JP2008511635A5 - - Google Patents
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- Publication number
- JP2008511635A5 JP2008511635A5 JP2007530162A JP2007530162A JP2008511635A5 JP 2008511635 A5 JP2008511635 A5 JP 2008511635A5 JP 2007530162 A JP2007530162 A JP 2007530162A JP 2007530162 A JP2007530162 A JP 2007530162A JP 2008511635 A5 JP2008511635 A5 JP 2008511635A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- aralkyl
- cycloalkyl
- heteroaralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 41
- 125000000217 alkyl group Chemical group 0.000 claims description 35
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 34
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 33
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 31
- 125000001072 heteroaryl group Chemical group 0.000 claims description 31
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 25
- 125000003545 alkoxy group Chemical group 0.000 claims description 22
- 125000003342 alkenyl group Chemical group 0.000 claims description 21
- 125000000304 alkynyl group Chemical group 0.000 claims description 21
- 125000004442 acylamino group Chemical group 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 229940124530 sulfonamide Drugs 0.000 claims description 3
- 150000003456 sulfonamides Chemical class 0.000 claims description 3
- 150000004820 halides Chemical class 0.000 claims 13
- 125000004423 acyloxy group Chemical group 0.000 claims 12
- 125000004104 aryloxy group Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 10
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 10
- 125000001769 aryl amino group Chemical group 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000005110 aryl thio group Chemical group 0.000 claims 6
- 229910052698 phosphorus Inorganic materials 0.000 claims 6
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 4
- 150000002825 nitriles Chemical class 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 125000005035 acylthio group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- -1 aralkylthio Hydroxyl Chemical group 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 2
- YYSFXUWWPNHNAZ-OSDRTFJJSA-N 851536-75-9 Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CCC2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-OSDRTFJJSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60502004P | 2004-08-27 | 2004-08-27 | |
| US60/605,020 | 2004-08-27 | ||
| US61717004P | 2004-10-08 | 2004-10-08 | |
| US60/617,170 | 2004-10-08 | ||
| US62567604P | 2004-11-05 | 2004-11-05 | |
| US60/625,676 | 2004-11-05 | ||
| US68316905P | 2005-05-19 | 2005-05-19 | |
| US60/683,169 | 2005-05-19 | ||
| PCT/US2005/030406 WO2006026430A2 (en) | 2004-08-27 | 2005-08-26 | Cyclopamine analogues and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012164081A Division JP2012232997A (ja) | 2004-08-27 | 2012-07-24 | シクロパミンアナログ及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511635A JP2008511635A (ja) | 2008-04-17 |
| JP2008511635A5 true JP2008511635A5 (enExample) | 2008-10-23 |
| JP5204486B2 JP5204486B2 (ja) | 2013-06-05 |
Family
ID=36000609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Expired - Fee Related JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
| JP2012164081A Pending JP2012232997A (ja) | 2004-08-27 | 2012-07-24 | シクロパミンアナログ及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012164081A Pending JP2012232997A (ja) | 2004-08-27 | 2012-07-24 | シクロパミンアナログ及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7230004B2 (enExample) |
| EP (3) | EP2316833B1 (enExample) |
| JP (2) | JP5204486B2 (enExample) |
| KR (1) | KR101487481B1 (enExample) |
| CN (1) | CN102241727B (enExample) |
| AU (1) | AU2005280112B2 (enExample) |
| BR (1) | BRPI0514444A (enExample) |
| CA (1) | CA2579078C (enExample) |
| ES (1) | ES2578728T3 (enExample) |
| IL (1) | IL181301A (enExample) |
| NO (1) | NO341137B1 (enExample) |
| WO (1) | WO2006026430A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US20170326118A1 (en) * | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
| CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| ES2578728T3 (es) * | 2004-08-27 | 2016-07-29 | Infinity Pharmaceuticals, Inc. | Proceso para la preparación de compuestos análogos de ciclopamina |
| WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2007123511A2 (en) * | 2006-03-24 | 2007-11-01 | Infinity Pharmaceuticals, Inc. | Dosing regimens for the treatment of cancer |
| EP2066320A1 (en) * | 2006-09-27 | 2009-06-10 | Irm, Llc | Methods and compositions for treating lymphoma and myeloma |
| TWI433674B (zh) * | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| CN101687877B (zh) | 2007-03-07 | 2014-07-23 | 无限发现股份有限公司 | 杂环环杷明类似物及其使用方法 |
| EP2134719B1 (en) * | 2007-03-07 | 2013-07-17 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
| PE20090806A1 (es) | 2007-04-18 | 2009-06-27 | Merck & Co Inc | Derivados de triazol que son antagonistas de smo |
| WO2009058945A1 (en) | 2007-10-30 | 2009-05-07 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| US8669243B2 (en) | 2007-10-30 | 2014-03-11 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| JP2011522773A (ja) * | 2007-12-27 | 2011-08-04 | インフィニティ ファーマスーティカルズ、インク． | 治療剤での癌の処置方法 |
| WO2009086451A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| US20100222287A1 (en) * | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| WO2009099625A2 (en) * | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
| EP2303275A4 (en) * | 2008-06-17 | 2012-05-09 | Univ Duke | STANDARD RECEPTOR MODULATORS |
| WO2010030948A2 (en) * | 2008-09-12 | 2010-03-18 | The Board Of Trustees Of The Leland Stanford Junior University | Hedgehog signaling and cancer stem cells in hematopoietic cell malignancies |
| US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
| EP2233566A1 (en) | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
| CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| WO2011057222A1 (en) * | 2009-11-06 | 2011-05-12 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
| CA2782527C (en) * | 2009-12-04 | 2019-09-17 | Oncoimmune Inc. | Uses of hypoxia-inducible factor inhibitors |
| WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
| CN102167812B (zh) * | 2010-02-26 | 2016-04-20 | 北京科美森医药研发有限公司 | 聚乙二醇化环巴胺类似物及其制备方法和用途 |
| JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
| WO2011156329A2 (en) * | 2010-06-11 | 2011-12-15 | Board Of Regents, The University Of Texas System | Methods of treating pain and morphine tolerance via modulation of hedgehog signalling pathway |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3238722B1 (en) | 2011-01-10 | 2019-03-13 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones |
| EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PE20141371A1 (es) | 2011-08-29 | 2014-10-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
| US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| EP2925363A4 (en) | 2012-11-29 | 2016-11-09 | Strasspharma Llc | METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY |
| NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
| KR20160013204A (ko) | 2013-05-30 | 2016-02-03 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절제를 사용하는 암의 치료 |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3964507A1 (en) | 2013-10-04 | 2022-03-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
| US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| CN114230571B (zh) | 2015-09-14 | 2025-07-08 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| US20170231968A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Method for relief of and treatment of pruritus |
| CN105622708B (zh) | 2016-02-14 | 2017-10-10 | 山东大学 | 治疗呼吸道合胞病毒感染的化合物及其制备方法与用途 |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| JP2023503926A (ja) * | 2019-11-22 | 2023-02-01 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｔａｓｐａｓｅ１阻害剤およびその使用 |
| EP4173639A4 (en) | 2020-06-26 | 2024-03-13 | RaQualia Pharma Inc. | METHOD FOR SELECTING A CANCER PATIENT FOR WHICH COMBINATION THERAPY OF A RETINOID AND A CANCER TREATMENT AGENT WILL BE EFFECTIVE, AND COMBINATION DRUG OF A RETINOID AND A CANCER TREATMENT AGENT |
| RU2739294C1 (ru) * | 2020-07-02 | 2020-12-22 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации | Способ лечения местно-распространенного рака ротоглотки |
| EP4185279A4 (en) | 2020-07-24 | 2024-05-01 | Secura Bio, Inc. | TREATING CANCER WITH PI3-KINASE ISOFORM MODULATORS |
