JP2019504899A5 - - Google Patents
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- Publication number
- JP2019504899A5 JP2019504899A5 JP2018561294A JP2018561294A JP2019504899A5 JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5 JP 2018561294 A JP2018561294 A JP 2018561294A JP 2018561294 A JP2018561294 A JP 2018561294A JP 2019504899 A5 JP2019504899 A5 JP 2019504899A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- halogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 Chemical compound **c1c(*)[n](CC(F)=CCN)c2c(*)c(*)nnc12 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016900478 | 2016-02-12 | ||
| AU2016900478A AU2016900478A0 (en) | 2016-02-12 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| AU2016902593 | 2016-07-01 | ||
| AU2016902593A AU2016902593A0 (en) | 2016-07-01 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| PCT/AU2017/000040 WO2017136871A1 (en) | 2016-02-12 | 2017-02-10 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504899A JP2019504899A (ja) | 2019-02-21 |
| JP2019504899A5 true JP2019504899A5 (enExample) | 2020-03-26 |
| JP6849197B2 JP6849197B2 (ja) | 2021-03-24 |
Family
ID=59562850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561294A Expired - Fee Related JP6849197B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561293A Active JP6843888B2 (ja) | 2016-02-12 | 2017-02-10 | リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10717734B2 (enExample) |
| EP (2) | EP3414226A4 (enExample) |
| JP (2) | JP6849197B2 (enExample) |
| KR (2) | KR102742235B1 (enExample) |
| CN (2) | CN109153642B (enExample) |
| AU (2) | AU2017217239A1 (enExample) |
| BR (2) | BR112018067442A8 (enExample) |
| CA (2) | CA3013850C (enExample) |
| CO (2) | CO2018009071A2 (enExample) |
| EA (2) | EA037302B9 (enExample) |
| IL (2) | IL261118A (enExample) |
| MX (1) | MX388745B (enExample) |
| PH (2) | PH12018501685A1 (enExample) |
| SG (2) | SG11201806727TA (enExample) |
| TW (2) | TW201738206A (enExample) |
| WO (2) | WO2017136870A1 (enExample) |
| ZA (2) | ZA201805664B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017136870A1 (en) | 2016-02-12 | 2017-08-17 | Pharmaxis Ltd. | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof |
| JP2020508996A (ja) * | 2017-03-02 | 2020-03-26 | ファーマクシス リミテッド | リシルオキシダーゼのハロアリルアミンピラゾール誘導体阻害剤およびその使用 |
| GB201716871D0 (en) | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
| CN110605143B (zh) * | 2017-10-27 | 2022-07-19 | 苏州大学 | 有机铁盐作为催化剂在合成烷基硼酯化合物中的应用 |
| AR117398A1 (es) | 2018-03-12 | 2021-08-04 | Abbvie Inc | Inhibidores de la señalización mediada por tirosina cinasa 2 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| MX2021001347A (es) * | 2018-08-03 | 2021-04-13 | Pharmaxis Ltd | Inhibidores derivados de haloalilamina sulfona de lisil oxidasas y sus usos. |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| TWI835945B (zh) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| US20200225249A1 (en) * | 2019-01-11 | 2020-07-16 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| CA3145738A1 (en) * | 2019-07-25 | 2021-01-28 | Pharmaxis Ltd. | Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof |
| US20220340561A1 (en) | 2019-07-29 | 2022-10-27 | Heparegenix Gmbh | Heteroaryl-substituted pyrazolo-pyridine protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| JP7639008B2 (ja) | 2020-01-15 | 2025-03-04 | ヘパリジェニックス ゲーエムベーハー | 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤 |
| US12578335B2 (en) | 2020-02-05 | 2026-03-17 | Syntara Limited | Bioprobes for lysyl oxidases and uses thereof |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| WO2021261601A1 (ja) | 2020-06-26 | 2021-12-30 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
| JP7384138B2 (ja) * | 2020-09-30 | 2023-11-21 | 株式会社島津製作所 | 電気泳動装置 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| AU2022357057A1 (en) * | 2021-10-01 | 2024-04-11 | Yuhan Corporation | Bicyclic fused ring derivative or salt thereof and pharmaceutical composition comprising same |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| JP2026503063A (ja) * | 2023-01-09 | 2026-01-27 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | Ｐｐａｒｇモジュレーター |
| CN117069611A (zh) * | 2023-07-12 | 2023-11-17 | 浙江工业大学 | 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法 |
