BRPI0618383A2 - derivados de 3-aril-isoxazol-4-carbonil-benzofurano - Google Patents

derivados de 3-aril-isoxazol-4-carbonil-benzofurano Download PDF

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Publication number
BRPI0618383A2
BRPI0618383A2 BRPI0618383-2A BRPI0618383A BRPI0618383A2 BR PI0618383 A2 BRPI0618383 A2 BR PI0618383A2 BR PI0618383 A BRPI0618383 A BR PI0618383A BR PI0618383 A2 BRPI0618383 A2 BR PI0618383A2
Authority
BR
Brazil
Prior art keywords
sup
isoxazole
carbonyl
aryl
benzofuran derivatives
Prior art date
Application number
BRPI0618383-2A
Other languages
English (en)
Inventor
Bernd Buettelmann
Bo Han
Henner Knust
Andrew Thomas
Matthias Nettekoven
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0618383A2 publication Critical patent/BRPI0618383A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

DERIVADOS DE 3-ARIL-ISOXAZOL-4-CARBONIL-BENZOFURANO. A presente invenção refere-se a derivados de 3-aril-isoxazol-4-carbonil-benzofurano de fórmula (I), em que R^1^ é hidrogênio ou halogênio; R^2^ é hidrogênio, halogênio, hidróxi, alcóxi inferior, OCF~3~, -OCH~2~- R, R^3^ é hidrogênio ou alcóxi inferior; ou R^2^R^3^ formam juntamente com o átomo ao qual eles encontram-s ligados um anel com -CH=CH-CH=-CH-; R é arila ou heteroarila, op- cionalmente substituida por halogênio ou alquila inferior, ou é C(O)NH- alquila inferior, ou é -C(O)-heteroarila, em que o grupo heteroarila é opcionalmente substituído por alquila inferior ou fenila, e com seus sais de adição de ácido farmaceuticamente aceitáveis. Foi descoberto que esta classe de compostos apresenta alta afinidade e seletividade com os sítios de ligação do receptor GABA A cc5 e poderia ser útil como intensificador de cognição ou para o tratamento de distúrbios cognitivos como mal de Alzheimer.
BRPI0618383-2A 2005-11-09 2006-10-27 derivados de 3-aril-isoxazol-4-carbonil-benzofurano BRPI0618383A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05110503 2005-11-09
PCT/EP2006/067879 WO2007054444A2 (en) 2005-11-09 2006-10-27 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives

Publications (1)

Publication Number Publication Date
BRPI0618383A2 true BRPI0618383A2 (pt) 2011-08-30

Family

ID=37876981

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618383-2A BRPI0618383A2 (pt) 2005-11-09 2006-10-27 derivados de 3-aril-isoxazol-4-carbonil-benzofurano

Country Status (13)

Country Link
US (1) US7388025B2 (pt)
EP (1) EP1948648B1 (pt)
JP (1) JP2009514924A (pt)
KR (1) KR101103129B1 (pt)
CN (1) CN101304994B (pt)
AT (1) ATE466858T1 (pt)
AU (1) AU2006311092B2 (pt)
BR (1) BRPI0618383A2 (pt)
CA (1) CA2628667A1 (pt)
DE (1) DE602006014185D1 (pt)
ES (1) ES2341131T3 (pt)
IL (1) IL190867A0 (pt)
WO (1) WO2007054444A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100828891B1 (ko) * 2006-02-23 2008-05-09 엘지이노텍 주식회사 Ｌｅｄ 패키지
WO2013046117A1 (en) 2011-09-26 2013-04-04 Koninklijke Philips Electronics N.V. Imaging system rotating gantry and subject support motion control
PT2809845T (pt) 2012-02-01 2019-03-22 Basf Se Processo para o fabrico de papel e cartão
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2013127731A1 (en) 2012-03-01 2013-09-06 Basf Se Process for the manufacture of paper and paperboard
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
EP2877463B1 (en) 2012-06-26 2018-11-07 Saniona A/S A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
IN2014DN11027A (pt) 2012-06-26 2015-09-25 Aniona Aps
CA2897185C (en) 2013-01-11 2018-10-09 Basf Se Process for the manufacture of paper and paperboard
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
TW202202495A (zh) * 2020-03-26 2022-01-16 匈牙利商羅特格登公司 作為ｇａｍｍａ－胺基丁酸Ａ受體次單元ａｌｐｈａ ５受體調節劑之㖠啶及吡啶并〔３，４－ｃ〕嗒𠯤衍生物
WO2021191837A1 (en) * 2020-03-26 2021-09-30 Richter Gedeon Nyrt. 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
HUP0401880A2 (hu) 2001-07-05 2005-01-28 Synaptic Pharmaceutical Corporation Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
IL159926A0 (en) * 2001-08-06 2004-06-20 Pharmacia Italia Spa Aminoisoxazole derivatives active as kinase inhibitors
GB0128160D0 (en) * 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds

Also Published As

Publication number Publication date
JP2009514924A (ja) 2009-04-09
AU2006311092B2 (en) 2011-05-12
US20070105922A1 (en) 2007-05-10
WO2007054444A3 (en) 2007-06-28
ATE466858T1 (de) 2010-05-15
ES2341131T3 (es) 2010-06-15
CN101304994B (zh) 2011-06-29
EP1948648A2 (en) 2008-07-30
DE602006014185D1 (de) 2010-06-17
IL190867A0 (en) 2008-11-03
KR101103129B1 (ko) 2012-01-04
WO2007054444A2 (en) 2007-05-18
KR20080065697A (ko) 2008-07-14
EP1948648B1 (en) 2010-05-05
US7388025B2 (en) 2008-06-17
CN101304994A (zh) 2008-11-12
AU2006311092A1 (en) 2007-05-18
CA2628667A1 (en) 2007-05-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.