JP2008540333A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008540333A5 JP2008540333A5 JP2008508218A JP2008508218A JP2008540333A5 JP 2008540333 A5 JP2008540333 A5 JP 2008540333A5 JP 2008508218 A JP2008508218 A JP 2008508218A JP 2008508218 A JP2008508218 A JP 2008508218A JP 2008540333 A5 JP2008540333 A5 JP 2008540333A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- halogen
- cycloalkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- PXACTUVBBMDKRW-UHFFFAOYSA-M 4-bromobenzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=C(Br)C=C1 PXACTUVBBMDKRW-UHFFFAOYSA-M 0.000 claims 1
- -1 COOR 7.1 Inorganic materials 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05009556.1 | 2005-04-30 | ||
| EP05009556 | 2005-04-30 | ||
| PCT/EP2006/061839 WO2006117314A2 (en) | 2005-04-30 | 2006-04-26 | Novel piperidin- substituted indoles and their use as ccr-3 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540333A JP2008540333A (ja) | 2008-11-20 |
| JP2008540333A5 true JP2008540333A5 (enExample) | 2012-07-05 |
| JP5080450B2 JP5080450B2 (ja) | 2012-11-21 |
Family
ID=36809076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508218A Expired - Fee Related JP5080450B2 (ja) | 2005-04-30 | 2006-04-26 | 新規なピペリジン置換インドール |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7759365B2 (enExample) |
| EP (1) | EP1994019B1 (enExample) |
| JP (1) | JP5080450B2 (enExample) |
| AR (1) | AR054266A1 (enExample) |
| AT (1) | ATE531706T1 (enExample) |
| CA (1) | CA2606550C (enExample) |
| TW (1) | TW200716597A (enExample) |
| WO (1) | WO2006117314A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06004626A (es) * | 2003-11-17 | 2006-06-27 | Boehringer Ingelheim Int | Indoles sustituidos con piperidina o sus heteroderivados y su uso como moduladores del receptor de quemocina (ccr3). |
| ATE537166T1 (de) * | 2006-10-27 | 2011-12-15 | Boehringer Ingelheim Int | Piperidylpropanthiole als ccr3-modulatoren |
| WO2008049875A1 (en) * | 2006-10-27 | 2008-05-02 | Boehringer Ingelheim International Gmbh | Novel substituted piperidyl-propane-thiols |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| EP3188730B1 (en) | 2014-09-05 | 2019-05-01 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| US10568876B2 (en) | 2014-09-05 | 2020-02-25 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 |
| WO2016036638A1 (en) | 2014-09-05 | 2016-03-10 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| RU2019117556A (ru) | 2016-11-18 | 2020-12-18 | Мерк Шарп И Доум Корп. | Индазольные производные, пригодные в качестве ингибиторов диацилглицерид o-ацилтрансферазы 2 |
| CN109963561A (zh) | 2016-11-18 | 2019-07-02 | 默沙东公司 | 可用作二酰基甘油酯o-酰基转移酶2的抑制剂的吲哚衍生物 |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359468A (en) * | 1981-02-25 | 1982-11-16 | Boehringer Ingelheim Ltd. | Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones |
| FR2533924A1 (fr) * | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant |
| US5322851A (en) * | 1990-07-02 | 1994-06-21 | H. Lundbeck A/S | Indole derivatives |
| DK36391D0 (da) * | 1991-03-01 | 1991-03-01 | Lundbeck & Co As H | Anvendelse af piperidylsubstituerede indolderivater til behandling af stofmisbrug |
| US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5521197A (en) | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト，インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| US5962473A (en) | 1996-08-16 | 1999-10-05 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F |
| AU4074897A (en) | 1996-09-18 | 1998-04-14 | Eli Lilly And Company | A method for the prevention of migraine |
| AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| YU47600A (sh) | 1998-01-27 | 2002-09-19 | Aventis Pharmaceuticals Products Inc. | SUPSTITUISANI OKSOAZAHETEROCIKLIL INHIBITORI FAKTORA Xa |
