JP2008514624A - カリクレインインヒビターおよびその使用 - Google Patents

カリクレインインヒビターおよびその使用 Download PDF

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Publication number
JP2008514624A
JP2008514624A JP2007533689A JP2007533689A JP2008514624A JP 2008514624 A JP2008514624 A JP 2008514624A JP 2007533689 A JP2007533689 A JP 2007533689A JP 2007533689 A JP2007533689 A JP 2007533689A JP 2008514624 A JP2008514624 A JP 2008514624A
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Prior art keywords
amino acid
group
acid selected
kallikrein
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2007533689A
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English (en)
Japanese (ja)
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JP2008514624A5 (enExample
Inventor
ロバート シー． ラドナー，
アーサー シー． レイ，
シリシュ ハイラニ，
アンソニー ウィリアムス，
シモーニ， マリア グラツィア デ
ルイージ ベルガマスキーニ，
ヘンリー ブレア，
トーマス ベック，
Original Assignee
ダイアックス コーポレーション
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Priority claimed from US10/953,902 external-priority patent/US7153829B2/en
Application filed by ダイアックス コーポレーション filed Critical ダイアックス コーポレーション
Publication of JP2008514624A publication Critical patent/JP2008514624A/ja
Publication of JP2008514624A5 publication Critical patent/JP2008514624A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007533689A 2004-09-27 2005-09-22 カリクレインインヒビターおよびその使用 Pending JP2008514624A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/953,902 US7153829B2 (en) 2002-06-07 2004-09-27 Kallikrein-inhibitor therapies
US11/125,639 US7235530B2 (en) 2004-09-27 2005-05-09 Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
PCT/US2005/034335 WO2006036860A2 (en) 2004-09-27 2005-09-22 Kallikrein inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011164650A Division JP5554756B2 (ja) 2004-09-27 2011-07-27 カリクレインインヒビターおよびその使用

Publications (2)

Publication Number Publication Date
JP2008514624A true JP2008514624A (ja) 2008-05-08
JP2008514624A5 JP2008514624A5 (enExample) 2008-10-16

Family

ID=36119484

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007533689A Pending JP2008514624A (ja) 2004-09-27 2005-09-22 カリクレインインヒビターおよびその使用
JP2011164650A Expired - Lifetime JP5554756B2 (ja) 2004-09-27 2011-07-27 カリクレインインヒビターおよびその使用
JP2013114068A Pending JP2013166791A (ja) 2004-09-27 2013-05-30 カリクレインインヒビターおよびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011164650A Expired - Lifetime JP5554756B2 (ja) 2004-09-27 2011-07-27 カリクレインインヒビターおよびその使用
JP2013114068A Pending JP2013166791A (ja) 2004-09-27 2013-05-30 カリクレインインヒビターおよびその使用

Country Status (6)

Country Link
US (12) US7235530B2 (enExample)
EP (3) EP3202414A1 (enExample)
JP (3) JP2008514624A (enExample)
AU (1) AU2005289621B2 (enExample)
CA (1) CA2581680C (enExample)
WO (1) WO2006036860A2 (enExample)

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JP2013516478A (ja) * 2010-01-06 2013-05-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
JP2016511267A (ja) * 2013-03-08 2016-04-14 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 遠隔虚血再灌流傷害の治療および予防
US10370453B2 (en) 2011-01-06 2019-08-06 Dyax Corp. Plasma kallikrein binding proteins
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US11299553B2 (en) 2013-03-15 2022-04-12 Takeda Pharmaceutical Company Limited Anti-plasma kallikrein antibodies

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US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US20050222023A1 (en) * 2002-02-07 2005-10-06 Hans-Peter Hauser Albumin-fused kunitz domain peptides
US7153829B2 (en) * 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE528014T1 (de) 2002-06-07 2011-10-15 Dyax Corp Polypeptid mit modifizierten kunitz domains
EP1542710B1 (en) 2002-08-28 2012-09-26 Dyax Corp. Methods for preserving organs and tissues
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
ES2447423T3 (es) * 2003-08-29 2014-03-12 Dyax Corp. Inhibidores de proteasa poli-pegilados
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20050245614A1 (en) * 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7235530B2 (en) * 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
LT1981519T (lt) * 2005-12-29 2018-04-25 Dyax Corp. Proteazės slopinimas
WO2007106746A2 (en) * 2006-03-10 2007-09-20 Dyax Corp. Formulations for ecallantide
ES2601554T3 (es) * 2006-03-16 2017-02-15 Dyax Corp. Péptidos inhibidores de calicreína plasmática para uso en el tratamiento de trastornos oftálmicos
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KR20210069112A (ko) 2011-09-08 2021-06-10 프레시전 인코포레이티드 결정성 디아실하이드라진 및 이의 용도
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