JP2008505902A5 - - Google Patents
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- Publication number
- JP2008505902A5 JP2008505902A5 JP2007520399A JP2007520399A JP2008505902A5 JP 2008505902 A5 JP2008505902 A5 JP 2008505902A5 JP 2007520399 A JP2007520399 A JP 2007520399A JP 2007520399 A JP2007520399 A JP 2007520399A JP 2008505902 A5 JP2008505902 A5 JP 2008505902A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formulation
- substituted
- aryl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 14
- 238000009472 formulation Methods 0.000 claims 8
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 5
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 5
- -1 acyloxymethyl ester Chemical class 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 229960004556 tenofovir Drugs 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- SGOIRFVFHAKUTI-UHFFFAOYSA-N 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Chemical compound N1=CN=C2N(CC(C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-UHFFFAOYSA-N 0.000 claims 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58683904P | 2004-07-09 | 2004-07-09 | |
| US60/586,839 | 2004-07-09 | ||
| PCT/US2005/023492 WO2006017044A2 (en) | 2004-07-09 | 2005-07-01 | Topical antiviral formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185587A Division JP2012255021A (ja) | 2004-07-09 | 2012-08-24 | 局所抗菌処方 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505902A JP2008505902A (ja) | 2008-02-28 |
| JP2008505902A5 true JP2008505902A5 (enExample) | 2008-08-07 |
| JP5121451B2 JP5121451B2 (ja) | 2013-01-16 |
Family
ID=35839705
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520399A Expired - Fee Related JP5121451B2 (ja) | 2004-07-09 | 2005-07-01 | 局所抗菌処方 |
| JP2012185587A Pending JP2012255021A (ja) | 2004-07-09 | 2012-08-24 | 局所抗菌処方 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012185587A Pending JP2012255021A (ja) | 2004-07-09 | 2012-08-24 | 局所抗菌処方 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US20060058265A1 (enExample) |
| EP (4) | EP2138163A3 (enExample) |
| JP (2) | JP5121451B2 (enExample) |
| KR (1) | KR101225707B1 (enExample) |
| CN (1) | CN1984640B (enExample) |
| AP (1) | AP2666A (enExample) |
| AR (1) | AR050424A1 (enExample) |
| AT (1) | ATE447396T1 (enExample) |
| AU (1) | AU2005272032B2 (enExample) |
| BR (1) | BRPI0513196A (enExample) |
| CA (1) | CA2570877C (enExample) |
| CY (1) | CY1109757T1 (enExample) |
| DE (1) | DE602005017497D1 (enExample) |
| DK (1) | DK1773296T3 (enExample) |
| EA (2) | EA017763B1 (enExample) |
| ES (1) | ES2336017T3 (enExample) |
| HR (2) | HRP20100038T1 (enExample) |
| IL (2) | IL180172A (enExample) |
| IS (1) | IS8584A (enExample) |
| MX (1) | MX2007000122A (enExample) |
| NO (1) | NO20070762L (enExample) |
| NZ (1) | NZ552172A (enExample) |
| PL (2) | PL1773296T3 (enExample) |
| PT (1) | PT1773296E (enExample) |
| RS (1) | RS51213B (enExample) |
| SI (1) | SI1773296T1 (enExample) |
| TW (1) | TW200612955A (enExample) |
| UA (1) | UA93354C2 (enExample) |
| WO (1) | WO2006017044A2 (enExample) |
| ZA (1) | ZA200700932B (enExample) |
Families Citing this family (60)
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| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
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| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US20080317679A1 (en) * | 2002-10-25 | 2008-12-25 | Foamix Ltd. | Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses |
| US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US20060233721A1 (en) * | 2002-10-25 | 2006-10-19 | Foamix Ltd. | Foam containing unique oil globules |
| US8119109B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| JP2006505583A (ja) | 2002-10-25 | 2006-02-16 | フォーミックス エルティーディー． | 化粧剤および医薬用フォーム |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| UA93354C2 (ru) * | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| EP1893396A2 (en) * | 2005-05-09 | 2008-03-05 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
