JP2008508352A5 - - Google Patents
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- Publication number
- JP2008508352A5 JP2008508352A5 JP2007524767A JP2007524767A JP2008508352A5 JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5 JP 2007524767 A JP2007524767 A JP 2007524767A JP 2007524767 A JP2007524767 A JP 2007524767A JP 2008508352 A5 JP2008508352 A5 JP 2008508352A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- phenyl
- indol
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- -1 methoxy, hydroxy Chemical group 0.000 claims 116
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 3
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000005956 isoquinolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- QRCGFTXRXYMJOS-UHFFFAOYSA-N 4h-1,4-benzoxazin-3-one Chemical compound C1=CC=C2NC(=O)COC2=C1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 Chemical compound O=C(NCCCN1CCCCC1)N1CCN(Cc2c(CCN=*3)c3ccc2)CC1 0.000 description 13
- KPWHQJNIRXSRBQ-UHFFFAOYSA-N CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 Chemical compound CC(CN(CC1)C(NCCCN2CCCCC2)=O)N1c1cccc(C)c1 KPWHQJNIRXSRBQ-UHFFFAOYSA-N 0.000 description 1
- BLVXFNBKHSONDD-UHFFFAOYSA-N Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 Chemical compound Cc1cc(N(CC2)CCN2C(NCCCN2CCCCC2)=O)ccc1 BLVXFNBKHSONDD-UHFFFAOYSA-N 0.000 description 1
- MHFWLJDIZUQWSE-UHFFFAOYSA-N Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O Chemical compound Cc1ccccc1N(CC1)CCN1C(NCCCN1CCCCC1)=O MHFWLJDIZUQWSE-UHFFFAOYSA-N 0.000 description 1
- DMAORECRYRHUBR-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1C1c2ccccc2CCC1 DMAORECRYRHUBR-UHFFFAOYSA-N 0.000 description 1
- VHORVPIINKLKEU-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1S(c(cc1)ccc1F)(=O)=O VHORVPIINKLKEU-UHFFFAOYSA-N 0.000 description 1
- DITLHGOUPJXJJL-UHFFFAOYSA-N O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S Chemical compound O=C(NCCCN1CCCCC1)N(CC1)CCN1c1ccccc1S DITLHGOUPJXJJL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401970A SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Novel compounds |
| PCT/SE2005/001188 WO2006014135A1 (en) | 2004-08-02 | 2005-07-27 | Novel piperidine derivatives as histamine h3 receptor ligands for treatment of depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508352A JP2008508352A (ja) | 2008-03-21 |
| JP2008508352A5 true JP2008508352A5 (cg-RX-API-DMAC7.html) | 2009-03-12 |
Family
ID=32906882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524767A Abandoned JP2008508352A (ja) | 2004-08-02 | 2005-07-27 | うつ病の治療のためのヒスタミンｈ３受容体リガンドとしての新規なピペリジン誘導体 |
Country Status (15)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723523B2 (en) | 2004-05-28 | 2010-05-25 | 4Sc Ag | Tetrahydropyridothiophenes |
| CA2569623A1 (en) | 2004-06-11 | 2005-12-22 | Altana Pharma Ag | Novel compounds and use of tetrahydropyridothiophenes |
| EP1795527B1 (en) * | 2004-09-07 | 2009-04-22 | Banyu Pharmaceutical Co., Ltd. | Carbamoyl-substituted spiro derivative |
| EP1798227A4 (en) * | 2004-09-09 | 2009-09-09 | Res Found Itsuu Lab | SEROTONIN 5-HT3 RECEPTOR AGONIST |
| GB0611907D0 (en) * | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
| AU2006212224A1 (en) | 2005-02-09 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| CA2596501A1 (en) | 2005-02-11 | 2006-08-17 | Altana Pharma Ag | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| EP1896484A2 (en) | 2005-05-25 | 2008-03-12 | Nycomed GmbH | Tetrahydropyridothiophenes for use in the treatment of cancer |
