JP2008533195A5 - - Google Patents
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- Publication number
- JP2008533195A5 JP2008533195A5 JP2008502641A JP2008502641A JP2008533195A5 JP 2008533195 A5 JP2008533195 A5 JP 2008533195A5 JP 2008502641 A JP2008502641 A JP 2008502641A JP 2008502641 A JP2008502641 A JP 2008502641A JP 2008533195 A5 JP2008533195 A5 JP 2008533195A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- prostaglandin
- compound
- prostaglandin compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 22
- -1 prostaglandin compound Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 206010009887 colitis Diseases 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000004682 mucosal barrier function Effects 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000025467 Gastrointestinal mucosal disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000006994 Precancerous Conditions Diseases 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 206010073360 Appendix cancer Diseases 0.000 claims 1
- 208000023514 Barrett esophagus Diseases 0.000 claims 1
- 208000023665 Barrett oesophagus Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 1
- 206010009895 Colitis ischaemic Diseases 0.000 claims 1
- 206010056979 Colitis microscopic Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000014997 Crohn colitis Diseases 0.000 claims 1
- 206010061825 Duodenal neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 206010036783 Proctitis ulcerative Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010054184 Small intestine carcinoma Diseases 0.000 claims 1
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 208000021780 appendiceal neoplasm Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 208000014793 distal colitis Diseases 0.000 claims 1
- 208000007784 diverticulitis Diseases 0.000 claims 1
- 201000000312 duodenum cancer Diseases 0.000 claims 1
- 208000010227 enterocolitis Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 201000008254 ileocolitis Diseases 0.000 claims 1
- 201000008222 ischemic colitis Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000004341 lymphocytic colitis Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000002471 spleen cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66320005P | 2005-03-21 | 2005-03-21 | |
| US60/663,200 | 2005-03-21 | ||
| US67992005P | 2005-05-11 | 2005-05-11 | |
| US60/679,920 | 2005-05-11 | ||
| US72197605P | 2005-09-30 | 2005-09-30 | |
| US60/721,976 | 2005-09-30 | ||
| PCT/JP2006/306380 WO2006101244A2 (en) | 2005-03-21 | 2006-03-22 | Method and composition for treating mucosal disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144537A Division JP5777574B2 (ja) | 2005-03-21 | 2012-06-27 | 粘膜障害の処置のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008533195A JP2008533195A (ja) | 2008-08-21 |
| JP2008533195A5 true JP2008533195A5 (enExample) | 2009-05-07 |
| JP5219797B2 JP5219797B2 (ja) | 2013-06-26 |
Family
ID=36754577
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502641A Expired - Fee Related JP5219797B2 (ja) | 2005-03-21 | 2006-03-22 | 粘膜障害の処置のための方法および組成物 |
| JP2012144537A Active JP5777574B2 (ja) | 2005-03-21 | 2012-06-27 | 粘膜障害の処置のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144537A Active JP5777574B2 (ja) | 2005-03-21 | 2012-06-27 | 粘膜障害の処置のための方法および組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060281818A1 (enExample) |
| EP (3) | EP1861169B1 (enExample) |
| JP (2) | JP5219797B2 (enExample) |
| KR (2) | KR20140072102A (enExample) |
| CN (1) | CN103948603A (enExample) |
| AU (1) | AU2006225515B2 (enExample) |
| BR (1) | BRPI0609672A2 (enExample) |
