JP2008526869A5 - - Google Patents

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Publication number
JP2008526869A5
JP2008526869A5 JP2007550462A JP2007550462A JP2008526869A5 JP 2008526869 A5 JP2008526869 A5 JP 2008526869A5 JP 2007550462 A JP2007550462 A JP 2007550462A JP 2007550462 A JP2007550462 A JP 2007550462A JP 2008526869 A5 JP2008526869 A5 JP 2008526869A5
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JP
Japan
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optionally substituted
heterocyclyl
aryl
alkyl
heteroaryl
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JP2007550462A
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English (en)
Japanese (ja)
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JP2008526869A (ja
JP5123668B2 (ja
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Priority claimed from PCT/US2006/000319 external-priority patent/WO2006076202A1/en
Publication of JP2008526869A publication Critical patent/JP2008526869A/ja
Publication of JP2008526869A5 publication Critical patent/JP2008526869A5/ja
Application granted granted Critical
Publication of JP5123668B2 publication Critical patent/JP5123668B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007550462A 2005-01-10 2006-01-06 医薬品としての複素環カルボキサミド化合物 Expired - Lifetime JP5123668B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64283905P 2005-01-10 2005-01-10
US60/642,839 2005-01-10
PCT/US2006/000319 WO2006076202A1 (en) 2005-01-10 2006-01-06 Heterocyclic carboxamide compounds as steroid nuclear receptors ligands

Publications (3)

Publication Number Publication Date
JP2008526869A JP2008526869A (ja) 2008-07-24
JP2008526869A5 true JP2008526869A5 (https=) 2009-03-19
JP5123668B2 JP5123668B2 (ja) 2013-01-23

Family

ID=36178222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007550462A Expired - Lifetime JP5123668B2 (ja) 2005-01-10 2006-01-06 医薬品としての複素環カルボキサミド化合物

Country Status (6)

