JP2008511329A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008511329A5 JP2008511329A5 JP2007530166A JP2007530166A JP2008511329A5 JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5 JP 2007530166 A JP2007530166 A JP 2007530166A JP 2007530166 A JP2007530166 A JP 2007530166A JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5
- Authority
- JP
- Japan
- Prior art keywords
- culture
- medium
- per unit
- glutamine
- unit volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60507404P | 2004-08-27 | 2004-08-27 | |
| US60509704P | 2004-08-27 | 2004-08-27 | |
| US60494104P | 2004-08-27 | 2004-08-27 | |
| US60/604,941 | 2004-08-27 | ||
| US60/605,074 | 2004-08-27 | ||
| US60/605,097 | 2004-08-27 | ||
| PCT/US2005/030437 WO2006026445A1 (en) | 2004-08-27 | 2005-08-26 | Production of polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511329A JP2008511329A (ja) | 2008-04-17 |
| JP2008511329A5 true JP2008511329A5 (enExample) | 2008-10-16 |
| JP4864892B2 JP4864892B2 (ja) | 2012-02-01 |
Family
ID=35482353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530166A Expired - Lifetime JP4864892B2 (ja) | 2004-08-27 | 2005-08-26 | ポリペプチドの製造 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7294484B2 (enExample) |
| EP (2) | EP2357250B1 (enExample) |
| JP (1) | JP4864892B2 (enExample) |
| KR (2) | KR101158447B1 (enExample) |
| CN (2) | CN101048511B (enExample) |
| AR (2) | AR051017A1 (enExample) |
| AU (1) | AU2005280034B2 (enExample) |
| BR (1) | BRPI0514703A (enExample) |
| CA (1) | CA2578141C (enExample) |
| CR (1) | CR8997A (enExample) |
| EC (1) | ECSP077353A (enExample) |
| EG (1) | EG26462A (enExample) |
| ES (1) | ES2628012T3 (enExample) |
| IL (1) | IL181589A0 (enExample) |
| MX (1) | MX2007002380A (enExample) |
| NO (1) | NO342433B1 (enExample) |
| SG (2) | SG190674A1 (enExample) |
| TW (1) | TWI384069B (enExample) |
| WO (1) | WO2006026445A1 (enExample) |
| ZA (1) | ZA200702483B (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953041A4 (en) | 1996-08-30 | 2003-01-29 | Life Technologies Inc | SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| SI1917276T1 (en) * | 2005-08-26 | 2018-05-31 | Ares Trading S.A. | PROCEDURE FOR PREPARATION OF GLYCOSYLATED INTERFERONE BETA |
| PE20070796A1 (es) * | 2005-10-24 | 2007-08-15 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
| US20070231895A1 (en) * | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| WO2007065918A2 (en) * | 2005-12-09 | 2007-06-14 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| ES2474573T3 (es) | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| CN101496387B (zh) | 2006-03-06 | 2012-09-05 | 思科技术公司 | 用于移动无线网络中的接入认证的系统和方法 |
| WO2008008360A1 (en) * | 2006-07-13 | 2008-01-17 | Wyeth | Production of glycoproteins |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| CA2842959A1 (en) | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
| JP5401319B2 (ja) * | 2006-11-03 | 2014-01-29 | ワイス・エルエルシー | 細胞培養における解糖阻害物質 |
| PT2078071E (pt) | 2006-11-08 | 2015-07-16 | Wyeth Llc | Meios concebidos racionalmente para cultura de células |
| KR20090127326A (ko) * | 2007-03-02 | 2009-12-10 | 와이어쓰 | 폴리펩티드의 생산을 위한 세포 배양물 중에서 구리 및 글루타메이트의 용도 |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| CN105567627B (zh) | 2007-04-26 | 2020-09-29 | 中外制药株式会社 | 使用含高浓度氨基酸的培养基的细胞培养方法 |
| ES2657055T3 (es) | 2007-08-09 | 2018-03-01 | Wyeth Llc | Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores |
| US8319819B2 (en) | 2008-03-26 | 2012-11-27 | Cisco Technology, Inc. | Virtual round-table videoconference |
| HUE027035T2 (hu) * | 2008-04-17 | 2016-08-29 | Wyeth Llc | Eljárások csont morfogenetikus fehérjék termelésének fokozására |
| KR101880919B1 (ko) | 2008-09-15 | 2018-07-24 | 제넨테크, 인크. | 세포 오스몰농도를 조절하기 위한 조성물 및 방법 |
| US8694658B2 (en) | 2008-09-19 | 2014-04-08 | Cisco Technology, Inc. | System and method for enabling communication sessions in a network environment |
| AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| CN102257005A (zh) | 2008-10-20 | 2011-11-23 | 雅培制药有限公司 | 在抗体纯化过程中的病毒灭活 |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| MY186219A (en) * | 2009-08-11 | 2021-06-30 | Genentech Inc | Production of proteins in glutamine-free cell culture media |
| GB0917647D0 (en) * | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| BR112012017243A2 (pt) * | 2010-01-13 | 2017-09-19 | Apt Therapeutics Inc | constructos terapêuticos de apirase, agentes de apirase, e métodos de produção |
| US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| JP6113653B2 (ja) | 2010-04-26 | 2017-04-12 | ノバルティス アーゲー | 改良型細胞培養培地 |
| PT3330370T (pt) | 2010-04-26 | 2021-05-11 | Novartis Ag | Processo para cultivo de células cho |
| RU2644651C2 (ru) * | 2010-04-26 | 2018-02-13 | Новартис Аг | Среда для культивирования клеток |
| TWI609890B (zh) | 2010-07-08 | 2018-01-01 | 巴克斯歐塔公司 | 在細胞培養物中生產重組adamts13的方法 |
| SG187198A1 (en) | 2010-08-05 | 2013-03-28 | Amgen Inc | Dipeptides to enhance yield and viability from cell cultures |
| WO2012023085A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
| CN102382794B (zh) * | 2010-09-01 | 2013-09-18 | 山东新时代药业有限公司 | 一种哺乳动物细胞的灌流培养方法 |
| US8599865B2 (en) | 2010-10-26 | 2013-12-03 | Cisco Technology, Inc. | System and method for provisioning flows in a mobile network environment |
| US8730297B2 (en) | 2010-11-15 | 2014-05-20 | Cisco Technology, Inc. | System and method for providing camera functions in a video environment |
| US9338394B2 (en) | 2010-11-15 | 2016-05-10 | Cisco Technology, Inc. | System and method for providing enhanced audio in a video environment |
| US9143725B2 (en) | 2010-11-15 | 2015-09-22 | Cisco Technology, Inc. | System and method for providing enhanced graphics in a video environment |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| WO2012147053A1 (en) | 2011-04-29 | 2012-11-01 | Biocon Research Limited | A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof |
| CA2838695C (en) | 2011-07-01 | 2017-02-14 | Amgen Inc. | Mammalian cell culture |
| US8682087B2 (en) | 2011-12-19 | 2014-03-25 | Cisco Technology, Inc. | System and method for depth-guided image filtering in a video conference environment |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US20130281355A1 (en) * | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| TW201514305A (zh) * | 2013-07-06 | 2015-04-16 | Cadila Healthcare Ltd | 製造單株抗體之改良方法 |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US11390663B2 (en) * | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015095809A1 (en) | 2013-12-20 | 2015-06-25 | Biogen Idec Ma Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
| RU2712562C2 (ru) | 2014-02-27 | 2020-01-29 | Ф.Хоффманн-Ля Рош Аг | Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов |
| US10544395B2 (en) | 2014-03-19 | 2020-01-28 | Pfizer Inc. | Method of cell culture |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TW202246486A (zh) * | 2014-06-09 | 2022-12-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| JP6698681B2 (ja) | 2014-12-01 | 2020-05-27 | アムジエン・インコーポレーテツド | 糖タンパク質のグリカン含量のレベルを操作するためのプロセス |
| AU2016271607C1 (en) * | 2015-05-29 | 2023-06-29 | Boehringer Ingelheim International Gmbh | Cell-controlled perfusion in continuous culture |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法(二) |
| CA2999224C (en) | 2015-09-23 | 2023-10-24 | Pfizer Inc. | Cells and method of cell culture |
| KR102069988B1 (ko) | 2015-11-17 | 2020-01-23 | 화이자 인코포레이티드 | 박테리아 세포 배양에서 폴리사카라이드를 생성하기 위한 배지 및 발효 방법 |
| ES2992543T3 (es) * | 2016-04-05 | 2024-12-13 | Pfizer | Proceso de cultivo celular |
| EP3372670B1 (en) * | 2017-03-09 | 2019-02-27 | Evonik Technochemie GmbH | Culture media comprising n-acyl-x-glutamine dipeptides |
| GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
| CN111836826B (zh) | 2017-10-23 | 2024-01-02 | 普罗根有限公司 | 修饰的egf蛋白,其制备方法及其用途 |
