TW200631609A - Enteric coated bead comprising ixabepilone, and preparation and administration thereof - Google Patents
Enteric coated bead comprising ixabepilone, and preparation and administration thereofInfo
- Publication number
- TW200631609A TW200631609A TW094140483A TW94140483A TW200631609A TW 200631609 A TW200631609 A TW 200631609A TW 094140483 A TW094140483 A TW 094140483A TW 94140483 A TW94140483 A TW 94140483A TW 200631609 A TW200631609 A TW 200631609A
- Authority
- TW
- Taiwan
- Prior art keywords
- enteric coated
- ixabepilone
- coated bead
- administration
- preparation
- Prior art date
Links
- 239000011324 bead Substances 0.000 title abstract 5
- FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 title abstract 2
- 229960002014 ixabepilone Drugs 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62897004P | 2004-11-18 | 2004-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200631609A true TW200631609A (en) | 2006-09-16 |
Family
ID=35976527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094140483A TW200631609A (en) | 2004-11-18 | 2005-11-17 | Enteric coated bead comprising ixabepilone, and preparation and administration thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20060153917A1 (https=) |
| EP (2) | EP1817013B1 (https=) |
| JP (1) | JP2008520696A (https=) |
| KR (1) | KR20070084325A (https=) |
| CN (1) | CN101083978A (https=) |
| AR (1) | AR052142A1 (https=) |
| AT (1) | ATE397442T1 (https=) |
| AU (1) | AU2005306464A1 (https=) |
| BR (1) | BRPI0518286A2 (https=) |
| CA (1) | CA2588400A1 (https=) |
| DE (1) | DE602005007376D1 (https=) |
| DK (1) | DK1817013T3 (https=) |
| ES (1) | ES2306278T3 (https=) |
| HR (1) | HRP20080349T3 (https=) |
| IL (1) | IL183116A0 (https=) |
| MX (1) | MX2007005763A (https=) |
| NO (1) | NO20072388L (https=) |
| PE (1) | PE20061058A1 (https=) |
| PL (1) | PL1817013T3 (https=) |
| PT (1) | PT1817013E (https=) |
| RU (1) | RU2349319C1 (https=) |
| SI (1) | SI1817013T1 (https=) |
| TW (1) | TW200631609A (https=) |
| WO (1) | WO2006055740A1 (https=) |
| ZA (1) | ZA200703955B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091725A (zh) | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | 一种中药颗粒及其制备方法 |
| US20110217426A1 (en) * | 2010-03-04 | 2011-09-08 | Perry Stephen C | Enteric coating composition |
| ME02464B (me) | 2010-03-12 | 2017-02-20 | Genzyme Corp | Kombinovana terapija za lečenje raka dojke |
| WO2012047802A2 (en) * | 2010-10-01 | 2012-04-12 | The Johns Hopkins University | Systems and methods for high-throughput microfluidic bead production |
| AU2012214553B2 (en) | 2011-02-11 | 2015-07-09 | Sociétés des Produits Nestlé S.A. | Multiparticulate L-menthol formulations and related methods |
| US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
| US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
| ES2706152T3 (es) | 2013-04-23 | 2019-03-27 | Zx Pharma Llc | Composición entérica de múltiples partículas revestida con subrevestimiento proteico |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| DK1186606T4 (da) * | 1995-11-17 | 2011-12-05 | Biotechnolog Forschung Gmbh | Epothilonderivater, deres fremstilling og anvendelse |
| JP4090529B2 (ja) * | 1996-01-24 | 2008-05-28 | フロイント産業株式会社 | 乳糖の球形粒及びその製造方法 |
| US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US6251911B1 (en) * | 1996-10-02 | 2001-06-26 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
| DK1367057T3 (da) * | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
| FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
| PT975638E (pt) * | 1997-02-25 | 2002-12-31 | Biotechnolog Forschung Mbh Gbf | Epothilons modificados nas cadeias laterais |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
| US7122207B2 (en) * | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
| DE69925293T2 (de) * | 1998-10-01 | 2006-01-26 | Powderject Research Ltd. | Sprühbeschichtete mikropartikel für nadellose spritzen |
| YU59001A (sh) * | 1999-02-18 | 2005-07-19 | Schering Ag. | 16-halogen-epotilon-derivati, postupak za njihovo dobijanje i njihova farmaceutska primena |
| BR0008379A (pt) * | 1999-02-22 | 2002-09-24 | Biotechnolog Forschung Gmbh | Epotilonas modificadas em c-21 |
| US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
| IL149030A0 (en) * | 2000-08-09 | 2002-11-10 | Panacea Biotec Ltd | Pharmaceutical compositions containing rifampicin, isoniazid or combinations thereof |
| UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
| EP1319011B1 (de) * | 2000-09-22 | 2012-12-05 | Helmholtz-Zentrum für Infektionsforschung GmbH | Triazolo-epothilone |
| EP1191127B1 (de) | 2000-09-26 | 2004-10-13 | Enthone-OMI (Deutschland) GmbH | Verfahren zur selektiven Metallisierung dielektrischer Materialien |
| IL156580A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
| NZ526871A (en) * | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
| HU229349B1 (en) * | 2001-01-25 | 2013-11-28 | Bristol Myers Squibb Co | Methods for preparation of pharmaceutical composition containing epothilone analogs useful for treatment of cancer |
| PL363363A1 (en) * | 2001-02-20 | 2004-11-15 | Bristol-Myers Squibb Company | Epothilone derivatives for the treatment of refractory tumors |
| BR0207487A (pt) * | 2001-02-20 | 2004-08-10 | Brystol Myers Squibb Company | Método de tratamento de tumores em mamìferos e uso de compostos de epotilona |
| WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
| JP4645789B2 (ja) * | 2001-06-18 | 2011-03-09 | Ｊｓｒ株式会社 | ネガ型感放射線性樹脂組成物 |
| AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| SI1483251T1 (sl) * | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| WO2003105828A1 (en) * | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1539111A1 (en) * | 2002-08-05 | 2005-06-15 | DSM IP Assets B.V. | Oral dosage forms of water insoluble drugs and methods of making the same |
| AU2003279911A1 (en) * | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
-
2005
- 2005-11-17 AR ARP050104839A patent/AR052142A1/es unknown
- 2005-11-17 CN CNA2005800393851A patent/CN101083978A/zh active Pending
- 2005-11-17 BR BRPI0518286-7A patent/BRPI0518286A2/pt not_active IP Right Cessation
- 2005-11-17 AU AU2005306464A patent/AU2005306464A1/en not_active Abandoned
- 2005-11-17 DK DK05824194T patent/DK1817013T3/da active
- 2005-11-17 US US11/281,855 patent/US20060153917A1/en not_active Abandoned
- 2005-11-17 CA CA002588400A patent/CA2588400A1/en not_active Abandoned
- 2005-11-17 PT PT05824194T patent/PT1817013E/pt unknown
- 2005-11-17 TW TW094140483A patent/TW200631609A/zh unknown
- 2005-11-17 RU RU2007122627/15A patent/RU2349319C1/ru not_active IP Right Cessation
- 2005-11-17 DE DE602005007376T patent/DE602005007376D1/de not_active Expired - Fee Related
- 2005-11-17 ES ES05824194T patent/ES2306278T3/es not_active Expired - Lifetime
- 2005-11-17 JP JP2007543252A patent/JP2008520696A/ja not_active Withdrawn
- 2005-11-17 EP EP05824194A patent/EP1817013B1/en not_active Expired - Lifetime
- 2005-11-17 WO PCT/US2005/041736 patent/WO2006055740A1/en not_active Ceased
- 2005-11-17 HR HR20080349T patent/HRP20080349T3/xx unknown
- 2005-11-17 PL PL05824194T patent/PL1817013T3/pl unknown
- 2005-11-17 MX MX2007005763A patent/MX2007005763A/es active IP Right Grant
- 2005-11-17 SI SI200530318T patent/SI1817013T1/sl unknown
- 2005-11-17 KR KR1020077011236A patent/KR20070084325A/ko not_active Withdrawn
- 2005-11-17 EP EP08008815A patent/EP1958625A1/en not_active Withdrawn
- 2005-11-17 PE PE2005001348A patent/PE20061058A1/es not_active Application Discontinuation
- 2005-11-17 AT AT05824194T patent/ATE397442T1/de not_active IP Right Cessation
-
2007
- 2007-05-09 NO NO20072388A patent/NO20072388L/no not_active Application Discontinuation
- 2007-05-10 IL IL183116A patent/IL183116A0/en unknown
- 2007-05-16 ZA ZA200703955A patent/ZA200703955B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306278T3 (es) | 2008-11-01 |
| SI1817013T1 (sl) | 2008-12-31 |
| PT1817013E (pt) | 2008-08-07 |
| ZA200703955B (en) | 2008-08-27 |
| MX2007005763A (es) | 2007-07-20 |
| EP1958625A1 (en) | 2008-08-20 |
| AU2005306464A1 (en) | 2006-05-26 |
| DK1817013T3 (da) | 2008-10-13 |
| DE602005007376D1 (de) | 2008-07-17 |
| US20060153917A1 (en) | 2006-07-13 |
| CN101083978A (zh) | 2007-12-05 |
| WO2006055740A1 (en) | 2006-05-26 |
| PL1817013T3 (pl) | 2009-01-30 |
| HRP20080349T3 (hr) | 2009-01-31 |
| IL183116A0 (en) | 2007-09-20 |
| RU2349319C1 (ru) | 2009-03-20 |
| AR052142A1 (es) | 2007-03-07 |
| NO20072388L (no) | 2007-06-14 |
| EP1817013B1 (en) | 2008-06-04 |
| ATE397442T1 (de) | 2008-06-15 |
| CA2588400A1 (en) | 2006-05-26 |
| JP2008520696A (ja) | 2008-06-19 |
| HK1106713A1 (en) | 2008-03-20 |
| EP1817013A1 (en) | 2007-08-15 |
| KR20070084325A (ko) | 2007-08-24 |
| BRPI0518286A2 (pt) | 2008-11-11 |
| PE20061058A1 (es) | 2006-10-13 |
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