| CA (2) | CA2601158C (enExample) |
| ES (1) | ES2592283T3 (enExample) |
| IL (1) | IL185861A (enExample) |
| MX (1) | MX2007011645A (enExample) |
| NO (1) | NO20075361L (enExample) |
| NZ (3) | NZ562351A (enExample) |
| WO (1) | WO2006101244A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4705782B2 (ja) * | 2002-10-23 | 2011-06-22 | スキャンポ・アーゲー | 肥満の処置のためのプロスタグランジン化合物 |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| EP2059247A1 (en) * | 2006-09-06 | 2009-05-20 | Sucampo AG | Method and composition for promoting gastrointestinal bicarbonate secretion |
| JP2011500853A (ja) | 2007-10-25 | 2011-01-06 | ファィトシューティカ， インコーポレイテッド | 炎症性腸疾患および／または過敏性腸管症候群に対する処置としてのｐｈｙ９０６の使用 |
| US8871752B2 (en) | 2008-02-19 | 2014-10-28 | Sucampo Ag | Method for modulating stem cell growth |
| MX2011012595A (es) * | 2009-05-27 | 2011-12-16 | Univ Osaka | Composicion farmaceutica que comprende el uso de derivados de prostaglandina para modular las funciones mediadas por claudina y el tratamiento de trastornos dermatologicos. |
| US8569279B2 (en) | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
| US9084815B2 (en) * | 2009-09-16 | 2015-07-21 | Sucampo Ag | Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor |
| KR20140043075A (ko) * | 2011-04-19 | 2014-04-08 | 수캄포 아게 | 사이토카인 활성의 조절 방법 |
| EP2701709A4 (en) * | 2011-04-27 | 2014-10-15 | Sucampo Ag | METHOD FOR MODULATING ION TRANSPORTERS |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US20150099802A1 (en) * | 2013-10-03 | 2015-04-09 | Sucampo Ag | Selective tumor treatment |
| US20160120840A1 (en) * | 2014-10-30 | 2016-05-05 | Sucampo Ag | Method and composition for treating nonerosive reflux disease |
| AU2016257315A1 (en) * | 2015-05-06 | 2017-11-23 | Université Catholique de Louvain | Use of a polypeptide for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status |
| WO2024217532A1 (zh) * | 2023-04-20 | 2024-10-24 | 中南大学湘雅二医院 | Carboprost在制备抗肿瘤药物中的应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2645710C2 (de) * | 1976-10-09 | 1985-06-27 | Merck Patent Gmbh, 6100 Darmstadt | Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung |
| GB1581886A (en) * | 1977-05-26 | 1980-12-31 | May & Baker Ltd | Prostanol derivatives |
| JPS58216155A (ja) * | 1982-06-10 | 1983-12-15 | Ono Pharmaceut Co Ltd | 新規なプロスタグランジンｄ類似化合物 |
| JPS591463A (ja) * | 1982-06-28 | 1984-01-06 | Ono Pharmaceut Co Ltd | 新規なプロスタグランジンｄ類似化合物 |
| FR2608924B1 (fr) * | 1986-12-29 | 1990-07-20 | Pasteur Institut | Compositions therapeutiques contenant des derives soufres de prostaglandines, nouveaux derives soufres et leur procede de preparation |
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| CA1323364C (en) * | 1987-01-28 | 1993-10-19 | Ryuzo Ueno | Prostaglandins e and anti ulcer agents containing same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5380709A (en) | 1987-01-28 | 1995-01-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5225439A (en) | 1987-01-28 | 1993-07-06 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5221763A (en) | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| US5317032A (en) | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| JP2579193B2 (ja) * | 1988-07-19 | 1997-02-05 | 小野薬品工業株式会社 | １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体 |
| CA2030345C (en) * | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
| TW249226B (enExample) | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| CA2046069C (en) * | 1990-07-10 | 2002-04-09 | Ryuji Ueno | Treatment of inflammatory diseases with 15-keto-prostaglandin compounds |
| US5234858A (en) | 1990-11-16 | 1993-08-10 | Micron Technology, Inc. | Stacked surrounding wall capacitor |
