JP2008526692A5 - - Google Patents
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- Publication number
- JP2008526692A5 JP2008526692A5 JP2007548675A JP2007548675A JP2008526692A5 JP 2008526692 A5 JP2008526692 A5 JP 2008526692A5 JP 2007548675 A JP2007548675 A JP 2007548675A JP 2007548675 A JP2007548675 A JP 2007548675A JP 2008526692 A5 JP2008526692 A5 JP 2008526692A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- pyridinyl
- pyridyl
- pyrimidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410103077.8 | 2004-12-31 | ||
| CN200410103077 | 2004-12-31 | ||
| CN200510107402.2 | 2005-09-30 | ||
| CNA2005101074022A CN1939910A (zh) | 2004-12-31 | 2005-09-30 | 氨基嘧啶类化合物及其盐和其制备方法与药物用途 |
| PCT/CN2005/002308 WO2006069525A1 (en) | 2004-12-31 | 2005-12-26 | Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526692A JP2008526692A (ja) | 2008-07-24 |
| JP2008526692A5 true JP2008526692A5 (https=) | 2011-03-10 |
| JP4698681B2 JP4698681B2 (ja) | 2011-06-08 |
Family
ID=36614492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548675A Expired - Lifetime JP4698681B2 (ja) | 2004-12-31 | 2005-12-26 | アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8183242B2 (https=) |
| EP (1) | EP1840122B1 (https=) |
| JP (1) | JP4698681B2 (https=) |
| CN (1) | CN1939910A (https=) |
| CA (1) | CA2602738C (https=) |
| ES (1) | ES2436758T3 (https=) |
| WO (1) | WO2006069525A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY146795A (en) * | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| EP2166860B1 (en) * | 2007-06-07 | 2016-09-21 | Intra-Cellular Therapies, Inc. | Novel heterocycle compounds and uses thereof |
| JP5710251B2 (ja) * | 2007-06-07 | 2015-04-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規ヘテロ環化合物およびその使用 |
| EP2512246B1 (en) * | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| CN102796079B (zh) * | 2011-05-27 | 2016-06-29 | 江苏豪森药业集团有限公司 | 一种甲磺酸氟马替尼的制备方法 |
| CN102816147B (zh) * | 2011-06-09 | 2016-06-08 | 江苏豪森药业集团有限公司 | 甲磺酸氟马替尼晶型b及其制备方法和用途 |
| CN102816146A (zh) * | 2011-06-10 | 2012-12-12 | 江苏豪森医药集团连云港宏创医药有限公司 | 甲磺酸氟马替尼晶型a及其制备方法和用途 |
| CN103709147A (zh) * | 2012-10-09 | 2014-04-09 | 江苏豪森医药集团连云港宏创医药有限公司 | 甲磺酸氟马替尼晶型及其制备方法和用途 |
| CN103396395B (zh) * | 2013-07-26 | 2014-09-03 | 天津法莫西医药科技有限公司 | 一种合成n-（5-硝基-2-甲基吡啶基-3-）-4-（3-吡啶基）-2-嘧啶胺及其中间体的方法 |
| CN103360366B (zh) * | 2013-07-26 | 2015-04-01 | 天津禾盛医药技术开发有限公司 | N-(5-硝基-2-甲基吡啶基-3-)-4-(3-吡啶基)-2-嘧啶胺及其中间体的制备方法 |
| CN105884746B (zh) * | 2016-05-05 | 2018-09-21 | 江苏豪森药业集团有限公司 | 氟马替尼的合成方法 |
| CN107652269A (zh) * | 2016-07-26 | 2018-02-02 | 江苏豪森药业集团有限公司 | 甲磺酸氟马替尼中间体纯化方法 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| CN109438365B (zh) * | 2018-12-06 | 2022-04-05 | 华南师范大学 | N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物 |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| CN114127065A (zh) * | 2019-03-05 | 2022-03-01 | 鸿仪有限责任公司 | 用于治疗神经退行性疾病和癌症的化合物 |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| CA3150681A1 (en) | 2019-08-14 | 2021-02-18 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN111072636B (zh) * | 2019-12-16 | 2022-08-23 | 江苏豪森药业集团有限公司 | 氟马替尼的合成方法 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| AU2022379973A1 (en) | 2021-11-08 | 2024-06-27 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043531A (zh) | 1988-12-12 | 1990-07-04 | 衡阳市动力配件厂 | 合金铸铁气缸套 |
| TW225528B (https=) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| GB9610044D0 (en) | 1996-05-14 | 1996-07-17 | Sandoz Ltd | Improvements in or relating to organic compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0022438D0 (en) * | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
| WO2002083668A1 (en) * | 2001-04-10 | 2002-10-24 | Vertex Pharmaceuticals Incorporated | Isoxaxole derivatives as inhibitors of src and other protein kinases |
| WO2002092573A2 (en) * | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
| CA2450769A1 (en) * | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
| US7288547B2 (en) * | 2002-03-11 | 2007-10-30 | Schering Ag | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| AU2003232650A1 (en) * | 2003-05-06 | 2004-11-26 | Il Yang Pharm Co., Ltd. | N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof |
| ATE454152T1 (de) * | 2003-06-13 | 2010-01-15 | Novartis Pharma Gmbh | 2-aminopyrimidin-derivate als raf-kinase-hemmer |
-
2005
- 2005-09-30 CN CNA2005101074022A patent/CN1939910A/zh active Pending
- 2005-12-26 US US11/794,250 patent/US8183242B2/en active Active
- 2005-12-26 ES ES05822296.9T patent/ES2436758T3/es not_active Expired - Lifetime
- 2005-12-26 EP EP05822296.9A patent/EP1840122B1/en not_active Expired - Lifetime
- 2005-12-26 JP JP2007548675A patent/JP4698681B2/ja not_active Expired - Lifetime
- 2005-12-26 CA CA2602738A patent/CA2602738C/en not_active Expired - Fee Related
- 2005-12-26 WO PCT/CN2005/002308 patent/WO2006069525A1/zh not_active Ceased
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