| WO2019106097A1 (en) * | 2017-11-30 | 2019-06-06 | F.Hoffmann-La Roche Ag | Process for culturing mammalian cells |
| IL321253A (en) | 2018-05-01 | 2025-08-01 | Amgen Inc | Antibodies with a modulated glycan profile |
| US11634499B2 (en) | 2018-11-13 | 2023-04-25 | Janssen Biotech, Inc. | Control of trace metals during production of anti-CD38 antibodies |
| JP2022513702A (ja) | 2018-12-06 | 2022-02-09 | ファイザー・インク | 阻害剤産生が低下した細胞およびその使用方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN113025648B (zh) * | 2019-12-09 | 2023-06-02 | 广东菲鹏制药股份有限公司 | Expi293细胞瞬时表达目标蛋白的方法及其应用 |
| TW202432837A (zh) | 2020-08-31 | 2024-08-16 | 美商再生元醫藥公司 | 用以改良細胞培養效能及減少天冬醯胺序列變異之天冬醯胺饋料策略 |
| JP2022060169A (ja) | 2020-10-02 | 2022-04-14 | ファイザー・インク | Rsv fタンパク質生産のための細胞培養工程 |
| US12031151B2 (en) | 2021-01-20 | 2024-07-09 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| WO2022254319A1 (en) | 2021-06-01 | 2022-12-08 | Pfizer Inc. | Cell culture method for producing sfgfr3 polypeptide |
| EP4413359A1 (en) | 2021-10-07 | 2024-08-14 | Regeneron Pharmaceuticals, Inc. | Ph meter calibration and correction |
| MX2024004107A (es) | 2021-10-07 | 2024-04-19 | Regeneron Pharma | Sistemas y metodos para modelar y controlar el ph. |
| CN119053626A (zh) | 2022-03-02 | 2024-11-29 | 瑞泽恩制药公司 | 高滴度抗体的制造工艺 |
| US20240010709A1 (en) | 2022-05-25 | 2024-01-11 | Genentech, Inc. | Methods for preparing mammalian cells for perfusion cell culture |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| US6291159B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| NZ235148A (en) | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| JPH0396383A (ja) | 1989-09-08 | 1991-04-22 | Riso Kagaku Corp | 画像形成装置 |
| DE59010933D1 (de) | 1989-09-12 | 2003-05-08 | Hoffmann La Roche | TFN-bindende Proteine |
| AU638762B2 (en) | 1989-10-05 | 1993-07-08 | Optein Inc | Cell-free synthesis and isolation of novel genes and polypeptides |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5538983A (en) | 1990-05-16 | 1996-07-23 | The Rockefeller University | Method of treating amyloidosis by modulation of calcium |
| US5156964A (en) | 1990-08-16 | 1992-10-20 | Cetus Corporation | Methods for adapting cells for increased product production through exposure to ammonia |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| GB2251249B (en) | 1990-12-28 | 1995-06-21 | Mogam Biotech Res Inst | High-density medium for animal cell culture |
| GB9118664D0 (en) | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| DE4313620A1 (de) * | 1993-04-26 | 1994-10-27 | Biotechnolog Forschung Gmbh | Hamsterzellinien und Verfahren zur Glykoproteingewinnung |
| JP3504963B2 (ja) | 1993-10-22 | 2004-03-08 | 智靖 羅 | 抗ヒト高親和性IgE受容体モノクローナル抗体に係るアミノ酸配列をコードするDNA断片 |
| US6310185B1 (en) | 1994-03-08 | 2001-10-30 | Memorial Sloan Kettering Cancer Center | Recombinant human anti-Lewis Y antibodies |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5589154A (en) | 1994-11-22 | 1996-12-31 | Rutgers, The State University Of New Jersey | Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US6656466B1 (en) * | 1995-06-06 | 2003-12-02 | Genetech, Inc. | Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition |
| JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
| US20020012991A1 (en) | 1997-04-07 | 2002-01-31 | Florence Chua Nee Ho Kit Fong | Cell culture media for enhanced protein production |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| CA2354862A1 (en) | 1998-10-19 | 2000-04-27 | Yeda Research And Development Co. Ltd. | Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens |
| PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| WO2002088307A2 (en) | 2001-04-30 | 2002-11-07 | Eli Lilly And Company | Humanized antibodies |
| ATE420114T1 (de) | 2001-04-30 | 2009-01-15 | Lilly Co Eli | Humanisierte antikörper die das beta-amyloid peptid erkennen& x9; |
