JP2008502332A5 - - Google Patents
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- Publication number
- JP2008502332A5 JP2008502332A5 JP2007515787A JP2007515787A JP2008502332A5 JP 2008502332 A5 JP2008502332 A5 JP 2008502332A5 JP 2007515787 A JP2007515787 A JP 2007515787A JP 2007515787 A JP2007515787 A JP 2007515787A JP 2008502332 A5 JP2008502332 A5 JP 2008502332A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sample
- methylated
- acid fragments
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 34
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 239000002777 nucleoside Substances 0.000 claims 9
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000007787 solid Substances 0.000 claims 6
- 102100033798 Homeobox protein aristaless-like 4 Human genes 0.000 claims 5
- 101000779608 Homo sapiens Homeobox protein aristaless-like 4 Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000011987 methylation Effects 0.000 claims 5
- 238000007069 methylation reaction Methods 0.000 claims 5
- 108091007507 ADAM12 Proteins 0.000 claims 4
- 102100031112 Disintegrin and metalloproteinase domain-containing protein 12 Human genes 0.000 claims 4
- 102100020856 Forkhead box protein F1 Human genes 0.000 claims 4
- 101000931494 Homo sapiens Forkhead box protein F1 Proteins 0.000 claims 4
- 101000658654 Homo sapiens Tetratricopeptide repeat protein 23-like Proteins 0.000 claims 4
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 claims 4
- 101000781608 Homo sapiens WSC domain-containing protein 2 Proteins 0.000 claims 4
- 101000964699 Homo sapiens Zinc finger protein 566 Proteins 0.000 claims 4
- 101000743808 Homo sapiens Zinc finger protein 677 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 108010032788 PAX6 Transcription Factor Proteins 0.000 claims 4
- 102100037506 Paired box protein Pax-6 Human genes 0.000 claims 4
- 102100021796 Sonic hedgehog protein Human genes 0.000 claims 4
- 101710113849 Sonic hedgehog protein Proteins 0.000 claims 4
- -1 TGFb2 Proteins 0.000 claims 4
- 102100026508 Tafazzin Human genes 0.000 claims 4
- 101710175789 Tafazzin Proteins 0.000 claims 4
- 102100034910 Tetratricopeptide repeat protein 23-like Human genes 0.000 claims 4
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 claims 4
- 102100036847 WSC domain-containing protein 2 Human genes 0.000 claims 4
- 102100040787 Zinc finger protein 566 Human genes 0.000 claims 4
- 102100039055 Zinc finger protein 677 Human genes 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- YUDSCJBUWTYENI-VPCXQMTMSA-N 4-amino-1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]pyrimidin-2-one Chemical group C1=CC(N)=NC(=O)N1[C@]1(C)O[C@H](CO)[C@@H](O)[C@H]1O YUDSCJBUWTYENI-VPCXQMTMSA-N 0.000 claims 1
- ZAYHVCMSTBRABG-UHFFFAOYSA-N 5-Methylcytidine Natural products O=C1N=C(N)C(C)=CN1C1C(O)C(O)C(CO)O1 ZAYHVCMSTBRABG-UHFFFAOYSA-N 0.000 claims 1
- ZAYHVCMSTBRABG-JXOAFFINSA-N 5-methylcytidine Chemical group O=C1N=C(N)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZAYHVCMSTBRABG-JXOAFFINSA-N 0.000 claims 1
- 108700028369 Alleles Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 231100000504 carcinogenesis Toxicity 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000007608 epigenetic mechanism Effects 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 230000010309 neoplastic transformation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0413688.3A GB0413688D0 (en) | 2004-06-18 | 2004-06-18 | Analysis of methylated nucleic acid |
| PCT/EP2005/002251 WO2005123942A2 (en) | 2004-06-18 | 2005-03-03 | Analysis of methylated nucleic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008502332A JP2008502332A (ja) | 2008-01-31 |
| JP2008502332A5 true JP2008502332A5 (enExample) | 2008-04-17 |
Family
ID=32750180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515787A Pending JP2008502332A (ja) | 2004-06-18 | 2005-03-03 | メチル化核酸の分析 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090270482A1 (enExample) |
| EP (1) | EP1761639B1 (enExample) |
| JP (1) | JP2008502332A (enExample) |
| AU (2) | AU2005254616A1 (enExample) |
| CA (1) | CA2568575A1 (enExample) |
| ES (1) | ES2401110T3 (enExample) |
| GB (1) | GB0413688D0 (enExample) |
| WO (1) | WO2005123942A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005034628B4 (de) * | 2005-07-19 | 2007-08-23 | Epigenomics Ag | Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA |
| EP1862555A1 (en) * | 2006-05-29 | 2007-12-05 | Klinikum der Universität Regensburg | Means and methods for diagnosing cancer or a corresponding predisposition |
| US20120196827A1 (en) * | 2006-06-12 | 2012-08-02 | Oncomethylome Sciences S.A. | Methylation markers for early detection and prognosis of colon cancers |
| CN102099485A (zh) * | 2007-10-23 | 2011-06-15 | 临床基因组学有限公司 | 诊断新生物的方法-ⅱ |
