JP2008511337A - ヘテロ多量体分子 - Google Patents

ヘテロ多量体分子 Download PDF

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Publication number
JP2008511337A
JP2008511337A JP2007530373A JP2007530373A JP2008511337A JP 2008511337 A JP2008511337 A JP 2008511337A JP 2007530373 A JP2007530373 A JP 2007530373A JP 2007530373 A JP2007530373 A JP 2007530373A JP 2008511337 A JP2008511337 A JP 2008511337A
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antibody
polypeptide
polypeptides
light chain
pair
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JP2007530373A
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Japanese (ja)
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JP2008511337A5 (enExample
Inventor
アーサー ジェイ． ヒャング，
バーバラ モファット，
ダニエル ジー． ヤンスラ，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2007530373A 2004-09-02 2005-09-01 ヘテロ多量体分子 Pending JP2008511337A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60717204P 2004-09-02 2004-09-02
PCT/US2005/031226 WO2006028936A2 (en) 2004-09-02 2005-09-01 Heteromultimeric molecules

Publications (2)

Publication Number Publication Date
JP2008511337A true JP2008511337A (ja) 2008-04-17
JP2008511337A5 JP2008511337A5 (enExample) 2008-10-16

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Family Applications (1)

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JP2007530373A Pending JP2008511337A (ja) 2004-09-02 2005-09-01 ヘテロ多量体分子

Country Status (7)

Country Link
US (1) US20060204493A1 (enExample)
EP (1) EP1789446A2 (enExample)
JP (1) JP2008511337A (enExample)
AU (1) AU2005282700A1 (enExample)
CA (1) CA2577082A1 (enExample)
MX (1) MX2007002856A (enExample)
WO (1) WO2006028936A2 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
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JP2013516966A (ja) * 2010-01-14 2013-05-16 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現し、低減したＴｓｐ活性を有する細菌宿主系統
JP2013516965A (ja) * 2010-01-14 2013-05-16 ユセベ ファルマ ソシエテ アノニム 変異体ｓｐｒ遺伝子及び野生型Ｔｓｐ遺伝子を含む細菌宿主系統
JP2013529190A (ja) * 2010-04-23 2013-07-18 ジェネンテック， インコーポレイテッド ヘテロ多量体タンパク質の産生
JP2014521313A (ja) * 2011-07-13 2014-08-28 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統
JP2014534198A (ja) * 2011-10-11 2014-12-18 ジェネンテック， インコーポレイテッド 二重特異性抗体の構築の改善
JP2015537212A (ja) * 2012-11-15 2015-12-24 ジェネンテック， インコーポレイテッド イオン強度媒介のｐｈ勾配イオン交換クロマトグラフィー
JP2016526909A (ja) * 2013-07-31 2016-09-08 アムジエン・インコーポレーテツド Ｆｃ含有ポリペプチドの安定化
WO2020067541A1 (ja) * 2018-09-28 2020-04-02 協和キリン株式会社 抗体組成物
WO2021201236A1 (ja) * 2020-04-01 2021-10-07 協和キリン株式会社 抗体組成物
US12030926B2 (en) 2014-05-06 2024-07-09 Genentech, Inc. Production of heteromultimeric proteins using mammalian cells

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