JP5080450B2 - 新規なピペリジン置換インドール - Google Patents

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Publication number

JP5080450B2

JP5080450B2 JP2008508218A JP2008508218A JP5080450B2 JP 5080450 B2 JP5080450 B2 JP 5080450B2 JP 2008508218 A JP2008508218 A JP 2008508218A JP 2008508218 A JP2008508218 A JP 2008508218A JP 5080450 B2 JP5080450 B2 JP 5080450B2

Authority

JP

Japan

Prior art keywords

alkyl

amino

acid

chloro

phenyl

Prior art date

2005-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 150000002475 indoles Chemical class 0.000 title description 4
• 125000003386 piperidinyl group Chemical group 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims description 89
• -1 COOR 7.1 Inorganic materials 0.000 claims description 84
• 150000003839 salts Chemical class 0.000 claims description 38
• 125000003118 aryl group Chemical group 0.000 claims description 35
• 125000001424 substituent group Chemical group 0.000 claims description 29
• 150000002367 halogens Chemical class 0.000 claims description 27
• 229910052736 halogen Inorganic materials 0.000 claims description 26
• 125000000217 alkyl group Chemical group 0.000 claims description 22
• 229910052739 hydrogen Inorganic materials 0.000 claims description 20
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 19
• 229910052799 carbon Inorganic materials 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 15
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 14
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 10
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
• 229910052757 nitrogen Inorganic materials 0.000 claims description 10
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• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 3
• ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 3
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