JP2008532516A - 遺伝子破壊、組成物、およびそれに関連する方法 - Google Patents
遺伝子破壊、組成物、およびそれに関連する方法 Download PDFInfo
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- JP2008532516A JP2008532516A JP2008500763A JP2008500763A JP2008532516A JP 2008532516 A JP2008532516 A JP 2008532516A JP 2008500763 A JP2008500763 A JP 2008500763A JP 2008500763 A JP2008500763 A JP 2008500763A JP 2008532516 A JP2008532516 A JP 2008532516A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66117305P | 2005-03-11 | 2005-03-11 | |
| US74052205P | 2005-11-29 | 2005-11-29 | |
| PCT/US2006/007353 WO2006098887A2 (en) | 2005-03-11 | 2006-02-27 | Gene disruptions, compositions and methods relating thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009049942A Division JP2009168820A (ja) | 2005-03-11 | 2009-03-03 | 遺伝子破壊、組成物、およびそれに関連する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008532516A true JP2008532516A (ja) | 2008-08-21 |
| JP2008532516A5 JP2008532516A5 (https=) | 2009-04-23 |
Family
ID=36992194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500763A Pending JP2008532516A (ja) | 2005-03-11 | 2006-02-27 | 遺伝子破壊、組成物、およびそれに関連する方法 |
| JP2009049942A Pending JP2009168820A (ja) | 2005-03-11 | 2009-03-03 | 遺伝子破壊、組成物、およびそれに関連する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009049942A Pending JP2009168820A (ja) | 2005-03-11 | 2009-03-03 | 遺伝子破壊、組成物、およびそれに関連する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110097330A1 (https=) |
| EP (1) | EP1863340A2 (https=) |
| JP (2) | JP2008532516A (https=) |
| AU (1) | AU2006223579A1 (https=) |
| CA (1) | CA2601677A1 (https=) |
| WO (1) | WO2006098887A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503842A (ja) * | 2009-09-03 | 2013-02-04 | キャンサー リサーチ テクノロジー リミテッド | Clec14a阻害剤 |
| JP2019505216A (ja) * | 2016-02-04 | 2019-02-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 操作されたangptl8遺伝子を有する非ヒト動物 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| PT1781682E (pt) | 2004-06-24 | 2013-05-14 | Mayo Foundation | B7-h5, um polipéptido coestimulante |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
| US8231872B2 (en) * | 2005-04-25 | 2012-07-31 | The Trustees Of Dartmouth College | Regulatory T cell mediator proteins and uses thereof |
| WO2007067991A2 (en) | 2005-12-08 | 2007-06-14 | Medarex, Inc. | Human monoclonal antibodies to o8e |
| CA2663523A1 (en) * | 2006-11-14 | 2008-10-23 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| WO2009105709A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
| JP5602850B2 (ja) | 2009-07-14 | 2014-10-08 | ザ スクリプス リサーチ インスティテュート | 間葉幹細胞分化 |
| AU2012267492A1 (en) * | 2011-06-10 | 2014-01-09 | President And Fellows Of Harvard College | Modulation of pancreatic beta cell proliferation |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| WO2013033513A1 (en) | 2011-08-31 | 2013-03-07 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| JP6356614B2 (ja) | 2012-02-17 | 2018-07-11 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 薬剤のミトコンドリア輸送のためのナノ粒子 |
| MA38369B1 (fr) | 2013-03-08 | 2018-10-31 | Novartis Ag | Peptides et compositions pour le traitement d'une lesion de l'articulation |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| EP2968569A4 (en) | 2013-03-15 | 2016-11-02 | Argenta Mfg Ltd | COUGAR FORMULATION |
| US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| US10961305B2 (en) | 2016-12-21 | 2021-03-30 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
