JP2008513439A5 - - Google Patents
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- Publication number
- JP2008513439A5 JP2008513439A5 JP2007531953A JP2007531953A JP2008513439A5 JP 2008513439 A5 JP2008513439 A5 JP 2008513439A5 JP 2007531953 A JP2007531953 A JP 2007531953A JP 2007531953 A JP2007531953 A JP 2007531953A JP 2008513439 A5 JP2008513439 A5 JP 2008513439A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- alopecia
- group
- tellurium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 201000004384 Alopecia Diseases 0.000 claims 18
- 231100000360 alopecia Toxicity 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000013543 active substance Substances 0.000 claims 6
- -1 hydroxy, thiohydroxy Chemical group 0.000 claims 6
- 229910052714 tellurium Inorganic materials 0.000 claims 6
- PORWMNRCUJJQNO-UHFFFAOYSA-N tellurium atom Chemical compound [Te] PORWMNRCUJJQNO-UHFFFAOYSA-N 0.000 claims 6
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims 4
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 4
- 229960004039 finasteride Drugs 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229960003632 minoxidil Drugs 0.000 claims 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000003779 hair growth Effects 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000000284 resting effect Effects 0.000 claims 3
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 206010068168 androgenetic alopecia Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229960000978 cyproterone acetate Drugs 0.000 claims 2
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000006260 foam Substances 0.000 claims 2
- 229940098330 gamma linoleic acid Drugs 0.000 claims 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 230000003676 hair loss Effects 0.000 claims 2
- 208000024963 hair loss Diseases 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229940124589 immunosuppressive drug Drugs 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229960004125 ketoconazole Drugs 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000006072 paste Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 230000003658 preventing hair loss Effects 0.000 claims 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
- 229940002683 retin-a Drugs 0.000 claims 2
- 239000010018 saw palmetto extract Substances 0.000 claims 2
- 229940063845 saw palmetto extract Drugs 0.000 claims 2
- 230000037390 scarring Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- LAJZODKXOMJMPK-UHFFFAOYSA-N tellurium dioxide Chemical compound O=[Te]=O LAJZODKXOMJMPK-UHFFFAOYSA-N 0.000 claims 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims 2
- 239000011726 vitamin B6 Substances 0.000 claims 2
- 235000019158 vitamin B6 Nutrition 0.000 claims 2
- 229940011671 vitamin b6 Drugs 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229960003459 allopurinol Drugs 0.000 claims 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 230000003698 anagen phase Effects 0.000 claims 1
- 201000002996 androgenic alopecia Diseases 0.000 claims 1
- 239000003529 anticholesteremic agent Substances 0.000 claims 1
- 239000002255 antigout agent Substances 0.000 claims 1
- 229960002708 antigout preparations Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229960001214 clofibrate Drugs 0.000 claims 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229960003627 gemfibrozil Drugs 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000003539 oral contraceptive agent Substances 0.000 claims 1
- 150000003498 tellurium compounds Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61066004P | 2004-09-17 | 2004-09-17 | |
| PCT/IL2005/000991 WO2006030439A2 (en) | 2004-09-17 | 2005-09-15 | Compositions and methods for inducing hair growth |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513439A JP2008513439A (ja) | 2008-05-01 |
| JP2008513439A5 true JP2008513439A5 (https=) | 2008-11-06 |
Family
ID=35985262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531953A Pending JP2008513439A (ja) | 2004-09-17 | 2005-09-15 | 発毛を誘導するための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20090269418A1 (https=) |
| EP (3) | EP1791535B1 (https=) |
| JP (1) | JP2008513439A (https=) |
| AT (1) | ATE402709T1 (https=) |
| AU (1) | AU2005283719A1 (https=) |
| CA (3) | CA2580643C (https=) |
| DE (1) | DE602005008622D1 (https=) |
| ES (2) | ES2312012T3 (https=) |
| PT (1) | PT1796660T (https=) |
| WO (3) | WO2006030439A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004304716B2 (en) | 2003-12-18 | 2010-05-27 | Biomas Ltd. | Tellurium derivatives for prevention and treatment of neurodegenerative processes |
