JP2002539125A5 - - Google Patents
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- Publication number
- JP2002539125A5 JP2002539125A5 JP2000604040A JP2000604040A JP2002539125A5 JP 2002539125 A5 JP2002539125 A5 JP 2002539125A5 JP 2000604040 A JP2000604040 A JP 2000604040A JP 2000604040 A JP2000604040 A JP 2000604040A JP 2002539125 A5 JP2002539125 A5 JP 2002539125A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- group
- virus
- compound
- antiviral compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 18
- 239000000203 mixture Substances 0.000 description 16
- 230000000840 anti-viral effect Effects 0.000 description 11
- 241000124008 Mammalia Species 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- HBOMLICNUCNMMY-UHFFFAOYSA-N 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1OC(CO)C(N=[N+]=[N-])C1 HBOMLICNUCNMMY-UHFFFAOYSA-N 0.000 description 3
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 description 3
- 241000700721 Hepatitis B virus Species 0.000 description 3
- 241000725303 Human immunodeficiency virus Species 0.000 description 3
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 description 3
- 229960004150 aciclovir Drugs 0.000 description 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 3
- 229960002963 ganciclovir Drugs 0.000 description 3
- 241001529453 unidentified herpesvirus Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- -1 2-hydroxymethyl-cyclopropyl Chemical group 0.000 description 1
- BXJHWYVXLGLDMZ-UHFFFAOYSA-N 6-O-methylguanine Chemical compound COC1=NC(N)=NC2=C1NC=N2 BXJHWYVXLGLDMZ-UHFFFAOYSA-N 0.000 description 1
- OCAODLAHPGXQIE-UHFFFAOYSA-N 6-azido-7h-purin-2-amine Chemical compound NC1=NC(N=[N+]=[N-])=C2NC=NC2=N1 OCAODLAHPGXQIE-UHFFFAOYSA-N 0.000 description 1
- RXTDSPFLZDZOIX-UHFFFAOYSA-N [2-(purin-9-ylmethylidene)cyclopropyl]methanol Chemical compound OCC1CC1=CN1C2=NC=NC=C2N=C1 RXTDSPFLZDZOIX-UHFFFAOYSA-N 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/267,839 US6352991B1 (en) | 1997-01-08 | 1999-03-12 | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| US09/267,839 | 1999-03-12 | ||
| PCT/US2000/006250 WO2000053603A1 (en) | 1999-03-12 | 2000-03-10 | 2-hydroxy methylcyclopro pylidenemethyl purines and -pyrimidines as antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002539125A JP2002539125A (ja) | 2002-11-19 |
| JP2002539125A5 true JP2002539125A5 (enExample) | 2007-04-26 |
Family
ID=23020343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604040A Pending JP2002539125A (ja) | 1999-03-12 | 2000-03-10 | 抗ウイルス剤としての２−ヒドロキシメチルシクロプロピリデンメチルプリンおよび−ピリミジン類 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6352991B1 (enExample) |
| EP (1) | EP1165560B1 (enExample) |
| JP (1) | JP2002539125A (enExample) |
| AT (1) | ATE282617T1 (enExample) |
| CA (1) | CA2366624C (enExample) |
| DE (1) | DE60015945T2 (enExample) |
| DK (1) | DK1165560T3 (enExample) |
| ES (1) | ES2234579T3 (enExample) |
| PT (1) | PT1165560E (enExample) |
| WO (1) | WO2000053603A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| AU2003267947B2 (en) * | 2002-03-15 | 2008-11-13 | The Regents Of The University Of Michigan | 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents |
| WO2004006867A2 (en) * | 2002-03-15 | 2004-01-22 | Wayne State University | 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| KR20070112464A (ko) * | 2005-03-22 | 2007-11-26 | 다이이찌 산쿄 가부시키가이샤 | 1-알킬피롤리딘 구조를 갖는 카르바페넴 유도체의 제조방법 |
| TWI377198B (en) * | 2005-08-24 | 2012-11-21 | Eisai R&D Man Co Ltd | Novel pyridine derivatives and pyrimidine derivatives (3) |
| US7473683B2 (en) | 2005-09-14 | 2009-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Nonpolar thymidine analogs |
| CN101454311B (zh) * | 2006-08-23 | 2013-03-27 | 卫材R&D管理有限公司 | 苯氧基吡啶衍生物的盐和其结晶及其制备方法 |
| JP2009132660A (ja) * | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| JP2009203226A (ja) * | 2008-01-31 | 2009-09-10 | Eisai R & D Management Co Ltd | ピリジン誘導体およびピリミジン誘導体を含有するレセプターチロシンキナーゼ阻害剤 |
| US20100311972A1 (en) * | 2008-02-18 | 2010-12-09 | Mitsuo Nagai | Method for producing phenoxypyridine derivative |
| WO2011022712A1 (en) * | 2009-08-21 | 2011-02-24 | Epiphany Biosciences, Inc. | Method of treating infectious mononucleosis with acylic nucleoside derivatives |
| CN104892709B (zh) * | 2015-06-04 | 2018-01-19 | 新乡学院 | 一种合成奈拉滨的方法 |
| US12221459B2 (en) * | 2018-03-09 | 2025-02-11 | Medivir Ab | Cancer treatment with (2,2-bishydroxymethyl) methylenecyclopropane nucleotides |
| CN108314655B (zh) * | 2018-03-29 | 2021-01-15 | 河南师范大学 | 一种铑催化不对称环丙化合成三元碳环嘧啶核苷类似物的方法 |
| CN113185514A (zh) * | 2021-03-11 | 2021-07-30 | 杨锦飞 | 一种抗乙型肝炎病毒药物的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62116582A (ja) * | 1985-09-24 | 1987-05-28 | ヘキスト・アクチエンゲゼルシヤフト | ６−および９−位が置換された２−アミノプリン |
| US4935427A (en) | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
| US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| WO1998030563A1 (en) * | 1997-01-08 | 1998-07-16 | The Regents Of The University Of Michigan | 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents |
-
1999
- 1999-03-12 US US09/267,839 patent/US6352991B1/en not_active Expired - Fee Related
-
2000
- 2000-03-10 ES ES00913872T patent/ES2234579T3/es not_active Expired - Lifetime
- 2000-03-10 CA CA002366624A patent/CA2366624C/en not_active Expired - Fee Related
- 2000-03-10 DK DK00913872T patent/DK1165560T3/da active
- 2000-03-10 AT AT00913872T patent/ATE282617T1/de active
- 2000-03-10 PT PT00913872T patent/PT1165560E/pt unknown
- 2000-03-10 DE DE60015945T patent/DE60015945T2/de not_active Expired - Lifetime
- 2000-03-10 EP EP00913872A patent/EP1165560B1/en not_active Expired - Lifetime
- 2000-03-10 JP JP2000604040A patent/JP2002539125A/ja active Pending
- 2000-03-10 WO PCT/US2000/006250 patent/WO2000053603A1/en not_active Ceased
-
2002
- 2002-01-14 US US10/047,202 patent/US6790841B2/en not_active Expired - Fee Related
-
2004
- 2004-08-06 US US10/913,219 patent/US6958345B2/en not_active Expired - Fee Related
-
2005
- 2005-10-25 US US11/257,776 patent/US20060122203A1/en not_active Abandoned
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