JP2008501805A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008501805A5 JP2008501805A5 JP2007527680A JP2007527680A JP2008501805A5 JP 2008501805 A5 JP2008501805 A5 JP 2008501805A5 JP 2007527680 A JP2007527680 A JP 2007527680A JP 2007527680 A JP2007527680 A JP 2007527680A JP 2008501805 A5 JP2008501805 A5 JP 2008501805A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- solvent system
- volatile solvent
- skin
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002904 solvent Substances 0.000 claims 67
- 239000000203 mixture Substances 0.000 claims 56
- 229940079593 drug Drugs 0.000 claims 50
- 239000003814 drug Substances 0.000 claims 50
- 238000009472 formulation Methods 0.000 claims 46
- -1 sorbitan ester Chemical class 0.000 claims 41
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 20
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 15
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 12
- 229920001577 copolymer Polymers 0.000 claims 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims 12
- 239000000194 fatty acid Substances 0.000 claims 12
- 229930195729 fatty acid Natural products 0.000 claims 12
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 10
- 239000000853 adhesive Substances 0.000 claims 10
- 230000001070 adhesive effect Effects 0.000 claims 10
- WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 claims 10
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 claims 10
- 229960000329 ribavirin Drugs 0.000 claims 10
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 9
- 229960004150 aciclovir Drugs 0.000 claims 9
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 8
- 229940055577 oleyl alcohol Drugs 0.000 claims 8
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 8
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims 7
- 239000003242 anti bacterial agent Substances 0.000 claims 7
- 229940088710 antibiotic agent Drugs 0.000 claims 7
- 239000003443 antiviral agent Substances 0.000 claims 7
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims 7
- 235000011187 glycerol Nutrition 0.000 claims 7
- 235000012907 honey Nutrition 0.000 claims 7
- 229960001179 penciclovir Drugs 0.000 claims 7
- 150000003431 steroids Chemical class 0.000 claims 7
- 229940093257 valacyclovir Drugs 0.000 claims 7
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 6
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 6
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 6
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 6
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 6
- 101100275473 Caenorhabditis elegans ctc-3 gene Proteins 0.000 claims 6
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 6
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 6
- 239000005770 Eugenol Substances 0.000 claims 6
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 6
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 6
- 101100168274 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cox-3 gene Proteins 0.000 claims 6
- 239000005642 Oleic acid Substances 0.000 claims 6
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 6
- 239000004264 Petrolatum Substances 0.000 claims 6
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims 6
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims 6
- 229940121375 antifungal agent Drugs 0.000 claims 6
- 239000003429 antifungal agent Substances 0.000 claims 6
- 229960003150 bupivacaine Drugs 0.000 claims 6
- 239000004359 castor oil Substances 0.000 claims 6
- 235000019438 castor oil Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 229960002896 clonidine Drugs 0.000 claims 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 6
- 229960003957 dexamethasone Drugs 0.000 claims 6
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 6
- 229960001259 diclofenac Drugs 0.000 claims 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 6
- 239000003974 emollient agent Substances 0.000 claims 6
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 6
- 229940093471 ethyl oleate Drugs 0.000 claims 6
- 229960002217 eugenol Drugs 0.000 claims 6
- 230000008020 evaporation Effects 0.000 claims 6
- 238000001704 evaporation Methods 0.000 claims 6
- 150000004665 fatty acids Chemical class 0.000 claims 6
- 150000002191 fatty alcohols Chemical class 0.000 claims 6
