BR112017001918A2 - derivados de 2-amino-benzimidazol e seu uso como inibidores de 5-lipoxigenase e/ou prostaglandina e sintase - Google Patents

derivados de 2-amino-benzimidazol e seu uso como inibidores de 5-lipoxigenase e/ou prostaglandina e sintase

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Publication number
BR112017001918A2
BR112017001918A2 BR112017001918A BR112017001918A BR112017001918A2 BR 112017001918 A2 BR112017001918 A2 BR 112017001918A2 BR 112017001918 A BR112017001918 A BR 112017001918A BR 112017001918 A BR112017001918 A BR 112017001918A BR 112017001918 A2 BR112017001918 A2 BR 112017001918A2
Authority
BR
Brazil
Prior art keywords
group
benzimidazole derivatives
lipoxygenase
amino
nr7r8
Prior art date
Application number
BR112017001918A
Other languages
English (en)
Inventor
Park Dongsik
Lee Doohyung
Choi Gahee
Kim Jaeseung
Seo Jeongjea
Kim Jeongjun
Ahn Jiye
Hwan Kim Jung
Nam Kiyean
Seo Minjung
Seo Mooyoung
Yeon Lee Sae
Lee Sangchul
Ahn Seohyun
Han Sung-Jun
Kang Sunhee
Jeon Yeejin
Yang Young-In
Lee Yunmi
Original Assignee
Pasteur Institut Korea
Qurient Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut Korea, Qurient Co Ltd filed Critical Pasteur Institut Korea
Publication of BR112017001918A2 publication Critical patent/BR112017001918A2/pt

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

a presente invenção refere-se derivados de benzimidazol tendo a fórmula geral i, em que n é 0 ou 1; x1 e x2 são independentemente, em cada ocorrência, cr5 ou n; y é c1-c6 alquileno, em que alquileno é opcionalmente substituído com um ou dois grupos c1-c3 alquila; r1 é selecionado do grupo consistindo em hidrogênio, halogênio, c1-c6 alcóxi, -nh2, -nhr6, -nr7r8 e ?nh-(r9)n-r10, n sendo 0 ou 1; r2 é selecionado do grupo consistindo em hidrogênio, halogênio, c1-c6 alquila, -nh2, -nhr6, -nr7r8 e ?nh-(r9)n-r10, r3 é selecionado do grupo consistindo em hidrogênio, hidroxila, or11, -nr7r8, c1-c6 alcóxi, c1-c6 alquila, c3-c10 cicloalquila, c1-c3 haloalquila, -c(o)nhr11, arila, heteroarila e heterociclila, em que cada uma das ditas cicloalquila, arila, heteroarila e heterociclila é opcionalmente e independentemente substituída com um a quatro grupos ra; e r4 é selecionado do grupo consistindo em ?nh2, -n(r12)(v)pr13, -nh(v)p-or14, -nhc(o)r15, e grupos de fórmula ia mostrados abaixo, e seu uso no tratamento de doenças, em particular doenças inflamatórias, câncer, acidente vascular cerebral e/ou doença de alzheimer.
BR112017001918A 2014-07-31 2015-07-31 derivados de 2-amino-benzimidazol e seu uso como inibidores de 5-lipoxigenase e/ou prostaglandina e sintase BR112017001918A2 (pt)

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10717733B2 (en) * 2016-02-12 2020-07-21 Pharmaxis Ltd. Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
GB201617630D0 (en) 2016-10-18 2016-11-30 Cellcentric Ltd Pharmaceutical compounds
CN107141282B (zh) * 2017-03-29 2019-11-05 重庆文理学院 一种苯并咪唑杂氮环丁酮衍生物及其在抗肿瘤药物中的应用
CN111417394B (zh) 2017-10-19 2023-11-07 帝人制药株式会社 苯并咪唑衍生物及其用途
GB201806320D0 (en) 2018-04-18 2018-05-30 Cellcentric Ltd Process
WO2020039088A2 (en) * 2018-08-24 2020-02-27 Xeniopro GmbH Novel compounds
TW202102492A (zh) * 2019-03-15 2021-01-16 日商日本曹達股份有限公司 雜環化合物及農園藝用殺菌劑
EP4081199A4 (en) * 2019-12-23 2024-01-17 SRI International LIPOXYGENASE INHIBITORS
EP4367112A1 (en) 2021-07-09 2024-05-15 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
DE2730720C2 (de) * 1977-07-07 1979-07-12 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von praktisch reinem l-Amino-8-nitro-43dihydroxy-anthrachinon
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
JPH06759B2 (ja) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
PA8535601A1 (es) * 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
CA2465978C (en) * 2001-09-14 2015-04-07 Soon Hyung Woo Inhibitors of histone deacetylase
EP1434579B1 (en) * 2001-10-09 2011-06-08 Amgen Inc. Imidazole derivatives as antiinflammatory agents
MXPA04008458A (es) 2002-03-01 2004-12-06 Smithkline Beecham Corp Diamino pirimidinas y su uso como inhibidores de angiogenesis.
EP1388341A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US20040117213A1 (en) * 2002-11-27 2004-06-17 Pache Eugene P. System and method for selective and detailed delivery of information over a network
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
MXPA05010859A (es) * 2003-04-11 2005-12-14 Smithkline Beecham Corp Antagonistas mchr1 heterociclicos.
DE10349587A1 (de) 2003-10-24 2005-05-25 Merck Patent Gmbh Benzimidazolylderivate
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
EP1735319B1 (en) 2004-03-26 2017-05-03 MethylGene Inc. Inhibitors of histone deacetylase
CN101489553A (zh) * 2006-07-03 2009-07-22 神经研究公司 单胺再摄取抑制剂和钾通道激活剂的组合
WO2008003766A2 (en) 2006-07-06 2008-01-10 Boehringer Ingelheim International Gmbh 4-heter0cycl0alkylpyri(mi)dines, process for the preparation thereof and their use as medicaments
JP5758074B2 (ja) 2006-09-29 2015-08-05 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド 目のアレルギーの処置に使用される方法および眼用装置
TW201030001A (en) * 2008-11-14 2010-08-16 Amgen Inc Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
CN101955483A (zh) * 2009-07-13 2011-01-26 上海药明康德新药开发有限公司 2-取代[1,2,4]三唑[1,5-a]苯并咪唑的合成方法
JP2013526546A (ja) * 2010-05-13 2013-06-24 アムジエン・インコーポレーテツド Ｐｄｅ１０阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物
US8546344B2 (en) * 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8466186B2 (en) * 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
CN103044337A (zh) * 2011-10-13 2013-04-17 南京理工大学 2-(n-烷基)氨基咪唑衍生物的合成方法
US10292390B2 (en) 2011-11-04 2019-05-21 Wisconsin Alumni Research Foundation Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives
CN103121969A (zh) * 2012-12-04 2013-05-29 中国科学院昆明植物研究所 苯并咪唑及其衍生物，其药物组合物及其应用
CN103450093A (zh) * 2013-09-06 2013-12-18 中国药科大学 2-苄氨基苯并咪唑类化合物及其用途

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