RU2349319C1 - Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления - Google Patents
Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления Download PDFInfo
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- RU2349319C1 RU2349319C1 RU2007122627/15A RU2007122627A RU2349319C1 RU 2349319 C1 RU2349319 C1 RU 2349319C1 RU 2007122627/15 A RU2007122627/15 A RU 2007122627/15A RU 2007122627 A RU2007122627 A RU 2007122627A RU 2349319 C1 RU2349319 C1 RU 2349319C1
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| US62897004P | 2004-11-18 | 2004-11-18 | |
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| RU2349319C1 true RU2349319C1 (ru) | 2009-03-20 |
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| RU2007122627/15A RU2349319C1 (ru) | 2004-11-18 | 2005-11-17 | Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления |
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| NO (1) | NO20072388L (https=) |
| PE (1) | PE20061058A1 (https=) |
| PL (1) | PL1817013T3 (https=) |
| PT (1) | PT1817013E (https=) |
| RU (1) | RU2349319C1 (https=) |
| SI (1) | SI1817013T1 (https=) |
| TW (1) | TW200631609A (https=) |
| WO (1) | WO2006055740A1 (https=) |
| ZA (1) | ZA200703955B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8951568B2 (en) | 2006-06-23 | 2015-02-10 | Tasly Pharmaceuticals Group Co., Ltd. | Granule and preparation method thereof |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110217426A1 (en) * | 2010-03-04 | 2011-09-08 | Perry Stephen C | Enteric coating composition |
| ME02464B (me) | 2010-03-12 | 2017-02-20 | Genzyme Corp | Kombinovana terapija za lečenje raka dojke |
| WO2012047802A2 (en) * | 2010-10-01 | 2012-04-12 | The Johns Hopkins University | Systems and methods for high-throughput microfluidic bead production |
| AU2012214553B2 (en) | 2011-02-11 | 2015-07-09 | Sociétés des Produits Nestlé S.A. | Multiparticulate L-menthol formulations and related methods |
| US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
| US8808736B2 (en) | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
| ES2706152T3 (es) | 2013-04-23 | 2019-03-27 | Zx Pharma Llc | Composición entérica de múltiples partículas revestida con subrevestimiento proteico |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020177615A1 (en) * | 2001-01-25 | 2002-11-28 | Rebanta Bandyopadhyay | Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones |
| US20030017210A1 (en) * | 1997-02-11 | 2003-01-23 | Laboratoires Des Produits Ethiques Ethypharm | Microgranules containing cisplatin |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US20030220378A1 (en) * | 2002-04-04 | 2003-11-27 | Lee Francis Y. F. | Oral administration of epothilones |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| DK1186606T4 (da) * | 1995-11-17 | 2011-12-05 | Biotechnolog Forschung Gmbh | Epothilonderivater, deres fremstilling og anvendelse |
| JP4090529B2 (ja) * | 1996-01-24 | 2008-05-28 | フロイント産業株式会社 | 乳糖の球形粒及びその製造方法 |
| US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US6251911B1 (en) * | 1996-10-02 | 2001-06-26 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
| DK1367057T3 (da) * | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
| PT975638E (pt) * | 1997-02-25 | 2002-12-31 | Biotechnolog Forschung Mbh Gbf | Epothilons modificados nas cadeias laterais |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
| US7122207B2 (en) * | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| DE19826988A1 (de) * | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
| DE69925293T2 (de) * | 1998-10-01 | 2006-01-26 | Powderject Research Ltd. | Sprühbeschichtete mikropartikel für nadellose spritzen |
| YU59001A (sh) * | 1999-02-18 | 2005-07-19 | Schering Ag. | 16-halogen-epotilon-derivati, postupak za njihovo dobijanje i njihova farmaceutska primena |
| BR0008379A (pt) * | 1999-02-22 | 2002-09-24 | Biotechnolog Forschung Gmbh | Epotilonas modificadas em c-21 |
| US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
| IL149030A0 (en) * | 2000-08-09 | 2002-11-10 | Panacea Biotec Ltd | Pharmaceutical compositions containing rifampicin, isoniazid or combinations thereof |
| UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
| EP1319011B1 (de) * | 2000-09-22 | 2012-12-05 | Helmholtz-Zentrum für Infektionsforschung GmbH | Triazolo-epothilone |
| EP1191127B1 (de) | 2000-09-26 | 2004-10-13 | Enthone-OMI (Deutschland) GmbH | Verfahren zur selektiven Metallisierung dielektrischer Materialien |
| IL156580A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