- 125000005456 glyceride group Chemical group 0.000 claims 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 6
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 6
- 229960002751 imiquimod Drugs 0.000 claims 6
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 6
- 229960004125 ketoconazole Drugs 0.000 claims 6
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 6
- 229960000991 ketoprofen Drugs 0.000 claims 6
- 229960004194 lidocaine Drugs 0.000 claims 6
- 150000004667 medium chain fatty acids Chemical class 0.000 claims 6
- 239000002480 mineral oil Substances 0.000 claims 6
- 235000010446 mineral oil Nutrition 0.000 claims 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 6
- 229940038597 peroxide anti-acne preparations for topical use Drugs 0.000 claims 6
- 150000002978 peroxides Chemical class 0.000 claims 6
- 235000019271 petrolatum Nutrition 0.000 claims 6
- 229940066842 petrolatum Drugs 0.000 claims 6
- 229960003471 retinol Drugs 0.000 claims 6
- 235000020944 retinol Nutrition 0.000 claims 6
- 239000011607 retinol Substances 0.000 claims 6
- 229960001549 ropivacaine Drugs 0.000 claims 6
- 235000019719 rose oil Nutrition 0.000 claims 6
- 239000010666 rose oil Substances 0.000 claims 6
- 229960004889 salicylic acid Drugs 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 6
- 229960002372 tetracaine Drugs 0.000 claims 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 6
- 239000008158 vegetable oil Substances 0.000 claims 6
- 239000000341 volatile oil Substances 0.000 claims 6
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 5
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 5
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 claims 5
- VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims 5
- 229920001353 Dextrin Polymers 0.000 claims 5
- 239000004375 Dextrin Substances 0.000 claims 5
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims 5
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 claims 5
- 229920002907 Guar gum Polymers 0.000 claims 5
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 5
- 102000014150 Interferons Human genes 0.000 claims 5
- 108010050904 Interferons Proteins 0.000 claims 5
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 5
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims 5
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 claims 5
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims 5
- 229960004748 abacavir Drugs 0.000 claims 5
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 claims 5
- 229960003805 amantadine Drugs 0.000 claims 5
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 5
- 229940035674 anesthetics Drugs 0.000 claims 5
- 229960002962 butenafine Drugs 0.000 claims 5
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 claims 5
- 229920002678 cellulose Polymers 0.000 claims 5
- 239000001913 cellulose Substances 0.000 claims 5
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 5
- 229960000724 cidofovir Drugs 0.000 claims 5
- 229960004022 clotrimazole Drugs 0.000 claims 5
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 5
- 229960005319 delavirdine Drugs 0.000 claims 5
- 235000019425 dextrin Nutrition 0.000 claims 5
- 229960002656 didanosine Drugs 0.000 claims 5
- 229960003913 econazole Drugs 0.000 claims 5
- 229960003804 efavirenz Drugs 0.000 claims 5
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 claims 5
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 5
- OTMFQLIUPDESAI-UHFFFAOYSA-N ethyl eugenol Natural products CCOC1=CC=C(CC=C)C=C1OC OTMFQLIUPDESAI-UHFFFAOYSA-N 0.000 claims 5
- 229960002963 ganciclovir Drugs 0.000 claims 5
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 5
- 239000003193 general anesthetic agent Substances 0.000 claims 5
- 239000000665 guar gum Substances 0.000 claims 5
- 235000010417 guar gum Nutrition 0.000 claims 5
- 229960002154 guar gum Drugs 0.000 claims 5
- 239000003906 humectant Substances 0.000 claims 5
- 229960004716 idoxuridine Drugs 0.000 claims 5
- 229960001936 indinavir Drugs 0.000 claims 5
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 claims 5
- 229940079322 interferon Drugs 0.000 claims 5
- 229940074928 isopropyl myristate Drugs 0.000 claims 5
- 229960001627 lamivudine Drugs 0.000 claims 5
