JP2008511329A5 - - Google Patents

Download PDF

Info

Publication number
JP2008511329A5
JP2008511329A5 JP2007530166A JP2007530166A JP2008511329A5 JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5 JP 2007530166 A JP2007530166 A JP 2007530166A JP 2007530166 A JP2007530166 A JP 2007530166A JP 2008511329 A5 JP2008511329 A5 JP 2008511329A5
Authority
JP
Japan
Prior art keywords
culture
medium
per unit
glutamine
unit volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007530166A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008511329A (ja
JP4864892B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/030437 external-priority patent/WO2006026445A1/en
Publication of JP2008511329A publication Critical patent/JP2008511329A/ja
Publication of JP2008511329A5 publication Critical patent/JP2008511329A5/ja
Application granted granted Critical
Publication of JP4864892B2 publication Critical patent/JP4864892B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007530166A 2004-08-27 2005-08-26 ポリペプチドの製造 Expired - Lifetime JP4864892B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US60507404P 2004-08-27 2004-08-27
US60509704P 2004-08-27 2004-08-27
US60494104P 2004-08-27 2004-08-27
US60/604,941 2004-08-27
US60/605,074 2004-08-27
US60/605,097 2004-08-27
PCT/US2005/030437 WO2006026445A1 (en) 2004-08-27 2005-08-26 Production of polypeptides

Publications (3)

Publication Number Publication Date
JP2008511329A JP2008511329A (ja) 2008-04-17
JP2008511329A5 true JP2008511329A5 (enExample) 2008-10-16
JP4864892B2 JP4864892B2 (ja) 2012-02-01

Family

ID=35482353

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007530166A Expired - Lifetime JP4864892B2 (ja) 2004-08-27 2005-08-26 ポリペプチドの製造

Country Status (20)

