JP2001335592A5 - - Google Patents
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- Publication number
- JP2001335592A5 JP2001335592A5 JP2000137982A JP2000137982A JP2001335592A5 JP 2001335592 A5 JP2001335592 A5 JP 2001335592A5 JP 2000137982 A JP2000137982 A JP 2000137982A JP 2000137982 A JP2000137982 A JP 2000137982A JP 2001335592 A5 JP2001335592 A5 JP 2001335592A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- ethynyl
- diaminopurine
- adenine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 11
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 6
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- VKKXEIQIGGPMHT-UHFFFAOYSA-N 7h-purine-2,8-diamine Chemical compound NC1=NC=C2NC(N)=NC2=N1 VKKXEIQIGGPMHT-UHFFFAOYSA-N 0.000 description 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 3
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000002777 nucleoside Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 description 2
- 229940124411 anti-hiv antiviral agent Drugs 0.000 description 2
- 150000003212 purines Chemical class 0.000 description 2
- ZHUBMCMWNICRIP-LDDIKCJXSA-N (2r,3s,4s,5r)-5-(6-aminopurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@@](CO)(C#C)[C@@H](O)[C@@H]1O ZHUBMCMWNICRIP-LDDIKCJXSA-N 0.000 description 1
- HMIGVKANVVLEOA-JOAULVNJSA-N (2r,3s,5r)-5-(6-aminopurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@](CO)(C#C)O1 HMIGVKANVVLEOA-JOAULVNJSA-N 0.000 description 1
- MPCMLKLBMSFTTJ-QRPMWFLTSA-N 2-amino-9-[(2r,4s,5r)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1C[C@H](O)[C@](CO)(C#C)O1 MPCMLKLBMSFTTJ-QRPMWFLTSA-N 0.000 description 1
- MUTAKMKPKAHXMQ-JOAULVNJSA-N 9-[(2r,4s,5r)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound C1[C@H](O)[C@](CO)(C#C)O[C@H]1N1C(NC=NC2=O)=C2N=C1 MUTAKMKPKAHXMQ-JOAULVNJSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000000262 haloalkenyl group Chemical group 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000137982A JP4076114B2 (ja) | 1999-05-12 | 2000-05-11 | ４’−ｃ−エチニルプリンヌクレオシド化合物 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13153999 | 1999-05-12 | ||
| JP11-131539 | 1999-05-12 | ||
| JP11-174920 | 1999-06-22 | ||
| JP17492099 | 1999-06-22 | ||
| JP31824699 | 1999-11-09 | ||
| JP11-318246 | 1999-11-09 | ||
| JP2000-81117 | 2000-03-23 | ||
| JP2000081117 | 2000-03-23 | ||
| JP2000137982A JP4076114B2 (ja) | 1999-05-12 | 2000-05-11 | ４’−ｃ−エチニルプリンヌクレオシド化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007314092A Division JP2008110983A (ja) | 1999-05-12 | 2007-12-05 | ４’−ｃ−エチニルヌクレオシド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001335592A JP2001335592A (ja) | 2001-12-04 |
| JP2001335592A5 true JP2001335592A5 (enExample) | 2007-08-30 |
| JP4076114B2 JP4076114B2 (ja) | 2008-04-16 |
Family
ID=27527275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000137982A Expired - Lifetime JP4076114B2 (ja) | 1999-05-12 | 2000-05-11 | ４’−ｃ−エチニルプリンヌクレオシド化合物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4076114B2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2502109C (en) * | 2004-03-24 | 2010-02-23 | Yamasa Corporation | 4'-c-substituted-2-haloadenosine derivative |
| JP2008069182A (ja) * | 2004-03-24 | 2008-03-27 | Yamasa Shoyu Co Ltd | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
| KR102072041B1 (ko) | 2011-12-22 | 2020-01-31 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| SI2827875T1 (sl) * | 2012-03-21 | 2019-04-30 | Alios Biopharma, Inc. | Substituirani nukleozidi, nukleotidi in njihovi analogi |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| JP6191989B2 (ja) * | 2014-02-12 | 2017-09-06 | 学校法人東京理科大学 | アデニン誘導体又はその薬理学的に許容しうる塩、その製造方法、及びその用途 |
| WO2018092728A1 (ja) | 2016-11-16 | 2018-05-24 | 国立研究開発法人国立国際医療研究センター | 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体 |
| EP3950696A4 (en) * | 2019-04-05 | 2023-01-04 | Nippon Shokubai Co., Ltd. | PRODUCTION OF BRIDGE ARTIFICIAL NUCLEOSIDE |
-
2000
- 2000-05-11 JP JP2000137982A patent/JP4076114B2/ja not_active Expired - Lifetime
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