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 5
- 229960002509 miconazole Drugs 0.000 claims 5
- 229960000884 nelfinavir Drugs 0.000 claims 5
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 claims 5
- 229960000689 nevirapine Drugs 0.000 claims 5
- 229960003752 oseltamivir Drugs 0.000 claims 5
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 5
- 229960001237 podophyllotoxin Drugs 0.000 claims 5
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims 5
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 229960000888 rimantadine Drugs 0.000 claims 5
- 229960000311 ritonavir Drugs 0.000 claims 5
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims 5
- 229960001852 saquinavir Drugs 0.000 claims 5
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims 5
- 229960001203 stavudine Drugs 0.000 claims 5
- 229960002722 terbinafine Drugs 0.000 claims 5
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 5
- 230000000699 topical effect Effects 0.000 claims 5
- 229960003962 trifluridine Drugs 0.000 claims 5
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 claims 5
- 239000000230 xanthan gum Substances 0.000 claims 5
- 235000010493 xanthan gum Nutrition 0.000 claims 5
- 229920001285 xanthan gum Polymers 0.000 claims 5
- 229940082509 xanthan gum Drugs 0.000 claims 5
- 229960001028 zanamivir Drugs 0.000 claims 5
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 5
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims 4
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical class NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 4
- 108010010803 Gelatin Proteins 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 4
- 235000010418 carrageenan Nutrition 0.000 claims 4
- 239000000679 carrageenan Substances 0.000 claims 4
- 229920001525 carrageenan Polymers 0.000 claims 4
- 229940113118 carrageenan Drugs 0.000 claims 4
- 229960003749 ciclopirox Drugs 0.000 claims 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims 4
- 230000002500 effect on skin Effects 0.000 claims 4
- 229920000159 gelatin Polymers 0.000 claims 4
- 239000008273 gelatin Substances 0.000 claims 4
- 235000019322 gelatine Nutrition 0.000 claims 4
- 235000011852 gelatine desserts Nutrition 0.000 claims 4
- 230000037311 normal skin Effects 0.000 claims 4
- 229960003483 oxiconazole Drugs 0.000 claims 4
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 239000008107 starch Substances 0.000 claims 4
- 235000019698 starch Nutrition 0.000 claims 4
- 229960002607 sulconazole Drugs 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229960002555 zidovudine Drugs 0.000 claims 4
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 3
- 239000004698 Polyethylene Substances 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 206010040880 Skin irritation Diseases 0.000 claims 3
- 229960001830 amprenavir Drugs 0.000 claims 3
- YMARZQAQMVYCKC-OEMFJLHTSA-N amprenavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 YMARZQAQMVYCKC-OEMFJLHTSA-N 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 3
- 238000005336 cracking Methods 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 3
- 229920000573 polyethylene Polymers 0.000 claims 3
- 230000036556 skin irritation Effects 0.000 claims 3
- 231100000475 skin irritation Toxicity 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 2
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims 2
- 229960000735 docosanol Drugs 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229960000523 zalcitabine Drugs 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- 206010059313 Anogenital warts Diseases 0.000 claims 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims 1
- 208000000907 Condylomata Acuminata Diseases 0.000 claims 1
- 208000004898 Herpes Labialis Diseases 0.000 claims 1
- 206010019973 Herpes virus infection Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 claims 1
- 201000004201 anogenital venereal wart Diseases 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57753604P | 2004-06-07 | 2004-06-07 | |
| US60/577,536 | 2004-06-07 | ||
| US11/146,917 US8907153B2 (en) | 2004-06-07 | 2005-06-06 | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US11/146,917 | 2005-06-06 | ||
