JP2008531721A - 複素環式アミド誘導体のナノ粒子状組成物 - Google Patents

複素環式アミド誘導体のナノ粒子状組成物 Download PDF

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Publication number
JP2008531721A
JP2008531721A JP2007558231A JP2007558231A JP2008531721A JP 2008531721 A JP2008531721 A JP 2008531721A JP 2007558231 A JP2007558231 A JP 2007558231A JP 2007558231 A JP2007558231 A JP 2007558231A JP 2008531721 A JP2008531721 A JP 2008531721A
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Prior art keywords
zafirlukast
chloride
composition
bromide
less
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Japanese (ja)
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JP2008531721A5 (enExample
Inventor
リバーシッジ，ギャリー
ジェンキンス，スコット
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エラン・ファルマ・インターナショナル・リミテッド
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Publication of JP2008531721A publication Critical patent/JP2008531721A/ja
Publication of JP2008531721A5 publication Critical patent/JP2008531721A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007558231A 2005-03-03 2006-03-02 複素環式アミド誘導体のナノ粒子状組成物 Pending JP2008531721A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65825905P 2005-03-03 2005-03-03
PCT/US2006/007465 WO2006096462A1 (en) 2005-03-03 2006-03-02 Nanoparticulate compositions of heterocyclic amide derivatives

Related Child Applications (1)

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JP2009045169A Division JP2009149679A (ja) 2005-03-03 2009-02-27 複素環式アミド誘導体のナノ粒子状組成物

Publications (2)

Publication Number Publication Date
JP2008531721A true JP2008531721A (ja) 2008-08-14
JP2008531721A5 JP2008531721A5 (enExample) 2009-04-16

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JP2007558231A Pending JP2008531721A (ja) 2005-03-03 2006-03-02 複素環式アミド誘導体のナノ粒子状組成物
JP2009045169A Pending JP2009149679A (ja) 2005-03-03 2009-02-27 複素環式アミド誘導体のナノ粒子状組成物

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Country Status (5)

Country Link
US (1) US20080254114A1 (enExample)
EP (1) EP1855651A4 (enExample)
JP (2) JP2008531721A (enExample)
CA (1) CA2598288A1 (enExample)
WO (1) WO2006096462A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523427A (ja) * 2009-04-09 2012-10-04 アルカーメス ファーマ アイルランド リミテッド 薬物送達組成物

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AU2014233560B2 (en) * 2009-04-09 2016-06-16 Alkermes Pharma Ireland Limited Drug delivery composition
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
US20140005269A1 (en) * 2010-11-26 2014-01-02 University Of The Witwatersrand, Johannesburg Polymeric matrix of polymer-lipid nanoparticles as a pharmaceutical dosage form
JP2016522251A (ja) * 2013-06-20 2016-07-28 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔｒｐａ１アンタゴニストを含むナノ粒子製剤
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
PT3174535T (pt) * 2014-08-01 2019-05-27 Glenmark Pharmaceuticals Sa Formulação nanoparticulada compreendendo um inibidor de mpges-1
PT109030B (pt) 2015-12-15 2019-09-25 Hovione Farmaciência, S.A. Preparação de partículas inaláveis de zafirlucaste

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JP2002537317A (ja) * 1999-02-26 2002-11-05 リポシン インコーポレイテッド 疎水性治療剤の改善された送達のための組成物および方法
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
WO2004050059A1 (en) * 2002-12-03 2004-06-17 Elan Pharma International Ltd. Low viscosity liquid dosage forms

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2012523427A (ja) * 2009-04-09 2012-10-04 アルカーメス ファーマ アイルランド リミテッド 薬物送達組成物
JP2015007111A (ja) * 2009-04-09 2015-01-15 アルカーメス ファーマ アイルランド リミテッド 薬物送達組成物

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JP2009149679A (ja) 2009-07-09
US20080254114A1 (en) 2008-10-16
WO2006096462A1 (en) 2006-09-14
EP1855651A1 (en) 2007-11-21
CA2598288A1 (en) 2006-09-14

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