JP2008094906A - 抗アレルゲン組成物 - Google Patents
抗アレルゲン組成物 Download PDFInfo
- Publication number
- JP2008094906A JP2008094906A JP2006276345A JP2006276345A JP2008094906A JP 2008094906 A JP2008094906 A JP 2008094906A JP 2006276345 A JP2006276345 A JP 2006276345A JP 2006276345 A JP2006276345 A JP 2006276345A JP 2008094906 A JP2008094906 A JP 2008094906A
- Authority
- JP
- Japan
- Prior art keywords
- allergen
- fiber
- water
- composition
- allergens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
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Abstract
抗アレルゲン組成物、特に不織布、繊維または繊維製品に加工できる、抗アレルゲン組成物および抗アレルゲン性能を有する不織布、繊維または繊維製品をを提供することを目的とする。
【解決手段】
カルボキシル基および/または水酸基を有する少なくとも一種類の水溶性高分子と、アルミニウムおよび/またはジルコニウムの塩を含有することを特徴とする抗アレルゲン組成物によってダニや花粉等のアレルゲンのアレルゲン性を低減化させることができ、またカーペット、畳、寝具類、カーテン、衣料品、ぬいぐるみ、マスク、フィルター材料、掃除用ウェットワイパー、電気掃除機の集塵袋等の不織布、繊維または繊維製品にアレルゲン性を低減化させる機能を付与することができる。
【選択図】 なし
Description
下記、表1に示す組成のものを、充分攪拌することにより、均一な溶液を得た。ポリビニルアルコールとしては日本合成化学株式会社製ゴーセノールを使用した。ポリアクリル酸は和光純薬工業製25%水溶液を使用した。
下記、表2に示す組成のものを、充分攪拌することにより、均一な溶液を得た。
(不織布への加工)
70g/m2の不織布(30cm×40cm、)を、実施例1〜4、比較例1〜5を各々15%となるように水で希釈した液に20分間浸漬し、しぼり率300%で処理後、105℃で20分間乾燥させた。処理した不織布を半分に切断し、一方をイオン交換水100mLに1時間浸漬することによって水洗を行った。水洗前および水洗後の不織布について抗アレルゲン試験を行った。
実施例または比較例を加工した不織布を5cm×5cmに切り取り、チャック付きポリ袋に投入し標準ダニアレルゲン懸濁液(アレルゲン量1000ng/mL)1mLを加え、試料とアレルゲンを接触させた。1時間後にチャック付きポリ袋からアレルゲン液を搾り出し、遠心分離後のこれら試料について Derf2酵素免疫測定法(ELISA)のサンドイッチ法にてダニアレルゲン低減化効果の測定を行った。まず、リン酸緩衝液(pH7.4、0.1重量%NaN3含有)で2μg/mLに希釈したDerf2 モノクローナル抗体15E11を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり100μLずつ添加し、4℃にて1日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2、0.1重量%NaN3含有)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。次に、加工不織布と接触させたダニアレルゲン抽出液試料を1ウェルあたり100μLずつ滴下し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。ペルオキシダーゼ標識したDerf2モノクローナル抗体を蒸留水で200μg/mLに溶解し、それをリン酸緩衝液{pH7.2、1重量%牛血清アルブミン及び0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で1000倍希釈した液を、1ウェルあたり100μLずつ添加した。37℃、60分間反応させた後、先ずリン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で、次いで蒸留水でプレートを洗浄した。0.1mol/Lリン酸緩衝液(pH6.2)13mLにオルト−フェニレンジアミンジヒドロクロライド(26mg Tablet、SIGMA CHEMICAL CO.製)と過酸化水素水13μLを加えたものを1ウェルあたり100μLずつ添加し、37℃、5分間反応させた。その後直ちに、2mol/L H2SO4を50μLずつ入れて反応を停止させ、マイクロプレート用分光光度計(Bio−Rad Laboratories Inc.製)で吸光度(OD490nm)を測定した。結果を表3に示した。
抗アレルゲン組成物によるスギ花粉アレルゲンCryj1の低減化効果の測定
実施例または比較例を加工した不織布を5cm×5cmに切り取り、チャック付きポリ袋に投入し標準スギ花粉アレルゲン液(アレルゲン量 35ng/mL)1mLを加え、試料とアレルゲンを接触させた。1時間後にチャック付きポリ袋からアレルゲン液を搾り出し、遠心分離後のこれら試料について Cryj1酵素免疫測定法(ELISA)のサンドイッチ法にてスギ花粉アレルゲン低減化効果の測定を行った。
まず、リン酸緩衝液(pH7.4、0.1重量%NaN3含有)で2μg/mLに希釈したCryj1 モノクローナル抗体013を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり100μLずつ添加し、4℃にて1日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2、0.1重量%NaN3含有)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。次に、加工不織布と接触させたスギ花粉アレルゲン抽出液試料を1ウェルあたり100μLずつ滴下し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。ペルオキシダーゼ標識したCryj1モノクローナル抗体053を蒸留水で200μg/mLに溶解し、それをリン酸緩衝液{pH7.2、1重量%牛血清アルブミン及び0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で1200倍希釈した液を、1ウェルあたり100μLずつ添加した。37℃、60分間反応させた後、先ずリン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}でプレートを洗浄した。0.1mol/Lリン酸緩衝液(pH6.2)13mLにオルト−フェニレンジアミンジヒドロクロライド(26mg Tablet、SIGMA CHEMICAL CO.製)と過酸化水素水13μLを加えたものを1ウェルあたり100μLずつ添加し、37℃、5分間反応させた。その後直ちに、2mol/L H2SO4を50μLずつ入れて反応を停止させ、マイクロプレート用分光光度計(Bio−Rad Laboratories Inc.製)で吸光度(OD490nm)を測定した。結果を表4に示した。
