JP2008504279A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008504279A5 JP2008504279A5 JP2007518300A JP2007518300A JP2008504279A5 JP 2008504279 A5 JP2008504279 A5 JP 2008504279A5 JP 2007518300 A JP2007518300 A JP 2007518300A JP 2007518300 A JP2007518300 A JP 2007518300A JP 2008504279 A5 JP2008504279 A5 JP 2008504279A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- membered
- carbonyl
- cyclopropyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000003118 aryl group Chemical group 0.000 claims 51
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 46
- 125000000753 cycloalkyl group Chemical group 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000005843 halogen group Chemical group 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 21
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 21
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 20
- 229910005965 SO 2 Inorganic materials 0.000 claims 20
- 125000005466 alkylenyl group Chemical group 0.000 claims 18
- 125000004429 atom Chemical group 0.000 claims 18
- 125000004432 carbon atom Chemical group C* 0.000 claims 16
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 13
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 12
- 125000003282 alkyl amino group Chemical group 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 7
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- -1 4,5,6,7-tetrahydro-thieno [2,3-c] pyridinyl Chemical group 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- KCKUJDZUDDFYSH-UHFFFAOYSA-N (1-cyclohexylsulfonylcyclopropyl)-(3-phenylpiperazin-1-yl)methanone Chemical compound C1CC1(S(=O)(=O)C1CCCCC1)C(=O)N(C1)CCNC1C1=CC=CC=C1 KCKUJDZUDDFYSH-UHFFFAOYSA-N 0.000 claims 1
- ZLOMSEDPUPTGFV-UHFFFAOYSA-N (1-cyclohexylsulfonylcyclopropyl)-(3-pyridin-4-ylpyrrolidin-1-yl)methanone Chemical compound C1CC1(S(=O)(=O)C1CCCCC1)C(=O)N(C1)CCC1C1=CC=NC=C1 ZLOMSEDPUPTGFV-UHFFFAOYSA-N 0.000 claims 1
- GPVIVLBVCZAEPJ-UHFFFAOYSA-N (1-cyclohexylsulfonylcyclopropyl)-pyrrolidin-1-ylmethanone Chemical compound C1CC1(S(=O)(=O)C1CCCCC1)C(=O)N1CCCC1 GPVIVLBVCZAEPJ-UHFFFAOYSA-N 0.000 claims 1
- WZFHTXODPVKARC-UHFFFAOYSA-N (1-phenylsulfanylcyclopropyl)-spiro[1,3-dihydroindene-2,4'-piperidine]-1'-ylmethanone Chemical compound C1CC2(CC3=CC=CC=C3C2)CCN1C(=O)C1(SC=2C=CC=CC=2)CC1 WZFHTXODPVKARC-UHFFFAOYSA-N 0.000 claims 1
- ZUHOZIJDAQQDKH-UHFFFAOYSA-N (3-methyl-4-phenylpiperazin-1-yl)-(1-phenylsulfanylcyclopropyl)methanone Chemical compound CC1CN(C(=O)C2(CC2)SC=2C=CC=CC=2)CCN1C1=CC=CC=C1 ZUHOZIJDAQQDKH-UHFFFAOYSA-N 0.000 claims 1
- OZFIQFOWJRHRJW-UHFFFAOYSA-N (3-phenylpiperidin-1-yl)-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1CC1(SC=1C=CC=CC=1)C(=O)N(C1)CCCC1C1=CC=CC=C1 OZFIQFOWJRHRJW-UHFFFAOYSA-N 0.000 claims 1
- XOTXLNBANZFMAV-UHFFFAOYSA-N 1'-(1-phenylsulfanylcyclopropanecarbonyl)spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1CC2(C3=CC=CC=C3C(=O)O2)CN1C(=O)C1(SC=2C=CC=CC=2)CC1 XOTXLNBANZFMAV-UHFFFAOYSA-N 0.000 claims 1
- UQCOPIMTSBBVTD-UHFFFAOYSA-N 1'-[1-(2,6-dichlorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound ClC1=CC=CC(Cl)=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 UQCOPIMTSBBVTD-UHFFFAOYSA-N 0.000 claims 1
- XQRJWZKXNWUPMX-UHFFFAOYSA-N 1'-[1-(3,4-dichlorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=C(Cl)C(Cl)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 XQRJWZKXNWUPMX-UHFFFAOYSA-N 0.000 claims 1