| PCT/US2005/020099 WO2005120473A2 (en) | 2004-06-07 | 2005-06-07 | Dermal peel-forming formulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013155944A Division JP5850889B2 (ja) | 2004-06-07 | 2013-07-26 | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008501805A JP2008501805A (ja) | 2008-01-24 |
| JP2008501805A5 true JP2008501805A5 (https=) | 2008-07-31 |
| JP5487461B2 JP5487461B2 (ja) | 2014-05-07 |
Family
ID=35460819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527680A Expired - Fee Related JP5487461B2 (ja) | 2004-06-07 | 2005-06-07 | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 |
| JP2013155944A Expired - Fee Related JP5850889B2 (ja) | 2004-06-07 | 2013-07-26 | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013155944A Expired - Fee Related JP5850889B2 (ja) | 2004-06-07 | 2013-07-26 | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8907153B2 (https=) |
| EP (1) | EP1753380A4 (https=) |
| JP (2) | JP5487461B2 (https=) |
| KR (1) | KR20070027694A (https=) |
| AU (1) | AU2005251805B2 (https=) |
| CA (1) | CA2569121C (https=) |
| WO (1) | WO2005120473A2 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| ES2637956T3 (es) | 2003-01-24 | 2017-10-18 | Stiefel Research Australia Pty Ltd | Espuma farmacéutica |
| JP2006527705A (ja) | 2003-06-19 | 2006-12-07 | コロプラスト アクティーゼルスカブ | 創傷ケアデバイス |
| BRPI0412752B8 (pt) * | 2003-07-24 | 2021-05-25 | Glaxosmithkline Llc | composição de filme de dissolução oral |
| US20070196457A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US20070196323A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs |
| US20070196293A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for treating photo damaged skin |
| US20070196452A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
| US20070189977A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Spray-on formulations and methods for dermal delivery of drugs |
| US20070189978A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for dermally treating musculoskeletal pain |
| US8741332B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US8741333B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20070196325A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for dermally treating infections |
| US20070190124A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs |
| US20070189980A1 (en) * | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for treating alopecia |
| US20080019927A1 (en) * | 2004-06-07 | 2008-01-24 | Jie Zhang | Compositions and methods for dermally treating neuropathy with minoxidil |
| US8080560B2 (en) * | 2004-12-17 | 2011-12-20 | 3M Innovative Properties Company | Immune response modifier formulations containing oleic acid and methods |
| TWI301542B (en) * | 2005-01-05 | 2008-10-01 | Ind Tech Res Inst | Taste sensing mixture and a sensor using the same and a sensory system using the same |
| GEP20125432B (en) | 2005-10-12 | 2012-03-26 | Unimed Pharmaceuticals Llc | Improved testosterone gel and use thereof |
| AU2006326388B2 (en) * | 2005-12-14 | 2013-01-24 | Nuvo Research Inc. | Compositions and methods for treating dermatological conditions |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US8337883B2 (en) * | 2006-11-03 | 2012-12-25 | Durect Corporation | Transdermal delivery systems |
| GB0622920D0 (en) * | 2006-11-17 | 2006-12-27 | Providence Capital Mangement | Topical treatment |
| WO2008070602A2 (en) * | 2006-12-04 | 2008-06-12 | Smithkline Beecham Corporation | Topical pharmaceutical composition |
| CA2675797A1 (en) * | 2007-01-16 | 2008-07-24 | Dermworx, Incorporated | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
| US9283177B2 (en) * | 2007-01-16 | 2016-03-15 | Juventio, Llc | Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic |
| US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
| US20130149362A1 (en) * | 2007-03-15 | 2013-06-13 | Benjamin Johnson | Treatment product and method |
| US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
| US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
| WO2009081262A1 (en) | 2007-12-18 | 2009-07-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| DK2079441T3 (da) | 2007-07-25 | 2010-12-13 | Ixodes Gmbh | Topisk antibiotisk sammensætning til forebyggelse af Lyme's sygdom |
| DE102007034976A1 (de) | 2007-07-26 | 2009-01-29 | Bayer Healthcare Ag | Arzneimittel zur transdermalen Anwendung bei Tieren |
