JP2008508352A5 - - Google Patents
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- Publication number
- JP2008508352A5 JP2008508352A5 JP2007524767A JP2007524767A JP2008508352A5 JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5 JP 2007524767 A JP2007524767 A JP 2007524767A JP 2007524767 A JP2007524767 A JP 2007524767A JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- phenyl
- indol
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- -1 methoxy, hydroxy Chemical group 0.000 claims 116
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 3
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000005956 isoquinolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- QRCGFTXRXYMJOS-UHFFFAOYSA-N 4h-1,4-benzoxazin-3-one Chemical compound C1=CC=C2NC(=O)COC2=C1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 Chemical compound O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 0.000 description 13
- KPWHQJNIRXSRBQ-UHFFFAOYSA-N CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 Chemical compound CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 KPWHQJNIRXSRBQ-UHFFFAOYSA-N 0.000 description 1
- BLVXFNBKHSONDD-UHFFFAOYSA-N Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 Chemical compound Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 BLVXFNBKHSONDD-UHFFFAOYSA-N 0.000 description 1
- MHFWLJDIZUQWSE-UHFFFAOYSA-N Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O Chemical compound Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O MHFWLJDIZUQWSE-UHFFFAOYSA-N 0.000 description 1
- DMAORECRYRHUBR-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 DMAORECRYRHUBR-UHFFFAOYSA-N 0.000 description 1
- VHORVPIINKLKEU-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O VHORVPIINKLKEU-UHFFFAOYSA-N 0.000 description 1
- DITLHGOUPJXJJL-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S DITLHGOUPJXJJL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401970A SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Novel compounds |
| PCT/SE2005/001188 WO2006014135A1 (en) | 2004-08-02 | 2005-07-27 | Novel piperidine derivatives as histamine h3 receptor ligands for treatment of depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508352A JP2008508352A (ja) | 2008-03-21 |
| JP2008508352A5 true JP2008508352A5 (enExample) | 2009-03-12 |
Family
ID=32906882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524767A Abandoned JP2008508352A (ja) | 2004-08-02 | 2005-07-27 | うつ病の治療のためのヒスタミンｈ３受容体リガンドとしての新規なピペリジン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070249618A1 (enExample) |
| EP (1) | EP1784394A1 (enExample) |
| JP (1) | JP2008508352A (enExample) |
| KR (1) | KR20070039118A (enExample) |
| CN (1) | CN1993340A (enExample) |
| AU (1) | AU2005267931A1 (enExample) |
| BR (1) | BRPI0514032A (enExample) |
| CA (1) | CA2576109A1 (enExample) |
| IL (1) | IL180547A0 (enExample) |
| MX (1) | MX2007001227A (enExample) |
| NO (1) | NO20071140L (enExample) |
| RU (1) | RU2007106969A (enExample) |
| SE (1) | SE0401970D0 (enExample) |
| WO (1) | WO2006014135A1 (enExample) |
| ZA (1) | ZA200700679B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4881297B2 (ja) | 2004-05-28 | 2012-02-22 | フォーエスシー アクチエンゲゼルシャフト | 新規のテトラヒドロピリドチオフェン |
| EP1758655A2 (en) | 2004-06-11 | 2007-03-07 | Altana Pharma AG | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
| CN101056861B (zh) * | 2004-09-07 | 2011-04-06 | 万有制药株式会社 | 氨基甲酰基取代螺衍生物 |
| CN101039927A (zh) * | 2004-09-09 | 2007-09-19 | 财团法人乙卯研究所 | 5－羟色胺5－ht3受体激动剂 |
| GB0611907D0 (en) * | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| JP2008529989A (ja) | 2005-02-09 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン |
| US7741488B2 (en) | 2005-02-11 | 2010-06-22 | 4Sc Ag | Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer |
| EP1896484A2 (en) | 2005-05-25 | 2008-03-12 | Nycomed GmbH | Tetrahydropyridothiophenes for use in the treatment of cancer |
| US7763728B2 (en) | 2005-05-25 | 2010-07-27 | 4Sc Ag | Tetrahydropyridothiophenes |
| AU2006275568A1 (en) | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| AU2007219509A1 (en) * | 2006-01-18 | 2007-09-07 | Siena Biotech S.P.A | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| US7514433B2 (en) * | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| TW200918062A (en) | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| US20110166124A1 (en) * | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| JP5778168B2 (ja) | 2009-12-04 | 2015-09-16 | スノビオン プハルマセウトイカルス インコーポレイテッド | 多環式化合物及びその使用方法 |
| DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
| CN116283877A (zh) | 2016-07-29 | 2023-06-23 | 赛诺维信制药公司 | 化合物、组合物及其用途 |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| JP7146782B2 (ja) | 2017-02-16 | 2022-10-04 | サノビオン ファーマシューティカルズ インク | 統合失調症を処置する方法 |
| CA3070993C (en) | 2017-08-02 | 2025-05-20 | Sunovion Pharmaceuticals Inc. | ISOCHROMANE COMPOUNDS AND THEIR USES |
| MX2020008537A (es) | 2018-02-16 | 2021-01-08 | Sunovion Pharmaceuticals Inc | Sales, formas cristalinas y metodos de produccion de las mismas. |
| US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
| EP3938045A1 (en) | 2019-03-14 | 2022-01-19 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
| IL297248A (en) | 2020-04-14 | 2022-12-01 | Sunovion Pharmaceuticals Inc | (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders |
| CN114685401A (zh) * | 2020-12-28 | 2022-07-01 | 江苏天士力帝益药业有限公司 | 一种二（4-甲基哌嗪-1-基）甲酮的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1183784B (de) * | 1963-05-16 | 1964-12-17 | Fuji Photo Film Co Ltd | Verfahren zur Empfindlichkeitssteigerung und Beschleunigung der Entwicklung von Halogensilberemulsionen in Photomaterialien |
| FR1589754A (enExample) * | 1968-10-17 | 1970-04-06 | ||
| JPS58169143A (ja) * | 1982-03-31 | 1983-10-05 | Fuji Photo Film Co Ltd | 重合画像形成方法 |
| TR200001312T2 (tr) * | 1997-11-10 | 2000-09-21 | Bristol-Myers Squibb Company | Benzotiyazol protein tirozin kinaz önleyicileri. |
| WO2001097786A2 (en) * | 2000-06-21 | 2001-12-27 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives |
-
2004
- 2004-08-02 SE SE0401970A patent/SE0401970D0/xx unknown
-
2005
- 2005-07-27 BR BRPI0514032-3A patent/BRPI0514032A/pt not_active Application Discontinuation
- 2005-07-27 WO PCT/SE2005/001188 patent/WO2006014135A1/en not_active Ceased
- 2005-07-27 CA CA002576109A patent/CA2576109A1/en not_active Abandoned
- 2005-07-27 JP JP2007524767A patent/JP2008508352A/ja not_active Abandoned
- 2005-07-27 CN CNA2005800262338A patent/CN1993340A/zh active Pending
- 2005-07-27 RU RU2007106969/04A patent/RU2007106969A/ru unknown
- 2005-07-27 US US11/572,966 patent/US20070249618A1/en not_active Abandoned
- 2005-07-27 EP EP05766829A patent/EP1784394A1/en not_active Withdrawn
- 2005-07-27 MX MX2007001227A patent/MX2007001227A/es not_active Application Discontinuation
- 2005-07-27 KR KR1020077002642A patent/KR20070039118A/ko not_active Withdrawn
- 2005-07-27 AU AU2005267931A patent/AU2005267931A1/en not_active Abandoned
-
2007
- 2007-01-04 IL IL180547A patent/IL180547A0/en unknown
- 2007-01-24 ZA ZA200700679A patent/ZA200700679B/xx unknown
- 2007-02-28 NO NO20071140A patent/NO20071140L/no not_active Application Discontinuation
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