JP2008503591A - ユビキチンリガーゼ阻害剤 - Google Patents
ユビキチンリガーゼ阻害剤 Download PDFInfo
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- JP2008503591A JP2008503591A JP2007518253A JP2007518253A JP2008503591A JP 2008503591 A JP2008503591 A JP 2008503591A JP 2007518253 A JP2007518253 A JP 2007518253A JP 2007518253 A JP2007518253 A JP 2007518253A JP 2008503591 A JP2008503591 A JP 2008503591A
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- alkyl
- heteroaryl
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- alkoxy
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Classifications
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
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- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58226104P | 2004-06-22 | 2004-06-22 | |
| US64610205P | 2005-01-21 | 2005-01-21 | |
| PCT/US2005/022157 WO2006002284A1 (en) | 2004-06-22 | 2005-06-22 | Ubiquitin ligase inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| JP2008503591A true JP2008503591A (ja) | 2008-02-07 |
| JP2008503591A5 JP2008503591A5 (OSRAM) | 2008-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2007518253A Pending JP2008503591A (ja) | 2004-06-22 | 2005-06-22 | ユビキチンリガーゼ阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050282818A1 (OSRAM) |
| EP (1) | EP1758873A1 (OSRAM) |
| JP (1) | JP2008503591A (OSRAM) |
| WO (1) | WO2006002284A1 (OSRAM) |
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| JP2016523517A (ja) * | 2013-05-02 | 2016-08-12 | イー３エックス バイオ インコーポレイテッド | ユビキチンリガーゼのモジュレーターを同定するための方法 |
| JP2017506674A (ja) * | 2014-02-27 | 2017-03-09 | トレヴェンティス コーポレーション | ベンゾフラザンを含有する抗アミロイド化合物 |
| KR20190111079A (ko) * | 2017-01-23 | 2019-10-01 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 이환 화합물 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014532688A (ja) * | 2011-11-02 | 2014-12-08 | ウニベルシダッド・アウトノマ・デ・マドリッド | ｐ３８を阻害するための薬物およびそれらの用途 |
| JP2016523517A (ja) * | 2013-05-02 | 2016-08-12 | イー３エックス バイオ インコーポレイテッド | ユビキチンリガーゼのモジュレーターを同定するための方法 |
| JP2017506674A (ja) * | 2014-02-27 | 2017-03-09 | トレヴェンティス コーポレーション | ベンゾフラザンを含有する抗アミロイド化合物 |
| KR20190111079A (ko) * | 2017-01-23 | 2019-10-01 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 이환 화합물 |
| JP2020506178A (ja) * | 2017-01-23 | 2020-02-27 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| KR102665763B1 (ko) * | 2017-01-23 | 2024-05-10 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 이환 화합물 |
| US11673901B2 (en) | 2017-12-15 | 2023-06-13 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric SHP2 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050282818A1 (en) | 2005-12-22 |
| WO2006002284A1 (en) | 2006-01-05 |
| EP1758873A1 (en) | 2007-03-07 |
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