CA2568575A1 - Analysis of methylated nucleic acid - Google Patents

Analysis of methylated nucleic acid Download PDF

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Publication number
CA2568575A1
CA2568575A1 CA002568575A CA2568575A CA2568575A1 CA 2568575 A1 CA2568575 A1 CA 2568575A1 CA 002568575 A CA002568575 A CA 002568575A CA 2568575 A CA2568575 A CA 2568575A CA 2568575 A1 CA2568575 A1 CA 2568575A1
Authority
CA
Canada
Prior art keywords
nucleic acid
methylated
sample
acid fragments
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002568575A
Other languages
English (en)
French (fr)
Inventor
Dirk Schuebeler
Michael Philippe Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2568575A1 publication Critical patent/CA2568575A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA002568575A 2004-06-18 2005-03-03 Analysis of methylated nucleic acid Abandoned CA2568575A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0413688.3A GB0413688D0 (en) 2004-06-18 2004-06-18 Analysis of methylated nucleic acid
GB0413688.3 2004-06-18
PCT/EP2005/002251 WO2005123942A2 (en) 2004-06-18 2005-03-03 Analysis of methylated nucleic acid

Publications (1)

Publication Number Publication Date
CA2568575A1 true CA2568575A1 (en) 2005-12-29

Family

ID=32750180

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002568575A Abandoned CA2568575A1 (en) 2004-06-18 2005-03-03 Analysis of methylated nucleic acid

Country Status (8)

Country Link
US (2) US20090270482A1 (enExample)
EP (1) EP1761639B1 (enExample)
JP (1) JP2008502332A (enExample)
AU (2) AU2005254616A1 (enExample)
CA (1) CA2568575A1 (enExample)
ES (1) ES2401110T3 (enExample)
GB (1) GB0413688D0 (enExample)
WO (1) WO2005123942A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005034628B4 (de) * 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
EP1862555A1 (en) * 2006-05-29 2007-12-05 Klinikum der Universität Regensburg Means and methods for diagnosing cancer or a corresponding predisposition
WO2007149269A2 (en) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
EP2644713B1 (en) * 2007-10-23 2018-07-04 Clinical Genomics Pty Ltd A method of diagnosing neoplasms - II
JP2009247260A (ja) * 2008-04-04 2009-10-29 Sumitomo Chemical Co Ltd Ｄｎａメチル化測定方法
KR101636596B1 (ko) * 2009-04-17 2016-07-11 내셔널 디펜스 메디컬 센터 검사 표지로서 표적 유전자의 메틸화율을 검출하는 방법
DK2529032T3 (en) 2010-01-26 2017-05-01 Nipd Genetics Ltd METHODS AND COMPOSITIONS FOR NON-INVASIVE PRE-NATIONAL DIAGNOSTICATION OF Fetal ANEUPLOIDITIES
US8278049B2 (en) 2010-04-26 2012-10-02 Ann & Robert H. Lurie Children's Hospital of Chicago Selective enrichment of CpG islands
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
JP5916058B2 (ja) * 2011-08-26 2016-05-11 国立大学法人東北大学 細胞ストレス状態のバイオマーカー
WO2013123481A1 (en) 2012-02-16 2013-08-22 Cornell University Methods and kit for characterizing the modified base status of a transcriptome
EP3037535A4 (en) * 2013-08-21 2017-04-05 Fujirebio Inc. Method for measuring modified nucleic-acid base using absorbent polynucleotide and kit therefor
PT3666902T (pt) 2015-05-22 2024-09-19 Medicover Public Co Ltd Análise paralela multiplexada de regiões genómicas alvo para testes pré-natais não invasivos
KR101735415B1 (ko) * 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
JP6900325B2 (ja) * 2016-01-27 2021-07-07 住友化学株式会社 センサーチップ及びセンシングシステム
CA3014911A1 (en) * 2016-02-23 2017-08-31 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
JP7457642B2 (ja) 2017-04-03 2024-03-28 ビオンテック ユーエス インコーポレイテッド タンパク質抗原およびその使用
US11793867B2 (en) 2017-12-18 2023-10-24 Biontech Us Inc. Neoantigens and uses thereof
WO2019246286A1 (en) 2018-06-19 2019-12-26 Neon Therapeutics, Inc. Neoantigens and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654183A (en) * 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5518901A (en) * 1993-04-19 1996-05-21 Murtagh; James J. Methods for adapting nucleic acid for detection, sequencing, and cloning using exonuclease
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
US5866323A (en) * 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
WO1998056952A1 (en) * 1997-06-09 1998-12-17 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6337392B1 (en) * 1998-05-07 2002-01-08 The Rockefeller University Lens transcriptional control elements and methods of use thereof
US6994971B1 (en) * 1999-10-08 2006-02-07 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
WO2001035995A2 (en) * 1999-11-19 2001-05-25 Tittle Thomas V Tr3-specific binding agents and methods for their use
CA2412609C (en) * 2000-06-23 2010-09-07 The University Of Chicago Methods for isolating centromere dna
US20030157481A1 (en) * 2001-12-10 2003-08-21 Benjamin Thomas L. Diagnosing and treating cancer cells using T-HR mutants and their targets
AU2002318336A1 (en) * 2001-06-08 2002-12-23 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
EP1476175A2 (en) * 2002-02-20 2004-11-17 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis
DK1400589T3 (da) * 2002-09-18 2006-11-27 Sirs Lab Gmbh Fremgangsmåde til påvisning af prokaryotisk DNA
AU2003900368A0 (en) * 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
JP3854943B2 (ja) * 2003-05-23 2006-12-06 独立行政法人科学技術振興機構 Ｄｎａメチル化率の測定方法
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia
DE602005023710D1 (de) * 2004-02-20 2010-11-04 Japan Science & Tech Agency Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung

Also Published As

Publication number Publication date
AU2005254616A1 (en) 2005-12-29
US20120288509A1 (en) 2012-11-15
AU2009202745A1 (en) 2009-07-30
WO2005123942A2 (en) 2005-12-29
US20090270482A1 (en) 2009-10-29
WO2005123942A3 (en) 2006-04-13
JP2008502332A (ja) 2008-01-31
GB0413688D0 (en) 2004-07-21
EP1761639A2 (en) 2007-03-14
ES2401110T3 (es) 2013-04-17
EP1761639B1 (en) 2013-01-02

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Effective date: 20150630