JP2008502332A - メチル化核酸の分析 - Google Patents

メチル化核酸の分析 Download PDF

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Publication number
JP2008502332A
JP2008502332A JP2007515787A JP2007515787A JP2008502332A JP 2008502332 A JP2008502332 A JP 2008502332A JP 2007515787 A JP2007515787 A JP 2007515787A JP 2007515787 A JP2007515787 A JP 2007515787A JP 2008502332 A JP2008502332 A JP 2008502332A
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nucleic acid
methylated
sample
antibody
methylation
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JP2007515787A
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Japanese (ja)
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JP2008502332A5 (enExample
Inventor
ディルク・シューベラー
ミシャエル・フィリップ・ウェーベ
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Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
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Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
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Publication of JP2008502332A publication Critical patent/JP2008502332A/ja
Publication of JP2008502332A5 publication Critical patent/JP2008502332A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2007515787A 2004-06-18 2005-03-03 メチル化核酸の分析 Pending JP2008502332A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413688.3A GB0413688D0 (en) 2004-06-18 2004-06-18 Analysis of methylated nucleic acid
PCT/EP2005/002251 WO2005123942A2 (en) 2004-06-18 2005-03-03 Analysis of methylated nucleic acid

Publications (2)

Publication Number Publication Date
JP2008502332A true JP2008502332A (ja) 2008-01-31
JP2008502332A5 JP2008502332A5 (enExample) 2008-04-17

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ID=32750180

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007515787A Pending JP2008502332A (ja) 2004-06-18 2005-03-03 メチル化核酸の分析

Country Status (8)

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US (2) US20090270482A1 (enExample)
EP (1) EP1761639B1 (enExample)
JP (1) JP2008502332A (enExample)
AU (2) AU2005254616A1 (enExample)
CA (1) CA2568575A1 (enExample)
ES (1) ES2401110T3 (enExample)
GB (1) GB0413688D0 (enExample)
WO (1) WO2005123942A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523822A (ja) * 2009-04-17 2012-10-11 ▲頼▼鴻政 癌検診の方法
JP2013044698A (ja) * 2011-08-26 2013-03-04 Tohoku Univ 細胞ストレス状態のバイオマーカー
JP2013517789A (ja) * 2010-01-26 2013-05-20 ニプド ジェネティクス リミテッド 胎児異数性の非侵襲性出生前診断の方法および組成物
KR101735415B1 (ko) * 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
WO2017130839A1 (ja) * 2016-01-27 2017-08-03 住友化学株式会社 センサーチップ及びセンシングシステム
US11111538B2 (en) 2015-05-22 2021-09-07 Nipd Genetics Public Company Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005034628B4 (de) * 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
EP1862555A1 (en) * 2006-05-29 2007-12-05 Klinikum der Universität Regensburg Means and methods for diagnosing cancer or a corresponding predisposition
US20120196827A1 (en) * 2006-06-12 2012-08-02 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
CN102099485A (zh) * 2007-10-23 2011-06-15 临床基因组学有限公司 诊断新生物的方法-ⅱ
JP2009247260A (ja) * 2008-04-04 2009-10-29 Sumitomo Chemical Co Ltd Dnaメチル化測定方法
US8278049B2 (en) 2010-04-26 2012-10-02 Ann & Robert H. Lurie Children's Hospital of Chicago Selective enrichment of CpG islands
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
WO2013123481A1 (en) 2012-02-16 2013-08-22 Cornell University Methods and kit for characterizing the modified base status of a transcriptome
US20160202249A1 (en) * 2013-08-21 2016-07-14 Fujirebio Inc. Method for measuring modified nucleobase using absorbent polynucleotide and kit for same
US10975417B2 (en) * 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
JP7457642B2 (ja) 2017-04-03 2024-03-28 ビオンテック ユーエス インコーポレイテッド タンパク質抗原およびその使用
TW201930340A (zh) 2017-12-18 2019-08-01 美商尼恩醫療公司 新抗原及其用途
CA3103983A1 (en) 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000842A2 (en) * 2000-06-23 2002-01-03 The University Of Chicago Methods for isolating centromere dna
WO2002101353A2 (en) * 2001-06-08 2002-12-19 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
WO2004033683A1 (de) * 2002-09-18 2004-04-22 Sirs-Lab Gmbh Verfahren zur anreicherung prokaryontischer dna
WO2004065625A1 (en) * 2003-01-24 2004-08-05 Human Genetic Signatures Pty Ltd Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid
JP2004347508A (ja) * 2003-05-23 2004-12-09 Japan Science & Technology Agency Dnaメチル化率の測定方法
WO2005080565A1 (ja) * 2004-02-20 2005-09-01 Japan Science And Technology Agency Dnaメチル化分析用dnaアレイ及びその製造方法並びにdnaメチル化分析方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654183A (en) * 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5518901A (en) * 1993-04-19 1996-05-21 Murtagh; James J. Methods for adapting nucleic acid for detection, sequencing, and cloning using exonuclease
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
US5866323A (en) * 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6337392B1 (en) * 1998-05-07 2002-01-08 The Rockefeller University Lens transcriptional control elements and methods of use thereof
US6994971B1 (en) * 1999-10-08 2006-02-07 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
MXPA02005069A (es) * 1999-11-19 2003-09-25 Wegmann Keith W Agentes de enlace especificos para t3 y metodos para su uso.
US20030157481A1 (en) * 2001-12-10 2003-08-21 Benjamin Thomas L. Diagnosing and treating cancer cells using T-HR mutants and their targets
AU2003206443A1 (en) * 2002-02-20 2003-09-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000842A2 (en) * 2000-06-23 2002-01-03 The University Of Chicago Methods for isolating centromere dna
WO2002101353A2 (en) * 2001-06-08 2002-12-19 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
WO2004033683A1 (de) * 2002-09-18 2004-04-22 Sirs-Lab Gmbh Verfahren zur anreicherung prokaryontischer dna
WO2004065625A1 (en) * 2003-01-24 2004-08-05 Human Genetic Signatures Pty Ltd Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid
JP2004347508A (ja) * 2003-05-23 2004-12-09 Japan Science & Technology Agency Dnaメチル化率の測定方法
WO2005080565A1 (ja) * 2004-02-20 2005-09-01 Japan Science And Technology Agency Dnaメチル化分析用dnaアレイ及びその製造方法並びにdnaメチル化分析方法

