JP2020530848A5 - - Google Patents
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- Publication number
- JP2020530848A5 JP2020530848A5 JP2020508398A JP2020508398A JP2020530848A5 JP 2020530848 A5 JP2020530848 A5 JP 2020530848A5 JP 2020508398 A JP2020508398 A JP 2020508398A JP 2020508398 A JP2020508398 A JP 2020508398A JP 2020530848 A5 JP2020530848 A5 JP 2020530848A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- membered
- group selected
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762545331P | 2017-08-14 | 2017-08-14 | |
| US62/545,331 | 2017-08-14 | ||
| PCT/US2018/046532 WO2019036374A1 (en) | 2017-08-14 | 2018-08-13 | 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND THEIR USE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530848A JP2020530848A (ja) | 2020-10-29 |
| JP2020530848A5 true JP2020530848A5 (https=) | 2021-09-30 |
Family
ID=63405487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508398A Ceased JP2020530848A (ja) | 2017-08-14 | 2018-08-13 | ３，４−二置換３−シクロブテン−１，２−ジオンおよびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11208377B2 (https=) |
| EP (1) | EP3668832A1 (https=) |
| JP (1) | JP2020530848A (https=) |
| KR (1) | KR20200037857A (https=) |
| CN (1) | CN111225900A (https=) |
| AU (1) | AU2018318075B2 (https=) |
| BR (1) | BR112020003245A2 (https=) |
| CA (1) | CA3072671A1 (https=) |
| RU (1) | RU2020106383A (https=) |
| WO (1) | WO2019036374A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112679328B (zh) * | 2019-10-17 | 2023-09-15 | 南京药石科技股份有限公司 | 一种3-三氟甲基-2-环己烯-1-酮的工业化生产方法 |
| KR20210100259A (ko) * | 2020-02-05 | 2021-08-17 | 주식회사 에피바이오텍 | 3,4-디아미노-3-시클로부텐-1,2-디온 유도체를 포함하는 탈모의 예방 또는 치료용 조성물 |
| BR112022021976A2 (pt) | 2020-04-30 | 2022-12-13 | Idorsia Pharmaceuticals Ltd | Composto, e, composição farmacêutica compreendendo um composto |
| US11945788B2 (en) * | 2021-06-07 | 2024-04-02 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| EP4423082A1 (en) | 2021-10-26 | 2024-09-04 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| KR20240090693A (ko) | 2021-10-28 | 2024-06-21 | 이도르시아 파마슈티컬스 리미티드 | Ccr6 수용체 조절인자 |
| WO2025092968A1 (zh) * | 2023-11-03 | 2025-05-08 | 武汉朗来科技发展有限公司 | 作为ccr6拮抗剂的化合物、其药物组合物和用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354763A (en) | 1993-11-17 | 1994-10-11 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5506252A (en) | 1993-11-17 | 1996-04-09 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| MXPA02011868A (es) | 2000-05-30 | 2003-04-10 | Smithkline Beecham Corp | Antagonistas de receptor de interleucina 8. |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US20040048897A1 (en) | 2001-01-16 | 2004-03-11 | Mccleland Brent | Il-8 receptor antagonists |
| RU2003126913A (ru) * | 2001-02-02 | 2005-03-10 | Шеринг Корпорейшн (US) | 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс |
| CZ20032639A3 (cs) | 2001-03-30 | 2004-04-14 | Smithkline Beecham Corporation | Způsoby přípravy sloučenin obsahujících fenol |
| US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040097547A1 (en) * | 2001-04-16 | 2004-05-20 | Taveras Arthur G. | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| PL208928B1 (pl) * | 2001-04-16 | 2011-06-30 | Pharmacopeia | 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040053953A1 (en) * | 2002-03-18 | 2004-03-18 | Schering Corporation | Treatment of chemokine mediated diseases |
| DE102005001053A1 (de) | 2005-01-07 | 2006-07-20 | Merck Patent Gmbh | Quadratsäurederivate |
| ES2386489T3 (es) * | 2007-06-06 | 2012-08-21 | Novartis Ag | Compuestos ciclobutanediona sustituidos anti-inflamatorios |
| US8563527B2 (en) | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| US20100305098A1 (en) | 2007-11-15 | 2010-12-02 | Qian Chen | Methods of use |
| US20090156459A1 (en) | 2007-11-16 | 2009-06-18 | Pharmain Corporation | Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| AU2009204700B2 (en) | 2008-01-18 | 2013-07-04 | Atopix Therapeutics Limited | Compounds having CRTH2 antagonist activity |
| EP2265581A1 (en) | 2008-01-22 | 2010-12-29 | Oxagen Limited | Compounds having crth2 antagonist activity |
| JP2011509991A (ja) | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| WO2010063802A1 (en) * | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
| FR2961695B1 (fr) | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
| WO2012047630A2 (en) | 2010-09-27 | 2012-04-12 | Martin Teintze | N-alkyl or n-aryl substituted guanide and biguanide compounds and methods of their use |
| US8648070B2 (en) * | 2010-12-17 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments |
| FR2981934B1 (fr) | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| FR2981935B1 (fr) | 2011-10-28 | 2015-08-07 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| EP3076968B1 (en) | 2013-12-02 | 2019-04-17 | ChemoCentryx, Inc. | Ccr6 compounds |
| US9618513B2 (en) | 2014-01-27 | 2017-04-11 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating colorectal cancer |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
-
2018
- 2018-08-13 JP JP2020508398A patent/JP2020530848A/ja not_active Ceased
- 2018-08-13 AU AU2018318075A patent/AU2018318075B2/en not_active Expired - Fee Related
- 2018-08-13 CA CA3072671A patent/CA3072671A1/en active Pending
- 2018-08-13 CN CN201880066725.7A patent/CN111225900A/zh active Pending
- 2018-08-13 RU RU2020106383A patent/RU2020106383A/ru unknown
- 2018-08-13 EP EP18760225.5A patent/EP3668832A1/en not_active Withdrawn
- 2018-08-13 WO PCT/US2018/046532 patent/WO2019036374A1/en not_active Ceased
- 2018-08-13 KR KR1020207007312A patent/KR20200037857A/ko not_active Ceased
- 2018-08-13 BR BR112020003245-0A patent/BR112020003245A2/pt not_active Application Discontinuation
- 2018-08-14 US US16/103,607 patent/US11208377B2/en active Active
-
2021
- 2021-12-08 US US17/545,940 patent/US20220402866A1/en not_active Abandoned
-
2024
- 2024-03-11 US US18/601,679 patent/US20240400501A1/en active Pending
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