ES2401110T3 - Análisis de ácido nucleico metilado - Google Patents

Análisis de ácido nucleico metilado Download PDF

Info

Publication number
ES2401110T3
ES2401110T3 ES05707697T ES05707697T ES2401110T3 ES 2401110 T3 ES2401110 T3 ES 2401110T3 ES 05707697 T ES05707697 T ES 05707697T ES 05707697 T ES05707697 T ES 05707697T ES 2401110 T3 ES2401110 T3 ES 2401110T3
Authority
ES
Spain
Prior art keywords
nucleic acid
methylated
sample
acid fragments
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05707697T
Other languages
English (en)
Spanish (es)
Inventor
Dirk Schuebeler
Michaël Philippe Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
Original Assignee
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Novartis Forschungsstiftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research, Novartis Forschungsstiftung filed Critical Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Application granted granted Critical
Publication of ES2401110T3 publication Critical patent/ES2401110T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ES05707697T 2004-06-18 2005-03-03 Análisis de ácido nucleico metilado Expired - Lifetime ES2401110T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0413688.3A GB0413688D0 (en) 2004-06-18 2004-06-18 Analysis of methylated nucleic acid
GB0413688 2004-06-18
PCT/EP2005/002251 WO2005123942A2 (en) 2004-06-18 2005-03-03 Analysis of methylated nucleic acid

Publications (1)

Publication Number Publication Date
ES2401110T3 true ES2401110T3 (es) 2013-04-17

Family

ID=32750180

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05707697T Expired - Lifetime ES2401110T3 (es) 2004-06-18 2005-03-03 Análisis de ácido nucleico metilado

Country Status (8)

Country Link
US (2) US20090270482A1 (enExample)
EP (1) EP1761639B1 (enExample)
JP (1) JP2008502332A (enExample)
AU (2) AU2005254616A1 (enExample)
CA (1) CA2568575A1 (enExample)
ES (1) ES2401110T3 (enExample)
GB (1) GB0413688D0 (enExample)
WO (1) WO2005123942A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005034628B4 (de) * 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
EP1862555A1 (en) * 2006-05-29 2007-12-05 Klinikum der Universität Regensburg Means and methods for diagnosing cancer or a corresponding predisposition
US20120196827A1 (en) * 2006-06-12 2012-08-02 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
CN102099485A (zh) * 2007-10-23 2011-06-15 临床基因组学有限公司 诊断新生物的方法-ⅱ
JP2009247260A (ja) * 2008-04-04 2009-10-29 Sumitomo Chemical Co Ltd Dnaメチル化測定方法
DK2420578T3 (en) * 2009-04-17 2017-10-02 Nat Defense Medical Center A method of screening for cancer
NZ601079A (en) * 2010-01-26 2014-08-29 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
US8278049B2 (en) 2010-04-26 2012-10-02 Ann & Robert H. Lurie Children's Hospital of Chicago Selective enrichment of CpG islands
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
JP5916058B2 (ja) * 2011-08-26 2016-05-11 国立大学法人東北大学 細胞ストレス状態のバイオマーカー
WO2013123481A1 (en) 2012-02-16 2013-08-22 Cornell University Methods and kit for characterizing the modified base status of a transcriptome
US20160202249A1 (en) * 2013-08-21 2016-07-14 Fujirebio Inc. Method for measuring modified nucleobase using absorbent polynucleotide and kit for same
WO2016189388A1 (en) 2015-05-22 2016-12-01 Nipd Genetics Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
KR101735415B1 (ko) * 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
WO2017130839A1 (ja) * 2016-01-27 2017-08-03 住友化学株式会社 センサーチップ及びセンシングシステム
US10975417B2 (en) * 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
JP7457642B2 (ja) 2017-04-03 2024-03-28 ビオンテック ユーエス インコーポレイテッド タンパク質抗原およびその使用
TW201930340A (zh) 2017-12-18 2019-08-01 美商尼恩醫療公司 新抗原及其用途
CA3103983A1 (en) 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654183A (en) * 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5518901A (en) * 1993-04-19 1996-05-21 Murtagh; James J. Methods for adapting nucleic acid for detection, sequencing, and cloning using exonuclease
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
US5866323A (en) * 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6337392B1 (en) * 1998-05-07 2002-01-08 The Rockefeller University Lens transcriptional control elements and methods of use thereof
US6994971B1 (en) * 1999-10-08 2006-02-07 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
MXPA02005069A (es) * 1999-11-19 2003-09-25 Wegmann Keith W Agentes de enlace especificos para t3 y metodos para su uso.
WO2002000842A2 (en) * 2000-06-23 2002-01-03 The University Of Chicago Methods for isolating centromere dna
US20030157481A1 (en) * 2001-12-10 2003-08-21 Benjamin Thomas L. Diagnosing and treating cancer cells using T-HR mutants and their targets
WO2002101353A2 (en) * 2001-06-08 2002-12-19 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
AU2003206443A1 (en) * 2002-02-20 2003-09-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis
ATE335816T1 (de) * 2002-09-18 2006-09-15 Sirs Lab Gmbh Verfahren zum nachweis prokaryontischer dna
AU2003900368A0 (en) * 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
JP3854943B2 (ja) * 2003-05-23 2006-12-06 独立行政法人科学技術振興機構 Dnaメチル化率の測定方法
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia
DE602005023710D1 (de) * 2004-02-20 2010-11-04 Japan Science & Tech Agency Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung

