JP2008536875A5 - - Google Patents
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- Publication number
- JP2008536875A5 JP2008536875A5 JP2008506821A JP2008506821A JP2008536875A5 JP 2008536875 A5 JP2008536875 A5 JP 2008536875A5 JP 2008506821 A JP2008506821 A JP 2008506821A JP 2008506821 A JP2008506821 A JP 2008506821A JP 2008536875 A5 JP2008536875 A5 JP 2008536875A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pharmaceutical composition
- bis
- optionally substituted
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 53
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 150000001408 amides Chemical class 0.000 claims 14
- -1 2,5-dimethoxyphenyl Chemical group 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 claims 7
- 229940123237 Taxane Drugs 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 5
- 208000021039 metastatic melanoma Diseases 0.000 claims 5
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical group [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 3
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical class [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims 2
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000001847 2-phenylcyclopropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
- 0 CC=C*=C(C)C(N(C)NCC(CC(NN(C)C(c1ccccc1)=S)=O)=O)=S Chemical compound CC=C*=C(C)C(N(C)NCC(CC(NN(C)C(c1ccccc1)=S)=O)=O)=S 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67213905P | 2005-04-15 | 2005-04-15 | |
| PCT/US2006/014531 WO2006113695A1 (en) | 2005-04-15 | 2006-04-13 | Combination cancer therapy with bis(thiohydrazide) amide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536875A JP2008536875A (ja) | 2008-09-11 |
| JP2008536875A5 true JP2008536875A5 (https=) | 2009-05-28 |
Family
ID=36694110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506821A Pending JP2008536875A (ja) | 2005-04-15 | 2006-04-13 | ビス（チオヒドラジド）アミド化合物による併用癌療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8017654B2 (https=) |
| EP (1) | EP1877048A1 (https=) |
| JP (1) | JP2008536875A (https=) |
| AU (1) | AU2006236378B2 (https=) |
| BR (1) | BRPI0610219A2 (https=) |
| CA (1) | CA2604907A1 (https=) |
| IL (1) | IL186662A (https=) |
| MX (1) | MX2007012688A (https=) |
| NZ (1) | NZ562572A (https=) |
| WO (1) | WO2006113695A1 (https=) |
| ZA (1) | ZA200708703B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| PL1781604T3 (pl) | 2004-06-23 | 2014-01-31 | Synta Pharmaceuticals Corp | Sole bis(tiohydrazydoamidu) do leczenia nowotworów |
| AU2005306471B2 (en) | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| WO2006113493A2 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| MX2007012688A (es) | 2005-04-15 | 2008-03-14 | Synta Pharmaceuticals Corp | Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. |
| US7709683B2 (en) | 2005-05-16 | 2010-05-04 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
| US7678832B2 (en) * | 2005-08-16 | 2010-03-16 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
| EP2063878A2 (en) * | 2006-08-21 | 2009-06-03 | Synta Pharmaceuticals Corporation | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| WO2008024299A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| RU2475478C2 (ru) | 2006-08-21 | 2013-02-20 | Синта Фармасьютиклз Корп. | Соединения для лечения пролиферативных расстройств |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| JP2010502616A (ja) * | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US20080118562A1 (en) * | 2006-09-11 | 2008-05-22 | Keizo Koya | Bis(thiohydrazide amides) formulation |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US8482732B2 (en) * | 2007-10-01 | 2013-07-09 | Maskless Lithography, Inc. | Alignment system for various materials and material flows |
| WO2009064374A2 (en) | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| NZ592400A (en) | 2008-10-22 | 2013-09-27 | Synta Pharmaceuticals Corp | Transition metal complexes of bis[thiohydrazide amide] compounds |
| MX2011004114A (es) | 2008-10-22 | 2011-08-15 | Synta Pharmaceuticals Corp | Complejos de metales de transicion de un compuesto bis (tiohidrazida amida). |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| EP2370402A2 (en) | 2008-12-01 | 2011-10-05 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| JP2014534238A (ja) * | 2011-11-10 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与 |
| WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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| JP2010502616A (ja) | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US20080118562A1 (en) | 2006-09-11 | 2008-05-22 | Keizo Koya | Bis(thiohydrazide amides) formulation |
| JP2010503674A (ja) | 2006-09-14 | 2010-02-04 | シンタ ファーマシューティカルズ コーポレーション | 血管形成治療用化合物 |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| EA200970483A1 (ru) * | 2006-11-14 | 2009-12-30 | Ксенопорт, Инк. | Применение пролекарств габапентина и прегабалина для лечения шума в ушах |
| US20090093538A1 (en) | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| US8093425B2 (en) | 2007-04-30 | 2012-01-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2009064374A2 (en) | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| TW200940050A (en) | 2007-11-28 | 2009-10-01 | Synta Pharmaceuticals Corp | Polymorphs of N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide) |
| US8637704B2 (en) | 2007-11-28 | 2014-01-28 | Synta Pharmaceuticals Corp. | Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide) |
-
2006
- 2006-04-13 MX MX2007012688A patent/MX2007012688A/es active IP Right Grant
- 2006-04-13 US US11/918,357 patent/US8017654B2/en not_active Expired - Fee Related
- 2006-04-13 AU AU2006236378A patent/AU2006236378B2/en not_active Ceased
- 2006-04-13 JP JP2008506821A patent/JP2008536875A/ja active Pending
- 2006-04-13 EP EP06750538A patent/EP1877048A1/en not_active Withdrawn
- 2006-04-13 CA CA002604907A patent/CA2604907A1/en not_active Abandoned
- 2006-04-13 NZ NZ562572A patent/NZ562572A/en not_active IP Right Cessation
- 2006-04-13 BR BRPI0610219-0A patent/BRPI0610219A2/pt not_active IP Right Cessation
- 2006-04-13 WO PCT/US2006/014531 patent/WO2006113695A1/en not_active Ceased
-
2007
- 2007-10-11 ZA ZA200708703A patent/ZA200708703B/xx unknown
- 2007-10-15 IL IL186662A patent/IL186662A/en not_active IP Right Cessation
-
2011
- 2011-09-12 US US13/230,315 patent/US20120232134A1/en not_active Abandoned
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