| KR940007277B1 (ko) | 1992-02-14 | 1994-08-12 | 한국과학기술원 | 2차 전지 전극용 수소 저장 합금 |
| US5376034A (en) | 1992-05-27 | 1994-12-27 | Brunswick Corporation | Marine drive exhaust system |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| JP3183615B2 (ja) * | 1994-06-03 | 2001-07-09 | 株式会社アールテック・ウエノ | 肝・胆道系疾患処置剤 |
| US6558708B1 (en) * | 1995-05-17 | 2003-05-06 | Cedars-Sinai Medical Center | Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
| CN102126998B (zh) | 1996-06-10 | 2013-06-12 | 苏坎波公司 | 内皮素拮抗剂 |
| US5876034A (en) | 1997-12-17 | 1999-03-02 | Stafford; James R. | Sporting fishing board game |
| US6492417B1 (en) * | 1997-12-22 | 2002-12-10 | Alcon Manufacturing, Ltd. | 11-deoxy-16-fluoro-PGF2α analogs as FP receptor antagonists |
| US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US6414016B1 (en) | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
| US6919082B2 (en) * | 2001-02-13 | 2005-07-19 | Kirin Beer Kabushiki Kaisha | Pharmacological composition containing yeast cell wall fraction |
| GB2375349A (en) * | 2001-02-13 | 2002-11-13 | Glaxo Group Ltd | Chloride intracellular channel-related proteins |
| GB0111497D0 (en) * | 2001-05-11 | 2001-07-04 | Medical Res Council | Therapeutic methods |
| WO2003030912A1 (en) | 2001-08-31 | 2003-04-17 | Sucampo Ag | Prostaglandin analogs as chloride channel opener |
| TWI331920B (en) | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
| TWI263505B (en) | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| JP4889219B2 (ja) | 2002-12-27 | 2012-03-07 | スキャンポ・アーゲー | 腹部不快感の処置のためのプロスタグランジン誘導体 |
| US7855226B2 (en) * | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US7169807B2 (en) * | 2004-04-09 | 2007-01-30 | Allergan, Inc. | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists |
| WO2006047476A2 (en) * | 2004-10-26 | 2006-05-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
-
2006
- 2006-03-21 US US11/384,491 patent/US20060281818A1/en not_active Abandoned
- 2006-03-22 JP JP2008502641A patent/JP5219797B2/ja not_active Expired - Fee Related
- 2006-03-22 EP EP06730328.9A patent/EP1861169B1/en not_active Not-in-force
- 2006-03-22 MX MX2007011645A patent/MX2007011645A/es active IP Right Grant
- 2006-03-22 KR KR1020147010206A patent/KR20140072102A/ko not_active Ceased
- 2006-03-22 BR BRPI0609672-7A patent/BRPI0609672A2/pt active Search and Examination
- 2006-03-22 WO PCT/JP2006/306380 patent/WO2006101244A2/en not_active Ceased
- 2006-03-22 KR KR1020077024144A patent/KR101456298B1/ko not_active Expired - Fee Related
- 2006-03-22 AU AU2006225515A patent/AU2006225515B2/en not_active Ceased
- 2006-03-22 EP EP11170921A patent/EP2384790A3/en not_active Withdrawn
- 2006-03-22 EP EP11170933.3A patent/EP2384791B1/en not_active Not-in-force
- 2006-03-22 NZ NZ562351A patent/NZ562351A/en not_active IP Right Cessation
- 2006-03-22 ES ES11170933.3T patent/ES2592283T3/es active Active
- 2006-03-22 CA CA2601158A patent/CA2601158C/en not_active Expired - Fee Related
- 2006-03-22 NZ NZ597857A patent/NZ597857A/xx not_active IP Right Cessation
- 2006-03-22 CN CN201410192607.4A patent/CN103948603A/zh active Pending
- 2006-03-22 CA CA2831416A patent/CA2831416C/en not_active Expired - Fee Related
- 2006-03-22 NZ NZ588878A patent/NZ588878A/en not_active IP Right Cessation
-
2007
- 2007-09-10 IL IL185861A patent/IL185861A/en not_active IP Right Cessation
- 2007-10-19 NO NO20075361A patent/NO20075361L/no not_active Application Discontinuation
-
2012
- 2012-06-27 JP JP2012144537A patent/JP5777574B2/ja active Active
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