JP2008518901A - インダゾール化合物を調製するための方法 - Google Patents

インダゾール化合物を調製するための方法 Download PDF

Info

Publication number
JP2008518901A
JP2008518901A JP2007538538A JP2007538538A JP2008518901A JP 2008518901 A JP2008518901 A JP 2008518901A JP 2007538538 A JP2007538538 A JP 2007538538A JP 2007538538 A JP2007538538 A JP 2007538538A JP 2008518901 A JP2008518901 A JP 2008518901A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
aryl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007538538A
Other languages
English (en)
Japanese (ja)
Inventor
バブ スリニヴァサン
ダグニノ， ジュニア． レイモンド
アレン オウルレット マイケル
シ ビング
ティアン キングピング
エドワード ズーク スコット
Original Assignee
ファイザー・インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ファイザー・インク filed Critical ファイザー・インク
Publication of JP2008518901A publication Critical patent/JP2008518901A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007538538A 2004-11-02 2005-10-21 インダゾール化合物を調製するための方法 Withdrawn JP2008518901A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62457504P 2004-11-02 2004-11-02
PCT/IB2005/003300 WO2006048745A1 (en) 2004-11-02 2005-10-21 Methods for preparing indazole compounds

Publications (1)

Publication Number Publication Date
JP2008518901A true JP2008518901A (ja) 2008-06-05

Family

ID=35528034

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007538538A Withdrawn JP2008518901A (ja) 2004-11-02 2005-10-21 インダゾール化合物を調製するための方法

Country Status (15)

Country Link
EP (1) EP1809625A1 (pt)
JP (1) JP2008518901A (pt)
KR (1) KR20070058689A (pt)
CN (1) CN101044138A (pt)
AR (1) AR051753A1 (pt)
AU (1) AU2005300311A1 (pt)
BR (1) BRPI0517921A (pt)
CA (1) CA2586176A1 (pt)
IL (1) IL182096A0 (pt)
MX (1) MX2007003603A (pt)
NO (1) NO20072747L (pt)
RU (1) RU2007114112A (pt)
TW (1) TW200614990A (pt)
WO (1) WO2006048745A1 (pt)
ZA (1) ZA200702317B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015152117A1 (ja) * 2014-03-31 2015-10-08 千寿製薬株式会社 アルキニルインダゾール誘導体及びその用途
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008122858A2 (en) 2007-04-05 2008-10-16 Pfizer Products Inc. Crystalline forms of 6- [2- (methylcarbamoyl) phenylsulfanyl] -3-e- [2- (pyridin-2-yl) ethenyl] indazole suitable for the treatment of abnormal cell growth in mammals
EP2214675B1 (en) 2007-10-25 2013-11-20 Genentech, Inc. Process for making thienopyrimidine compounds
EP2163544A1 (en) * 2008-09-16 2010-03-17 Pfizer, Inc. Methods of preparing indazole compounds
EP2760434A1 (en) 2011-09-30 2014-08-06 Pfizer Inc Pharmaceutical compositions of n-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1h-indazol-6-ylsulfanyl]-benzamide
RU2014116407A (ru) 2011-11-11 2015-12-20 Пфайзер Инк. N-метил-2-[3-((e)-2-пиридин-2-ил-винил)-1н-индазол-6-илсульфанил]-бензамид для лечения хронического миелоидного лейкоза
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
CN103387565B (zh) * 2013-07-29 2014-10-29 苏州明锐医药科技有限公司 阿西替尼的制备方法
CN103570696B (zh) * 2013-11-06 2016-02-24 湖南欧亚生物有限公司 一种阿西替尼中间体的制备方法以及在制备阿西替尼中的应用
WO2015067224A1 (en) 2013-11-08 2015-05-14 Zentiva, K.S. Salts of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethanyl] indazole
PT3498734T (pt) 2014-02-04 2021-12-06 Pfizer Combinação de um antagonista da pd-1 e um inibidor do vegfr para tratamento de cancro
CN104072484B (zh) * 2014-07-07 2016-07-06 渤海大学 氮-(4-(芳巯基)-1氢-吲唑-3-基)-1-(芳杂环取代)甲基亚胺类化合物及其药学上可接受的盐及其制备方法和应用
EP3185866A1 (en) 2014-08-25 2017-07-05 Pfizer Inc. Combination of a pd-1 antagonist and an alk inhibitor for treating cancer
CN112263677A (zh) 2015-02-26 2021-01-26 默克专利股份公司 用于治疗癌症的pd-1/pd-l1抑制剂
US9580406B2 (en) 2015-04-28 2017-02-28 Signa S.A. De C.V. Processes for the preparation of axitinib
IL256245B (en) 2015-06-16 2022-09-01 Merck Patent Gmbh Treatments that combine a pd-l1 antagonist
WO2018065938A1 (en) 2016-10-06 2018-04-12 Pfizer Inc. Dosing regimen of avelumab for the treatment of cancer
US20220370606A1 (en) 2018-12-21 2022-11-24 Pfizer Inc. Combination Treatments Of Cancer Comprising A TLR Agonist
US20220194921A1 (en) 2019-04-18 2022-06-23 Synthon B.V. Process for preparation of axitinib
CN112209861A (zh) * 2019-07-11 2021-01-12 鲁南制药集团股份有限公司 一种阿昔替尼中间体化合物及其制备方法
CN112442010B (zh) * 2019-08-30 2023-10-03 润佳（苏州）医药科技有限公司 一类前药化合物及其在治疗癌症方面的应用
CN111440102B (zh) * 2020-04-26 2022-02-15 大连凯飞化学股份有限公司 一种二硫代二苯甲酰胺类化合物的制备方法
WO2023166420A1 (en) 2022-03-03 2023-09-07 Pfizer Inc. Multispecific antibodies and uses thereof
CN114591338B (zh) * 2022-03-31 2023-05-09 苏州欧康维视生物科技有限公司 一种Syk和VEGFR2双靶点抑制剂的制备方法及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
JP3814285B2 (ja) * 2002-12-19 2006-08-23 ファイザー・インク 眼疾患の治療に有用なプロテインキナーゼ阻害剤としての２−（１ｈ−インダゾール−６−イルアミノ）−ベンズアミド化合物
US7521447B2 (en) * 2003-03-03 2009-04-21 Array Biopharma Inc. P38 inhibitors and methods of use thereof
WO2005094823A1 (ja) * 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. Ｆｌｔ－３阻害剤