| DK1715785T3 (da) * | 2004-01-22 | 2014-06-30 | Biomas Ltd | Terapeutiske fremgangsmåder og farmaceutiske sammensætninger tilbehandling af vorter med tellurforbindelser |
| CA2580805A1 (en) * | 2004-09-17 | 2006-03-23 | Biomas Ltd. | Use of tellurium compounds as adjuvants |
| EP1791535B1 (en) | 2004-09-17 | 2008-07-30 | BioMAS Ltd. | Novel tellurium compounds and their use as immunomodulators |
| WO2006075314A2 (en) | 2005-01-11 | 2006-07-20 | Jemtex Ink Jet Printing Ltd. | Inkjet printer and method of controlling same |
| AU2006290297A1 (en) * | 2005-09-15 | 2007-03-22 | Biomas Ltd. | Use of tellurium compounds for protection from ultra-violet radiation |
| WO2007138103A1 (en) * | 2006-06-01 | 2007-12-06 | Nobera Pharma, S.L. | Use of allopurinol for the treatment of palmar plantar erythrodysesthesia |
| EP1862166A1 (en) * | 2006-06-01 | 2007-12-05 | Yolanda Rodemer | Use of allopurinol for the treatment of palmar plantar erythrodysesthesia |
| WO2008032227A2 (en) | 2006-09-11 | 2008-03-20 | Biomas, Ltd. | Topical formulations of tellurium-containing compounds |
| WO2009066300A2 (en) * | 2007-11-23 | 2009-05-28 | Biomas Ltd. | Methods and compositions for inhibiting integrins using tellurium-containing compounds |
| WO2009066301A2 (en) * | 2007-11-23 | 2009-05-28 | Biomas Ltd. | Methods and compositions for treating pox virus with tellurium-containing compounds |
| US20120035260A1 (en) * | 2009-01-08 | 2012-02-09 | Biomas Ltd. | Tellurium-containing compounds for affecting female's reproductive system following chemotherapy and/or radiotherapy |
| WO2010079488A1 (en) * | 2009-01-08 | 2010-07-15 | Biomas Ltd. | Tellurium-containing compounds for affecting male's fertility following chemotherapy and/or radiotherapy |
| EP2246057A1 (en) | 2009-04-29 | 2010-11-03 | Nobera Pharma, S.L. | Use of allopurinol for the treatment of hand foot skin reaction |
| WO2010146547A1 (en) * | 2009-06-16 | 2010-12-23 | Biomas Ltd. | Tellurium-containing compounds for facilitating transplantation |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| WO2012065065A1 (en) * | 2010-11-12 | 2012-05-18 | Follica, Inc. | Methods and compositions for modulating hair growth, wound healing and scar revision |
| AU2011338530B2 (en) | 2010-12-06 | 2017-06-15 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| EP3865139B1 (en) | 2015-02-18 | 2023-05-03 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| US11427538B2 (en) * | 2017-04-28 | 2022-08-30 | Kyoto University | Organic tellurium compound, method for producing same, living radical polymerization initiator, method for producing vinyl polymer, and vinyl polymer |
| CA3067746A1 (en) | 2017-06-30 | 2019-01-03 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
| EP3687528A4 (en) * | 2017-09-29 | 2021-07-21 | The Regents of the University of California | COMPOSITIONS AND PROCEDURES FOR MODULATING HAIR GROWTH |
| JP2021042161A (ja) * | 2019-09-11 | 2021-03-18 | 国立大学法人東海国立大学機構 | 脱毛剤、脱毛モデル動物及び白髪モデル動物 |
| WO2022006040A1 (en) | 2020-06-30 | 2022-01-06 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
Family Cites Families (36)
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| US3369550A (en) | 1967-02-17 | 1968-02-20 | Thomas A. Armao | Cryogenic clamps |
| GB1427415A (en) | 1973-09-21 | 1976-03-10 | Armao T A | Cryosurgical instruments |
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| US5102908A (en) * | 1985-03-15 | 1992-04-07 | Michael Albeck | Method of treating Acquired Immunedeficiency Syndrome (AIDS) using organic tellurium and selenium derivatives |
| US4962207A (en) * | 1985-09-30 | 1990-10-09 | Bar-Ilan University | Organic derivatives of tellurium and selenium |
| US4761490A (en) * | 1985-03-15 | 1988-08-02 | Bar-Ilan University | Organic derivatives of tellurium and selenium and their use to stimulate cytokine production |
| US5093135A (en) * | 1985-09-30 | 1992-03-03 | Michael Albeck | Compounds for the induction of in vivo and in vitro production of cytokines |
| US4764461A (en) * | 1985-09-30 | 1988-08-16 | Bar-Ilan University | Tellurium and selenium compounds for the induction of in vivo and in vitro production of cytokines |
| US4752614A (en) * | 1985-09-30 | 1988-06-21 | Bar-Ilan University | Pharmaceutical compositions of tellerium and selenium compounds for the induction of in vivo and in vitro production of cytokines |
| US4929739A (en) * | 1988-03-24 | 1990-05-29 | Bar-Ilan University | Complexes of tellurium and selenium derivatives |
| DE4007473A1 (de) | 1990-03-09 | 1991-09-12 | Tomsk G Med I | Kryoskalpell |
| US5271925A (en) | 1990-03-09 | 1993-12-21 | Benjamin Sredni | Method for protecting against the effects of radiation which is based on the administration of a selenium or tellurium based compound |