| CN118388576A (zh) * | 2024-03-27 | 2024-07-26 | 四川大学 | 环巴胺的合成方法 |
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| JP2851054B2 (ja) * | 1989-03-15 | 1999-01-27 | サントリー株式会社 | ベンズオキセピン誘導体 |
| NZ278765A (en) | 1993-12-30 | 1998-05-27 | Harvard College | Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| US7709454B2 (en) * | 1997-06-20 | 2010-05-04 | New York University | Methods and compositions for inhibiting tumorigenesis |
| US6238876B1 (en) * | 1997-06-20 | 2001-05-29 | New York University | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6867216B1 (en) * | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
| US7291626B1 (en) * | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| DE60028411T2 (de) * | 1999-10-13 | 2007-01-04 | Johns Hopkins University School Of Medicine | Verbindungen zur regulierung des hedgehog-signalwegs, zusammensetzungen und verwendungen davon |
| IL133809A0 (en) * | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
| US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| ES2623711T3 (es) * | 2000-10-13 | 2017-07-12 | Curis, Inc. | Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos |
| AU2002247847A1 (en) * | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
| CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| JP2003192919A (ja) | 2001-10-17 | 2003-07-09 | Asahi Denka Kogyo Kk | 難燃性合成樹脂組成物 |
| GB0221539D0 (en) * | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
| US20080118493A1 (en) * | 2003-07-15 | 2008-05-22 | Beachy Philip A | Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity |
| US20080095761A1 (en) * | 2003-10-01 | 2008-04-24 | The Johns Hopkins University | Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
| US20070231828A1 (en) * | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
| US20080057071A1 (en) * | 2003-10-20 | 2008-03-06 | Watkins David N | Use Of Hedgehog Pathway Inhibitors In Small-Cell Lung Cancer |
| JP4239907B2 (ja) * | 2004-06-21 | 2009-03-18 | 沖電気工業株式会社 | レベルシフタ回路、表示装置の駆動回路、表示装置、及び階調選択回路のストレステスト方法 |
| ES2578728T3 (es) | 2004-08-27 | 2016-07-29 | Infinity Pharmaceuticals, Inc. | Proceso para la preparación de compuestos análogos de ciclopamina |
| WO2006039569A1 (en) | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
| WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2007123511A2 (en) | 2006-03-24 | 2007-11-01 | Infinity Pharmaceuticals, Inc. | Dosing regimens for the treatment of cancer |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| WO2008089123A2 (en) | 2007-01-12 | 2008-07-24 | Infinity Discovery, Inc. | Methods for analysis of hedgehog pathway inhibitors |
| EP2134719B1 (en) * | 2007-03-07 | 2013-07-17 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
-
2005
- 2005-08-26 ES ES10012778.6T patent/ES2578728T3/es not_active Expired - Lifetime
- 2005-08-26 JP JP2007530162A patent/JP5204486B2/ja not_active Expired - Fee Related
- 2005-08-26 BR BRPI0514444-2A patent/BRPI0514444A/pt not_active Application Discontinuation
- 2005-08-26 AU AU2005280112A patent/AU2005280112B2/en not_active Ceased
- 2005-08-26 CN CN201110094391.4A patent/CN102241727B/zh not_active Expired - Fee Related
- 2005-08-26 WO PCT/US2005/030406 patent/WO2006026430A2/en not_active Ceased
- 2005-08-26 EP EP10012778.6A patent/EP2316833B1/en not_active Expired - Lifetime
- 2005-08-26 KR KR1020077006979A patent/KR101487481B1/ko not_active Expired - Fee Related
- 2005-08-26 US US11/213,534 patent/US7230004B2/en not_active Expired - Lifetime
- 2005-08-26 EP EP05791140.6A patent/EP1817308B1/en not_active Expired - Lifetime
- 2005-08-26 CA CA2579078A patent/CA2579078C/en not_active Expired - Lifetime
- 2005-08-26 EP EP10012704.2A patent/EP2316832B1/en not_active Expired - Lifetime
-
2007
- 2007-02-13 IL IL181301A patent/IL181301A/en active IP Right Grant
- 2007-03-08 NO NO20071264A patent/NO341137B1/no unknown
- 2007-04-18 US US11/737,035 patent/US7407967B2/en not_active Expired - Lifetime
-
2008
- 2008-07-10 US US12/171,208 patent/US7875628B2/en not_active Expired - Lifetime
-
2010
- 2010-12-15 US US12/969,024 patent/US8236956B2/en not_active Expired - Fee Related
-
2012
- 2012-07-24 JP JP2012164081A patent/JP2012232997A/ja active Pending