JPWO2020148525A5 - - Google Patents

Info

Publication number

JPWO2020148525A5

JPWO2020148525A5 JP2021540809A JP2021540809A JPWO2020148525A5 JP WO2020148525 A5 JPWO2020148525 A5 JP WO2020148525A5 JP 2021540809 A JP2021540809 A JP 2021540809A JP 2021540809 A JP2021540809 A JP 2021540809A JP WO2020148525 A5 JPWO2020148525 A5 JP WO2020148525A5

Authority

JP

Japan

Prior art keywords

seq

referred

peptide ligand

ligand according

peptide

Prior art date

2023-01-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 description 23
• 239000003446 ligand Substances 0.000 description 20
• 235000001014 amino acid Nutrition 0.000 description 6
• 150000001413 amino acids Chemical class 0.000 description 6
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 6
• 108700012439 CA9 Proteins 0.000 description 4
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 125000003275 alpha amino acid group Chemical group 0.000 description 3
• 229920001184 polypeptide Polymers 0.000 description 3
• 102000004196 processed proteins & peptides Human genes 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
• 239000002062 molecular scaffold Substances 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• FYBFGAFWCBMEDG-UHFFFAOYSA-N 1-[3,5-di(prop-2-enoyl)-1,3,5-triazinan-1-yl]prop-2-en-1-one Chemical compound C=CC(=O)N1CN(C(=O)C=C)CN(C(=O)C=C)C1 FYBFGAFWCBMEDG-UHFFFAOYSA-N 0.000 description 1
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 125000000539 amino acid group Chemical group 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 230000009137 competitive binding Effects 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 239000002254 cytotoxic agent Substances 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1