- IZWHHWNIHBUWPY-UHFFFAOYSA-N 1'-[1-(3,5-dichlorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound ClC1=CC(Cl)=CC(SC2(CC2)C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)=C1 IZWHHWNIHBUWPY-UHFFFAOYSA-N 0.000 claims 1
- DYMFZKQMTQQBOT-UHFFFAOYSA-N 1'-[1-(3-chloro-4-fluorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=C(Cl)C(F)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 DYMFZKQMTQQBOT-UHFFFAOYSA-N 0.000 claims 1
- GZSMZIDDJWPIMT-UHFFFAOYSA-N 1'-[1-(4-chlorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 GZSMZIDDJWPIMT-UHFFFAOYSA-N 0.000 claims 1
- PGBVVTQCCZJNNQ-UHFFFAOYSA-N 1'-[1-(4-fluorophenyl)sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=CC(F)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 PGBVVTQCCZJNNQ-UHFFFAOYSA-N 0.000 claims 1
- WMWOJVODFSMTQW-UHFFFAOYSA-N 1'-[1-[3-(trifluoromethyl)phenyl]sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound FC(F)(F)C1=CC=CC(SC2(CC2)C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)=C1 WMWOJVODFSMTQW-UHFFFAOYSA-N 0.000 claims 1
- SXIPZUFARNSJEJ-UHFFFAOYSA-N 1'-[1-[4-(4-fluorophenyl)phenyl]sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=CC(F)=CC=C1C(C=C1)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 SXIPZUFARNSJEJ-UHFFFAOYSA-N 0.000 claims 1
- GMMUWWOAGPQJAM-UHFFFAOYSA-N 1'-[1-[4-(trifluoromethoxy)phenyl]sulfanylcyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2C(=O)O3)CC1 GMMUWWOAGPQJAM-UHFFFAOYSA-N 0.000 claims 1
- 125000004605 1,2,3,4-tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- DZLCJULGPKUTBL-UHFFFAOYSA-N 1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1C2CCC3=CC=CC=C3C2CN1C(=O)C1(SC=2C=CC=CC=2)CC1 DZLCJULGPKUTBL-UHFFFAOYSA-N 0.000 claims 1
- AFUKREKRACCNKC-UHFFFAOYSA-N 2,3,3a,4,5,9b-hexahydro-1h-benzo[e]isoindole Chemical compound C1=CC=C2C3CNCC3CCC2=C1 AFUKREKRACCNKC-UHFFFAOYSA-N 0.000 claims 1
- HXJSHSBBPDVMDI-UHFFFAOYSA-N 3,3a,4,9b-tetrahydro-1h-chromeno[3,4-c]pyrrol-2-yl-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1C2COC3=CC=CC=C3C2CN1C(=O)C1(SC=2C=CC=CC=2)CC1 HXJSHSBBPDVMDI-UHFFFAOYSA-N 0.000 claims 1
- YNDBVTREHJJWAT-UHFFFAOYSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl-[1-(4-chlorophenyl)sulfanylcyclopropyl]methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2C3CCCCC3CCC2)CC1 YNDBVTREHJJWAT-UHFFFAOYSA-N 0.000 claims 1
- DJNGUNYUJSDHND-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1CC2=CC=CC=C2CN1C(=O)C1(SC=2C=CC=CC=2)CC1 DJNGUNYUJSDHND-UHFFFAOYSA-N 0.000 claims 1
- IVTKVVCRDWLNKG-UHFFFAOYSA-N 4,5,7,7a-tetrahydro-3ah-thieno[2,3-c]pyridin-6-yl-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1CC2C=CSC2CN1C(=O)C1(SC=2C=CC=CC=2)CC1 IVTKVVCRDWLNKG-UHFFFAOYSA-N 0.000 claims 1
- VOHNTQPXXJRRHW-UHFFFAOYSA-N 5,7-dihydro-4h-thieno[2,3-c]pyridin-6-yl-(1-phenylsulfanylcyclopropyl)methanone Chemical compound C1CC=2C=CSC=2CN1C(=O)C1(SC=2C=CC=CC=2)CC1 VOHNTQPXXJRRHW-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010070901 Diabetic dyslipidaemia Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- IXLKGMHWBMIPDZ-GOSISDBHSA-N [(1s)-1-(hydroxymethyl)-3,4-dihydro-1h-isoquinolin-2-yl]-(1-phenylsulfanylcyclopropyl)methanone Chemical compound N1([C@@H](C2=CC=CC=C2CC1)CO)C(=O)C1(SC=2C=CC=CC=2)CC1 IXLKGMHWBMIPDZ-GOSISDBHSA-N 0.000 claims 1
- BTCNEIUGAWMUBQ-HUUCEWRRSA-N [(4ar,8as)-3,4,4a,5,6,7,8,8a-octahydro-1h-isoquinolin-2-yl]-[1-(4-chlorophenyl)sulfanylcyclopropyl]methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2C[C@H]3CCCC[C@@H]3CC2)CC1 BTCNEIUGAWMUBQ-HUUCEWRRSA-N 0.000 claims 1
