|
US6861422B2
(en)
*
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
DE102004029784A1
(de)
*
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004033670A1
(de)
*
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
|
US20060074088A1
(en)
*
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
US7728134B2
(en)
*
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
|
US20060035903A1
(en)
*
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
US7759485B2
(en)
*
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
EP1632493A1
(de)
*
|
2004-08-25 |
2006-03-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1630163A1
(de)
*
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004058337A1
(de)
*
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
US7439358B2
(en)
*
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
|
ATE479434T1
(de)
|
2006-02-14 |
2010-09-15 |
Vertex Pharma |
Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
|
|
EP2010542B1
(en)
|
2006-04-12 |
2012-01-25 |
Vertex Pharmaceuticals Incorporated |
4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridines as plk1 protein kinase inhibitors for the treatment of proliferative disorders
|
|
CN101484457B
(zh)
*
|
2006-04-12 |
2014-09-03 |
弗特克斯药品有限公司 |
作为用于治疗增殖病症的蛋白激酶PLK1抑制剂的4,5-二氢-[1,2,4]三唑并[4,3-f]蝶啶
|
|
TW200808325A
(en)
*
|
2006-07-06 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds
|
|
JP2010505962A
(ja)
|
2006-10-09 |
2010-02-25 |
武田薬品工業株式会社 |
キナーゼ阻害剤
|
|
EP2223925A1
(en)
*
|
2006-10-09 |
2010-09-01 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
ES2627352T3
(es)
*
|
2006-10-19 |
2017-07-27 |
Signal Pharmaceuticals, Llc |
Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas
|
|
EP2185559A1
(en)
*
|
2007-08-03 |
2010-05-19 |
Boehringer Ingelheim International GmbH |
Crystalline form of a dihydropteridione derivative
|
|
AU2008287339A1
(en)
|
2007-08-15 |
2009-02-19 |
Vertex Pharmaceuticals Incorporated |
4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases
|
|
EP2100894A1
(en)
|
2008-03-12 |
2009-09-16 |
4Sc Ag |
Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
|
|
EP2112152A1
(en)
|
2008-04-22 |
2009-10-28 |
GPC Biotech AG |
Dihydropteridinones as Plk Inhibitors
|
|
CA2728729C
(en)
|
2008-06-23 |
2016-09-27 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors
|
|
EP2318412B1
(en)
|
2008-06-23 |
2013-08-14 |
Vertex Pharmceuticals Incorporated |
Protein kinase inhibitors
|
|
US8110578B2
(en)
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
UY32306A
(es)
|
2008-12-09 |
2010-07-30 |
Gilead Sciences Inc |
Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos
|
|
GEP20207129B
(en)
|
2009-06-17 |
2020-07-10 |
Vertex Pharma |
Inhibitors of influenza viruses replication
|
|
WO2011031965A1
(en)
|
2009-09-14 |
2011-03-17 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors
|
|
SG179207A1
(en)
|
2009-09-25 |
2012-04-27 |
Vertex Pharma |
Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
|
|
MX2012003484A
(es)
|
2009-09-25 |
2012-04-20 |
Vertex Pharma |
Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa.
|
|
NZ599549A
(en)
|
2009-10-26 |
2013-11-29 |
Signal Pharm Llc |
Methods of synthesis and purification of heteroaryl compounds
|
|
EP2325185A1
(en)
|
2009-10-28 |
2011-05-25 |
GPC Biotech AG |
Plk inhibitor
|
|
BR112012019459A2
(pt)
|
2010-02-03 |
2017-10-17 |
Signal Pharm Llc |
identificação de mutação de lkb1 como um biomarcador preditivo para sensibilidade para inibidores de tor quinase.