| HU229349B1 (en) * | 2001-01-25 | 2013-11-28 | Bristol Myers Squibb Co | Methods for preparation of pharmaceutical composition containing epothilone analogs useful for treatment of cancer |
| PL363363A1 (en) * | 2001-02-20 | 2004-11-15 | Bristol-Myers Squibb Company | Epothilone derivatives for the treatment of refractory tumors |
| BR0207487A (pt) * | 2001-02-20 | 2004-08-10 | Brystol Myers Squibb Company | Método de tratamento de tumores em mamìferos e uso de compostos de epotilona |
| WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
| JP4645789B2 (ja) * | 2001-06-18 | 2011-03-09 | Ｊｓｒ株式会社 | ネガ型感放射線性樹脂組成物 |
| AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| SI1483251T1 (sl) * | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| WO2003105828A1 (en) * | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1539111A1 (en) * | 2002-08-05 | 2005-06-15 | DSM IP Assets B.V. | Oral dosage forms of water insoluble drugs and methods of making the same |
| AU2003279911A1 (en) * | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
-
2005
- 2005-11-17 AR ARP050104839A patent/AR052142A1/es unknown
- 2005-11-17 CN CNA2005800393851A patent/CN101083978A/zh active Pending
- 2005-11-17 BR BRPI0518286-7A patent/BRPI0518286A2/pt not_active IP Right Cessation
- 2005-11-17 AU AU2005306464A patent/AU2005306464A1/en not_active Abandoned
- 2005-11-17 DK DK05824194T patent/DK1817013T3/da active
- 2005-11-17 US US11/281,855 patent/US20060153917A1/en not_active Abandoned
- 2005-11-17 CA CA002588400A patent/CA2588400A1/en not_active Abandoned
- 2005-11-17 PT PT05824194T patent/PT1817013E/pt unknown
- 2005-11-17 TW TW094140483A patent/TW200631609A/zh unknown
- 2005-11-17 RU RU2007122627/15A patent/RU2349319C1/ru not_active IP Right Cessation
- 2005-11-17 DE DE602005007376T patent/DE602005007376D1/de not_active Expired - Fee Related
- 2005-11-17 ES ES05824194T patent/ES2306278T3/es not_active Expired - Lifetime
- 2005-11-17 JP JP2007543252A patent/JP2008520696A/ja not_active Withdrawn
- 2005-11-17 EP EP05824194A patent/EP1817013B1/en not_active Expired - Lifetime
- 2005-11-17 WO PCT/US2005/041736 patent/WO2006055740A1/en not_active Ceased
- 2005-11-17 HR HR20080349T patent/HRP20080349T3/xx unknown
- 2005-11-17 PL PL05824194T patent/PL1817013T3/pl unknown
- 2005-11-17 MX MX2007005763A patent/MX2007005763A/es active IP Right Grant
- 2005-11-17 SI SI200530318T patent/SI1817013T1/sl unknown
- 2005-11-17 KR KR1020077011236A patent/KR20070084325A/ko not_active Withdrawn
- 2005-11-17 EP EP08008815A patent/EP1958625A1/en not_active Withdrawn
- 2005-11-17 PE PE2005001348A patent/PE20061058A1/es not_active Application Discontinuation
- 2005-11-17 AT AT05824194T patent/ATE397442T1/de not_active IP Right Cessation
-
2007
- 2007-05-09 NO NO20072388A patent/NO20072388L/no not_active Application Discontinuation
- 2007-05-10 IL IL183116A patent/IL183116A0/en unknown
- 2007-05-16 ZA ZA200703955A patent/ZA200703955B/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US20030017210A1 (en) * | 1997-02-11 | 2003-01-23 | Laboratoires Des Produits Ethiques Ethypharm | Microgranules containing cisplatin |
| US20020177615A1 (en) * | 2001-01-25 | 2002-11-28 | Rebanta Bandyopadhyay | Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones |
| US20030220378A1 (en) * | 2002-04-04 | 2003-11-27 | Lee Francis Y. F. | Oral administration of epothilones |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8951568B2 (en) | 2006-06-23 | 2015-02-10 | Tasly Pharmaceuticals Group Co., Ltd. | Granule and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306278T3 (es) | 2008-11-01 |
| SI1817013T1 (sl) | 2008-12-31 |
| PT1817013E (pt) | 2008-08-07 |
| ZA200703955B (en) | 2008-08-27 |
| MX2007005763A (es) | 2007-07-20 |
| EP1958625A1 (en) | 2008-08-20 |
| AU2005306464A1 (en) | 2006-05-26 |
| DK1817013T3 (da) | 2008-10-13 |
| DE602005007376D1 (de) | 2008-07-17 |
| US20060153917A1 (en) | 2006-07-13 |
| CN101083978A (zh) | 2007-12-05 |
| WO2006055740A1 (en) | 2006-05-26 |
| PL1817013T3 (pl) | 2009-01-30 |
| HRP20080349T3 (hr) | 2009-01-31 |
| IL183116A0 (en) | 2007-09-20 |
| AR052142A1 (es) | 2007-03-07 |
| NO20072388L (no) | 2007-06-14 |
| EP1817013B1 (en) | 2008-06-04 |
| ATE397442T1 (de) | 2008-06-15 |
| CA2588400A1 (en) | 2006-05-26 |
| JP2008520696A (ja) | 2008-06-19 |
| HK1106713A1 (en) | 2008-03-20 |
| EP1817013A1 (en) | 2007-08-15 |
| KR20070084325A (ko) | 2007-08-24 |
| BRPI0518286A2 (pt) | 2008-11-11 |
| TW200631609A (en) | 2006-09-16 |
| PE20061058A1 (es) | 2006-10-13 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20091118 |