JP2008514624A5 - - Google Patents

Info

Publication number

JP2008514624A5

JP2008514624A5 JP2007533689A JP2007533689A JP2008514624A5 JP 2008514624 A5 JP2008514624 A5 JP 2008514624A5 JP 2007533689 A JP2007533689 A JP 2007533689A JP 2007533689 A JP2007533689 A JP 2007533689A JP 2008514624 A5 JP2008514624 A5 JP 2008514624A5

Authority

JP

Japan

Prior art keywords

composition

amino acid

group

acid selected

ala

Prior art date

2005-09-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000203 mixture Substances 0.000 claims 52
• 150000001413 amino acids Chemical group 0.000 claims 46
• 208000006011 Stroke Diseases 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 15
• 108090000765 processed proteins & peptides Proteins 0.000 claims 15
• 102000004196 processed proteins & peptides Human genes 0.000 claims 15
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
• 206010063837 Reperfusion injury Diseases 0.000 claims 8
• 201000006474 Brain Ischemia Diseases 0.000 claims 7
• 206010008120 Cerebral ischaemia Diseases 0.000 claims 7
• 101000975003 Homo sapiens Kallistatin Proteins 0.000 claims 7
• 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 claims 7
• 102100023012 Kallistatin Human genes 0.000 claims 7
• 206010008118 cerebral infarction Diseases 0.000 claims 7
• SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 4
• 241000024188 Andala Species 0.000 claims 4
• 208000007536 Thrombosis Diseases 0.000 claims 4
• 239000000504 antifibrinolytic agent Substances 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 239000003527 fibrinolytic agent Substances 0.000 claims 4
• 229960000103 thrombolytic agent Drugs 0.000 claims 4
• 206010014498 Embolic stroke Diseases 0.000 claims 3
• 208000005189 Embolism Diseases 0.000 claims 3
• 102000001399 Kallikrein Human genes 0.000 claims 3
• 108060005987 Kallikrein Proteins 0.000 claims 3
• 230000000740 bleeding effect Effects 0.000 claims 3
• 239000003112 inhibitor Substances 0.000 claims 3
• 238000001356 surgical procedure Methods 0.000 claims 3
• 108010039627 Aprotinin Proteins 0.000 claims 2
• 108010000437 Deamino Arginine Vasopressin Proteins 0.000 claims 2
• 229940100095 amicar Drugs 0.000 claims 2
• 229960002684 aminocaproic acid Drugs 0.000 claims 2
• 229960004405 aprotinin Drugs 0.000 claims 2
• 238000013132 cardiothoracic surgery Methods 0.000 claims 2
• NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 claims 2
• 229960004281 desmopressin Drugs 0.000 claims 2
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 2
• JZDHUJAFXGNDSB-WHFBIAKZSA-N Glu-Ala Chemical group OC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O JZDHUJAFXGNDSB-WHFBIAKZSA-N 0.000 claims 1
• 102000003827 Plasma Kallikrein Human genes 0.000 claims 1
• 108090000113 Plasma Kallikrein Proteins 0.000 claims 1
• GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 claims 1
• 239000005862 Whey Substances 0.000 claims 1
• 102000007544 Whey Proteins Human genes 0.000 claims 1
• 108010046377 Whey Proteins Proteins 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 210000004351 coronary vessel Anatomy 0.000 claims 1
• 229940099355 cyklokapron Drugs 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 230000007107 neurocognitive deficit Effects 0.000 claims 1
• ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 1
• 229960003073 pirfenidone Drugs 0.000 claims 1
• 230000008718 systemic inflammatory response Effects 0.000 claims 1
• GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims 1
• 229960000401 tranexamic acid Drugs 0.000 claims 1