 2006-05-08 JP JP2008510556A patent/JP2008540486A/ja not_active Withdrawn
- 2006-05-08 KR KR1020077028279A patent/KR20080005601A/ko not_active Withdrawn
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| ZA200708776B (en) | 2008-10-29 |
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| IL186804A0 (en) | 2008-06-05 |
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| US20080221111A1 (en) | 2008-09-11 |
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| AU2006245770A1 (en) | 2006-11-16 |
| MX2007013766A (es) | 2008-01-28 |
| BRPI0612796A2 (pt) | 2010-11-30 |
| CN101171005A (zh) | 2008-04-30 |
| EA200702358A1 (ru) | 2008-04-28 |
| JP2008540486A (ja) | 2008-11-20 |
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