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523822A (ja) * 2009-04-17 2012-10-11 ▲頼▼鴻政 癌検診の方法
JP2013517789A (ja) * 2010-01-26 2013-05-20 ニプド ジェネティクス リミテッド 胎児異数性の非侵襲性出生前診断の方法および組成物
US9249462B2 (en) 2010-01-26 2016-02-02 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
JP2013044698A (ja) * 2011-08-26 2013-03-04 Tohoku Univ 細胞ストレス状態のバイオマーカー
US11111538B2 (en) 2015-05-22 2021-09-07 Nipd Genetics Public Company Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
US12421551B2 (en) 2015-05-22 2025-09-23 Medicover Public Co Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
US12480160B2 (en) 2015-05-22 2025-11-25 Medicover Public Co Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
KR101735415B1 (ko) * 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
WO2017130839A1 (ja) * 2016-01-27 2017-08-03 住友化学株式会社 センサーチップ及びセンシングシステム
JPWO2017130839A1 (ja) * 2016-01-27 2018-11-22 住友化学株式会社 センサーチップ及びセンシングシステム

Also Published As

Publication number Publication date
CA2568575A1 (en) 2005-12-29
US20120288509A1 (en) 2012-11-15
AU2005254616A1 (en) 2005-12-29
ES2401110T3 (es) 2013-04-17
GB0413688D0 (en) 2004-07-21
US20090270482A1 (en) 2009-10-29
WO2005123942A3 (en) 2006-04-13
EP1761639A2 (en) 2007-03-14
EP1761639B1 (en) 2013-01-02
WO2005123942A2 (en) 2005-12-29
AU2009202745A1 (en) 2009-07-30

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