Country Link
US (1) US7294484B2 (enExample)
EP (2) EP2357250B1 (enExample)
JP (1) JP4864892B2 (enExample)
KR (2) KR101158447B1 (enExample)
CN (2) CN101048511B (enExample)
AR (2) AR051017A1 (enExample)
AU (1) AU2005280034B2 (enExample)
BR (1) BRPI0514703A (enExample)
CA (1) CA2578141C (enExample)
CR (1) CR8997A (enExample)
EC (1) ECSP077353A (enExample)
EG (1) EG26462A (enExample)
ES (1) ES2628012T3 (enExample)
IL (1) IL181589A0 (enExample)
MX (1) MX2007002380A (enExample)
NO (1) NO342433B1 (enExample)
SG (2) SG190674A1 (enExample)
TW (1) TWI384069B (enExample)
WO (1) WO2006026445A1 (enExample)
ZA (1) ZA200702483B (enExample)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953041A4 (en) 1996-08-30 2003-01-29 Life Technologies Inc SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
SI1917276T1 (en) * 2005-08-26 2018-05-31 Ares Trading S.A. PROCEDURE FOR PREPARATION OF GLYCOSYLATED INTERFERONE BETA
PE20070796A1 (es) * 2005-10-24 2007-08-15 Wyeth Corp Metodo de produccion proteica utilizando compuestos anti-senescencia
US20070231895A1 (en) * 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
WO2007065918A2 (en) * 2005-12-09 2007-06-14 Ares Trading S.A. Method for purifying fsh or a fsh mutant
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
CN101496387B (zh) 2006-03-06 2012-09-05 思科技术公司 用于移动无线网络中的接入认证的系统和方法
WO2008008360A1 (en) * 2006-07-13 2008-01-17 Wyeth Production of glycoproteins
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
CA2842959A1 (en) 2006-09-13 2008-03-20 Abbvie Inc. Cell culture improvements
JP5401319B2 (ja) * 2006-11-03 2014-01-29 ワイス・エルエルシー 細胞培養における解糖阻害物質
PT2078071E (pt) 2006-11-08 2015-07-16 Wyeth Llc Meios concebidos racionalmente para cultura de células
KR20090127326A (ko) * 2007-03-02 2009-12-10 와이어쓰 폴리펩티드의 생산을 위한 세포 배양물 중에서 구리 및 글루타메이트의 용도
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
CN105567627B (zh) 2007-04-26 2020-09-29 中外制药株式会社 使用含高浓度氨基酸的培养基的细胞培养方法
ES2657055T3 (es) 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
US8319819B2 (en) 2008-03-26 2012-11-27 Cisco Technology, Inc. Virtual round-table videoconference
HUE027035T2 (hu) * 2008-04-17 2016-08-29 Wyeth Llc Eljárások csont morfogenetikus fehérjék termelésének fokozására
KR101880919B1 (ko) 2008-09-15 2018-07-24 제넨테크, 인크. 세포 오스몰농도를 조절하기 위한 조성물 및 방법
US8694658B2 (en) 2008-09-19 2014-04-08 Cisco Technology, Inc. System and method for enabling communication sessions in a network environment
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
CN102257005A (zh) 2008-10-20 2011-11-23 雅培制药有限公司 在抗体纯化过程中的病毒灭活
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
MY186219A (en) * 2009-08-11 2021-06-30 Genentech Inc Production of proteins in glutamine-free cell culture media
GB0917647D0 (en) * 2009-10-08 2009-11-25 Glaxosmithkline Biolog Sa Expression system
BR112012017243A2 (pt) * 2010-01-13 2017-09-19 Apt Therapeutics Inc constructos terapêuticos de apirase, agentes de apirase, e métodos de produção
US20110262965A1 (en) 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
JP6113653B2 (ja) 2010-04-26 2017-04-12 ノバルティス アーゲー 改良型細胞培養培地
PT3330370T (pt) 2010-04-26 2021-05-11 Novartis Ag Processo para cultivo de células cho
RU2644651C2 (ru) * 2010-04-26 2018-02-13 Новартис Аг Среда для культивирования клеток
TWI609890B (zh) 2010-07-08 2018-01-01 巴克斯歐塔公司 在細胞培養物中生產重組adamts13的方法
SG187198A1 (en) 2010-08-05 2013-03-28 Amgen Inc Dipeptides to enhance yield and viability from cell cultures
WO2012023085A1 (en) 2010-08-20 2012-02-23 Wyeth Llc Cell culture of growth factor-free adapted cells
CN102382794B (zh) * 2010-09-01 2013-09-18 山东新时代药业有限公司 一种哺乳动物细胞的灌流培养方法
US8599865B2 (en) 2010-10-26 2013-12-03 Cisco Technology, Inc. System and method for provisioning flows in a mobile network environment
US8730297B2 (en) 2010-11-15 2014-05-20 Cisco Technology, Inc. System and method for providing camera functions in a video environment
US9338394B2 (en) 2010-11-15 2016-05-10 Cisco Technology, Inc. System and method for providing enhanced audio in a video environment
US9143725B2 (en) 2010-11-15 2015-09-22 Cisco Technology, Inc. System and method for providing enhanced graphics in a video environment
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2012147053A1 (en) 2011-04-29 2012-11-01 Biocon Research Limited A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof
CA2838695C (en) 2011-07-01 2017-02-14 Amgen Inc. Mammalian cell culture
US8682087B2 (en) 2011-12-19 2014-03-25 Cisco Technology, Inc. System and method for depth-guided image filtering in a video conference environment
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
WO2014035475A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
TW201514305A (zh) * 2013-07-06 2015-04-16 Cadila Healthcare Ltd 製造單株抗體之改良方法
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US11390663B2 (en) * 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2015095809A1 (en) 2013-12-20 2015-06-25 Biogen Idec Ma Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
RU2712562C2 (ru) 2014-02-27 2020-01-29 Ф.Хоффманн-Ля Рош Аг Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов
US10544395B2 (en) 2014-03-19 2020-01-28 Pfizer Inc. Method of cell culture
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TW202246486A (zh) * 2014-06-09 2022-12-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
JP6698681B2 (ja) 2014-12-01 2020-05-27 アムジエン・インコーポレーテツド 糖タンパク質のグリカン含量のレベルを操作するためのプロセス
AU2016271607C1 (en) * 2015-05-29 2023-06-29 Boehringer Ingelheim International Gmbh Cell-controlled perfusion in continuous culture
TW202440904A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法(二)
CA2999224C (en) 2015-09-23 2023-10-24 Pfizer Inc. Cells and method of cell culture
KR102069988B1 (ko) 2015-11-17 2020-01-23 화이자 인코포레이티드 박테리아 세포 배양에서 폴리사카라이드를 생성하기 위한 배지 및 발효 방법
ES2992543T3 (es) * 2016-04-05 2024-12-13 Pfizer Proceso de cultivo celular
EP3372670B1 (en) * 2017-03-09 2019-02-27 Evonik Technochemie GmbH Culture media comprising n-acyl-x-glutamine dipeptides
GB201708655D0 (en) 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
KR102190790B1 (ko) * 2018-10-19 2020-12-15 주식회사 프로젠 변형된 egf 단백질의 생산 방법
CN111836826B (zh) 2017-10-23 2024-01-02 普罗根有限公司 修饰的egf蛋白,其制备方法及其用途
WO2019106097A1 (en) * 2017-11-30 2019-06-06 F.Hoffmann-La Roche Ag Process for culturing mammalian cells
IL321253A (en) 2018-05-01 2025-08-01 Amgen Inc Antibodies with a modulated glycan profile
US11634499B2 (en) 2018-11-13 2023-04-25 Janssen Biotech, Inc. Control of trace metals during production of anti-CD38 antibodies
JP2022513702A (ja) 2018-12-06 2022-02-09 ファイザー・インク 阻害剤産生が低下した細胞およびその使用方法
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN113025648B (zh) * 2019-12-09 2023-06-02 广东菲鹏制药股份有限公司 Expi293细胞瞬时表达目标蛋白的方法及其应用
TW202432837A (zh) 2020-08-31 2024-08-16 美商再生元醫藥公司 用以改良細胞培養效能及減少天冬醯胺序列變異之天冬醯胺饋料策略
JP2022060169A (ja) 2020-10-02 2022-04-14 ファイザー・インク Rsv fタンパク質生産のための細胞培養工程
US12031151B2 (en) 2021-01-20 2024-07-09 Regeneron Pharmaceuticals, Inc. Methods of improving protein titer in cell culture
WO2022254319A1 (en) 2021-06-01 2022-12-08 Pfizer Inc. Cell culture method for producing sfgfr3 polypeptide
EP4413359A1 (en) 2021-10-07 2024-08-14 Regeneron Pharmaceuticals, Inc. Ph meter calibration and correction
MX2024004107A (es) 2021-10-07 2024-04-19 Regeneron Pharma Sistemas y metodos para modelar y controlar el ph.
CN119053626A (zh) 2022-03-02 2024-11-29 瑞泽恩制药公司 高滴度抗体的制造工艺
US20240010709A1 (en) 2022-05-25 2024-01-11 Genentech, Inc. Methods for preparing mammalian cells for perfusion cell culture