Claims (4)
- カルボキシル基および/または水酸基を有する少なくとも一種類の水溶性高分子と、アルミニウムおよび/またはジルコニウムの塩を含有することを特徴とする抗アレルゲン組成物。
- カルボキシル基および/または水酸基を有する少なくとも一種類の水溶性高分子が、ポリビニルアルコールおよび/またはポリアクリル酸であることを特徴とする請求項1記載の抗アレルゲン組成物。
- 請求項1または2記載の抗アレルゲン組成物を加工した不織布、繊維または繊維製品。
- 請求項1または2記載の抗アレルゲン組成物を、不織布、繊維または繊維製品に加工し、環境中に存在するアレルゲンのアレルゲン性を低減化させる方法。
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009173690A (ja) * | 2008-01-21 | 2009-08-06 | Japan Exlan Co Ltd | アレルゲン除去剤および該アレルゲン除去剤を付与してなるアレルゲン除去性能を有する製品 |
JP2016075005A (ja) * | 2014-10-08 | 2016-05-12 | 住化エンバイロメンタルサイエンス株式会社 | アレルゲン低減化壁紙およびその製造方法 |
GB2545405A (en) * | 2015-12-10 | 2017-06-21 | Louver-Lite Ltd | Coating composition |
WO2018055127A1 (fr) | 2016-09-23 | 2018-03-29 | Devan Chemicals | Composition de revêtement pour un textile |
FR3056607A1 (fr) * | 2016-09-23 | 2018-03-30 | Valeo Systemes Thermiques | Composition de revetement pour un textile |
JP2018172475A (ja) * | 2017-03-31 | 2018-11-08 | 大和化学工業株式会社 | 抗アレルゲン組成物及び該組成物によって処理された繊維・不織布又は繊維・不織布製品 |
JP2018177936A (ja) * | 2017-04-11 | 2018-11-15 | フマキラー株式会社 | 睡眠環境改善剤、睡眠環境改善製品及び睡眠環境改善方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001139479A (ja) * | 1999-09-01 | 2001-05-22 | Shinto Fine Co Ltd | 抗アレルゲン組成物及びアレルゲン不活化方法 |
JP2001247467A (ja) * | 2000-03-08 | 2001-09-11 | Shinto Fine Co Ltd | 抗アレルゲン組成物及びアレルゲン不活化方法 |
JP2004510841A (ja) * | 2000-09-29 | 2004-04-08 | ザ プロクター アンド ギャンブル カンパニー | アレルゲン中和組成物 |
JP2005194658A (ja) * | 2004-01-06 | 2005-07-21 | Sekisui Chem Co Ltd | アレルゲン抑制剤、並びに、アレルゲン抑制処理繊維及びその製造方法 |
-
2006
- 2006-10-10 JP JP2006276345A patent/JP4968899B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001139479A (ja) * | 1999-09-01 | 2001-05-22 | Shinto Fine Co Ltd | 抗アレルゲン組成物及びアレルゲン不活化方法 |
JP2001247467A (ja) * | 2000-03-08 | 2001-09-11 | Shinto Fine Co Ltd | 抗アレルゲン組成物及びアレルゲン不活化方法 |
JP2004510841A (ja) * | 2000-09-29 | 2004-04-08 | ザ プロクター アンド ギャンブル カンパニー | アレルゲン中和組成物 |
JP2005194658A (ja) * | 2004-01-06 | 2005-07-21 | Sekisui Chem Co Ltd | アレルゲン抑制剤、並びに、アレルゲン抑制処理繊維及びその製造方法 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009173690A (ja) * | 2008-01-21 | 2009-08-06 | Japan Exlan Co Ltd | アレルゲン除去剤および該アレルゲン除去剤を付与してなるアレルゲン除去性能を有する製品 |
JP2016075005A (ja) * | 2014-10-08 | 2016-05-12 | 住化エンバイロメンタルサイエンス株式会社 | アレルゲン低減化壁紙およびその製造方法 |
GB2545405A (en) * | 2015-12-10 | 2017-06-21 | Louver-Lite Ltd | Coating composition |
WO2018055127A1 (fr) | 2016-09-23 | 2018-03-29 | Devan Chemicals | Composition de revêtement pour un textile |
FR3056607A1 (fr) * | 2016-09-23 | 2018-03-30 | Valeo Systemes Thermiques | Composition de revetement pour un textile |
JP2018172475A (ja) * | 2017-03-31 | 2018-11-08 | 大和化学工業株式会社 | 抗アレルゲン組成物及び該組成物によって処理された繊維・不織布又は繊維・不織布製品 |
JP2018177936A (ja) * | 2017-04-11 | 2018-11-15 | フマキラー株式会社 | 睡眠環境改善剤、睡眠環境改善製品及び睡眠環境改善方法 |
JP2021191853A (ja) * | 2017-04-11 | 2021-12-16 | フマキラー株式会社 | 睡眠環境改善方法 |
JP7169017B2 (ja) | 2017-04-11 | 2022-11-10 | フマキラー株式会社 | 睡眠環境改善方法 |
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