- CVFQHONHWKFKRZ-UHFFFAOYSA-N [1-(4-chlorophenyl)sulfanylcyclopropyl]-(3-phenylpiperazin-1-yl)methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC(NCC2)C=2C=CC=CC=2)CC1 CVFQHONHWKFKRZ-UHFFFAOYSA-N 0.000 claims 1
- QNFLODIDAIIVBY-UHFFFAOYSA-N [1-(4-chlorophenyl)sulfanylcyclopropyl]-(3-pyridin-2-ylpyrrolidin-1-yl)methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC(CC2)C=2N=CC=CC=2)CC1 QNFLODIDAIIVBY-UHFFFAOYSA-N 0.000 claims 1
- ONBSHJJVSBHMQA-UHFFFAOYSA-N [1-(4-chlorophenyl)sulfanylcyclopropyl]-(3-pyridin-4-ylpyrrolidin-1-yl)methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC(CC2)C=2C=CN=CC=2)CC1 ONBSHJJVSBHMQA-UHFFFAOYSA-N 0.000 claims 1
- HEXZORPQMGUHAJ-UHFFFAOYSA-N [1-(4-chlorophenyl)sulfanylcyclopropyl]-[3-(3-fluorophenyl)pyrrolidin-1-yl]methanone Chemical compound FC1=CC=CC(C2CN(CC2)C(=O)C2(CC2)SC=2C=CC(Cl)=CC=2)=C1 HEXZORPQMGUHAJ-UHFFFAOYSA-N 0.000 claims 1
- WPBXRCGYVUUKSW-UHFFFAOYSA-N [1-(4-chlorophenyl)sulfanylcyclopropyl]-spiro[1h-2-benzofuran-3,3'-pyrrolidine]-1'-ylmethanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2CO3)CC1 WPBXRCGYVUUKSW-UHFFFAOYSA-N 0.000 claims 1
- VWASVTOLPDBAJG-UHFFFAOYSA-N [1-[4-(4-fluorophenyl)phenyl]sulfanylcyclopropyl]-spiro[1h-2-benzofuran-3,3'-pyrrolidine]-1'-ylmethanone Chemical compound C1=CC(F)=CC=C1C(C=C1)=CC=C1SC1(C(=O)N2CC3(CC2)C2=CC=CC=C2CO3)CC1 VWASVTOLPDBAJG-UHFFFAOYSA-N 0.000 claims 1
- KCINEKNNHYGGPH-UHFFFAOYSA-N [3-(3-fluorophenyl)pyrrolidin-1-yl]-(1-phenylsulfanylcyclopropyl)methanone Chemical compound FC1=CC=CC(C2CN(CC2)C(=O)C2(CC2)SC=2C=CC=CC=2)=C1 KCINEKNNHYGGPH-UHFFFAOYSA-N 0.000 claims 1
- DIWAYWYQMFGEIX-UHFFFAOYSA-N [3-(4-chlorophenyl)pyrrolidin-1-yl]-[1-(4-chlorophenyl)sulfanylcyclopropyl]methanone Chemical compound C1=CC(Cl)=CC=C1SC1(C(=O)N2CC(CC2)C=2C=CC(Cl)=CC=2)CC1 DIWAYWYQMFGEIX-UHFFFAOYSA-N 0.000 claims 1
- QJEWBKDCLCTGLS-UHFFFAOYSA-N [3-(hydroxymethyl)-4-(2-hydroxyphenyl)pyrrolidin-1-yl]-(1-phenylsulfanylcyclopropyl)methanone Chemical compound OCC1CN(C(=O)C2(CC2)SC=2C=CC=CC=2)CC1C1=CC=CC=C1O QJEWBKDCLCTGLS-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 0 *C(*)(C(N1CC[U]CC1)=O)I* Chemical compound *C(*)(C(N1CC[U]CC1)=O)I* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58256104P | 2004-06-24 | 2004-06-24 | |
| PCT/US2005/022412 WO2006002350A1 (en) | 2004-06-24 | 2005-06-23 | Amido compounds and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504279A JP2008504279A (ja) | 2008-02-14 |
| JP2008504279A5 true JP2008504279A5 (enExample) | 2008-08-07 |
Family
ID=35782142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518300A Withdrawn JP2008504279A (ja) | 2004-06-24 | 2005-06-23 | アミド化合物およびその医薬としての使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060009491A1 (enExample) |
| EP (1) | EP1773773A4 (enExample) |
| JP (1) | JP2008504279A (enExample) |
| CA (1) | CA2589565A1 (enExample) |
| WO (1) | WO2006002350A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| BRPI0512410A (pt) * | 2004-06-24 | 2008-03-04 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
| AU2005267331A1 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| BRPI0512535A (pt) | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
| EP1768954A4 (en) * | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| EP1773780A4 (en) * | 2004-06-24 | 2008-01-09 | Incyte Corp | AMIDO COMPOUNDS AND USES THEREOF AS PHARMACEUTICAL PRODUCTS |