| WO2010008600A1 (en) * | 2008-07-16 | 2010-01-21 | Dermworx Incorporated | Topical drug delivery system |
| TR201802083T4 (tr) * | 2008-10-24 | 2018-03-21 | Glaxosmithkline Biologicals Sa | Lipidatlı imidazokinolin türevleri. |
| AU2009312474B2 (en) | 2008-11-07 | 2014-12-04 | Insuline Medical Ltd. | Device and method for drug delivery |
| US9012477B2 (en) * | 2009-01-06 | 2015-04-21 | Nuvo Research Inc. | Method of treating neuropathic pain |
| US8193232B2 (en) * | 2009-02-13 | 2012-06-05 | Topica Pharmaceuticals, Inc. | Anti-fungal formulation |
| PT2400951T (pt) | 2009-02-25 | 2018-11-26 | Mayne Pharma Llc | Composições de espuma tópica |
| WO2011035120A2 (en) * | 2009-09-17 | 2011-03-24 | Gk Ventures, L.L.C. | Therapeutic composition to treat lesions caused by herpes simplex virus |
| US9693976B2 (en) | 2010-01-14 | 2017-07-04 | Crescita Therapeutics Inc. | Solid-forming local anesthetic formulations for pain control |
| EP2510930A1 (en) | 2011-04-15 | 2012-10-17 | Bionanoplus, S.L. | Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof |
| EP2714019A1 (en) * | 2011-05-26 | 2014-04-09 | Novartis AG | Compositions for percutaneous administration of physiologically active agents |
| JP2014520834A (ja) * | 2011-07-15 | 2014-08-25 | フェマロン エス．ペ．エール．エル． | Ｈｐｖの治療用の組成物および方法 |
| US8673279B2 (en) | 2011-08-31 | 2014-03-18 | Avon Products, Inc. | Cosmetic liquid extractor comprising nonionic polymers |
| CN104519869A (zh) | 2012-07-06 | 2015-04-15 | 利奥制药有限公司 | 用于递送活性成分至皮肤的包含成膜聚合物的局部组合物 |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| GB201317718D0 (en) | 2013-10-07 | 2013-11-20 | Buzzz Pharmaceuticals Ltd | Novel formulation |
| CN103520097B (zh) * | 2013-10-25 | 2015-12-30 | 北京金康驰医药投资有限公司 | 一种扎那米韦注射液及其制备方法 |
| WO2015080348A1 (ko) * | 2013-11-28 | 2015-06-04 | 주식회사 뉴앤뉴 | 문신용 입술 팩 화장료 조성물 및 이의 제조방법 |
| WO2016164315A1 (en) * | 2015-04-06 | 2016-10-13 | 3M Innovative Properties Company | Removable film forming gel compositions and methods for their application |
| EP3346998B1 (en) * | 2015-08-17 | 2025-04-16 | Sidmak Laboratories (India) PVT. Ltd. | Topical film delivery system |
| KR101671484B1 (ko) * | 2016-07-21 | 2016-11-01 | 김정환 | 오셀타미비르(Oseltamivir)를 포함하는 인유두종 바이러스 치료용 약학적 조성물 |
| EP3556368B1 (en) | 2016-12-16 | 2021-05-26 | Kaneka Corporation | Onychomycosis therapeutic agent |
| US20210161726A1 (en) * | 2017-11-06 | 2021-06-03 | Besthealth4U Unipessoal Lda | Adhesion Materials and Methods of Manufacture |
| JP6573019B1 (ja) * | 2018-10-25 | 2019-09-11 | 千住金属工業株式会社 | フラックス及びソルダペースト |
| CN115379823A (zh) * | 2020-01-23 | 2022-11-22 | 俄亥俄州立创新基金会 | 药妆组合物 |
| US20230181471A1 (en) * | 2020-07-09 | 2023-06-15 | Hoffmann-La Roche Inc. | Concentrated compositions of proteins, their preparation and use thereof |
| CN114668719B (zh) * | 2022-02-21 | 2023-06-16 | 广东食品药品职业学院 | 双氢睾酮混悬剂与双氢睾酮冻干粉及其制备方法 |
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| CN114600803B (zh) * | 2022-03-15 | 2023-05-09 | 北京协和建昊医药技术开发有限责任公司 | 一种斑马鱼cyp3a4代谢酶抑制模型、建立方法及应用 |
| CN116307280B (zh) * | 2023-05-18 | 2023-08-01 | 成都理工大学 | 一种酸性气藏气井储层硫堵损伤量化评估方法 |
| US12514756B1 (en) | 2024-10-08 | 2026-01-06 | Covidien Lp | Dermal patch and systems, kits, and methods associated therewith |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US574060A (en) * | 1896-12-29 | Centrifugal extractor | ||
| FR2047874A6 (https=) | 1969-06-10 | 1971-03-19 | Nouvel Lucien | |
| US4107161A (en) | 1972-05-13 | 1978-08-15 | J. Uriach & Cia. S.A. | Bis(triamcinolone acetonide)-4,4'-methylenebis-(3-methoxy-2-naphthoate) |
| GB2004746B (en) | 1977-10-03 | 1982-03-10 | Scherico Ltd | Stable hopical anaesthetic compositions |
| SE7713617L (sv) | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | Antitranspirationsmedel |
| JPS5528918A (en) | 1978-08-18 | 1980-02-29 | Kuraray Co Ltd | Coating material |
| US4430325A (en) | 1981-12-23 | 1984-02-07 | Colgate-Palmolive Company | Topical treatment of skin lesions |
| JPS5939825A (ja) | 1982-08-30 | 1984-03-05 | Terumo Corp | 外用基剤組成物 |
| CA1248450A (en) | 1984-04-05 | 1989-01-10 | Kazuo Kigasawa | Soft patch |
| US4645502A (en) | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
| US4780320A (en) | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
