NO20071967L - Imidazo-benzodiazepinderivater - Google Patents

Imidazo-benzodiazepinderivater

Info

Publication number
NO20071967L
NO20071967L NO20071967A NO20071967A NO20071967L NO 20071967 L NO20071967 L NO 20071967L NO 20071967 A NO20071967 A NO 20071967A NO 20071967 A NO20071967 A NO 20071967A NO 20071967 L NO20071967 L NO 20071967L
Authority
NO
Norway
Prior art keywords
imidazo
benzodiazepine
cognitive
triazolo
gaba
Prior art date
Application number
NO20071967A
Other languages
English (en)
Inventor
Andrew William Thomas
Henner Knust
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20071967L publication Critical patent/NO20071967L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår substituert imidazo[1,5-a][1,2,4]triazolo[1,5d][1,4]benzodiazepinderivater av den følgende formel: hvor R1, R2 og R3 er som definert i kravene og deres farmasøytisk akseptable syreaddisjonssalter. Det er funnet at denne klasse forbindelser viser høy affinitet og selektivitet for GABA A a5 reseptor bindingsseter, og de kan være anvendelige som kognitiv enhancere eller for behandling av kognitive lidelser, angst, schizofreni eller Alzheimer's sykdom.
NO20071967A 2004-10-20 2007-04-17 Imidazo-benzodiazepinderivater NO20071967L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04105169 2004-10-20
PCT/EP2005/010908 WO2006045430A1 (en) 2004-10-20 2005-10-11 Imidazo-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
NO20071967L true NO20071967L (no) 2007-05-14

Family

ID=36035782

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071967A NO20071967L (no) 2004-10-20 2007-04-17 Imidazo-benzodiazepinderivater

Country Status (18)

Country Link
US (1) US7514426B2 (no)
EP (1) EP1805184B1 (no)
JP (1) JP4783375B2 (no)
KR (1) KR100923399B1 (no)
CN (1) CN101044145B (no)
AR (1) AR051395A1 (no)
AU (1) AU2005299032B2 (no)
BR (1) BRPI0519991A2 (no)
CA (1) CA2584259C (no)
ES (1) ES2399439T3 (no)
IL (1) IL182585A0 (no)
MX (1) MX2007004639A (no)
NO (1) NO20071967L (no)
NZ (1) NZ554439A (no)
RU (1) RU2007112940A (no)
TW (1) TWI303247B (no)
WO (1) WO2006045430A1 (no)
ZA (1) ZA200703172B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005007265D1 (de) * 2004-12-14 2008-07-10 Hoffmann La Roche Tetrazyklische imidazobenzodiazepine als gaba-rezeptormodulatoren
ES2348356T3 (es) * 2005-10-11 2010-12-03 F. Hoffmann-La Roche Ag Derivados de imidazo-benzodiazepina.
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
EP2298296A1 (en) 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects
CA2837818A1 (en) * 2010-06-03 2011-12-08 The Regents Of The University Of California Methods and compositions for treating a subject for central nervous system (cns) injury
EP2457569A1 (en) 2010-11-05 2012-05-30 F. Hoffmann-La Roche AG Use of active pharmaceutical compounds for the treatment of central nervous system conditions
KR20130083927A (ko) * 2010-11-05 2013-07-23 에프. 호프만-라 로슈 아게 중추 신경계 질환의 치료를 위한 활성 약학 화합물의 용도
CN103313712B (zh) 2010-11-15 2016-10-26 艾吉因生物股份有限公司 用于治疗认知障碍的哒嗪衍生物、组合物和方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
AU2014368961B2 (en) 2013-12-20 2019-10-17 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
BR112020026062B1 (pt) 2018-06-19 2023-04-04 Agenebio, Inc Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
ZA881538B (en) * 1987-03-10 1988-09-12 F. Hoffmann-La Roche & Co. Aktiengesellschaft Imidazodiazepine derivatives
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
TW201311B (no) * 1991-06-17 1993-03-01 Hoffmann La Roche
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

Also Published As

Publication number Publication date
JP2008517011A (ja) 2008-05-22
EP1805184B1 (en) 2013-01-09
KR20070054731A (ko) 2007-05-29
RU2007112940A (ru) 2008-11-27
NZ554439A (en) 2009-09-25
US20060084642A1 (en) 2006-04-20
WO2006045430A1 (en) 2006-05-04
ES2399439T3 (es) 2013-04-01
TW200630372A (en) 2006-09-01
TWI303247B (en) 2008-11-21
EP1805184A1 (en) 2007-07-11
CA2584259A1 (en) 2006-05-04
KR100923399B1 (ko) 2009-10-23
US7514426B2 (en) 2009-04-07
JP4783375B2 (ja) 2011-09-28
AU2005299032A1 (en) 2006-05-04
BRPI0519991A2 (pt) 2009-04-07
MX2007004639A (es) 2007-06-08
CN101044145B (zh) 2010-06-16
IL182585A0 (en) 2007-07-24
AR051395A1 (es) 2007-01-10
CA2584259C (en) 2013-04-02
CN101044145A (zh) 2007-09-26
AU2005299032B2 (en) 2011-11-17
ZA200703172B (en) 2008-08-27

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