| US5213899A (en) * | 1990-12-17 | 1993-05-25 | General Electric Company | Room temperature vulcanizable silicone compositions |
| US5262149A (en) * | 1992-08-13 | 1993-11-16 | Benjamin Sredni | Method of treating or preventing alopecia |
| ES2128761T3 (es) | 1994-09-01 | 1999-05-16 | Upjohn Co | Formulacion de tirilazad con cosolvente para administracion parenteral. |
| US5576347A (en) * | 1994-11-14 | 1996-11-19 | Sredni; Benjamin | Method of treating gastric ulcers |
| DE69534535T2 (de) * | 1994-12-15 | 2006-07-06 | Baker Norton Pharmaceuticals, Inc., Miami | Verfahren und mittel zur verminderung der tumorentwicklung mittels einer kombination aus einer taxanverbindung und einer tellur und/oder selenverbindung |
| US5654328A (en) * | 1994-12-15 | 1997-08-05 | Sredni; Benjamin | Method and composition for reducing tumor development with a combination of platinum and tellurium or selenium compounds |
| TWI243828B (en) * | 1998-03-19 | 2005-11-21 | Vertex Pharma | Inhibitors of caspases |
| US6428534B1 (en) * | 1999-02-24 | 2002-08-06 | Cryovascular Systems, Inc. | Cryogenic angioplasty catheter |
| US6355618B1 (en) * | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| KR20020025959A (ko) * | 2000-05-23 | 2002-04-04 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 및 이의 용도 |
| WO2001094351A1 (en) * | 2000-06-07 | 2001-12-13 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6747008B1 (en) | 2000-06-19 | 2004-06-08 | University Of Southern California | Methods for treating and preventing alopecia |
| AU2001218024A1 (en) | 2000-06-19 | 2002-01-02 | University Of Southern California | Methods for treating and preventing alopecia |
| DE60127860T2 (de) * | 2000-11-21 | 2008-01-17 | Vertex Pharmaceuticals Inc., Cambridge | Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung |
| US20030148970A1 (en) | 2001-01-12 | 2003-08-07 | Besterman Jeffrey M. | Methods for specifically inhibiting histone deacetylase-4 |
| WO2002094263A2 (en) * | 2001-05-23 | 2002-11-28 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6472381B1 (en) | 2001-10-12 | 2002-10-29 | Biomas Inc. | Method of treating psoriasis |
| IL146694A (en) * | 2001-11-22 | 2010-12-30 | Biomas Ltd | Use of an aqueous solution containing a biologically active complex of tellurium dioxide for manufacturing a medicament |
| PL374598A1 (en) * | 2002-06-28 | 2005-10-31 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US7612091B2 (en) * | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| AU2004304716B2 (en) * | 2003-12-18 | 2010-05-27 | Biomas Ltd. | Tellurium derivatives for prevention and treatment of neurodegenerative processes |
| JP4718553B2 (ja) | 2004-09-15 | 2011-07-06 | イタマール メディカル リミテッド | 血流および静脈容量の測定 |
| CA2580805A1 (en) | 2004-09-17 | 2006-03-23 | Biomas Ltd. | Use of tellurium compounds as adjuvants |
| EP1791535B1 (en) * | 2004-09-17 | 2008-07-30 | BioMAS Ltd. | Novel tellurium compounds and their use as immunomodulators |
-
2005
- 2005-09-15 EP EP05779419A patent/EP1791535B1/en not_active Expired - Lifetime
- 2005-09-15 EP EP05784166A patent/EP1802292A4/en not_active Withdrawn
- 2005-09-15 AU AU2005283719A patent/AU2005283719A1/en not_active Abandoned
- 2005-09-15 CA CA2580643A patent/CA2580643C/en not_active Expired - Fee Related
- 2005-09-15 CA CA002580804A patent/CA2580804A1/en not_active Abandoned
- 2005-09-15 US US11/662,743 patent/US20090269418A1/en not_active Abandoned
- 2005-09-15 ES ES05779419T patent/ES2312012T3/es not_active Expired - Lifetime
- 2005-09-15 JP JP2007531953A patent/JP2008513439A/ja active Pending
- 2005-09-15 WO PCT/IL2005/000991 patent/WO2006030439A2/en not_active Ceased
- 2005-09-15 DE DE602005008622T patent/DE602005008622D1/de not_active Expired - Lifetime
- 2005-09-15 US US11/663,032 patent/US7709524B2/en not_active Expired - Fee Related
- 2005-09-15 US US11/663,031 patent/US7652065B2/en not_active Expired - Fee Related
- 2005-09-15 WO PCT/IL2005/000990 patent/WO2006030438A2/en not_active Ceased
- 2005-09-15 WO PCT/IL2005/000989 patent/WO2006030437A2/en not_active Ceased
- 2005-09-15 EP EP05779639.3A patent/EP1796660B1/en not_active Expired - Lifetime
- 2005-09-15 PT PT57796393T patent/PT1796660T/pt unknown
- 2005-09-15 AT AT05779419T patent/ATE402709T1/de not_active IP Right Cessation
- 2005-09-15 CA CA2580642A patent/CA2580642C/en not_active Expired - Fee Related
- 2005-09-15 ES ES05779639.3T patent/ES2614113T3/es not_active Expired - Lifetime
-
2009
- 2009-12-02 US US12/629,071 patent/US20100081623A1/en not_active Abandoned
-
2010
- 2010-03-22 US US12/728,362 patent/US8623908B2/en not_active Expired - Fee Related
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