| US5091171B2 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
| JP2504077B2 (ja) | 1987-10-21 | 1996-06-05 | 日産化学工業株式会社 | 抗真菌剤組成物 |
| JP2635338B2 (ja) | 1987-10-22 | 1997-07-30 | 帝國製薬株式会社 | 保護膜形成型製剤 |
| IE64726B1 (en) | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| US5378730A (en) | 1988-06-09 | 1995-01-03 | Alza Corporation | Permeation enhancer comprising ethanol and monoglycerides |
| EP0386960A3 (en) | 1989-03-07 | 1991-10-23 | American Cyanamid Company | Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings |
| JP2797401B2 (ja) | 1989-04-19 | 1998-09-17 | 日産化学工業株式会社 | 爪用抗真菌剤組成物 |
| US4956171A (en) | 1989-07-21 | 1990-09-11 | Paco Pharmaceutical Services, Inc. | Transdermal drug delivery using a dual permeation enhancer and method of performing the same |
| US5183459A (en) | 1989-08-14 | 1993-02-02 | Avery Dennison Corporation | Emulsion pressure-sensitive adhesive polymers in bandage and medical tape constructions |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| IE82916B1 (en) | 1990-11-02 | 2003-06-11 | Elan Corp Plc | Formulations and their use in the treatment of neurological diseases |
| CA2040460C (en) | 1990-05-01 | 1997-06-10 | Tacey X. Viegas | Drug delivery with thermoreversible gels |
| CA2101083C (en) | 1991-02-01 | 2004-09-14 | Karl F. Popp | Improved flexible collodion compositions |
| DE4116912A1 (de) | 1991-05-18 | 1992-11-26 | Schering Ag | Mittel zur transdermalen applikation enthaltend ergolin-derivate |
| US5747022A (en) | 1993-07-30 | 1998-05-05 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic mask |
| US5460820B1 (en) | 1993-08-03 | 1999-08-03 | Theratech Inc | Method for providing testosterone and optionally estrogen replacement therapy to women |
| MX9604208A (es) | 1994-03-21 | 1998-05-31 | John Brown Thomsen | Gel para el tratamiento de enfermedades de la piely para la desinfeccion de la piel. |
| ATE180971T1 (de) | 1994-03-30 | 1999-06-15 | Gs Dev Ab | Verwendung von fettsäureester als bioklebstoffe |
| US5536263A (en) | 1994-03-30 | 1996-07-16 | Lectec Corporation | Non-occulusive adhesive patch for applying medication to the skin |
| DK0752898T3 (da) | 1994-03-30 | 1999-02-15 | Alza Corp | Mindskning af hudirritation ved elektrotransport-tilførsel |
| US5589156A (en) | 1994-05-02 | 1996-12-31 | Henry; Richard A. | Prilocaine and hydrofluourocarbon aerosol preparations |
| US5707981A (en) | 1994-07-28 | 1998-01-13 | Psorial, L.L.C. | Synergistic pharmaceutical compositions |
| DE4443888A1 (de) | 1994-12-09 | 1996-06-13 | Bayer Ag | Dermal applizierbare Formulierungen von Parasitiziden |
| US6245347B1 (en) | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
| US5658583A (en) | 1995-07-28 | 1997-08-19 | Zhang; Jie | Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals |
| FR2740678B1 (fr) | 1995-11-06 | 1999-05-14 | Oreal | Utilisation en cosmetique d'une composition solide ayant une matrice gelifiee et compositions cosmetiques ou dermatologiques mises en oeuvre |
| US5906814A (en) | 1995-12-07 | 1999-05-25 | The Andrew Jergens Company | Topical film-forming compositions |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5747060A (en) | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| SE9601421D0 (sv) | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
| US5955097A (en) | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| US6290986B1 (en) | 1996-10-24 | 2001-09-18 | Pharmaceutical Applications Associates, Llc | Method and composition for transdermal administration of pharmacologic agents |
| AUPO379596A0 (en) | 1996-11-22 | 1996-12-19 | Soltec Research Pty Ltd | Percutaneous delivery system |
| EP1021204B1 (en) | 1997-09-26 | 2005-12-28 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US20040018241A1 (en) | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
| DE69838338T2 (de) | 1997-10-22 | 2008-05-21 | Jens Rochester Ponikau | Verwendung von antimykotica zur topischen behandlung von pilz-induzierten schleimhautentzündungen |
| SE9704031D0 (sv) | 1997-11-05 | 1997-11-05 | Astra Ab | Novel formulation |
| US20030059471A1 (en) | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
| US6036966A (en) | 1998-02-17 | 2000-03-14 | Youssefyeh; Rena T. | Skin treatment compositions comprising protein and enzyme extracts |