Also Published As

Publication number Publication date
CA2568575A1 (en) 2005-12-29
US20120288509A1 (en) 2012-11-15
AU2005254616A1 (en) 2005-12-29
GB0413688D0 (en) 2004-07-21
US20090270482A1 (en) 2009-10-29
WO2005123942A3 (en) 2006-04-13
JP2008502332A (ja) 2008-01-31
EP1761639A2 (en) 2007-03-14
EP1761639B1 (en) 2013-01-02
WO2005123942A2 (en) 2005-12-29
AU2009202745A1 (en) 2009-07-30

Similar Documents

Publication Publication Date Title
US20120288509A1 (en) Analysis of methylated nucleic acid
CN107586835B (zh) 一种基于单链接头的下一代测序文库的构建方法及其应用
US20220205045A1 (en) Raf1 fusions
US20190389969A1 (en) Ntrk2 fusions
ES3009026T3 (en) High-throughput screening of regulatory element function with epigenome editing technologies
US10246750B2 (en) Method for detection of a TECR:PKN1 or an ANXA4:PKN1 gene fusion
ES2667346T3 (es) Estrategias de secuenciación de región genómica 3-D de interés
CN102220412B (zh) 用于检测甲基化dna的试剂盒和方法
JP6806668B2 (ja) 核酸をプロービングおよびマッピングするためのrna誘導型システム
US10370725B2 (en) FGR fusions
ES2243047T3 (es) Deteccion sistematica diferencial cualitativa.
WO2001066719A1 (fr) Nouveau gene clone en neuroblastome humain et nouveaux fragments de gene
KR101838394B1 (ko) 뇌실하 영역의 돌연변이 유전자를 이용한 교모세포종 조직 기원의 예측 방법 및 동물 모델
CN110093423A (zh) 基因标志物在肺腺癌诊治中的用途
CN107922976A (zh) 对聚腺苷二磷酸核糖聚合酶及端锚聚合酶双重抑制剂的灵敏度确定方法
AU2011203953B2 (en) Analysis of methylated nucleic acid
JP2006504426A (ja) Rnaスプライス部位の検出のための定性的差異スクリーニング
Jin et al. Epigenome editing and epigenetic gene regulation in disease phenotypes
CN115074365B (zh) 靶向GATM基因的sgRNA及其应用
MacLennan et al. How structural variation shapes the cancer epigenome
Qiu Evolution of Inflammatory Memory and Therapy-Resistant States in Cancer Cells
CN114990219A (zh) 基因pthlh作为靶点在食管鳞癌辅助诊断、预后判断和治疗中的应用
Ichino Characterization of the role of Arabidopsis methyl-readers MBD5 and MBD6 in transcriptional silencing
Schrier Regulation of Multiple Cellular Processes by the Long Noncoding RNA LINC00662
KR101760246B1 (ko) 신규한 slco2b1 다형성 마커 및 이의 용도