RU2349319C1 - Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления - Google Patents

Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления Download PDF

Info

Publication number
RU2349319C1
RU2349319C1 RU2007122627/15A RU2007122627A RU2349319C1 RU 2349319 C1 RU2349319 C1 RU 2349319C1 RU 2007122627/15 A RU2007122627/15 A RU 2007122627/15A RU 2007122627 A RU2007122627 A RU 2007122627A RU 2349319 C1 RU2349319 C1 RU 2349319C1
Authority
RU
Russia
Prior art keywords
active ingredient
coated
enteric
ixabepilone
particles
Prior art date
Application number
RU2007122627/15A
Other languages
English (en)
Russian (ru)
Inventor
Измат УЛЛАХ (US)
Измат УЛЛАХ
Гари Джеймс ВИЛИ (US)
Гари Джеймс ВИЛИ
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Application granted granted Critical
Publication of RU2349319C1 publication Critical patent/RU2349319C1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU2007122627/15A 2004-11-18 2005-11-17 Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления RU2349319C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62897004P 2004-11-18 2004-11-18
US60/628,970 2004-11-18

Publications (1)

Publication Number Publication Date
RU2349319C1 true RU2349319C1 (ru) 2009-03-20

Family

ID=35976527

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007122627/15A RU2349319C1 (ru) 2004-11-18 2005-11-17 Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления

Country Status (25)

Country Link
US (1) US20060153917A1 (https=)
EP (2) EP1817013B1 (https=)
JP (1) JP2008520696A (https=)
KR (1) KR20070084325A (https=)
CN (1) CN101083978A (https=)
AR (1) AR052142A1 (https=)
AT (1) ATE397442T1 (https=)
AU (1) AU2005306464A1 (https=)
BR (1) BRPI0518286A2 (https=)
CA (1) CA2588400A1 (https=)
DE (1) DE602005007376D1 (https=)
DK (1) DK1817013T3 (https=)
ES (1) ES2306278T3 (https=)
HR (1) HRP20080349T3 (https=)
IL (1) IL183116A0 (https=)
MX (1) MX2007005763A (https=)
NO (1) NO20072388L (https=)
PE (1) PE20061058A1 (https=)
PL (1) PL1817013T3 (https=)
PT (1) PT1817013E (https=)
RU (1) RU2349319C1 (https=)
SI (1) SI1817013T1 (https=)
TW (1) TW200631609A (https=)
WO (1) WO2006055740A1 (https=)
ZA (1) ZA200703955B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951568B2 (en) 2006-06-23 2015-02-10 Tasly Pharmaceuticals Group Co., Ltd. Granule and preparation method thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110217426A1 (en) * 2010-03-04 2011-09-08 Perry Stephen C Enteric coating composition
SI2835053T1 (sl) * 2010-03-12 2016-09-30 Genzyme Corporation Kombinirana terapija za zdravljenje raka dojke
WO2012047802A2 (en) * 2010-10-01 2012-04-12 The Johns Hopkins University Systems and methods for high-throughput microfluidic bead production
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
WO2012109216A1 (en) 2011-02-11 2012-08-16 Zx Pharma, Llc Multiparticulate l-menthol formulations and related methods
CA2909591C (en) 2013-04-23 2017-03-28 Zx Pharma, Llc Enteric coated multiparticulate composition with proteinaceous subcoat

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020177615A1 (en) * 2001-01-25 2002-11-28 Rebanta Bandyopadhyay Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones
US20030017210A1 (en) * 1997-02-11 2003-01-23 Laboratoires Des Produits Ethiques Ethypharm Microgranules containing cisplatin
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US20030220378A1 (en) * 2002-04-04 2003-11-27 Lee Francis Y. F. Oral administration of epothilones