| AU2005273986A1 (en) * | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| AU2005304560C1 (en) * | 2004-11-10 | 2013-05-09 | Incyte Holdings Corporation | Lactam compounds and their use as pharmaceuticals |
| US8110581B2 (en) | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| CN101103016A (zh) * | 2004-11-18 | 2008-01-09 | 因塞特公司 | 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法 |
| ATE555081T1 (de) * | 2005-01-05 | 2012-05-15 | Abbott Lab | Adamantyl-derivate als inhibitoren des 11-beta- hydroxysteroid-dehydrogenase-1-enzyms |
| CN102816081A (zh) * | 2005-01-05 | 2012-12-12 | 雅培制药有限公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| JP5140577B2 (ja) * | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
| CA2621255A1 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| AU2006322060A1 (en) * | 2005-12-05 | 2007-06-14 | Incyte Corporation | Lactam compounds and methods of using the same |
| WO2007084314A2 (en) * | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| BRPI0707408A2 (pt) * | 2006-01-31 | 2011-05-03 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
| RU2008132333A (ru) * | 2006-02-07 | 2010-03-20 | Вайет (Us) | Ингибиторы 11-бета hsd1 |
| WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| US20070208001A1 (en) * | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US7838544B2 (en) | 2006-05-17 | 2010-11-23 | Incyte Corporation | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same |
| CL2008001839A1 (es) * | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| JP5736098B2 (ja) * | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| DK2227466T3 (da) | 2007-11-30 | 2011-08-08 | Bayer Schering Pharma Ag | Heteroaryl-substituerede piperidiner |
| WO2010096371A2 (en) | 2009-02-18 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the cb2 receptor |
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022892A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| CN102812011A (zh) | 2009-11-16 | 2012-12-05 | 梅利科技公司 | [1,5]-二氮杂环辛间四烯衍生物 |
| EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| EP2595959B1 (en) | 2010-07-22 | 2015-11-04 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| CN110357833B (zh) * | 2019-06-03 | 2022-05-24 | 杭州维坦医药科技有限公司 | 芳杂乙酰胺类衍生物及其制备和应用 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL262366A (enExample) * | 1960-03-14 | |||
| US3201466A (en) * | 1963-03-08 | 1965-08-17 | Gulf Oil Corp | Substituted cyclopropanecarboxanilide herbicides |
| US3849403A (en) * | 1968-04-29 | 1974-11-19 | American Home Prod | 2,3,4,5-tetrahydro-1,1,5,5-tetrasubstituted-1h-3-benzazepines |
| DE2114420A1 (de) * | 1971-03-25 | 1972-10-05 | Merck Patent Gmbh, 6100 Darmstadt | Substituierte Phenylalkanol-Derivate und Verfahren zu ihrer Herstellung |
| US3923350A (en) * | 1974-03-11 | 1975-12-02 | Commercial Metals Company | Precision bearing assembly |
| GB1460389A (en) * | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
| US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
| TR18917A (tr) * | 1974-10-31 | 1977-12-09 | Ciba Geigy Ag | 1-(bis-triflormetilfenil)-2-oksopirolidin-4-karbonik asitleri ve bunlarin tuerevleri |
| FR2312247A1 (fr) * | 1975-05-30 | 1976-12-24 | Parcor | Derives de la thieno-pyridine, leur procede de preparation et leurs applications |
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4439606A (en) * | 1982-05-06 | 1984-03-27 | American Cyanamid Company | Antiatherosclerotic 1-piperazinecarbonyl compounds |
| US4701459A (en) * | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
