JP2008503591A5 - - Google Patents
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- Publication number
- JP2008503591A5 JP2008503591A5 JP2007518253A JP2007518253A JP2008503591A5 JP 2008503591 A5 JP2008503591 A5 JP 2008503591A5 JP 2007518253 A JP2007518253 A JP 2007518253A JP 2007518253 A JP2007518253 A JP 2007518253A JP 2008503591 A5 JP2008503591 A5 JP 2008503591A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- mono
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003118 aryl group Chemical group 0.000 claims 66
- 125000001072 heteroaryl group Chemical group 0.000 claims 64
- 125000005843 halogen group Chemical group 0.000 claims 60
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 51
- 229910052799 carbon Inorganic materials 0.000 claims 43
- 125000000623 heterocyclic group Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 150000001204 N-oxides Chemical class 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 25
- 239000012453 solvate Substances 0.000 claims 25
- 229940002612 prodrug Drugs 0.000 claims 24
- 239000000651 prodrug Substances 0.000 claims 24
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 22
- -1 chloro, bromo, fluoro, iodo Chemical group 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 150000001721 carbon Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 150000004677 hydrates Chemical class 0.000 claims 5
- 210000004102 animal cell Anatomy 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000044159 Ubiquitin Human genes 0.000 claims 2
- 108090000848 Ubiquitin Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 241000257303 Hymenoptera Species 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 102000003714 TNF receptor-associated factor 6 Human genes 0.000 claims 1
- 108090000009 TNF receptor-associated factor 6 Proteins 0.000 claims 1
- 230000004721 adaptive immunity Effects 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000004097 bone metabolism Effects 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 230000021617 central nervous system development Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 230000005296 lymph node development Effects 0.000 claims 1
- 230000023247 mammary gland development Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 230000006128 skin development Effects 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58226104P | 2004-06-22 | 2004-06-22 | |
| US64610205P | 2005-01-21 | 2005-01-21 | |
| PCT/US2005/022157 WO2006002284A1 (en) | 2004-06-22 | 2005-06-22 | Ubiquitin ligase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008503591A JP2008503591A (ja) | 2008-02-07 |
| JP2008503591A5 true JP2008503591A5 (OSRAM) | 2008-08-14 |
Family
ID=34979690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518253A Pending JP2008503591A (ja) | 2004-06-22 | 2005-06-22 | ユビキチンリガーゼ阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050282818A1 (OSRAM) |
| EP (1) | EP1758873A1 (OSRAM) |
| JP (1) | JP2008503591A (OSRAM) |
| WO (1) | WO2006002284A1 (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2005023771A1 (ja) * | 2003-09-05 | 2006-11-02 | 小野薬品工業株式会社 | ケモカインレセプターアンタゴニストおよびその医薬用途 |
| DK1848718T3 (da) * | 2005-02-04 | 2012-08-27 | Millennium Pharm Inc | E1 aktiveringsenzymhæmmere |
| WO2006105127A2 (en) * | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| PT1989206E (pt) * | 2006-02-02 | 2012-10-15 | Millennium Pharm Inc | Inibidores da enzima de ativação e1 |
