JP2008531018A - 免疫刺激性オリゴヌクレオチド - Google Patents

免疫刺激性オリゴヌクレオチド Download PDF

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JP2008531018A
JP2008531018A JP2007557215A JP2007557215A JP2008531018A JP 2008531018 A JP2008531018 A JP 2008531018A JP 2007557215 A JP2007557215 A JP 2007557215A JP 2007557215 A JP2007557215 A JP 2007557215A JP 2008531018 A JP2008531018 A JP 2008531018A
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oligonucleotide
seq
phosphodiester
guanine
nucleotide
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JP2008531018A5 (enExample
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アーサー エム． クリーグ，
ウルリケ サミュロウィッツ，
イョルク フォルメル，
Original Assignee
コーリー ファーマシューティカル グループ，インコーポレイテッド
コーリー ファーマシューティカル ゲーエムベーハー
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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JP2007557215A 2005-02-24 2006-02-24 免疫刺激性オリゴヌクレオチド Pending JP2008531018A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65593105P 2005-02-24 2005-02-24
PCT/US2006/006778 WO2006091915A2 (en) 2005-02-24 2006-02-24 Immunostimulatory oligonucleotides

Publications (2)

Publication Number Publication Date
JP2008531018A true JP2008531018A (ja) 2008-08-14
JP2008531018A5 JP2008531018A5 (enExample) 2009-04-09

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US (1) US20080009455A9 (enExample)
EP (1) EP1851314A2 (enExample)
JP (1) JP2008531018A (enExample)
CN (1) CN101160401A (enExample)
AU (1) AU2006216493A1 (enExample)
CA (1) CA2598992A1 (enExample)
WO (1) WO2006091915A2 (enExample)

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WO2014010718A1 (ja) * 2012-07-13 2014-01-16 株式会社新日本科学 キラル核酸アジュバント
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries

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US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
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