| US6231875B1 (en) | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
| CA2325553A1 (en) | 1998-04-17 | 1999-10-28 | Penederm Inc. | Topical formulations for the treatment of nail fungal diseases |
| US20020182260A1 (en) * | 1998-05-29 | 2002-12-05 | Cellegy Pharmaceuticals, Inc. | Anti-inflammatory agents and methods for their preparation and use |
| JP4275768B2 (ja) * | 1998-06-18 | 2009-06-10 | 久光製薬株式会社 | 水性粘着膏体 |
| CN1314822A (zh) | 1998-06-29 | 2001-09-26 | 宝洁公司 | 一次性废物处理装置 |
| JP2000086440A (ja) | 1998-09-10 | 2000-03-28 | Noevir Co Ltd | ピールオフ型パック化粧料 |
| US6635674B1 (en) | 1998-11-06 | 2003-10-21 | Bristol-Myers Squibb Co. | Pharmaceutical preparations for external use containing non-steroidal anti-inflammatory and analgesic agents |
| US20040141925A1 (en) | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
| US6391869B1 (en) | 1998-12-14 | 2002-05-21 | Cellergy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| CA2267049A1 (en) | 1999-02-05 | 2000-08-05 | Bioglan Laboratories Ltd. | Pharmaceutical compositions |
| US6962691B1 (en) | 1999-05-20 | 2005-11-08 | U & I Pharmaceuticals Ltd. | Topical spray compositions |
| US6528086B2 (en) | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
| AUPQ419099A0 (en) * | 1999-11-23 | 1999-12-16 | Ko, Thomas Sai Ying | Novel compositions and methods |
| US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| US20030124176A1 (en) | 1999-12-16 | 2003-07-03 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
| US6432415B1 (en) | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US6495124B1 (en) | 2000-02-14 | 2002-12-17 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| AU2001243189B2 (en) | 2000-02-16 | 2005-06-09 | Cpex Pharmaceuticals, Inc. | Pharmaceutical composition |
| EP1177786A4 (en) | 2000-03-07 | 2004-09-22 | Teijin Ltd | EXTENDABLE PLASTER |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| AU2001282886A1 (en) | 2000-07-13 | 2002-01-30 | Pharmacia Corporation | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| DE10060550C1 (de) | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| US20020111377A1 (en) | 2000-12-22 | 2002-08-15 | Albany College Of Pharmacy | Transdermal delivery of cannabinoids |
| BR0206307A (pt) | 2001-01-09 | 2004-07-20 | Israel Dvoretzky | Composição terapêutica formadora de pelìcula e sistema de tratamento para a mesma |
| JP2002226354A (ja) | 2001-02-01 | 2002-08-14 | Noevir Co Ltd | ピールオフ型パック化粧料 |
| US6830758B2 (en) | 2001-04-02 | 2004-12-14 | Lectec Corporation | Psoriasis patch |
| CA2446622C (en) | 2001-05-11 | 2012-08-14 | Elan Corporation, Plc | Isostearic acid salts as permeation enhancers |
| US6821508B2 (en) | 2001-06-27 | 2004-11-23 | Rutgers, The State University | Composition and method for topical nail treatment |
| NZ532310A (en) | 2001-10-05 | 2007-02-23 | Combinatorx Inc | Combinations comprising a tetra-substituted pyrimidopyrimidine and a corticosteroid for the treatment of immunoinflammatory disorders |
| FR2832311B1 (fr) | 2001-11-21 | 2004-04-16 | Besins Int Belgique | Poudre filmogene, compositions la comprenant, leurs procedes de preparation et leurs utilisations |
| US20030118655A1 (en) | 2001-12-21 | 2003-06-26 | Nikhil Kundel | Film forming liquid composition |
| KR100843001B1 (ko) | 2002-01-16 | 2008-07-01 | 동화약품공업주식회사 | 구강점막 부착형 필름제제 |
| US6653346B1 (en) | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| US20030185915A1 (en) | 2002-03-28 | 2003-10-02 | Jaime Carlo | Synergetic composition for the treatment of psoriasis and other skin disorders and method therefor |
| TR200201556A2 (tr) | 2002-06-12 | 2004-01-21 | Orva İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Kortikosteroid ve nonsteroidal antienflamatuar içeren farmasötik bileşim |
| US20030049307A1 (en) | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
| EP1542695A1 (en) | 2002-09-17 | 2005-06-22 | Nippon Boehringer Ingelheim Co., Ltd. | Pharmaceutical composition for topical delivery of meloxicam comprising an amine or amine as penetration enhancer. |
| US20040143026A1 (en) | 2002-12-31 | 2004-07-22 | Shah Kishore R. | Bioadhesive hydrophilic composition for treatment of mammalian skin |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| WO2005065079A2 (en) | 2003-11-10 | 2005-07-21 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| US20070196452A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