| AU2013203433B2 (en) * | 2006-08-08 | 2016-07-28 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| BRPI0715176A8 (pt) * | 2006-08-08 | 2018-04-10 | Millennium Pharm Inc | compostos de heteroarila utéis como inibidores de enzimas de ativação e1 |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| WO2008115259A2 (en) * | 2006-08-10 | 2008-09-25 | Rigel Pharmaceuticals, Inc. | Derivatives of benzoxadiazole suitable for the treatment of cell proliferative diseases |
| CN101583622B (zh) * | 2006-11-02 | 2012-11-07 | 舒泰神（北京）生物制药股份有限公司 | 用于破坏与泛素化相关的酶的相互作用的抑制剂和其应用 |
| ES2304112B1 (es) * | 2007-02-23 | 2009-08-13 | Universidad De Zaragoza | Uso de compuestos como inhibidores de la flavodoxina de helicobacter. |
| ES2304220B1 (es) * | 2007-03-02 | 2009-09-11 | Universidad De Zaragoza | Composicion para el tratamiento de enfermedades infecciosas. |
| ES2304221B1 (es) * | 2007-03-02 | 2009-09-11 | Universidad De Zaragoza | Composicion para el tratamiento de enfermedades infecciosas causadas por helicobacter. |
| WO2008124838A1 (en) * | 2007-04-10 | 2008-10-16 | University Of Maryland, Baltimore | Compounds that inhibit human dna ligases and methods of treating cancer |
| WO2008154241A1 (en) * | 2007-06-08 | 2008-12-18 | Abbott Laboratories | 5-heteroaryl substituted indazoles as kinase inhibitors |
| WO2009025854A1 (en) * | 2007-08-22 | 2009-02-26 | Burnham Institute For Medical Research | Smips: small molecule inhibitors of p27 depletion in cancers and other proliferative diseases |
| GB0717982D0 (en) * | 2007-09-14 | 2007-10-24 | Univ Durham | Method and means relating to multiple herbicide resistance in plants |
| JP2011510033A (ja) * | 2008-01-25 | 2011-03-31 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 化合物 |
| WO2010005534A2 (en) * | 2008-06-30 | 2010-01-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Proteasome inhibitors for selectively inducing apoptosis in cancer cells |
| HRP20150355T1 (hr) | 2009-01-12 | 2015-06-19 | Pfizer Limited | Sulfonamidni derivati |
| WO2010102286A2 (en) * | 2009-03-06 | 2010-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Proteasome inhibitors having chymotrypsin-like activity |
| US20120122896A1 (en) * | 2009-05-08 | 2012-05-17 | Pike Pharma Gmbh | 2,1,3-benzoxadiazol derivatives for the inhibition of influenza a and b virus and respiratory syncytial virus replication |
| SG175929A1 (en) | 2009-05-14 | 2011-12-29 | Millennium Pharm Inc | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| GB201007187D0 (en) | 2010-04-29 | 2010-06-09 | Iti Scotland Ltd | Ubiquitination modulators |
| US9145407B2 (en) | 2010-07-09 | 2015-09-29 | Pfizer Limited | Sulfonamide compounds |
| EP2675275B1 (en) | 2011-02-14 | 2017-12-20 | The Regents Of The University Of Michigan | Compositions and methods for the treatment of obesity and related disorders |
| CN103889988B (zh) | 2011-08-24 | 2018-05-04 | 米伦纽姆医药公司 | Nedd8-活化酶的抑制剂 |
| US9486422B2 (en) | 2011-10-06 | 2016-11-08 | The Regents Of The University Of Michigan | Small molecule inhibitors of Mcl-1 and the uses of thereof |
| ES2396764B1 (es) * | 2011-11-02 | 2013-12-19 | Universidad Autónoma de Madrid | FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES. |
| WO2013123169A1 (en) | 2012-02-17 | 2013-08-22 | Millennium Pharmaceuticals, Inc. | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| GB201212456D0 (en) | 2012-07-12 | 2012-08-29 | Univ Sheffield | Treatment of muscular dystrophy |
| AU2013305663B2 (en) | 2012-08-24 | 2017-11-02 | Treventis Corporation | Benzofurazan anti-amyloid compounds and methods |
| JP2016523517A (ja) * | 2013-05-02 | 2016-08-12 | イー３エックス バイオ インコーポレイテッド | ユビキチンリガーゼのモジュレーターを同定するための方法 |
| WO2014179734A1 (en) | 2013-05-02 | 2014-11-06 | The Regents Of The University Of Michigan | Deuterated amlexanox |
| JP6378759B2 (ja) | 2013-07-02 | 2018-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｓｕｍｏ活性化酵素阻害剤として有用なヘテロアリール化合物 |