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
RU2013132681A
(ru)
|
2010-12-16 |
2015-01-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Ингибиторы репликации вирусов гриппа
|
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
CN103998036B
(zh)
|
2011-10-19 |
2017-05-31 |
西格诺药品有限公司 |
利用tor激酶抑制剂治疗癌症
|
|
US9351974B2
(en)
|
2011-11-10 |
2016-05-31 |
OSI Pharmaceuticals, LLC |
Substituted pteridinones for the treatment of cancer
|
|
BR112014013332B1
(pt)
|
2011-12-02 |
2022-09-06 |
Signal Pharmaceuticals, Llc |
Composições farmacêuticas de 7-(6-(2-hidroxi-propan-2-il)piridin-3-il)-1-((trans)-4- metoxicicloexil)-3,4-diidropirazino [2,3-b]pirazin-2(1h)-ona, uma forma sólida dessa e métodos de seu uso
|
|
CN104271159B
(zh)
|
2012-02-24 |
2017-11-28 |
西格诺药品有限公司 |
利用tor激酶抑制剂联合治疗来治疗非小细胞肺癌的方法
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
SG11201505446WA
(en)
|
2013-01-16 |
2015-08-28 |
Signal Pharm Llc |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
|
|
MY189663A
(en)
|
2013-04-17 |
2022-02-23 |
Signal Pharm Llc |
Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
|
|
WO2014172425A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
JP6382946B2
(ja)
|
2013-04-17 |
2018-08-29 |
シグナル ファーマシューティカルズ,エルエルシー |
ジヒドロピラジノ−ピラジンによる癌治療
|
|
HK1221168A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
|
|
CA2908742C
(en)
|
2013-04-17 |
2021-06-01 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
|
|
EP3549940A1
(en)
|
2013-04-17 |
2019-10-09 |
Signal Pharmaceuticals, LLC |
Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
WO2014172436A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
|
|
CN107474051B
(zh)
|
2013-05-29 |
2020-10-30 |
西格诺药品有限公司 |
二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
|
|
JP2016525532A
(ja)
|
2013-07-26 |
2016-08-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
骨髄異形成症候群の処置
|
|
HUE038820T2
(hu)
|
2013-11-13 |
2018-11-28 |
Vertex Pharma |
Eljárás influenzavírusok replikációjának inhibitorai elõállítására
|
|
PT3068776T
(pt)
|
2013-11-13 |
2019-08-26 |
Vertex Pharma |
Inibidores da replicação de vírus da gripe
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
WO2015160880A1
(en)
|
2014-04-16 |
2015-10-22 |
Signal Pharmaceuticals, Llc |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US9718824B2
(en)
|
2014-04-16 |
2017-08-01 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
|
|
EP3131552B1
(en)
|
2014-04-16 |
2020-07-15 |
Signal Pharmaceuticals, LLC |
Methods for treating cancer using tor kinase inhibitor combination therapy
|
|
SI3166607T1
(sl)
|
2014-07-11 |
2023-01-31 |
Gilead Sciences, Inc. |
Modulatorji toličnih receptorjev za zdravljenje HIV-a
|
|
WO2016010886A1
(en)
|
2014-07-14 |
2016-01-21 |
Signal Pharmaceuticals, Llc |
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
CN107074860B
(zh)
|
2014-09-16 |
2022-07-15 |
吉利德科学公司 |
制备toll样受体调节剂的方法
|
|
CN110305133A
(zh)
|
2014-09-16 |
2019-10-08 |
吉利德科学公司 |
Toll样受体调节剂的固体形式
|
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
IL271491B2
(en)
|
2017-06-22 |
2023-09-01 |
Celgene Corp |
Treatment of carcinoma of the liver characterized by hepatitis b virus infection
|
|
EP3784669B1
(en)
|
2018-04-24 |
2023-10-25 |
Vertex Pharmaceuticals Incorporated |
Pteridinone compounds and uses thereof
|
|
CN113924114A
(zh)
|
2019-05-22 |
2022-01-11 |
吉利德科学公司 |
Tlr7调节化合物和hiv疫苗的组合
|