KR20180119582A - 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 - Google Patents

라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 Download PDF

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KR20180119582A
KR20180119582A KR1020187024804A KR20187024804A KR20180119582A KR 20180119582 A KR20180119582 A KR 20180119582A KR 1020187024804 A KR1020187024804 A KR 1020187024804A KR 20187024804 A KR20187024804 A KR 20187024804A KR 20180119582 A KR20180119582 A KR 20180119582A
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cycloalkyl
halogen
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앨리슨 도로시 핀드레이
크레이그 이반 터너
만다르 데오드하
조나단 스튜어트 풋
울프강 자로리맥
웬빈 조우
알란 던컨 로버트슨
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파맥시스 엘티디
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KR1020187024804A 2016-02-12 2017-02-10 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도 Withdrawn KR20180119582A (ko)

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Application Number Priority Date Filing Date Title
AU2016900478 2016-02-12
AU2016900478A AU2016900478A0 (en) 2016-02-12 Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
AU2016902593A AU2016902593A0 (en) 2016-07-01 Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
AU2016902593 2016-07-01
PCT/AU2017/000040 WO2017136871A1 (en) 2016-02-12 2017-02-10 Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof

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KR1020187024805A Active KR102742235B1 (ko) 2016-02-12 2017-02-10 라이실 옥시다제의 할로알릴아민 인돌 및 아자인돌 유도체 억제제 및 이의 용도

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180119582A (ko) 2016-02-12 2018-11-02 파맥시스 엘티디 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도
JP2020508996A (ja) * 2017-03-02 2020-03-26 ファーマクシス リミテッド リシルオキシダーゼのハロアリルアミンピラゾール誘導体阻害剤およびその使用
GB201716871D0 (en) 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds
CN110605143B (zh) * 2017-10-27 2022-07-19 苏州大学 有机铁盐作为催化剂在合成烷基硼酯化合物中的应用
AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
AU2019315330B2 (en) * 2018-08-03 2024-10-17 Syntara Limited Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof
TW202039486A (zh) 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
TWI835945B (zh) 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
WO2020146639A2 (en) * 2019-01-11 2020-07-16 Viscient Biosciences, Inc. Compositions and methods for the diagnosis and treatment of diseases of the liver
WO2020161209A1 (en) 2019-02-06 2020-08-13 Syngenta Crop Protection Ag Herbicidal fused pyridazine compounds
WO2020161208A1 (en) 2019-02-06 2020-08-13 Syngenta Crop Protection Ag Herbicidal fused pyridazine compounds
MX2022001031A (es) * 2019-07-25 2022-02-23 Pharmaxis Ltd Inhibidores derivados de difluorohaloalilamina-sulfona de lisil-oxidasas, metodos de preparacion y usos de los mismos.
CN114269745B (zh) 2019-07-29 2025-04-22 海帕瑞吉尼克斯股份有限公司 用于促进肝再生或减少或预防肝细胞死亡的杂芳基取代的吡唑并吡啶蛋白激酶抑制剂
ES2984974T3 (es) 2020-01-15 2024-10-31 Heparegenix Gmbh Derivados de 3-benzoil-1H-pirrolo[2,3-b]piridina como inhibidores de MKK4 para el tratamiento de hepatopatías
WO2021155439A1 (en) * 2020-02-05 2021-08-12 Pharmaxis Ltd. Bioprobes for lysyl oxidases and uses thereof
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
WO2021261601A1 (ja) 2020-06-26 2021-12-30 ラクオリア創薬株式会社 レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬
JP7384138B2 (ja) * 2020-09-30 2023-11-21 株式会社島津製作所 電気泳動装置
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
CA3233505A1 (en) * 2021-10-01 2023-04-06 Yuhan Corporation Bicyclic fused ring derivative or salt thereof and pharmaceutical composition comprising same
US12233056B2 (en) 2022-04-06 2025-02-25 Syntara Limited Lysyl oxidase inhibitors for treating myeloid malignancies
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
KR20250129803A (ko) * 2023-01-09 2025-08-29 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 Pparg 조정제
CN117069611A (zh) * 2023-07-12 2023-11-17 浙江工业大学 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4699928A (en) 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US5182297A (en) 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5021456A (en) 1988-02-25 1991-06-04 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4997854A (en) * 1989-08-25 1991-03-05 Trustees Of Boston University Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates
US9161922B2 (en) 2005-07-01 2015-10-20 Case Western Reserve University Amine oxidase inhibitors
EP2004166A2 (en) * 2006-03-31 2008-12-24 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
US20080293936A1 (en) * 2007-05-23 2008-11-27 Elmar Reinhold Burchardt Novel inhibitors of lysyl oxidase
AU2014200520A1 (en) 2007-08-02 2014-02-20 Gilead Biologics, Inc. Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
EP2185198B1 (en) 2007-08-02 2015-01-14 Gilead Biologics, Inc. Lox and l0xl2 inhibitors and uses thereof
EP2217239A2 (en) * 2007-11-07 2010-08-18 Foldrx Pharmaceuticals, Inc. Modulation of protein trafficking
CA2706465A1 (en) * 2007-11-21 2009-05-28 Pharmaxis Ltd. Haloallylamine inhibitors of ssao/vap-1 and uses therefor
ES2660892T3 (es) * 2009-03-23 2018-03-26 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
US20110044907A1 (en) 2009-08-21 2011-02-24 Derek Marshall In vivo screening assays
ES2583091T3 (es) 2011-02-11 2016-09-19 Glaxosmithkline Intellectual Property Development Limited Inhibidores de catepsina C
PT2844637T (pt) * 2012-05-02 2018-04-17 Boehringer Ingelheim Int Inibidores de 3-haloalilamina substituídos de ssao e as suas utilizações
AU2015295248B2 (en) * 2014-07-31 2019-05-16 Institut Pasteur Korea 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors
KR20180119582A (ko) 2016-02-12 2018-11-02 파맥시스 엘티디 라이실 옥시다제의 인돌 및 아자인돌 할로알릴아민 유도체 억제제 및 이의 용도

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