| CA2977360C (en) * | 2014-02-27 | 2022-09-27 | Treventis Corporation | Anti-amyloid compounds containing benzofurazan |
| CN106164059A (zh) * | 2014-04-11 | 2016-11-23 | 爱默蕾大学 | 用天冬酰胺内肽酶（aep）抑制剂以及相关组合物对神经退行性疾病的治疗 |
| JP6603712B2 (ja) | 2014-07-01 | 2019-11-06 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物 |
| EP3221299A1 (en) | 2014-11-21 | 2017-09-27 | BSIM2 Biomolecular Simulations Lda. | 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof |
| BR112017027205A2 (pt) | 2015-06-15 | 2019-06-18 | Bsim2 Biomolecular Simulations S A | derivados de bis-furano como estabilizadores de transtirretina (ttr) e inibidores da amilóide para o tratamento de polineuropatia amiloidótica familiar (fap). |
| EP3407974A4 (en) | 2016-01-29 | 2019-08-28 | The Regents Of The University Of Michigan | Amlexanox Analogs |
| TW202413340A (zh) | 2016-07-12 | 2024-04-01 | 美商銳新醫藥公司 | 作為異位shp2抑制劑之2,5-雙取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪 |
| CN106565694B (zh) * | 2016-10-09 | 2019-10-15 | 北京化工大学 | 一种nbd-有机胺类荧光探针及其制备方法和应用 |
| SG11201906209SA (en) * | 2017-01-23 | 2019-08-27 | Revolution Medicines Inc | Bicyclic compounds as allosteric shp2 inhibitors |
| RU2019126455A (ru) | 2017-01-23 | 2021-02-24 | Революшн Медсинз, Инк. | Пиридиновые соединения в качестве аллостерических ингибиторов shp2 |
| US10888564B2 (en) | 2017-01-26 | 2021-01-12 | Institute For Cancer Research | Inhibitors of HIV-1 integrase multimerization |
| JP2020536881A (ja) | 2017-10-12 | 2020-12-17 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としてのピリジン、ピラジンおよびトリアジン化合物 |
| RU2020123241A (ru) | 2017-12-15 | 2022-01-17 | Революшн Медсинз, Инк. | Полициклические соединения в качестве аллостерических ингибиторов shp2 |
| WO2021152601A1 (en) * | 2020-02-02 | 2021-08-05 | Ramot At Tel-Aviv University Ltd. | Novel activators of the lipidating transporter atp binding cassette protein type 1 (abca1) and therapeutic uses thereof |
| CN113149930B (zh) * | 2021-04-16 | 2022-09-02 | 天津大学 | 一种细胞糖转运通道抑制剂 |
| CN113582940B (zh) * | 2021-09-07 | 2022-05-20 | 四川大学华西医院 | 一类脂滴特异性荧光探针及其合成方法 |
| WO2025117672A1 (en) * | 2023-12-01 | 2025-06-05 | Hotspot Therapeutics, Inc. | Indazolyl-piperidine sulfonamides and related compounds and their use in therapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604926D0 (en) * | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| DE10000739A1 (de) * | 2000-01-11 | 2001-07-12 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| DE10045599B4 (de) * | 2000-09-15 | 2004-06-03 | Wella Ag | Haarfärbemittel auf der Basis von 4-Nitro-2,1,3-benzoxadiazol-Derivaten und dessen Verwendung als Farbstoff zum Färben von Haaren |
| AU2002213467A1 (en) * | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
| CN1585768A (zh) * | 2001-11-14 | 2005-02-23 | 默克专利股份有限公司 | 作为精神药物的吡唑衍生物 |
| GB0215650D0 (en) * | 2002-07-05 | 2002-08-14 | Cyclacel Ltd | Bisarylsufonamide compounds |
| US20040157836A1 (en) * | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| US7491718B2 (en) * | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
| WO2005007621A2 (en) * | 2003-05-30 | 2005-01-27 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| EP1680431A1 (en) * | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
-
2005
- 2005-06-22 WO PCT/US2005/022157 patent/WO2006002284A1/en not_active Ceased
- 2005-06-22 US US11/158,957 patent/US20050282818A1/en not_active Abandoned
- 2005-06-22 EP EP05767481A patent/EP1758873A1/en not_active Withdrawn
- 2005-06-22 JP JP2007518253A patent/JP2008503591A/ja active Pending
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