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
NZ235148A (en) 1989-09-05 1991-12-23 Immunex Corp Tumour necrosis factor receptor protein and dna sequences
US5605690A (en) 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
JPH0396383A (ja) 1989-09-08 1991-04-22 Riso Kagaku Corp 画像形成装置
DE59010933D1 (de) 1989-09-12 2003-05-08 Hoffmann La Roche TFN-bindende Proteine
AU638762B2 (en) 1989-10-05 1993-07-08 Optein Inc Cell-free synthesis and isolation of novel genes and polypeptides
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5538983A (en) 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
US5156964A (en) 1990-08-16 1992-10-20 Cetus Corporation Methods for adapting cells for increased product production through exposure to ammonia
US5122469A (en) * 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
GB2251249B (en) 1990-12-28 1995-06-21 Mogam Biotech Res Inst High-density medium for animal cell culture
GB9118664D0 (en) 1991-08-30 1991-10-16 Celltech Ltd Cell culture
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US6607884B1 (en) * 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
DE4313620A1 (de) * 1993-04-26 1994-10-27 Biotechnolog Forschung Gmbh Hamsterzellinien und Verfahren zur Glykoproteingewinnung
JP3504963B2 (ja) 1993-10-22 2004-03-08 智靖 羅 抗ヒト高親和性IgE受容体モノクローナル抗体に係るアミノ酸配列をコードするDNA断片
US6310185B1 (en) 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6656466B1 (en) * 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
JP4306813B2 (ja) 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US20020012991A1 (en) 1997-04-07 2002-01-31 Florence Chua Nee Ho Kit Fong Cell culture media for enhanced protein production
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
CA2354862A1 (en) 1998-10-19 2000-04-27 Yeda Research And Development Co. Ltd. Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
WO2002088307A2 (en) 2001-04-30 2002-11-07 Eli Lilly And Company Humanized antibodies
ATE420114T1 (de) 2001-04-30 2009-01-15 Lilly Co Eli Humanisierte antikörper die das beta-amyloid peptid erkennen& x9;
WO2002101019A2 (en) * 2001-06-13 2002-12-19 Genentech, Inc. Methods of culturing animal cells and polypeptide production in animal cells
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
PL375045A1 (en) 2002-02-21 2005-11-14 Wyeth Gasp1: a follistatin domain containing protein
BR0307871A (pt) 2002-02-21 2005-04-12 Wyeth Corp Proteìnas contendo domìnio de folistatina
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
TWI379693B (en) 2002-05-02 2012-12-21 Wyeth Corp Calicheamicin derivative-carrier conjugates
US6924124B1 (en) 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
US7261893B2 (en) * 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20040223966A1 (en) 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig

Similar Documents

Publication Publication Date Title
JP2008511329A5 (enExample)
JP2008511328A5 (enExample)
JP2008511330A5 (enExample)
RU2458988C2 (ru) ПОЛУЧЕНИЕ РЕКОМБИНАНТНОГО БЕЛКА pФНО-lg
RU2418858C2 (ru) Получение антител против амилоида бета
CN109337861B (zh) 一种支持产物高表达的cho细胞无血清培养基
JP2009084284A5 (enExample)
WO2007036291A3 (de) Verbessertes zellkulturmedium
JP2013188217A (ja) 光学活性キラルアミンの調製方法
JP2010533499A5 (enExample)
JP2010110331A5 (enExample)
JPH0142676B2 (enExample)
Wróbel et al. Replication regulation of colE1-like plasmids in amino acid-starvedEscherichia coli
RU2306338C2 (ru) Mob'-ПРОИЗВОДНАЯ ПЛАЗМИДА RSF1010, НЕ СОДЕРЖАЩАЯ ГЕНЫ УСТОЙЧИВОСТИ К АНТИБИОТИКАМ, БАКТЕРИЯ, СОДЕРЖАЩАЯ УКАЗАННУЮ ПЛАЗМИДУ, И СПОСОБ ПОЛУЧЕНИЯ ПОЛЕЗНЫХ МЕТАБОЛИТОВ
CA2561624A1 (en) Fed-batch fermentation process and culture medium for the production of plasmid dna in e. coli on a manufacturing scale
JP2007533329A5 (enExample)
JPS62288A (ja) 発酵法によるl−アミノ酸の製造方法
KR20180109267A (ko) 결빙제어용 dna 나노구조체 및 이의 제조방법
CN110878275A (zh) 大肠杆菌发酵专用培养基的制作工艺
RU2007108719A (ru) Производство полипептидов
JP2017504349A (ja) L−アミノ酸の生産能が向上された微生物、及びそれを利用してl−アミノ酸を生産する方法
CN105886567A (zh) 一种l-天冬氨酸制取工艺
JPH0339087A (ja) 凍結乾燥培地及び培地入りバッグ
JPS58134994A (ja) 発酵法によるl−フエニルアラニンの製造法
DE602006003883D1 (de) Verfahren zur herstellung von alphaformkristallen von sapropterinhydrochlorid