Country Link
US (1) US20110144128A1 (https=)
EP (1) EP1844020B1 (https=)
JP (1) JP5123668B2 (https=)
AU (1) AU2006205220B2 (https=)
CA (1) CA2593156C (https=)
WO (1) WO2006076202A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8937184B2 (en) * 2005-02-16 2015-01-20 Abbvie B.V. 1H-imidazole derivatives as cannabinoid CB2 receptor modulators
JP2008530179A (ja) * 2005-02-16 2008-08-07 ソルベイ・フアーマシユーチカルズ・ベー・ブイ カンナビノイドｃｂ２受容体モジュレーターとしての１ｈ−イミダゾール誘導体
BRPI0612287A8 (pt) 2005-06-27 2019-01-22 Exelixis Inc composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
WO2007024744A2 (en) * 2005-08-21 2007-03-01 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptor ligands
US8137963B2 (en) * 2006-08-24 2012-03-20 Hiroshima University Method for highly amplifying target gene in mammalian cell and vector therefor
DK2089367T3 (da) 2006-10-31 2012-02-06 Pfizer Prod Inc Pyrazolinforbindelser som mineralocorticoidreceptor-antagonister
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
EP2133330B1 (en) * 2007-04-09 2014-01-01 Daiichi Sankyo Company, Limited Atropisomer of pyrrole derivative
WO2009124037A1 (en) * 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
US8410279B2 (en) * 2008-06-11 2013-04-02 Genentech, Inc. Substituted pyrroles and methods of use
WO2010098286A1 (ja) * 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
TWI532725B (zh) 2010-01-26 2016-05-11 賽諾菲阿凡提斯公司 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
ES2566934T3 (es) 2010-05-10 2016-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
US9241944B2 (en) 2010-06-16 2016-01-26 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and compositions for stimulating reepithelialisation during wound healing
US20140322242A1 (en) * 2010-11-24 2014-10-30 Icahn School Of Medicine At Mount Sinai Materials and methods for the prevention and treatment of cancer
TWI523844B (zh) 2011-01-26 2016-03-01 賽諾菲公司 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
AR085013A1 (es) 2011-01-26 2013-08-07 Sanofi Aventis Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas
CA2840516A1 (en) * 2011-06-29 2013-01-03 President And Fellows Of Harvard College Small molecule cd38 inhibitors and methods of using same
KR20140049020A (ko) 2011-07-26 2014-04-24 사노피 치환된 ３-（티아졸-４-카보닐）- 또는 ３-（티아졸-２-카보닐）아미노프로피온산 유도체 및 이의 약제로서의 용도
MY169319A (en) 2011-07-26 2019-03-21 Sanofi Sa 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
EP2765859B1 (en) * 2011-10-13 2017-01-18 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
US20130123325A1 (en) 2011-11-14 2013-05-16 Sven Ruf Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases
WO2013072328A1 (en) 2011-11-14 2013-05-23 Sanofi Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases
BR112015002152B1 (pt) * 2012-08-02 2021-04-27 Nerviano Medical Sciences S.R.L. Compostos de pirróis substituídos ativos como inibidores de quinases, processo para a preparação de tais compostos, composição farmacêutica, método in vitro para a inibição da atividade de proteínas quinases da família jak e produto compreendendo os referidos compostos
AR094412A1 (es) 2013-01-10 2015-07-29 Gruenenthal Gmbh Carboxamidas basadas en pirazolilo i
KR20150103752A (ko) 2013-01-10 2015-09-11 그뤼넨탈 게엠베하 Crac 채널 억제제로서의 피라졸릴계 카복스아미드 ⅱ
SG11201506190QA (en) 2013-03-28 2015-09-29 Sanofi Sa Biaryl-propionic acid derivatives and their use as pharmaceuticals
TW201522318A (zh) 2013-03-28 2015-06-16 Sanofi Sa 聯芳基丙酸及其作為醫藥品之用途
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
WO2015197187A1 (en) 2014-06-24 2015-12-30 Grünenthal GmbH Pyrazolyl-based carboxamides v
AU2018346597B2 (en) 2017-10-06 2023-07-13 Forma Therapeutics, Inc. Inhibiting Ubiquitin Specific Peptidase 30
JP7449242B2 (ja) 2018-05-17 2024-03-13 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的ペプチダーゼ３０（ｕｓｐ３０）阻害剤として有用な縮合二環化合物
CN108822079B (zh) * 2018-05-31 2019-12-06 陈刚 一种酯类衍生物及其在防治心脑血管疾病中的应用
CN108840856B (zh) * 2018-05-31 2019-12-24 陈�峰 一种酯类衍生物及其在防治心脑血管疾病中的应用
JP7530889B2 (ja) 2018-10-05 2024-08-08 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的プロテアーゼ３０（ｕｓｐ３０）阻害剤として作用する縮合ピロリン
EP3950674A4 (en) * 2019-10-25 2022-12-28 Sunshine Lake Pharma Co., Ltd. Pyrrole amide compound and use thereof
AU2022264993A1 (en) * 2021-04-26 2023-11-09 Sunshine Lake Pharma Co., Ltd. Preparation method for pyrrole amide compound
CN115784961B (zh) * 2021-09-10 2026-03-31 上海鼎雅药物化学科技有限公司 埃沙西林酮及其中间体的合成方法
CN113929591A (zh) * 2021-10-09 2022-01-14 中国科学技术大学 具有抗增殖活性的抑制剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2104931B1 (https=) * 1970-09-08 1975-01-10 Ferlux
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
CA2387892A1 (en) * 1999-10-18 2001-04-26 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
MY138097A (en) * 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
US20020004511A1 (en) * 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents
AU2002338642A1 (en) * 2001-04-13 2002-10-28 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
ATE536345T1 (de) * 2001-05-31 2011-12-15 Nihon Nohyaku Co Ltd Substituierte anilidderivate, deren zwischenprodukte, chemikalien für die landwirtschaft und den gartenbau und deren verwendung
AU2002319627A1 (en) * 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
TWI231757B (en) * 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
AU2003209388A1 (en) * 2002-01-29 2003-09-02 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
JP2004189738A (ja) * 2002-11-29 2004-07-08 Nippon Nohyaku Co Ltd 置換アニリド誘導体、その中間体及び農園芸用薬剤並びにその使用方法
WO2004085419A1 (de) * 2003-03-24 2004-10-07 Basf Aktiengesellschaft Trifluormethyl-thiophencarbonsäureanilide und ihre verwendung als fungizide
EP1653949A4 (en) * 2003-08-07 2009-04-22 Merck & Co Inc PYRAZOL CARBOXAMIDE AS AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
CA2573426C (en) * 2004-07-30 2015-11-17 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents

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