JP2008531018A5 - - Google Patents

Info

Publication number

JP2008531018A5

JP2008531018A5 JP2007557215A JP2007557215A JP2008531018A5 JP 2008531018 A5 JP2008531018 A5 JP 2008531018A5 JP 2007557215 A JP2007557215 A JP 2007557215A JP 2007557215 A JP2007557215 A JP 2007557215A JP 2008531018 A5 JP2008531018 A5 JP 2008531018A5

Authority

JP

Japan

Prior art keywords

oligonucleotide

seq

internucleotide linkage

guanine

nucleotide

Prior art date

2006-02-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108091034117 Oligonucleotide Proteins 0.000 claims 76
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 32
• 239000002773 nucleotide Substances 0.000 claims 27
• 125000003729 nucleotide group Chemical group 0.000 claims 27
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 14
• 150000004713 phosphodiesters Chemical class 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 7
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 5
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 5
• -1 5-halogenocytosine Chemical compound 0.000 claims 4
• 108090000695 Cytokines Proteins 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 4
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical class O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 230000004044 response Effects 0.000 claims 4
• 206010020751 Hypersensitivity Diseases 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 230000007815 allergy Effects 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 208000006673 asthma Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical class NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 claims 2
• NLLCDONDZDHLCI-UHFFFAOYSA-N 6-amino-5-hydroxy-1h-pyrimidin-2-one Chemical compound NC=1NC(=O)N=CC=1O NLLCDONDZDHLCI-UHFFFAOYSA-N 0.000 claims 2
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical class N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
• 208000036065 Airway Remodeling Diseases 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Chemical class OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims 2
• 108090001005 Interleukin-6 Proteins 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 238000002512 chemotherapy Methods 0.000 claims 2
• 230000002500 effect on skin Effects 0.000 claims 2
• 238000009169 immunotherapy Methods 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 claims 2
• 230000000241 respiratory effect Effects 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 238000001356 surgical procedure Methods 0.000 claims 2
• 230000008685 targeting Effects 0.000 claims 2
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 2
• 229940035893 uracil Drugs 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• YKUFMYSNUQLIQS-UHFFFAOYSA-N 2-amino-5-methyl-1h-pyrimidin-6-one Chemical compound CC1=CNC(N)=NC1=O YKUFMYSNUQLIQS-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
• TVICROIWXBFQEL-UHFFFAOYSA-N 6-(ethylamino)-1h-pyrimidin-2-one Chemical compound CCNC1=CC=NC(=O)N1 TVICROIWXBFQEL-UHFFFAOYSA-N 0.000 claims 1
• CLGFIVUFZRGQRP-UHFFFAOYSA-N 7,8-dihydro-8-oxoguanine Chemical compound O=C1NC(N)=NC2=C1NC(=O)N2 CLGFIVUFZRGQRP-UHFFFAOYSA-N 0.000 claims 1
• LOSIULRWFAEMFL-UHFFFAOYSA-N 7-deazaguanine Chemical compound O=C1NC(N)=NC2=C1CC=N2 LOSIULRWFAEMFL-UHFFFAOYSA-N 0.000 claims 1
• MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical class NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
• 206010017533 Fungal infection Diseases 0.000 claims 1
• 241000711549 Hepacivirus C Species 0.000 claims 1
• 241000700721 Hepatitis B virus Species 0.000 claims 1
• 229930010555 Inosine Natural products 0.000 claims 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
• 208000031888 Mycoses Diseases 0.000 claims 1
• 208000030852 Parasitic disease Diseases 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 claims 1
• 229940104302 cytosine Drugs 0.000 claims 1
• BOKOVLFWCAFYHP-UHFFFAOYSA-N dihydroxy-methoxy-sulfanylidene-$l^{5}-phosphane Chemical compound COP(O)(O)=S BOKOVLFWCAFYHP-UHFFFAOYSA-N 0.000 claims 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical group CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 claims 1
• 229960002949 fluorouracil Drugs 0.000 claims 1
• 229960003786 inosine Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 229960003087 tioguanine Drugs 0.000 claims 1