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015152117A1 (ja) * 2014-03-31 2015-10-08 千寿製薬株式会社 アルキニルインダゾール誘導体及びその用途
JPWO2015152117A1 (ja) * 2014-03-31 2017-04-13 千寿製薬株式会社 アルキニルインダゾール誘導体及びその用途
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Also Published As

Publication number Publication date
AR051753A1 (es) 2007-02-07
WO2006048745A1 (en) 2006-05-11
CN101044138A (zh) 2007-09-26
BRPI0517921A (pt) 2008-10-21
TW200614990A (en) 2006-05-16
MX2007003603A (es) 2007-05-21
IL182096A0 (en) 2007-07-24
ZA200702317B (en) 2008-09-25
RU2007114112A (ru) 2008-12-10
EP1809625A1 (en) 2007-07-25
NO20072747L (no) 2007-07-31
AU2005300311A1 (en) 2006-05-11
CA2586176A1 (en) 2006-05-11
KR20070058689A (ko) 2007-06-08

Similar Documents

Publication Publication Date Title
JP2008518901A (ja) インダゾール化合物を調製するための方法
CN101094836A (zh) 制备吲唑化合物的方法
US7232910B2 (en) Methods of preparing indazole compounds
JP2013227349A (ja) （＋）−オピエートの生成のためのプロセスおよび化合物
EP3325485B1 (en) Methods of preparing cytotoxic benzodiazepine derivatives
US20070203196A1 (en) Methods of preparing indazole compounds
JP4823385B2 (ja) スピロケタール誘導体の結晶およびその製造方法
CA2515715C (en) Methods for producing cyclic benzamidine derivatives
TW202024059A (zh) 吡啶並〔２，３－ｄ〕嘧啶－７（８ｈ）－酮的合成
JP2024054201A (ja) １－［（３ｒ，４ｓ）－４－シアノテトラヒドロピラン－３－イル］－３－［（２－フルオロ－６－メトキシ－４－ピリジル）アミノ］ピラゾール－４－カルボキサミドの調製方法
JP4326471B2 (ja) 有機化合物の製造方法
JP5711669B2 (ja) スピロケタール誘導体の製造方法
AU2005300241A2 (en) Methods for preparing indazole compounds
JP2009508898A (ja) １’−ヒドロキシ−２’−置換シクロヘキシルアゼチジン−２−オン化合物の調製方法
CN107304179B (zh) 一种lcz696中间体的合成方法
JP6705111B2 (ja) トリアジノン化合物
JP2024526159A (ja) Ｃｙｐ１１ａ１阻害薬及びその中間体を調製する方法
RO133248A2 (ro) Amine biciclo[2.2.1]heptanice protejate la grupa hidroxil
US20060217554A1 (en) Processes for producing pyrazoloacridone derivative and synthetic intermediate thereof
JPH0714949B2 (ja) 光学活性なヘキサン酸誘導体の製造法
JPH05170746A (ja) ２−チオアシクロピリミジンヌクレオシド誘導体の 製造法
JPH0633265B2 (ja) テイリバリンの製造方法
JPH066549B2 (ja) ２−ヒドロキシメチル−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオンの製造方法
JP2002105053A (ja) ピリジン化合物の製造方法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080818

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090105