| EP1893618A2 (en) | 2005-05-25 | 2008-03-05 | Nycomed GmbH | Tetrahydropyridothiophenes for use in the treatment of cancer |
| EP1909797A4 (en) | 2005-08-02 | 2013-02-27 | Neurogen Corp | DIPIPERAZINYL KETONE AND RELATED ANALOG |
| EP1991528A2 (en) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| US7514433B2 (en) * | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| TW200918062A (en) | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| US20110166124A1 (en) * | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
| WO2011069063A2 (en) | 2009-12-04 | 2011-06-09 | Sunovion Pharmaceuticals, Inc. | Multicyclic compounds and methods of use thereof |
| DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
| AU2017301767A1 (en) | 2016-07-29 | 2019-02-14 | Pgi Drug Discovery Llc | Compounds and compositions and uses thereof |
| HUE070203T2 (hu) | 2016-07-29 | 2025-05-28 | Sumitomo Pharma America Inc | Vegyületek és készítmények és alkalmazásaik |
| WO2018151861A1 (en) | 2017-02-16 | 2018-08-23 | Sunovion Pharamaceuticials Inc. | Methods of treating schizophrenia |
| AU2018312559B2 (en) | 2017-08-02 | 2022-06-02 | Pgi Drug Discovery Llc | Isochroman compounds and uses thereof |
| CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
| US10689360B1 (en) * | 2019-01-30 | 2020-06-23 | Insilico Medicine Ip Limited | TLR inhibitors |
| KR20210139376A (ko) | 2019-03-14 | 2021-11-22 | 선오비온 파마슈티컬스 인코포레이티드 | 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물 |
| EP4135690A1 (en) | 2020-04-14 | 2023-02-22 | Sunovion Pharmaceuticals Inc. | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders |
| CN114685401A (zh) * | 2020-12-28 | 2022-07-01 | 江苏天士力帝益药业有限公司 | 一种二（4-甲基哌嗪-1-基）甲酮的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1183784B (de) * | 1963-05-16 | 1964-12-17 | Fuji Photo Film Co Ltd | Verfahren zur Empfindlichkeitssteigerung und Beschleunigung der Entwicklung von Halogensilberemulsionen in Photomaterialien |
| FR1589754A (cg-RX-API-DMAC7.html) * | 1968-10-17 | 1970-04-06 | ||
| JPS58169143A (ja) * | 1982-03-31 | 1983-10-05 | Fuji Photo Film Co Ltd | 重合画像形成方法 |
| PL340727A1 (en) * | 1997-11-10 | 2001-02-26 | Bristol Myers Squibb Co | Benzothiazolic inhibitors of proteinous thyrosinic kinase |
| AU2001281817B2 (en) * | 2000-06-21 | 2005-11-24 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives |
-
2004
- 2004-08-02 SE SE0401970A patent/SE0401970D0/xx unknown
-
2005
- 2005-07-27 AU AU2005267931A patent/AU2005267931A1/en not_active Abandoned
- 2005-07-27 MX MX2007001227A patent/MX2007001227A/es not_active Application Discontinuation
- 2005-07-27 JP JP2007524767A patent/JP2008508352A/ja not_active Abandoned
- 2005-07-27 KR KR1020077002642A patent/KR20070039118A/ko not_active Withdrawn
- 2005-07-27 WO PCT/SE2005/001188 patent/WO2006014135A1/en not_active Ceased
- 2005-07-27 CN CNA2005800262338A patent/CN1993340A/zh active Pending
- 2005-07-27 EP EP05766829A patent/EP1784394A1/en not_active Withdrawn
- 2005-07-27 RU RU2007106969/04A patent/RU2007106969A/ru unknown
- 2005-07-27 CA CA002576109A patent/CA2576109A1/en not_active Abandoned
- 2005-07-27 US US11/572,966 patent/US20070249618A1/en not_active Abandoned
- 2005-07-27 BR BRPI0514032-3A patent/BRPI0514032A/pt not_active Application Discontinuation
-
2007
- 2007-01-04 IL IL180547A patent/IL180547A0/en unknown
- 2007-01-24 ZA ZA200700679A patent/ZA200700679B/xx unknown
- 2007-02-28 NO NO20071140A patent/NO20071140L/no not_active Application Discontinuation
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