| US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| FR2672213B1 (fr) * | 1991-02-05 | 1995-03-10 | Sanofi Sa | Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres. |
| FR2678272B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2705343B1 (fr) * | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| DE9403308U1 (de) * | 1994-02-28 | 1994-04-28 | INA Wälzlager Schaeffler KG, 91074 Herzogenaurach | Ausgleichsgetriebe für ein Kraftfahrzeug |
| FR2724656B1 (fr) * | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5693567A (en) * | 1995-06-07 | 1997-12-02 | Xerox Corporation | Separately etching insulating layer for contacts within array and for peripheral pads |
| FR2736053B1 (fr) * | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| GB9517622D0 (en) * | 1995-08-29 | 1995-11-01 | Univ Edinburgh | Regulation of intracellular glucocorticoid concentrations |
| GB9604311D0 (en) * | 1996-02-29 | 1996-05-01 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase |
| GB9600235D0 (en) * | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
| NZ334389A (en) * | 1996-08-28 | 2001-05-25 | Ube Industries | Cyclic amine derivatives |
| IL122072A (en) * | 1996-11-14 | 2001-03-19 | Akzo Nobel Nv | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| CA2322171C (en) * | 1998-02-27 | 2009-10-27 | Sankyo Company Limited | Cyclic amino compounds |
| ES2165274B1 (es) * | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| WO2001036386A1 (en) * | 1999-11-17 | 2001-05-25 | Sumitomo Pharmaceuticals Co., Ltd. | Diabetic remedy containing dipiperazine derivative |
| AU780419C (en) * | 1999-12-03 | 2005-09-29 | Ono Pharmaceutical Co. Ltd. | Triazaspiro(5.5)undecane derivatives and drugs containing the same as the active ingredient |
| US7294637B2 (en) * | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
| US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US7365205B2 (en) * | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| US6547958B1 (en) * | 2001-07-13 | 2003-04-15 | Chevron U.S.A. Inc. | Hydrocarbon conversion using zeolite SSZ-59 |
| US7074788B2 (en) * | 2001-11-22 | 2006-07-11 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| US6818772B2 (en) * | 2002-02-22 | 2004-11-16 | Abbott Laboratories | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor |
| GB0213715D0 (en) * | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| US20040072802A1 (en) * | 2002-10-09 | 2004-04-15 | Jingwu Duan | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| CA2501611A1 (en) * | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
| WO2004035581A1 (ja) * | 2002-10-18 | 2004-04-29 | Ono Pharmaceutical Co., Ltd. | スピロ複素環誘導体化合物およびその化合物を有効成分とする薬剤 |
| EP1683797A1 (en) * | 2003-11-13 | 2006-07-26 | Ono Pharmaceutical Co., Ltd. | Heterocyclic spiro compound |
| TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| DE602005017033D1 (de) * | 2004-06-16 | 2009-11-19 | Wyeth Corp | Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung |
| AU2005267331A1 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| BRPI0512535A (pt) * | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
| EP1773780A4 (en) * | 2004-06-24 | 2008-01-09 | Incyte Corp | AMIDO COMPOUNDS AND USES THEREOF AS PHARMACEUTICAL PRODUCTS |
| EP1768954A4 (en) * | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| BRPI0512410A (pt) * | 2004-06-24 | 2008-03-04 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