| DE69908330T2 (de) * | 1998-03-09 | 2004-02-12 | H. Lundbeck A/S | 5-heteroaryl-substituierte indole |
| EP1067130A4 (en) * | 1998-12-04 | 2004-02-11 | Toray Industries | TRIAZOLO DERIVATIVES, AND CHIMIOKIN INHIBITORS CONTAINING THESE DERIVATIVES AS ACTIVE INGREDIENT |
| ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| AU5567000A (en) * | 1999-06-24 | 2001-01-09 | Toray Industries, Inc. | Alpha1b-adrenergic receptor antagonists |
| EP1242072A4 (en) | 1999-12-17 | 2004-02-04 | Bristol Myers Squibb Co | ANTIPSYCHOTIC HETEROCYCLIC COMPOUNDS |
| MXPA02012927A (es) | 2000-07-21 | 2003-05-15 | Lundbeck & Co As H | Derivados de indol utiles para el tratamiento de padecimientos del sistema nervioso central. |
| HK1052705B (en) * | 2000-08-14 | 2006-09-29 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazole |
| GB0107907D0 (en) * | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
| AU2002351733A1 (en) * | 2001-12-19 | 2003-06-30 | H. Lundbeck A/S | 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives |
| CA2477074A1 (en) * | 2002-02-22 | 2003-08-28 | H. Lundbeck A/S | 5-heteroaryl substituted indoles |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| AU2003284984B2 (en) * | 2002-10-30 | 2008-10-23 | Merck Sharp & Dohme Corp. | Gamma-aminoamide modulators of chemokine receptor activity |
| DE602004003965T2 (de) | 2003-08-25 | 2007-04-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Halogenalkyl- und piperidinsubstituierte benzimidazolderivate |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| MXPA06004626A (es) * | 2003-11-17 | 2006-06-27 | Boehringer Ingelheim Int | Indoles sustituidos con piperidina o sus heteroderivados y su uso como moduladores del receptor de quemocina (ccr3). |
-
2006
- 2006-04-26 WO PCT/EP2006/061839 patent/WO2006117314A2/en not_active Ceased
- 2006-04-26 US US11/380,232 patent/US7759365B2/en active Active
- 2006-04-26 JP JP2008508218A patent/JP5080450B2/ja not_active Expired - Fee Related
- 2006-04-26 CA CA2606550A patent/CA2606550C/en not_active Expired - Fee Related
- 2006-04-26 AT AT06743381T patent/ATE531706T1/de active
- 2006-04-26 EP EP06743381A patent/EP1994019B1/en not_active Expired - Lifetime
- 2006-04-28 TW TW095115409A patent/TW200716597A/zh unknown
- 2006-04-28 AR AR20060101713A patent/AR054266A1/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025037925A5 (enExample) | ||
| JP2010535722A5 (enExample) | ||
| EP4473980A3 (en) | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of psma-expressing cancers | |
| JP2017119663A5 (enExample) | ||
| ATE556058T1 (de) | 1-(2h)-isochinolonderivat | |
| JP2007508359A5 (enExample) | ||
| JP2008510828A5 (enExample) | ||
| RU2014140735A (ru) | ПРОИЗВОДНЫЕ ПИРАЗОЛО[1, 5-a]ПИРИМИДИНА, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| JP2013531029A5 (enExample) | ||
| JP2014525420A5 (enExample) | ||
| RU2007103815A (ru) | Производное тиенопиразола, имеющее ингибирующую фосфодиэстеразу 7(pde 7) активность | |
| JP2011500539A5 (enExample) | ||
| JP2017508789A5 (enExample) | ||
| EA200601830A1 (ru) | Ортозамещённые арильные или гетероарильные амидные соединения | |
| TW200738682A (en) | Isoquinoline derivatives | |
| CY1114932T1 (el) | Αντιπαρασιτικοι παραγοντες | |
| MX2010008101A (es) | Derivados de indol 2-carboxamidas y de azaindol 2-carboxamidas sustituidos con un silanilo, su preparacion y su aplicacion en terapeutica. | |
| TN2009000081A1 (en) | 2-ARYL-6-PHENYLIMIDAZO[1,2- α ] PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | |
| JP2011046700A5 (enExample) | ||
| RU2008139192A (ru) | N-формилгидроксиламины | |
| JP2015522650A5 (enExample) | ||
| NO20070457L (no) | Pyrazolderivater | |
| JP2010520851A5 (enExample) | ||
| RU2020102453A (ru) | Фармацевтические композиции | |
| JP2009539912A5 (enExample) |