JPWO2020148526A5 - - Google Patents
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- JPWO2020148526A5 JPWO2020148526A5 JP2021563433A JP2021563433A JPWO2020148526A5 JP WO2020148526 A5 JPWO2020148526 A5 JP WO2020148526A5 JP 2021563433 A JP2021563433 A JP 2021563433A JP 2021563433 A JP2021563433 A JP 2021563433A JP WO2020148526 A5 JPWO2020148526 A5 JP WO2020148526A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- referred
- sar
- peptide ligand
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 22
- 239000003446 ligand Substances 0.000 description 19
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 108700012439 CA9 Proteins 0.000 description 4
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 239000002254 cytotoxic agent Substances 0.000 description 3
- 231100000599 cytotoxic agent Toxicity 0.000 description 3
- 239000002062 molecular scaffold Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GHITVUOBZBZMND-UHFFFAOYSA-N 1,3,5-tris(bromomethyl)benzene Chemical compound BrCC1=CC(CBr)=CC(CBr)=C1 GHITVUOBZBZMND-UHFFFAOYSA-N 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 125000002619 bicyclic group Chemical group 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1900526.3 | 2019-01-15 | ||
| GBGB1900526.3A GB201900526D0 (en) | 2019-01-15 | 2019-01-15 | Bicyclic peptide ligands specific for caix |
| PCT/GB2020/050070 WO2020148526A1 (en) | 2019-01-15 | 2020-01-15 | Bicyclic peptide ligands specific for caix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022517442A JP2022517442A (ja) | 2022-03-08 |
| JPWO2020148526A5 true JPWO2020148526A5 (enExample) | 2023-01-25 |
Family
ID=65528170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563433A Pending JP2022517442A (ja) | 2019-01-15 | 2020-01-15 | Ｃａｉｘに特異的な二環式ペプチドリガンド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220133732A1 (enExample) |
| EP (1) | EP3911743A1 (enExample) |
| JP (1) | JP2022517442A (enExample) |
| CN (1) | CN113383074A (enExample) |
| GB (1) | GB201900526D0 (enExample) |
| WO (1) | WO2020148526A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017008575B1 (pt) | 2014-10-29 | 2021-07-13 | Bicyclerd Limited | Ligantes de peptídeos bicíclicos específicos a mt1-mmp, conjugado de fármaco, processo para preparação de um conjugado de fármaco e composição farmacêutica |
| CN118772242A (zh) | 2017-08-04 | 2024-10-15 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| BR112020014576A2 (pt) | 2018-02-23 | 2020-12-08 | Bicycletx Limited | Ligantes peptídicos bicíclicos multiméricos |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| CN113474045A (zh) | 2018-12-21 | 2021-10-01 | 拜斯科技术开发有限公司 | Pd-l1特异性的双环肽配体 |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| EP4448544A2 (en) | 2021-12-17 | 2024-10-23 | 3B Pharmaceuticals GmbH | Carbonic anhydrase ix ligands |
| KR102701447B1 (ko) * | 2022-02-11 | 2024-09-03 | (주)씨바이오멕스 | 탄산탈수소효소 ix를 표적으로 하는 펩타이드 리간드,이를 포함하는 펩타이드 구조체 및 이들의 용도 |
| WO2024041535A1 (zh) * | 2022-08-22 | 2024-02-29 | 赣州和美药业股份有限公司 | 纳米组合物及其制备方法和用途 |
| CN120230182B (zh) * | 2025-05-29 | 2025-08-22 | 北京肿瘤医院(北京大学肿瘤医院) | 经修饰的caix靶向环肽及其核素标记物与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| JP5372380B2 (ja) | 2005-01-24 | 2013-12-18 | ペプスキャン システムズ ベー．フェー． | 結合化合物、免疫原性化合物およびペプチド模倣体 |
| ES2509959T5 (en) | 2008-02-05 | 2024-12-19 | Bicyclerd Ltd | Methods and compositions |
| BR112017008575B1 (pt) | 2014-10-29 | 2021-07-13 | Bicyclerd Limited | Ligantes de peptídeos bicíclicos específicos a mt1-mmp, conjugado de fármaco, processo para preparação de um conjugado de fármaco e composição farmacêutica |
| GB201607827D0 (en) * | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| US10857196B2 (en) * | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| CN111032678A (zh) * | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
-
2019
- 2019-01-15 GB GBGB1900526.3A patent/GB201900526D0/en not_active Ceased
-
2020
- 2020-01-15 US US17/422,933 patent/US20220133732A1/en not_active Abandoned
- 2020-01-15 EP EP20701119.8A patent/EP3911743A1/en not_active Withdrawn
- 2020-01-15 CN CN202080009486.9A patent/CN113383074A/zh active Pending
- 2020-01-15 JP JP2021563433A patent/JP2022517442A/ja active Pending
- 2020-01-15 WO PCT/GB2020/050070 patent/WO2020148526A1/en not_active Ceased