| JP2009247260A (ja) * | 2008-04-04 | 2009-10-29 | Sumitomo Chemical Co Ltd | Ｄｎａメチル化測定方法 |
| DK2420578T3 (en) * | 2009-04-17 | 2017-10-02 | Nat Defense Medical Center | A method of screening for cancer |
| NZ601079A (en) * | 2010-01-26 | 2014-08-29 | Nipd Genetics Ltd | Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies |
| US8278049B2 (en) | 2010-04-26 | 2012-10-02 | Ann & Robert H. Lurie Children's Hospital of Chicago | Selective enrichment of CpG islands |
| US20120004132A1 (en) * | 2010-07-02 | 2012-01-05 | Affymetrix, Inc. | Detection of Nucleic Acids and Proteins |
| JP5916058B2 (ja) * | 2011-08-26 | 2016-05-11 | 国立大学法人東北大学 | 細胞ストレス状態のバイオマーカー |
| WO2013123481A1 (en) | 2012-02-16 | 2013-08-22 | Cornell University | Methods and kit for characterizing the modified base status of a transcriptome |
| US20160202249A1 (en) * | 2013-08-21 | 2016-07-14 | Fujirebio Inc. | Method for measuring modified nucleobase using absorbent polynucleotide and kit for same |
| WO2016189388A1 (en) | 2015-05-22 | 2016-12-01 | Nipd Genetics Ltd | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
| KR101735415B1 (ko) * | 2015-07-31 | 2017-05-16 | 한국과학기술연구원 | 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법 |
| WO2017130839A1 (ja) * | 2016-01-27 | 2017-08-03 | 住友化学株式会社 | センサーチップ及びセンシングシステム |
| US10975417B2 (en) * | 2016-02-23 | 2021-04-13 | Dovetail Genomics, Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
| JP7457642B2 (ja) | 2017-04-03 | 2024-03-28 | ビオンテック ユーエス インコーポレイテッド | タンパク質抗原およびその使用 |
| TW201930340A (zh) | 2017-12-18 | 2019-08-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| CA3103983A1 (en) | 2018-06-19 | 2019-12-26 | Biontech Us Inc. | Neoantigens and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654183A (en) * | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
| US5518901A (en) * | 1993-04-19 | 1996-05-21 | Murtagh; James J. | Methods for adapting nucleic acid for detection, sequencing, and cloning using exonuclease |
| US5714325A (en) * | 1993-09-24 | 1998-02-03 | New England Medical Center Hospitals | Prenatal diagnosis by isolation of fetal granulocytes from maternal blood |
| US5866323A (en) * | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
| AU7829398A (en) * | 1997-06-09 | 1998-12-30 | University Of Southern California | A cancer diagnostic method based upon dna methylation differences |
| US6337392B1 (en) * | 1998-05-07 | 2002-01-08 | The Rockefeller University | Lens transcriptional control elements and methods of use thereof |
| US6994971B1 (en) * | 1999-10-08 | 2006-02-07 | University Of Utah Research Foundation | Particle analysis assay for biomolecular quantification |
| MXPA02005069A (es) * | 1999-11-19 | 2003-09-25 | Wegmann Keith W | Agentes de enlace especificos para t3 y metodos para su uso. |
| WO2002000842A2 (en) * | 2000-06-23 | 2002-01-03 | The University Of Chicago | Methods for isolating centromere dna |
| US20030157481A1 (en) * | 2001-12-10 | 2003-08-21 | Benjamin Thomas L. | Diagnosing and treating cancer cells using T-HR mutants and their targets |
| WO2002101353A2 (en) * | 2001-06-08 | 2002-12-19 | U.S. Genomics, Inc. | Methods and products for analyzing nucleic acids based on methylation status |
| AU2003206443A1 (en) * | 2002-02-20 | 2003-09-09 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis |
| ATE335816T1 (de) * | 2002-09-18 | 2006-09-15 | Sirs Lab Gmbh | Verfahren zum nachweis prokaryontischer dna |
| AU2003900368A0 (en) * | 2003-01-24 | 2003-02-13 | Human Genetic Signatures Pty Ltd | Assay for nucleic acid molecules |
| JP3854943B2 (ja) * | 2003-05-23 | 2006-12-06 | 独立行政法人科学技術振興機構 | Ｄｎａメチル化率の測定方法 |
| EP1524523A1 (en) * | 2003-10-17 | 2005-04-20 | Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts | Use of ADAM 12 for diagnosis and therapy of preeclampsia |
| DE602005023710D1 (de) * | 2004-02-20 | 2010-11-04 | Japan Science & Tech Agency | Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung |
-
2004
- 2004-06-18 GB GBGB0413688.3A patent/GB0413688D0/en not_active Ceased
-
2005
- 2005-03-03 US US11/571,026 patent/US20090270482A1/en not_active Abandoned
- 2005-03-03 WO PCT/EP2005/002251 patent/WO2005123942A2/en not_active Ceased
- 2005-03-03 AU AU2005254616A patent/AU2005254616A1/en not_active Abandoned
- 2005-03-03 EP EP05707697A patent/EP1761639B1/en not_active Expired - Lifetime
- 2005-03-03 ES ES05707697T patent/ES2401110T3/es not_active Expired - Lifetime
- 2005-03-03 JP JP2007515787A patent/JP2008502332A/ja active Pending
- 2005-03-03 CA CA002568575A patent/CA2568575A1/en not_active Abandoned
-
2009
- 2009-07-07 AU AU2009202745A patent/AU2009202745A1/en not_active Ceased
-
2012
- 2012-05-03 US US13/463,570 patent/US20120288509A1/en not_active Abandoned
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