TW201739454A - 離胺醯氧化酶之吲哚及氮雜吲哚鹵化烯丙胺衍生物抑制劑及其用途 - Google Patents
離胺醯氧化酶之吲哚及氮雜吲哚鹵化烯丙胺衍生物抑制劑及其用途 Download PDFInfo
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Classifications
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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| AU2016902593A AU2016902593A0 (en) | 2016-07-01 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof |
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| TW106104664A TW201738206A (zh) | 2016-02-12 | 2017-02-13 | 離胺醯氧化酶之鹵化烯丙胺吲哚及氮雜吲哚衍生物抑制劑及其用途 |
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| BR112018067442A8 (pt) | 2016-02-12 | 2024-01-09 | Pharmaxis Ltd | Composto, composição farmacêutica, método de inibir a atividade da amina oxidase, método de tratar uma condição e uso de um composto |
| CN110709385A (zh) * | 2017-03-02 | 2020-01-17 | 法玛西斯有限公司 | 赖氨酰氧化酶的卤代烯丙胺吡唑衍生物抑制剂及其用途 |
| GB201716871D0 (en) | 2017-10-13 | 2017-11-29 | Inst Of Cancer Research: Royal Cancer Hospital | Compounds |
| CN107903281B (zh) * | 2017-10-27 | 2019-10-29 | 苏州大学 | 一种合成烷基硼酯化合物的方法 |
| AR117398A1 (es) | 2018-03-12 | 2021-08-04 | Abbvie Inc | Inhibidores de la señalización mediada por tirosina cinasa 2 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR102780601B1 (ko) | 2018-08-03 | 2025-03-12 | 파맥시스 엘티디 | 라이실 옥시다제의 할로알릴아민 설폰 유도체 저해제 및 이의 용도 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| TWI835945B (zh) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| WO2020146639A2 (en) * | 2019-01-11 | 2020-07-16 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| JP2022544031A (ja) * | 2019-07-25 | 2022-10-17 | ファーマクシス リミテッド | リシルオキシダーゼのジフルオロハロアリルアミンスルホン誘導体阻害剤、調製方法、及びそれらの使用 |
| KR102878355B1 (ko) | 2019-07-29 | 2025-10-28 | 헤파레게닉스 게엠베하 | 간 재생 촉진 또는 간세포 사멸 감소 또는 예방을 위한 헤테로아릴-치환된 피라졸로-피리딘 단백질 키나제 억제제 |
| ES2984974T3 (es) | 2020-01-15 | 2024-10-31 | Heparegenix Gmbh | Derivados de 3-benzoil-1H-pirrolo[2,3-b]piridina como inhibidores de MKK4 para el tratamiento de hepatopatías |
| WO2021155439A1 (en) * | 2020-02-05 | 2021-08-12 | Pharmaxis Ltd. | Bioprobes for lysyl oxidases and uses thereof |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| CA3184767A1 (en) | 2020-06-26 | 2021-12-30 | Raqualia Pharma Inc. | Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent |
| JP7384138B2 (ja) * | 2020-09-30 | 2023-11-21 | 株式会社島津製作所 | 電気泳動装置 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| WO2023055124A1 (ko) * | 2021-10-01 | 2023-04-06 | 주식회사유한양행 | 바이사이클릭 융합환 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| KR20250129803A (ko) * | 2023-01-09 | 2025-08-29 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | Pparg 조정제 |
| CN117069611A (zh) * | 2023-07-12 | 2023-11-17 | 浙江工业大学 | 一种1-(2,4,6-三氯苯基)丙-2-酮o-甲基肟的制备方法 |
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| US4997854A (en) * | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
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| WO2009066152A2 (en) * | 2007-11-21 | 2009-05-28 | Pharmaxis Ltd. | Haloallylamine inhibitors of ssao/vap-1 and uses therefor |
| EP2411001B1 (en) * | 2009-03-23 | 2018-01-17 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| US20110044907A1 (en) | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
| US8841463B2 (en) * | 2011-02-11 | 2014-09-23 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin C inhibitors |
| DK2844637T5 (en) * | 2012-05-02 | 2018-08-13 | Boehringer Ingelheim Int | SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS BY SSAO AND USES THEREOF |
| AU2015295248B2 (en) * | 2014-07-31 | 2019-05-16 | Institut Pasteur Korea | 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors |
| BR112018067442A8 (pt) | 2016-02-12 | 2024-01-09 | Pharmaxis Ltd | Composto, composição farmacêutica, método de inibir a atividade da amina oxidase, método de tratar uma condição e uso de um composto |
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2017
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- 2017-02-10 SG SG11201806700RA patent/SG11201806700RA/en unknown
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- 2017-02-10 JP JP2018561294A patent/JP6849197B2/ja not_active Expired - Fee Related
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- 2017-02-10 EA EA201891674A patent/EA201891674A1/ru unknown
- 2017-02-10 AU AU2017217239A patent/AU2017217239A1/en not_active Abandoned
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- 2017-02-13 TW TW106104662A patent/TW201739454A/zh unknown
- 2017-02-13 TW TW106104664A patent/TW201738206A/zh unknown
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2018
- 2018-08-07 PH PH12018501686A patent/PH12018501686A1/en unknown
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2020
- 2020-06-11 US US16/899,116 patent/US11098045B2/en active Active
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