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713246A (en) * 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
JP4183099B2 (ja) * 1995-11-17 2008-11-19 ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング(ゲー・ベー・エフ) エポチロンcおよびd、製造法ならびに組成物
JP4090529B2 (ja) * 1996-01-24 2008-05-28 フロイント産業株式会社 乳糖の球形粒及びその製造方法
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US6251911B1 (en) * 1996-10-02 2001-06-26 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
ES2312695T3 (es) * 1996-11-18 2009-03-01 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Epotilones e y f.
JP2001513098A (ja) * 1997-02-25 2001-08-28 ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー(ゲー ベー エフ) 側鎖を修飾したエポチロン
GB9801231D0 (en) 1997-06-05 1998-03-18 Merck & Co Inc A method of treating cancer
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6040321A (en) 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
FR2775187B1 (fr) * 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6399638B1 (en) * 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
US6498257B1 (en) * 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
UA69413C2 (uk) * 1998-05-22 2004-09-15 Брістол-Майерс Сквібб Компані Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
UA73092C2 (uk) * 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
US5997905A (en) * 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
IL142276A0 (en) * 1998-10-01 2002-03-10 Powderject Res Ltd Spray coated microparticles for use in needleless syringes
MXPA01008328A (es) * 1999-02-18 2002-06-04 Schering Ag Derivados de 18 -haluro epotilona, metodo para su produccion y su uso farmaceutico.
CZ301498B6 (cs) * 1999-02-22 2010-03-24 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) C-21 modifikované epothilony
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
KR100620404B1 (ko) * 2000-08-09 2006-09-13 파나세아 바이오테크 리미티드 항결핵 약물의 신규 약제학적 조성물 및 그의 제조방법
UA75365C2 (en) 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
CA2422500A1 (en) * 2000-09-22 2003-03-18 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) Triazolo-epothilones
EP1191127B1 (de) 2000-09-26 2004-10-13 Enthone-OMI (Deutschland) GmbH Verfahren zur selektiven Metallisierung dielektrischer Materialien
ES2304240T3 (es) * 2001-01-25 2008-10-01 Bristol-Myers Squibb Company Procedimientos para la preparacion de preparaciones farmaceuticas que contienen analogos de epotilona para el tratamiento de cancer.
EE200300323A (et) * 2001-01-25 2003-10-15 Bristol-Myers Squibb Company Epotilooni analoogi sisaldav parenteraalne ravimpreparaat, meetod selle valmistamiseks ning kasutamine
KR20040028720A (ko) * 2001-02-20 2004-04-03 브리스톨-마이어스스퀴브컴파니 치료불응성 종양 치료용 에포틸론 유도체
CN1774253A (zh) 2001-02-20 2006-05-17 布里斯托尔-迈尔斯斯奎布公司 用环氧丙酯酮衍生物治疗顽固性肿瘤
IL157443A0 (en) * 2001-03-14 2004-03-28 Bristol Myers Squibb Co Pharmaceutical compositions for the treatment of cancer including an epothilone analog and a chemotherapeutic agent
MXPA03010909A (es) * 2001-06-01 2004-02-17 Bristol Myers Squibb Co Derivados de epotilona.
JP4645789B2 (ja) * 2001-06-18 2011-03-09 Jsr株式会社 ネガ型感放射線性樹脂組成物
SI1483251T1 (sl) * 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
AU2003218107A1 (en) * 2002-03-12 2003-09-29 Bristol-Myers Squibb Company C12-cyano epothilone derivatives
TW200400191A (en) * 2002-05-15 2004-01-01 Bristol Myers Squibb Co Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
WO2003105828A1 (en) * 2002-06-14 2003-12-24 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
EP1539111A1 (en) * 2002-08-05 2005-06-15 DSM IP Assets B.V. Oral dosage forms of water insoluble drugs and methods of making the same
US7091193B2 (en) * 2002-10-09 2006-08-15 Kosan Biosciences Incorporated Therapeutic formulations
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
EP1824458A1 (en) * 2004-11-18 2007-08-29 Bristol-Myers Squibb Company Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US20030017210A1 (en) * 1997-02-11 2003-01-23 Laboratoires Des Produits Ethiques Ethypharm Microgranules containing cisplatin
US20020177615A1 (en) * 2001-01-25 2002-11-28 Rebanta Bandyopadhyay Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones
US20030220378A1 (en) * 2002-04-04 2003-11-27 Lee Francis Y. F. Oral administration of epothilones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951568B2 (en) 2006-06-23 2015-02-10 Tasly Pharmaceuticals Group Co., Ltd. Granule and preparation method thereof

Also Published As

Publication number Publication date
KR20070084325A (ko) 2007-08-24
EP1958625A1 (en) 2008-08-20
JP2008520696A (ja) 2008-06-19
ES2306278T3 (es) 2008-11-01
ATE397442T1 (de) 2008-06-15
EP1817013A1 (en) 2007-08-15
BRPI0518286A2 (pt) 2008-11-11
CA2588400A1 (en) 2006-05-26
ZA200703955B (en) 2008-08-27
TW200631609A (en) 2006-09-16
HK1106713A1 (en) 2008-03-20
US20060153917A1 (en) 2006-07-13
WO2006055740A1 (en) 2006-05-26
SI1817013T1 (sl) 2008-12-31
HRP20080349T3 (hr) 2009-01-31
NO20072388L (no) 2007-06-14
IL183116A0 (en) 2007-09-20
PL1817013T3 (pl) 2009-01-30
PT1817013E (pt) 2008-08-07
PE20061058A1 (es) 2006-10-13
AU2005306464A1 (en) 2006-05-26
DK1817013T3 (da) 2008-10-13
MX2007005763A (es) 2007-07-20
DE602005007376D1 (de) 2008-07-17
AR052142A1 (es) 2007-03-07
EP1817013B1 (en) 2008-06-04
CN101083978A (zh) 2007-12-05

Similar Documents

Publication Publication Date Title
JP6560289B2 (ja) 新たな医薬組成物
EP0533297B1 (en) Controlled-release pharmaceutical formulations
AU2018250470A1 (en) Extended release suspension compositions
EP3445349A1 (en) Extended release suspension compositions
SK656388A3 (en) Pharmaceutical preparation consisting of granules with tetracycline compound
SE512835C2 (sv) Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
WO2016188472A1 (zh) Mek抑制剂的药物组合物及其制备方法
HRP20010198A2 (en) Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same
CS270588B2 (en) Coating suitable for application on surface of pharmaceutical granules
WO2022125882A1 (en) Oral capsule cannabinoid formulations
RU2349319C1 (ru) Гранула, покрытая энтеросолюбильной оболочкой, содержащая иксабепилон, и способ ее приготовления
JP3221891B2 (ja) 咀嚼可能な製薬錠剤調製のための回転造粒及び味覚遮蔽被覆加工
WO2009074995A1 (en) Taste masked chewable compositions of sildenafil citrate
KR20070104392A (ko) 로시글리타존을 포함하는 경구 투여 제형
KR20040084930A (ko) 서방 제제 및 그의 제조 방법
KR20100045528A (ko) 6-머캅토퓨린의 서방형 제제
HK1106713B (en) Enteric coated bead comprising ixabepilone
JP3505734B2 (ja) エカベトナトリウム含有経口投与用製剤
WO2005077357A1 (en) Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof
EP3796899B1 (en) Novel pharmaceutical composition of tamsulosin and dutasteride
US20060134214A1 (en) Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof
EP4346796A1 (en) Delayed release compositions of dimethyl fumarate
WO2009089138A1 (en) Oral administration of ixabepilone

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20091118