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| US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
| US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
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| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
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| PT2579871E (pt) * | 2010-06-11 | 2015-11-17 | Gilead Sciences Inc | Formulações antivirais tópicas para a prevenção da transmissão do hsv-2 |
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| ES2734495T3 (es) | 2011-12-22 | 2019-12-10 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
| WO2013187984A1 (en) | 2012-06-13 | 2013-12-19 | Evofem, Inc. | Compositions and methods for enhancing the efficacy of contraceptive microbicides |
| CN102786549B (zh) * | 2012-08-13 | 2013-07-03 | 洛阳聚慧投资股份有限公司 | 一组具有抑制hiv-1病毒复制活性的替诺福韦双酯化合物、制备方法及其药物用途 |
| CN107312039B (zh) * | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
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| EP2968127A4 (en) * | 2013-03-15 | 2016-09-07 | Conrad | LOW GLYCEROL PREPARATIONS FOR HIV TREATMENT AND PREVENTION |
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| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
| CN110225750A (zh) | 2016-10-04 | 2019-09-10 | 伊沃菲姆股份有限公司 | 细菌性阴道病的治疗和预防方法 |
| RS66222B1 (sr) | 2017-12-07 | 2024-12-31 | Univ Emory | N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim |
| CN108096206A (zh) * | 2018-02-01 | 2018-06-01 | 海南天煌制药有限公司 | 一种富马酸替诺福韦二吡呋酯片剂及其制备方法 |
| AU2019365204B2 (en) * | 2018-10-23 | 2025-08-07 | Eastern Virginia Medical School | Pharmaceutical compositions and methods of making on demand solid dosage formulations |
| EP4031141A4 (en) * | 2019-09-20 | 2023-10-18 | Abbott Rapid Diagnostics International Unlimited Company | ANTIBODIES TO TENOFOVIR AND DERIVATIVES THEREOF |
| CN112891323B (zh) * | 2020-01-22 | 2023-08-18 | 首都医科大学附属北京地坛医院 | 一种抗hiv外用消毒剂及其制备方法 |
| CN117338733B (zh) * | 2023-10-12 | 2024-05-28 | 杭州和泽坤元药业有限公司 | 一种富马酸替诺福韦二吡呋酯片及其制备工艺 |
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-
2005
- 2005-01-07 UA UAA200701335A patent/UA93354C2/ru unknown
- 2005-07-01 CN CN2005800232101A patent/CN1984640B/zh not_active Expired - Fee Related
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- 2005-07-01 PL PL05771562T patent/PL1773296T3/pl unknown
- 2005-07-01 AU AU2005272032A patent/AU2005272032B2/en not_active Ceased
- 2005-07-01 WO PCT/US2005/023492 patent/WO2006017044A2/en not_active Ceased
- 2005-07-01 EP EP09173071A patent/EP2138163A3/en not_active Withdrawn
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- 2005-07-01 EP EP05771562A patent/EP1773296B1/en not_active Expired - Lifetime
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- 2005-07-01 RS RSP-2010/0030A patent/RS51213B/sr unknown
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- 2005-07-01 SI SI200530903T patent/SI1773296T1/sl unknown
- 2005-07-01 AT AT05771562T patent/ATE447396T1/de active
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- 2005-07-01 EP EP09173070A patent/EP2138162A3/en not_active Withdrawn
- 2005-07-01 KR KR1020077002108A patent/KR101225707B1/ko not_active Expired - Fee Related
- 2005-07-01 EA EA201370001A patent/EA201370001A1/ru unknown
- 2005-07-01 DK DK05771562.5T patent/DK1773296T3/da active
- 2005-07-06 TW TW094122885A patent/TW200612955A/zh unknown
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2006
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- 2006-12-21 IS IS8584A patent/IS8584A/is unknown
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2007
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2010
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- 2010-05-27 IL IL206031A patent/IL206031A0/en unknown
- 2010-09-24 US US12/890,337 patent/US9283182B2/en active Active
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2012
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2015
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