JP2008505927A - ポリマー部分を含む多価vla−4拮抗薬 - Google Patents
ポリマー部分を含む多価vla−4拮抗薬 Download PDFInfo
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- JP2008505927A JP2008505927A JP2007520561A JP2007520561A JP2008505927A JP 2008505927 A JP2008505927 A JP 2008505927A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2008505927 A JP2008505927 A JP 2008505927A
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- Prior art keywords
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- alkyl
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- 0 C*C(C(C*CC1C)N1S(I=[Al])(=O)=O)=O Chemical compound C*C(C(C*CC1C)N1S(I=[Al])(=O)=O)=O 0.000 description 17
- GBMMEPHESZWJMM-UHFFFAOYSA-N CC(C)(C)OC(C(C1)(C1c(cc1)ccc1OC(N(CC1)CCN1C(C(F)(F)F)=O)=O)NC=O)=O Chemical compound CC(C)(C)OC(C(C1)(C1c(cc1)ccc1OC(N(CC1)CCN1C(C(F)(F)F)=O)=O)NC=O)=O GBMMEPHESZWJMM-UHFFFAOYSA-N 0.000 description 1
- MMTLCMVXARDMLF-BJKOFHAPSA-N CC(C)(C)OC([C@H](Cc(cc1)ccc1N(c(nccc1)c1N1)C1=O)NC([C@H](C(C)(C)SC1)N1S(c1cnccc1)(=O)=O)=O)=O Chemical compound CC(C)(C)OC([C@H](Cc(cc1)ccc1N(c(nccc1)c1N1)C1=O)NC([C@H](C(C)(C)SC1)N1S(c1cnccc1)(=O)=O)=O)=O MMTLCMVXARDMLF-BJKOFHAPSA-N 0.000 description 1
- KOKMXULHQYHWSW-UHFFFAOYSA-N CCC(CN(CC1)C(C(F)(F)F)=O)N1C(OC(C)(C)C)=O Chemical compound CCC(CN(CC1)C(C(F)(F)F)=O)N1C(OC(C)(C)C)=O KOKMXULHQYHWSW-UHFFFAOYSA-N 0.000 description 1
- VGNDPQKEQSUUNZ-UHFFFAOYSA-N O=C(C(F)(F)F)N(CC1)CCN1C(Cl)=O Chemical compound O=C(C(F)(F)F)N(CC1)CCN1C(Cl)=O VGNDPQKEQSUUNZ-UHFFFAOYSA-N 0.000 description 1
- VCMQRVDQQAMQTJ-UHFFFAOYSA-N O=C(C(F)(F)F)N1CCNCC1 Chemical compound O=C(C(F)(F)F)N1CCNCC1 VCMQRVDQQAMQTJ-UHFFFAOYSA-N 0.000 description 1
- MWSBQDCULAJLON-UHFFFAOYSA-N O=Sc1cccnc1 Chemical compound O=Sc1cccnc1 MWSBQDCULAJLON-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/785—Polymers containing nitrogen
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008505927A true JP2008505927A (ja) | 2008-02-28 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007520561A Pending JP2008505927A (ja) | 2004-07-08 | 2005-07-08 | ポリマー部分を含む多価vla−4拮抗薬 |
Country Status (20)
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008540686A (ja) * | 2005-05-20 | 2008-11-20 | イーラン ファーマスーティカルズ、インコーポレイテッド | Vla−4アンタゴニストとしてのイミダゾロンフェニルアラニン誘導体 |
JP2009501246A (ja) * | 2005-07-08 | 2009-01-15 | イーラン ファーマスーティカルズ、インコーポレイテッド | 治療用、農業用、及び食品用添加剤化合物のポリマー複合体の調製 |
JP2009510097A (ja) * | 2005-09-29 | 2009-03-12 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4によって媒介される白血球接着を阻害するピリミジニルアミド化合物 |
JP2012197319A (ja) * | 2005-09-29 | 2012-10-18 | Elan Pharmaceuticals Inc | Vla−4によって媒介される白血球粘着を阻害するカルバメート化合物 |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4754693B2 (ja) * | 1999-01-22 | 2011-08-24 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4関連障害を処置するアシル誘導体 |
CA2554188A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
EP2258400A3 (en) | 2004-07-08 | 2011-08-10 | Elan Pharmaceuticals, Inc. | Multivalent VLA-4 antagonists comprising polymer moieties |
US20090111828A1 (en) * | 2005-11-23 | 2009-04-30 | Astrazeneca Ab | L-alanine derivatives |
EA017110B1 (ru) * | 2006-02-27 | 2012-09-28 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
HUE047230T2 (hu) * | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
EP1991267B1 (en) | 2006-03-03 | 2017-12-20 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
BRPI0712013A2 (pt) * | 2006-05-22 | 2011-12-27 | Elan Pharm Inc | preparaÇço de conjugados polimÉricos de compostos terapÊuticos, agrÍcolas e aditivos alimentares |
JP2009539815A (ja) * | 2006-06-09 | 2009-11-19 | アストラゼネカ アクチボラグ | 固形腫瘍の治療用のa5b1アンタゴニストとしてのN−(ベンゾイル)−O−[2−(ピリジン−2−イルアミノ)エチル]−L−チロシン誘導体と関連化合物 |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
WO2008153967A1 (en) * | 2007-06-08 | 2008-12-18 | Contec Therapeutics, Inc. | Bk1 antagonist conjugates |
US8269009B2 (en) * | 2007-12-07 | 2012-09-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
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