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| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4454158A (en) | 1981-06-01 | 1984-06-12 | Merrell Toraude Et Compagnie | Allyl amine MAO inhibitors |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4699928A (en) | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) * | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) * | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| WO2004018997A2 (en) | 2002-08-20 | 2004-03-04 | Neurogenetics, Inc. | Methods and compositions for modulating amyloid beta |
| US9161922B2 (en) | 2005-07-01 | 2015-10-20 | Case Western Reserve University | Amine oxidase inhibitors |
| EP2004166A2 (en) | 2006-03-31 | 2008-12-24 | La Jolla Pharmaceutical Company | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases |
| US20080293936A1 (en) | 2007-05-23 | 2008-11-27 | Elmar Reinhold Burchardt | Novel inhibitors of lysyl oxidase |
| AU2014200520A1 (en) | 2007-08-02 | 2014-02-20 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
| ES2402334T3 (es) * | 2007-08-02 | 2013-04-30 | Gilead Biologics, Inc | Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis |
| AU2008323694A1 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| JP2011504485A (ja) * | 2007-11-21 | 2011-02-10 | ファーマクシス リミテッド | Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途 |
| WO2010111060A1 (en) * | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| WO2011022670A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| US8841463B2 (en) * | 2011-02-11 | 2014-09-23 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin C inhibitors |
| PT2844637T (pt) * | 2012-05-02 | 2018-04-17 | Boehringer Ingelheim Int | Inibidores de 3-haloalilamina substituídos de ssao e as suas utilizações |
| CN106879256B (zh) * | 2014-07-31 | 2021-08-03 | 韩国巴斯德研究所 | 2-氨基-苯并咪唑衍生物及其作为5-脂氧合酶和/或前列腺素e合成酶抑制剂的应用 |
| WO2017136870A1 (en) | 2016-02-12 | 2017-08-17 | Pharmaxis Ltd. | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof |
-
2017
- 2017-02-10 WO PCT/AU2017/000039 patent/WO2017136870A1/en not_active Ceased
- 2017-02-10 US US16/076,985 patent/US10717734B2/en active Active
- 2017-02-10 KR KR1020187024805A patent/KR102742235B1/ko active Active
- 2017-02-10 KR KR1020187024804A patent/KR20180119582A/ko not_active Withdrawn
- 2017-02-10 CN CN201780019653.6A patent/CN109153642B/zh not_active Expired - Fee Related
- 2017-02-10 JP JP2018561294A patent/JP6849197B2/ja not_active Expired - Fee Related
- 2017-02-10 CN CN201780019641.3A patent/CN109071533B/zh active Active
- 2017-02-10 JP JP2018561293A patent/JP6843888B2/ja active Active
- 2017-02-10 BR BR112018067442A patent/BR112018067442A8/pt not_active Application Discontinuation
- 2017-02-10 CA CA3013850A patent/CA3013850C/en active Active
- 2017-02-10 EP EP17749813.6A patent/EP3414226A4/en not_active Withdrawn
- 2017-02-10 AU AU2017217239A patent/AU2017217239A1/en not_active Abandoned
- 2017-02-10 EA EA201891676A patent/EA037302B9/ru unknown
- 2017-02-10 EA EA201891674A patent/EA201891674A1/ru unknown
- 2017-02-10 SG SG11201806727TA patent/SG11201806727TA/en unknown
- 2017-02-10 MX MX2018009645A patent/MX388745B/es unknown
- 2017-02-10 BR BR112018016484-4A patent/BR112018016484B1/pt active IP Right Grant
- 2017-02-10 AU AU2017217238A patent/AU2017217238B2/en active Active
- 2017-02-10 SG SG11201806700RA patent/SG11201806700RA/en unknown
- 2017-02-10 CA CA3013819A patent/CA3013819A1/en not_active Abandoned
- 2017-02-10 EP EP17749812.8A patent/EP3414244A4/en active Pending
- 2017-02-10 WO PCT/AU2017/000040 patent/WO2017136871A1/en not_active Ceased
- 2017-02-10 US US16/076,979 patent/US10717733B2/en active Active
- 2017-02-13 TW TW106104664A patent/TW201738206A/zh unknown
- 2017-02-13 TW TW106104662A patent/TW201739454A/zh unknown
-
2018
- 2018-08-07 PH PH12018501685A patent/PH12018501685A1/en unknown
- 2018-08-07 PH PH12018501686A patent/PH12018501686A1/en unknown
- 2018-08-12 IL IL261118A patent/IL261118A/en unknown
- 2018-08-12 IL IL261119A patent/IL261119B/en unknown
- 2018-08-24 ZA ZA2018/05664A patent/ZA201805664B/en unknown
- 2018-08-24 ZA ZA2018/05675A patent/ZA201805675B/en unknown
- 2018-08-28 CO CONC2018/0009071A patent/CO2018009071A2/es unknown
- 2018-08-28 CO CONC2018/0009068A patent/CO2018009068A2/es unknown
-
2020
- 2020-06-11 US US16/899,116 patent/US11098045B2/en active Active