JP2007534698A5 - - Google Patents

Info

Publication number

JP2007534698A5

JP2007534698A5 JP2007509735A JP2007509735A JP2007534698A5 JP 2007534698 A5 JP2007534698 A5 JP 2007534698A5 JP 2007509735 A JP2007509735 A JP 2007509735A JP 2007509735 A JP2007509735 A JP 2007509735A JP 2007534698 A5 JP2007534698 A5 JP 2007534698A5

Authority

JP

Japan

Prior art keywords

peptide

purified

complex

acid ester

gallic acid

Prior art date

2005-04-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• QJYNZEYHSMRWBK-NIKIMHBISA-N 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose Chemical group OC1=C(O)C(O)=CC(C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 QJYNZEYHSMRWBK-NIKIMHBISA-N 0.000 claims 26
• 239000000203 mixture Substances 0.000 claims 24
• LNTHITQWFMADLM-UHFFFAOYSA-N anhydrous gallic acid Natural products OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• -1 gallic acid ester Chemical class 0.000 claims 19
• 229940074391 gallic acid Drugs 0.000 claims 16
• 235000004515 gallic acid Nutrition 0.000 claims 16
• 238000009472 formulation Methods 0.000 claims 11
• WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 10
• WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 10
• 229940030275 epigallocatechin gallate Drugs 0.000 claims 10
• 238000000034 method Methods 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 6
• 150000003839 salts Chemical group 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• 108060003951 Immunoglobulin Proteins 0.000 claims 3
• 229940083963 Peptide antagonist Drugs 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 102000018358 immunoglobulin Human genes 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• 239000002244 precipitate Substances 0.000 claims 3
• 238000013268 sustained release Methods 0.000 claims 3
• 239000012730 sustained-release form Substances 0.000 claims 3
• BWKMGYQJPOAASG-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Chemical compound C1=CC=C2CNC(C(=O)O)CC2=C1 BWKMGYQJPOAASG-UHFFFAOYSA-N 0.000 claims 2
• LRHRHAWNXCGABU-UHFFFAOYSA-N 2-(cyclopentylazaniumyl)acetate Chemical compound OC(=O)CNC1CCCC1 LRHRHAWNXCGABU-UHFFFAOYSA-N 0.000 claims 2
• WFDSWNXTPKLLOT-UHNVWZDZSA-N 2-[[(2s,4r)-4-hydroxypyrrolidin-1-ium-2-carbonyl]amino]acetate Chemical compound O[C@H]1CN[C@H](C(=O)NCC(O)=O)C1 WFDSWNXTPKLLOT-UHNVWZDZSA-N 0.000 claims 2
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 2
• FUKDBQGFSJUXGX-RWMBFGLXSA-N Lys-Arg-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N)C(=O)O FUKDBQGFSJUXGX-RWMBFGLXSA-N 0.000 claims 2
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 2
• 229960002591 hydroxyproline Drugs 0.000 claims 2
• 108010050297 hydroxyprolyl-glycine Proteins 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000011259 mixed solution Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1