| BR112019022447A2 (pt) | 2017-04-27 | 2020-06-09 | Retinopathy Answer Limited | sistema e método para análise de imagem funduscópica automatizada |
| US11306144B2 (en) | 2017-08-25 | 2022-04-19 | Five Prime Therapeutics, Inc. | B7-H4 antibodies and methods of use thereof |
| BR112020016986A2 (pt) | 2018-02-21 | 2021-03-02 | Five Prime Therapeutics, Inc. | formulações de anticorpo contra b7-h4 |
| KR20200144094A (ko) | 2018-03-02 | 2020-12-28 | 파이브 프라임 테라퓨틱스, 인크. | B7-h4 항체 및 이의 사용 방법 |
| WO2019173283A1 (en) | 2018-03-05 | 2019-09-12 | Marquette University | Method and apparatus for non-invasive hemoglobin level prediction |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣3多肽之持續遞送 |
| EP3965740A1 (en) * | 2019-05-10 | 2022-03-16 | KetoSwiss AG | Ketone bodies enclosed in microbeads |
| US12559551B2 (en) | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518361A (ja) * | 1998-09-01 | 2003-06-10 | ジェネンテック・インコーポレーテッド | 更なるproポリペプチドとその配列 |
| JP2003525585A (ja) * | 1999-03-08 | 2003-09-02 | ジェネンテック・インコーポレーテッド | 腫瘍治療のための組成物及び方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030166132A1 (en) * | 1998-08-26 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| KR100553300B1 (ko) * | 1999-03-08 | 2006-02-20 | 제넨테크, 인크. | 혈관신생 및 심혈관형성의 촉진 또는 억제 방법 |
| AU6802801A (en) * | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2002040662A2 (en) * | 2000-11-15 | 2002-05-23 | Deltagen, Inc. | Transgenic mice containing targeted gene disruptions |
| AU2002239539A1 (en) * | 2000-12-06 | 2002-06-18 | Deltagen, Inc. | Transgenic mice containing targeted gene disruptions |
-
2006
- 2006-02-27 AU AU2006223579A patent/AU2006223579A1/en not_active Abandoned
- 2006-02-27 JP JP2008500763A patent/JP2008532516A/ja active Pending
- 2006-02-27 CA CA002601677A patent/CA2601677A1/en not_active Abandoned
- 2006-02-27 US US11/722,967 patent/US20110097330A1/en not_active Abandoned
- 2006-02-27 WO PCT/US2006/007353 patent/WO2006098887A2/en not_active Ceased
- 2006-02-27 EP EP06736637A patent/EP1863340A2/en not_active Withdrawn
-
2009
- 2009-03-03 JP JP2009049942A patent/JP2009168820A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003518361A (ja) * | 1998-09-01 | 2003-06-10 | ジェネンテック・インコーポレーテッド | 更なるproポリペプチドとその配列 |
| JP2003525585A (ja) * | 1999-03-08 | 2003-09-02 | ジェネンテック・インコーポレーテッド | 腫瘍治療のための組成物及び方法 |
| JP2003274978A (ja) * | 1999-03-08 | 2003-09-30 | Genentech Inc | 腫瘍治療のための組成物及び方法 |
| JP2003274980A (ja) * | 1999-03-08 | 2003-09-30 | Genentech Inc | 腫瘍治療のための組成物及び方法 |
| JP2003274977A (ja) * | 1999-03-08 | 2003-09-30 | Genentech Inc | 腫瘍治療のための組成物及び方法 |
| JP2003274979A (ja) * | 1999-03-08 | 2003-09-30 | Genentech Inc | 腫瘍治療のための組成物及び方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503842A (ja) * | 2009-09-03 | 2013-02-04 | キャンサー リサーチ テクノロジー リミテッド | Clec14a阻害剤 |
| JP2019505216A (ja) * | 2016-02-04 | 2019-02-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 操作されたangptl8遺伝子を有する非ヒト動物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1863340A2 (en) | 2007-12-12 |
| US20110097330A1 (en) | 2011-04-28 |
| WO2006098887A3 (en) | 2007-08-09 |
| CA2601677A1 (en) | 2006-09-21 |
| WO2006098887A2 (en) | 2006-09-21 |
| AU2006223579A1 (en) | 2006-09-21 |
| JP2009168820A (ja) | 2009-07-30 |
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