| WO2002101019A2 (en) * | 2001-06-13 | 2002-12-19 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| PL375045A1 (en) | 2002-02-21 | 2005-11-14 | Wyeth | Gasp1: a follistatin domain containing protein |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| TWI379693B (en) | 2002-05-02 | 2012-12-21 | Wyeth Corp | Calicheamicin derivative-carrier conjugates |
| US6924124B1 (en) | 2002-08-23 | 2005-08-02 | Immunex Corporation | Feeding strategies for cell culture |
| US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
| US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
-
2005
- 2005-08-25 TW TW94129070A patent/TWI384069B/zh not_active IP Right Cessation
- 2005-08-25 US US11/213,308 patent/US7294484B2/en not_active Expired - Lifetime
- 2005-08-26 KR KR1020077004807A patent/KR101158447B1/ko not_active Expired - Lifetime
- 2005-08-26 ES ES05792494T patent/ES2628012T3/es not_active Expired - Lifetime
- 2005-08-26 KR KR1020117006936A patent/KR20110036780A/ko not_active Ceased
- 2005-08-26 SG SG2013041199A patent/SG190674A1/en unknown
- 2005-08-26 BR BRPI0514703-4A patent/BRPI0514703A/pt not_active Application Discontinuation
- 2005-08-26 CA CA 2578141 patent/CA2578141C/en not_active Expired - Lifetime
- 2005-08-26 SG SG200907913-8A patent/SG158092A1/en unknown
- 2005-08-26 EP EP11156236.9A patent/EP2357250B1/en not_active Revoked
- 2005-08-26 EP EP05792494.6A patent/EP1789571B1/en not_active Revoked
- 2005-08-26 JP JP2007530166A patent/JP4864892B2/ja not_active Expired - Lifetime
- 2005-08-26 AU AU2005280034A patent/AU2005280034B2/en not_active Expired
- 2005-08-26 CN CN2005800368991A patent/CN101048511B/zh not_active Expired - Fee Related
- 2005-08-26 MX MX2007002380A patent/MX2007002380A/es active IP Right Grant
- 2005-08-26 CN CN201210189727.XA patent/CN102827905B/zh not_active Expired - Fee Related
- 2005-08-26 AR ARP050103594 patent/AR051017A1/es not_active Application Discontinuation
- 2005-08-26 WO PCT/US2005/030437 patent/WO2006026445A1/en not_active Ceased
-
2007
- 2007-02-27 IL IL181589A patent/IL181589A0/en unknown
- 2007-02-27 EG EGNA2007000223 patent/EG26462A/en active
- 2007-03-16 CR CR8997A patent/CR8997A/es unknown
- 2007-03-26 NO NO20071572A patent/NO342433B1/no not_active IP Right Cessation
- 2007-03-26 ZA ZA2007/02483A patent/ZA200702483B/en unknown
- 2007-03-27 EC ECSP077353 patent/ECSP077353A/es unknown
-
2012
- 2012-06-14 AR ARP120102112 patent/AR086932A2/es not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008511329A5 (enExample) | ||
| JP2008511328A5 (enExample) | ||
| JP2008511330A5 (enExample) | ||
| RU2458988C2 (ru) | ПОЛУЧЕНИЕ РЕКОМБИНАНТНОГО БЕЛКА pФНО-lg | |
| RU2418858C2 (ru) | Получение антител против амилоида бета | |
| CN109337861B (zh) | 一种支持产物高表达的cho细胞无血清培养基 | |
| JP2009084284A5 (enExample) | ||
| WO2007036291A3 (de) | Verbessertes zellkulturmedium | |
| JP2013188217A (ja) | 光学活性キラルアミンの調製方法 | |
| JP2010533499A5 (enExample) | ||
| JP2010110331A5 (enExample) | ||
| JPH0142676B2 (enExample) | ||
| Wróbel et al. | Replication regulation of colE1-like plasmids in amino acid-starvedEscherichia coli | |
| RU2306338C2 (ru) | Mob'-ПРОИЗВОДНАЯ ПЛАЗМИДА RSF1010, НЕ СОДЕРЖАЩАЯ ГЕНЫ УСТОЙЧИВОСТИ К АНТИБИОТИКАМ, БАКТЕРИЯ, СОДЕРЖАЩАЯ УКАЗАННУЮ ПЛАЗМИДУ, И СПОСОБ ПОЛУЧЕНИЯ ПОЛЕЗНЫХ МЕТАБОЛИТОВ | |
| CA2561624A1 (en) | Fed-batch fermentation process and culture medium for the production of plasmid dna in e. coli on a manufacturing scale | |
| JP2007533329A5 (enExample) | ||
| JPS62288A (ja) | 発酵法によるl−アミノ酸の製造方法 | |
| KR20180109267A (ko) | 결빙제어용 dna 나노구조체 및 이의 제조방법 | |
| CN110878275A (zh) | 大肠杆菌发酵专用培养基的制作工艺 | |
| RU2007108719A (ru) | Производство полипептидов | |
| JP2017504349A (ja) | L−アミノ酸の生産能が向上された微生物、及びそれを利用してl−アミノ酸を生産する方法 | |
| CN105886567A (zh) | 一种l-天冬氨酸制取工艺 | |
| JPH0339087A (ja) | 凍結乾燥培地及び培地入りバッグ | |
| JPS58134994A (ja) | 発酵法によるl−フエニルアラニンの製造法 | |
| DE602006003883D1 (de) | Verfahren zur herstellung von alphaformkristallen von sapropterinhydrochlorid |