| US20070189978A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for dermally treating musculoskeletal pain |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20070196457A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US20070189980A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Compositions and methods for treating alopecia |
| US20080019927A1 (en) | 2004-06-07 | 2008-01-24 | Jie Zhang | Compositions and methods for dermally treating neuropathy with minoxidil |
| US20070190124A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs |
| US20070196323A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs |
| US20070196293A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for treating photo damaged skin |
| US20070196325A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Compositions and methods for dermally treating infections |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US20070189977A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Spray-on formulations and methods for dermal delivery of drugs |
| US20070196453A1 (en) | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs |
| CN101137623B (zh) | 2005-03-15 | 2013-03-27 | 奈科明有限责任公司 | N-磺酰基吡咯及其作为组蛋白脱乙酰酶抑制剂的用途 |
| CN1739487A (zh) | 2005-08-30 | 2006-03-01 | 南京泰恒药物技术有限公司 | 药物凝胶喷雾制剂及其制备方法 |
| AU2006326388B2 (en) | 2005-12-14 | 2013-01-24 | Nuvo Research Inc. | Compositions and methods for treating dermatological conditions |
| EP1959931A4 (en) | 2005-12-14 | 2012-08-22 | Zars Pharma Inc | COMPOSITIONS AND METHODS FOR THE DERMAL TREATMENT OF PAIN |
| WO2007070695A2 (en) | 2005-12-14 | 2007-06-21 | Zars, Inc. | Flux-enabling compositions and methods for dermal delivery of drugs |
| US20070193453A1 (en) | 2006-02-02 | 2007-08-23 | Chef'n Corporation | Basting device |
| US20070280972A1 (en) | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| CN102970974B (zh) | 2010-05-06 | 2015-03-04 | 卢福研究公司 | 用于治疗皮炎和牛皮癣的去炎松缩酮制剂 |
-
2005
- 2005-06-06 US US11/146,917 patent/US8907153B2/en active Active
- 2005-06-07 KR KR20077000444A patent/KR20070027694A/ko not_active Withdrawn
- 2005-06-07 EP EP05760457A patent/EP1753380A4/en not_active Withdrawn
- 2005-06-07 WO PCT/US2005/020099 patent/WO2005120473A2/en not_active Ceased
- 2005-06-07 CA CA 2569121 patent/CA2569121C/en not_active Expired - Lifetime
- 2005-06-07 AU AU2005251805A patent/AU2005251805B2/en not_active Ceased
- 2005-06-07 JP JP2007527680A patent/JP5487461B2/ja not_active Expired - Fee Related
-
2013
- 2013-07-26 JP JP2013155944A patent/JP5850889B2/ja not_active Expired - Fee Related
-
2014
- 2014-11-05 US US14/533,419 patent/US9675562B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008501805A5 (https=) | ||
| JP5850889B2 (ja) | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 | |
| CN101378729B (zh) | 治疗皮肤症状的制剂和方法 | |
| US20070280972A1 (en) | Adhesive solid gel-forming formulations for dermal drug delivery | |
| RU2004118487A (ru) | Тонкоизмельченный пленкообразующий порошок, содержащие его композиции, способы его получения и применения | |
| US20070196323A1 (en) | Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs | |
| US20120294907A1 (en) | Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs | |
| JP5137286B2 (ja) | フェンタニル含有口腔粘膜貼付剤 | |
| US20070196457A1 (en) | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs | |
| JP2011506337A5 (https=) | ||
| JP2010529116A (ja) | マトリックス型経皮投与剤およびその製造方法 | |
| AU2006326034A1 (en) | Flux-enabling compositions and methods for dermal delivery of drugs | |
| CN101530401A (zh) | 一种用于治疗急慢性炎性疼痛的复方透皮贴片 | |
| TW200413026A (en) | Multilayered transmucosal therapeutic system | |
| WO2001039754A1 (fr) | Dispositif transdermique comprenant un reservoir et une matrice contenant le meme principe actif | |
| JPH057368B2 (https=) | ||
| CN114615974A (zh) | 环加氧酶抑制剂的局部制剂及其用途 | |
| JP5179184B2 (ja) | 歯用自己粘着フィルム | |
| JP4890856B2 (ja) | ジクロフェナク含有貼付剤 | |
| CN104415024B (zh) | 含双氯芬酸的巴布剂、及其组合物和制备方法 | |
| KR100552651B1 (ko) | 비스테로이드성 소염진통제 함유 플라스터 | |
| JP2019122702A (ja) | 口腔内粘膜保護フィルム | |
| AU2009323051B2 (en) | Bioadhesive patch | |
| Padula et al. | In vitro evaluation of bioadhesive films containing ibuprofen | |
| CN102970974A (zh) | 用于治疗皮炎和牛皮癣的去炎松缩酮制剂 |