JP2008520696A5 - - Google Patents
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- Publication number
- JP2008520696A5 JP2008520696A5 JP2007543252A JP2007543252A JP2008520696A5 JP 2008520696 A5 JP2008520696 A5 JP 2008520696A5 JP 2007543252 A JP2007543252 A JP 2007543252A JP 2007543252 A JP2007543252 A JP 2007543252A JP 2008520696 A5 JP2008520696 A5 JP 2008520696A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- active ingredient
- enteric
- enteric coated
- coated beads
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002245 particle Substances 0.000 claims 21
- 239000011324 bead Substances 0.000 claims 17
- 239000004480 active ingredient Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 8
- 239000011230 binding agent Substances 0.000 claims 5
- 239000002702 enteric coating Substances 0.000 claims 5
- 238000009505 enteric coating Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 claims 4
- 229960002014 ixabepilone Drugs 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000004211 gastric acid Anatomy 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 240000007472 Leucaena leucocephala Species 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- HLKZFSVWBQSKKH-UHFFFAOYSA-N but-3-enoic acid;1-ethenylpyrrolidin-2-one Chemical compound OC(=O)CC=C.C=CN1CCCC1=O HLKZFSVWBQSKKH-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960002900 methylcellulose Drugs 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000010408 potassium alginate Nutrition 0.000 claims 1
- 239000000737 potassium alginate Substances 0.000 claims 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 0 CC(CC(*C(CC(*)C(*)(C=C)C(C(*)C(C(*)CCC1)O)=N)=C)/C(/[*+])=C/c2c[s]c(*)n2)C1(C)[N+] Chemical compound CC(CC(*C(CC(*)C(*)(C=C)C(C(*)C(C(*)CCC1)O)=N)=C)/C(/[*+])=C/c2c[s]c(*)n2)C1(C)[N+] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62897004P | 2004-11-18 | 2004-11-18 | |
| PCT/US2005/041736 WO2006055740A1 (en) | 2004-11-18 | 2005-11-17 | Enteric coated bead comprising ixabepilone, and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008520696A JP2008520696A (ja) | 2008-06-19 |
| JP2008520696A5 true JP2008520696A5 (https=) | 2009-01-15 |
Family
ID=35976527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543252A Withdrawn JP2008520696A (ja) | 2004-11-18 | 2005-11-17 | イキサベピロンを含む腸溶性被覆ビーズおよびその製造 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20060153917A1 (https=) |
| EP (2) | EP1817013B1 (https=) |
| JP (1) | JP2008520696A (https=) |
| KR (1) | KR20070084325A (https=) |
| CN (1) | CN101083978A (https=) |
| AR (1) | AR052142A1 (https=) |
| AT (1) | ATE397442T1 (https=) |
| AU (1) | AU2005306464A1 (https=) |
| BR (1) | BRPI0518286A2 (https=) |
| CA (1) | CA2588400A1 (https=) |
| DE (1) | DE602005007376D1 (https=) |
| DK (1) | DK1817013T3 (https=) |
| ES (1) | ES2306278T3 (https=) |
| HR (1) | HRP20080349T3 (https=) |
| IL (1) | IL183116A0 (https=) |
| MX (1) | MX2007005763A (https=) |
| NO (1) | NO20072388L (https=) |
| PE (1) | PE20061058A1 (https=) |
| PL (1) | PL1817013T3 (https=) |
| PT (1) | PT1817013E (https=) |
| RU (1) | RU2349319C1 (https=) |
| SI (1) | SI1817013T1 (https=) |
| TW (1) | TW200631609A (https=) |
| WO (1) | WO2006055740A1 (https=) |
| ZA (1) | ZA200703955B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091725A (zh) | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | 一种中药颗粒及其制备方法 |
| US20110217426A1 (en) * | 2010-03-04 | 2011-09-08 | Perry Stephen C | Enteric coating composition |
| SI2835053T1 (sl) * | 2010-03-12 | 2016-09-30 | Genzyme Corporation | Kombinirana terapija za zdravljenje raka dojke |
| WO2012047802A2 (en) * | 2010-10-01 | 2012-04-12 | The Johns Hopkins University | Systems and methods for high-throughput microfluidic bead production |
| US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
| US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
| WO2012109216A1 (en) | 2011-02-11 | 2012-08-16 | Zx Pharma, Llc | Multiparticulate l-menthol formulations and related methods |
| CA2909591C (en) | 2013-04-23 | 2017-03-28 | Zx Pharma, Llc | Enteric coated multiparticulate composition with proteinaceous subcoat |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| JP4183099B2 (ja) * | 1995-11-17 | 2008-11-19 | ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） | エポチロンｃおよびｄ、製造法ならびに組成物 |
| JP4090529B2 (ja) * | 1996-01-24 | 2008-05-28 | フロイント産業株式会社 | 乳糖の球形粒及びその製造方法 |
| US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US6251911B1 (en) * | 1996-10-02 | 2001-06-26 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
| ES2312695T3 (es) * | 1996-11-18 | 2009-03-01 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Epotilones e y f. |
| FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| JP2001513098A (ja) * | 1997-02-25 | 2001-08-28 | ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー（ゲー ベー エフ） | 側鎖を修飾したエポチロン |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| US7122207B2 (en) * | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
| DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
| IL142276A0 (en) * | 1998-10-01 | 2002-03-10 | Powderject Res Ltd | Spray coated microparticles for use in needleless syringes |
| MXPA01008328A (es) * | 1999-02-18 | 2002-06-04 | Schering Ag | Derivados de 18 -haluro epotilona, metodo para su produccion y su uso farmaceutico. |
| CZ301498B6 (cs) * | 1999-02-22 | 2010-03-24 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) | C-21 modifikované epothilony |
| US6518421B1 (en) | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
| KR100620404B1 (ko) * | 2000-08-09 | 2006-09-13 | 파나세아 바이오테크 리미티드 | 항결핵 약물의 신규 약제학적 조성물 및 그의 제조방법 |
| UA75365C2 (en) | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
| CA2422500A1 (en) * | 2000-09-22 | 2003-03-18 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) | Triazolo-epothilones |
| EP1191127B1 (de) | 2000-09-26 | 2004-10-13 | Enthone-OMI (Deutschland) GmbH | Verfahren zur selektiven Metallisierung dielektrischer Materialien |
| ES2304240T3 (es) * | 2001-01-25 | 2008-10-01 | Bristol-Myers Squibb Company | Procedimientos para la preparacion de preparaciones farmaceuticas que contienen analogos de epotilona para el tratamiento de cancer. |
| WO2002058699A1 (en) * | 2001-01-25 | 2002-08-01 | Bristol-Myers Squibb Company | Pharmaceutical forms of epothilones for oral administration |
| EE200300323A (et) * | 2001-01-25 | 2003-10-15 | Bristol-Myers Squibb Company | Epotilooni analoogi sisaldav parenteraalne ravimpreparaat, meetod selle valmistamiseks ning kasutamine |
| KR20040028720A (ko) * | 2001-02-20 | 2004-04-03 | 브리스톨-마이어스스퀴브컴파니 | 치료불응성 종양 치료용 에포틸론 유도체 |
| CN1774253A (zh) | 2001-02-20 | 2006-05-17 | 布里斯托尔-迈尔斯斯奎布公司 | 用环氧丙酯酮衍生物治疗顽固性肿瘤 |
| IL157443A0 (en) * | 2001-03-14 | 2004-03-28 | Bristol Myers Squibb Co | Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent |
| MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
| JP4645789B2 (ja) * | 2001-06-18 | 2011-03-09 | Ｊｓｒ株式会社 | ネガ型感放射線性樹脂組成物 |
| SI1483251T1 (sl) * | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| WO2003105828A1 (en) * | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1539111A1 (en) * | 2002-08-05 | 2005-06-15 | DSM IP Assets B.V. | Oral dosage forms of water insoluble drugs and methods of making the same |
| US7091193B2 (en) * | 2002-10-09 | 2006-08-15 | Kosan Biosciences Incorporated | Therapeutic formulations |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
-
2005
- 2005-11-17 AR ARP050104839A patent/AR052142A1/es unknown
- 2005-11-17 DK DK05824194T patent/DK1817013T3/da active
- 2005-11-17 EP EP05824194A patent/EP1817013B1/en not_active Expired - Lifetime
- 2005-11-17 KR KR1020077011236A patent/KR20070084325A/ko not_active Withdrawn
- 2005-11-17 RU RU2007122627/15A patent/RU2349319C1/ru not_active IP Right Cessation
- 2005-11-17 EP EP08008815A patent/EP1958625A1/en not_active Withdrawn
- 2005-11-17 HR HR20080349T patent/HRP20080349T3/xx unknown
- 2005-11-17 AT AT05824194T patent/ATE397442T1/de not_active IP Right Cessation
- 2005-11-17 MX MX2007005763A patent/MX2007005763A/es active IP Right Grant
- 2005-11-17 CN CNA2005800393851A patent/CN101083978A/zh active Pending
- 2005-11-17 BR BRPI0518286-7A patent/BRPI0518286A2/pt not_active IP Right Cessation
- 2005-11-17 JP JP2007543252A patent/JP2008520696A/ja not_active Withdrawn
- 2005-11-17 PT PT05824194T patent/PT1817013E/pt unknown
- 2005-11-17 DE DE602005007376T patent/DE602005007376D1/de not_active Expired - Fee Related
- 2005-11-17 TW TW094140483A patent/TW200631609A/zh unknown
- 2005-11-17 US US11/281,855 patent/US20060153917A1/en not_active Abandoned
- 2005-11-17 ES ES05824194T patent/ES2306278T3/es not_active Expired - Lifetime
- 2005-11-17 CA CA002588400A patent/CA2588400A1/en not_active Abandoned
- 2005-11-17 AU AU2005306464A patent/AU2005306464A1/en not_active Abandoned
- 2005-11-17 SI SI200530318T patent/SI1817013T1/sl unknown
- 2005-11-17 WO PCT/US2005/041736 patent/WO2006055740A1/en not_active Ceased
- 2005-11-17 PE PE2005001348A patent/PE20061058A1/es not_active Application Discontinuation
- 2005-11-17 PL PL05824194T patent/PL1817013T3/pl unknown
-
2007
- 2007-05-09 NO NO20072388A patent/NO20072388L/no not_active Application Discontinuation
- 2007-05-10 IL IL183116A patent/IL183116A0/en unknown
- 2007-05-16 ZA ZA200703955A patent/ZA200703955B/xx unknown
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