ES2436758T3 - Compuestos de aminopirimidina y sus sales, proceso de preparación y su uso farmacéutico - Google Patents

Compuestos de aminopirimidina y sus sales, proceso de preparación y su uso farmacéutico Download PDF

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Publication number
ES2436758T3
ES2436758T3 ES05822296.9T ES05822296T ES2436758T3 ES 2436758 T3 ES2436758 T3 ES 2436758T3 ES 05822296 T ES05822296 T ES 05822296T ES 2436758 T3 ES2436758 T3 ES 2436758T3
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ES
Spain
Prior art keywords
amino
compound
methyl
halogen
pyrid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05822296.9T
Other languages
English (en)
Spanish (es)
Inventor
Aifeng Lv
Baohai Yang
Chunyong Hu
Piaoyang Sun
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2436758T3 publication Critical patent/ES2436758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES05822296.9T 2004-12-31 2005-12-26 Compuestos de aminopirimidina y sus sales, proceso de preparación y su uso farmacéutico Expired - Lifetime ES2436758T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN200410103077 2004-12-31
CN200410103077 2004-12-31
CN200510107402 2005-09-30
CNA2005101074022A CN1939910A (zh) 2004-12-31 2005-09-30 氨基嘧啶类化合物及其盐和其制备方法与药物用途
PCT/CN2005/002308 WO2006069525A1 (en) 2004-12-31 2005-12-26 Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

Publications (1)

Publication Number Publication Date
ES2436758T3 true ES2436758T3 (es) 2014-01-07

Family

ID=36614492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05822296.9T Expired - Lifetime ES2436758T3 (es) 2004-12-31 2005-12-26 Compuestos de aminopirimidina y sus sales, proceso de preparación y su uso farmacéutico

Country Status (7)

Country Link
US (1) US8183242B2 (https=)
EP (1) EP1840122B1 (https=)
JP (1) JP4698681B2 (https=)
CN (1) CN1939910A (https=)
CA (1) CA2602738C (https=)
ES (1) ES2436758T3 (https=)
WO (1) WO2006069525A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
WO2008153959A1 (en) * 2007-06-07 2008-12-18 Intra-Cellular Therapies, Inc. Novel heterocycle compounds and uses thereof
ES2607794T3 (es) * 2007-06-07 2017-04-04 Intra-Cellular Therapies, Inc. Compuestos heterocíclicos novedosos y usos de los mismos
US8735417B2 (en) 2009-12-17 2014-05-27 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
CN102796079B (zh) * 2011-05-27 2016-06-29 江苏豪森药业集团有限公司 一种甲磺酸氟马替尼的制备方法
CN102816147B (zh) * 2011-06-09 2016-06-08 江苏豪森药业集团有限公司 甲磺酸氟马替尼晶型b及其制备方法和用途
CN102816146A (zh) * 2011-06-10 2012-12-12 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型a及其制备方法和用途
CN103709147A (zh) * 2012-10-09 2014-04-09 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型及其制备方法和用途
CN103360366B (zh) * 2013-07-26 2015-04-01 天津禾盛医药技术开发有限公司 N-(5-硝基-2-甲基吡啶基-3-)-4-(3-吡啶基)-2-嘧啶胺及其中间体的制备方法
CN103396395B (zh) * 2013-07-26 2014-09-03 天津法莫西医药科技有限公司 一种合成n-（5-硝基-2-甲基吡啶基-3-）-4-（3-吡啶基）-2-嘧啶胺及其中间体的方法
CN105884746B (zh) * 2016-05-05 2018-09-21 江苏豪森药业集团有限公司 氟马替尼的合成方法
CN107652269A (zh) * 2016-07-26 2018-02-02 江苏豪森药业集团有限公司 甲磺酸氟马替尼中间体纯化方法
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN109438365B (zh) * 2018-12-06 2022-04-05 华南师范大学 N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
CA3132730A1 (en) * 2019-03-05 2020-09-10 Hongyi & Associates Llc Compounds for treating neurodegenerative diseases and cancers
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
AU2020364007A1 (en) 2019-10-11 2022-04-28 Incyte Corporation Bicyclic amines as CDK2 inhibitors
CN111072636B (zh) * 2019-12-16 2022-08-23 江苏豪森药业集团有限公司 氟马替尼的合成方法
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
CA3237696A1 (en) 2021-11-08 2023-05-11 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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CN1043531A (zh) 1988-12-12 1990-07-04 衡阳市动力配件厂 合金铸铁气缸套
TW225528B (https=) * 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9610044D0 (en) 1996-05-14 1996-07-17 Sandoz Ltd Improvements in or relating to organic compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0021726D0 (en) * 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
WO2002083668A1 (en) * 2001-04-10 2002-10-24 Vertex Pharmaceuticals Incorporated Isoxaxole derivatives as inhibitors of src and other protein kinases
AU2002308748A1 (en) * 2001-05-16 2002-11-25 Vertex Pharmaceuticals Incorporated Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
US6825190B2 (en) * 2001-06-15 2004-11-30 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors and uses thereof
US7288547B2 (en) * 2002-03-11 2007-10-30 Schering Ag CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
WO2004099186A1 (en) * 2003-05-06 2004-11-18 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
AU2004246800B2 (en) 2003-06-13 2008-12-04 Novartis Ag 2-aminopyrimidine derivatives as Raf kinase inhibitors

Also Published As

Publication number Publication date
CA2602738C (en) 2011-12-20
EP1840122A1 (en) 2007-10-03
WO2006069525A1 (en) 2006-07-06
HK1095146A1 (en) 2007-04-27
EP1840122A4 (en) 2011-03-09
JP4698681B2 (ja) 2011-06-08
US8183242B2 (en) 2012-05-22
JP2008526692A (ja) 2008-07-24
US20080312251A1 (en) 2008-12-18
CN1939910A (zh) 2007-04-04
EP1840122B1 (en) 2013-08-28
CA2602738A1 (en) 2006-07-06

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