| AU2005273986A1 (en) * | 2004-08-10 | 2006-02-23 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| AU2005304560C1 (en) * | 2004-11-10 | 2013-05-09 | Incyte Holdings Corporation | Lactam compounds and their use as pharmaceuticals |
| CN101103016A (zh) * | 2004-11-18 | 2008-01-09 | 因塞特公司 | 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法 |
| CN102816081A (zh) * | 2005-01-05 | 2012-12-12 | 雅培制药有限公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| KR100979577B1 (ko) * | 2005-03-03 | 2010-09-01 | 에프. 호프만-라 로슈 아게 | 2형 진성 당뇨병의 치료를 위한11-베타-하이드록시스테로이드 탈수소효소의 억제제로서1-설폰일-피페리딘-3-카복실산 아마이드 유도체 |
| CA2621255A1 (en) * | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| AU2006322060A1 (en) * | 2005-12-05 | 2007-06-14 | Incyte Corporation | Lactam compounds and methods of using the same |
| WO2007084314A2 (en) * | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| BRPI0707408A2 (pt) * | 2006-01-31 | 2011-05-03 | Incyte Corp | compostos de amido e seu uso como produtos farmacêuticos |
| WO2007101270A1 (en) * | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| US20070208001A1 (en) * | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| US20070293529A1 (en) * | 2006-05-01 | 2007-12-20 | Yun-Long Li | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 |
| US7838544B2 (en) * | 2006-05-17 | 2010-11-23 | Incyte Corporation | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same |
| CL2008001839A1 (es) * | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2005
- 2005-06-23 CA CA002589565A patent/CA2589565A1/en not_active Abandoned
- 2005-06-23 JP JP2007518300A patent/JP2008504279A/ja not_active Withdrawn
- 2005-06-23 US US11/159,488 patent/US20060009491A1/en not_active Abandoned
- 2005-06-23 EP EP05766841A patent/EP1773773A4/en not_active Withdrawn
- 2005-06-23 WO PCT/US2005/022412 patent/WO2006002350A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008504279A5 (enExample) | ||
| JP2008504278A5 (enExample) | ||
| JP2008504274A5 (enExample) | ||
| JP2008504275A5 (enExample) | ||
| RU2497813C2 (ru) | 4-(4-циано-2-тиоарил)-дигидропиримидиноны и их применение | |
| JP2007536252A5 (enExample) | ||
| RU2330019C2 (ru) | Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и способ лечения хемокин-опосредованного болезненного состояния с их использованием | |
| ES2569327T3 (es) | Promotores de la apoptosis que contienen N-acilsulfonamida | |
| RU2012112151A (ru) | Соединения как модуляторы тирозинкиназы | |
| CA2560689A1 (en) | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes | |
| JP2023123854A5 (enExample) | ||
| JP2012515761A5 (enExample) | ||
| JP2017522374A5 (enExample) | ||
| RU2009141522A (ru) | Дифенилдигидроимидазопиридиноны | |
| RU2011107437A (ru) | Ингибиторы кинуренин-3-моноксигеназы | |
| WO2005113542B1 (en) | N-cyclic sulfonamido inhibitors of gamma secretase | |
| RU2005102004A (ru) | Замещенные хинолины как антагонисты рецептора ccr5 | |
| CA2487489A1 (en) | Mitotic kinesin inhibitors | |
| HK1245791A1 (zh) | 用於雄激素受体的靶向降解的化合物和方法 | |
| RU2010106974A (ru) | Ариловые эфиры пирролидина в качестве антагонистов рецепторов nk3 | |
| CA2587800A1 (en) | Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes | |
| RU2010108687A (ru) | Ариловые эфиры пирролидина в качестве антагонистов рецепторов nk3 | |
| RU2008126391A (ru) | Производные 1,5-замещенного индол-2-иламида | |
| HRP20151064T1 (hr) | Amido spojevi i njihova upotreba kao farmaceutski proizvodi | |
| RU2011146872A (ru) | Производные пролина в качестве ингибиторов катепсина |