JP2008536875A - ビス（チオヒドラジド）アミド化合物による併用癌療法 - Google Patents

ビス（チオヒドラジド）アミド化合物による併用癌療法 Download PDF

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JP2008536875A
JP2008536875A JP2008506821A JP2008506821A JP2008536875A JP 2008536875 A JP2008536875 A JP 2008536875A JP 2008506821 A JP2008506821 A JP 2008506821A JP 2008506821 A JP2008506821 A JP 2008506821A JP 2008536875 A JP2008536875 A JP 2008536875A
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methyl
bis
optionally substituted
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taxane
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JP2008536875A5 (https=
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トーマス エー． ダール
マシュー マクレオド
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シンタ ファーマシューティカルズ コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008506821A 2005-04-15 2006-04-13 ビス（チオヒドラジド）アミド化合物による併用癌療法 Pending JP2008536875A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67213905P 2005-04-15 2005-04-15
PCT/US2006/014531 WO2006113695A1 (en) 2005-04-15 2006-04-13 Combination cancer therapy with bis(thiohydrazide) amide compounds

Publications (2)

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JP2008536875A true JP2008536875A (ja) 2008-09-11
JP2008536875A5 JP2008536875A5 (https=) 2009-05-28

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JP2008506821A Pending JP2008536875A (ja) 2005-04-15 2006-04-13 ビス（チオヒドラジド）アミド化合物による併用癌療法

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US (2) US8017654B2 (https=)
EP (1) EP1877048A1 (https=)
JP (1) JP2008536875A (https=)
AU (1) AU2006236378B2 (https=)
BR (1) BRPI0610219A2 (https=)
CA (1) CA2604907A1 (https=)
IL (1) IL186662A (https=)
MX (1) MX2007012688A (https=)
NZ (1) NZ562572A (https=)
WO (1) WO2006113695A1 (https=)
ZA (1) ZA200708703B (https=)

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JP2014524038A (ja) * 2011-03-07 2014-09-18 マスクレス・リソグラフィー・インコーポレーテッド 様々な材料および材料流れのための位置合わせシステム

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CN1993318B (zh) 2004-06-23 2012-10-03 Synta医药公司 用于治疗癌症的双（硫代-酰肼酰胺）盐
JP5204489B2 (ja) 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
WO2006113493A2 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
KR20080008399A (ko) 2005-05-16 2008-01-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 염의 합성 방법
KR20080035642A (ko) * 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
TWI440632B (zh) 2006-08-21 2014-06-11 Synta Pharmaceuticals Corp 用於治療增生性疾病的化合物
EP2061451A2 (en) * 2006-08-21 2009-05-27 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for treating melanoma
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
JP2010502616A (ja) 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
AU2007294969A1 (en) * 2006-09-11 2008-03-20 Synta Pharmaceuticals Corp. Bis (thiohydrazide amides) formulation
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
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CN102256937B (zh) 2008-10-22 2014-12-17 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
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JP5631327B2 (ja) 2008-12-01 2014-11-26 シンタ ファーマシューティカルズ コーポレーション 増殖性障害を治療するための化合物
US8822532B2 (en) 2009-12-04 2014-09-02 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
EP2560627A1 (en) 2010-04-20 2013-02-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers
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US20150057357A1 (en) 2012-01-05 2015-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bis (thiohydrazide amide) compounds for treating cancers

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JPN6012028829; 古江尚: 癌と化学療法 Ｖｏｌ．２６，　Ｎｏ．５, 1999, ｐ．５８９-５９６ *
JPN6012028831; 藤本幹夫: 日本化学療法学会雑誌 Ｖｏｌ．５２，　ｓｕｐｐｌｅｍｅｎｔ-Ｂ, 2004, ｐ．９１ *
JPN6012028834; 伊藤良則: 癌の臨床 Ｖｏｌ．４６，　Ｎｏ．５, 2000, ｐ．７２５-７３１ *
JPN6012028836; 堀越昇: 日本臨床 Ｖｏｌ．６１，　Ｎｏ．６, 2003, ｐ．１０２１-１０２４ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524038A (ja) * 2011-03-07 2014-09-18 マスクレス・リソグラフィー・インコーポレーテッド 様々な材料および材料流れのための位置合わせシステム

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